Search Results - "Yager, J."

Sphingolipids as Potential Therapeutic Targets against Enveloped Human RNA Viruses by Yager, Eric J., Konan, Kouacou V.

“…Several notable human diseases are caused by enveloped RNA viruses: Influenza, AIDS, hepatitis C, dengue hemorrhagic fever, microcephaly, and Guillain–Barré…”
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Proposal of a 2-Tier Histologic Grading System for Canine Cutaneous Mast Cell Tumors to More Accurately Predict Biological Behavior by Kiupel, M., Webster, J. D., Bailey, K. L., Best, S., DeLay, J., Detrisac, C. J., Fitzgerald, S. D., Gamble, D., Ginn, P. E., Goldschmidt, M. H., Hendrick, M. J., Howerth, E. W., Janovitz, E. B., Langohr, I., Lenz, S. D., Lipscomb, T. P., Miller, M. A., Misdorp, W., Moroff, S., Mullaney, T. P., Neyens, I., O’Toole, D., Ramos-Vara, J., Scase, T. J., Schulman, F. Y., Sledge, D., Smedley, R. C., Smith, K., W. Snyder, P., Southorn, E., Stedman, N. L., Steficek, B. A., Stromberg, P. C., Valli, V. E., Weisbrode, S. E., Yager, J., Heller, J., Miller, R.

“…Currently, prognostic and therapeutic determinations for canine cutaneous mast cell tumors (MCTs) are primarily based on histologic grade. However, the use of…”
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Endogenous estrogens as carcinogens through metabolic activation by Yager, J D

“…A common thread linking the main risks for developing breast cancer in women is cumulative, excessive exposure to estrogen. The standard paradigm to account…”
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T-cell immunosenescence: lessons learned from mouse models of aging by Maue, Alexander C, Yager, Eric J, Swain, Susan L, Woodland, David L, Blackman, Marcia A, Haynes, Laura

“…It is well established that increasing age is associated with a decreased capacity of the immune system to mediate effective immune responses to vaccination…”
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Incidence of acquired demyelination of the CNS in Canadian children by BANWELL, B, KENNEDY, J, SEBIRE, G, MEANEY, B, DILENGE, M.-E, LORTIE, A, WHITING, S, DOJA, A, LEVIN, S, MACDONALD, E. A, MEEK, D, WOOD, E, SADOVNICK, D, LOWRY, N, BUCKLEY, D, YIM, C, AWUKU, M, GUIMOND, C, COOPER, P, GRAND'MAISON, F, BAIRD, J. B, BHAN, V, BAR-OR, A, ARNOLD, D. L, MAGALHAES, S, WAMBERA, K, CONNOLLY, M. B, YAGER, J, MAH, J. K, SHAH, N

“…The incidence of acquired demyelination of the CNS (acquired demyelinating syndromes [ADS]) in children is unknown. It is important that physicians recognize…”
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Degraded mitochondrial DNA is a newly identified subtype of the damage associated molecular pattern (DAMP) family and possible trigger of neurodegeneration by Mathew, Alex, Lindsley, Tara A, Sheridan, Anna, Bhoiwala, Devang L, Hushmendy, Shazaan F, Yager, Eric J, Ruggiero, Elizabeth A, Crawford, Dana R

“…We previously showed a preferential degradation and down-regulation of mitochondrial DNA and RNA in hamster fibroblasts in response to hydrogen peroxide…”
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Broccoli sprout supplementation during pregnancy prevents brain injury in the newborn rat following placental insufficiency by Black, A.M., Armstrong, E.A., Scott, O., Juurlink, B.J.H., Yager, J.Y.

“…•Placental insufficiency causes fetal growth restriction (FGR).•FGR is associated with developmental disability and increased cerebral palsy (CP).•Broccoli…”
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Melanocytes and keratinocytes have distinct and shared responses to ultraviolet radiation and arsenic by Cooper, K.L., Yager, J.W., Hudson, L.G.

“…•Melanocytes are more resistant to UV toxicity than keratinocytes.•Greater arsenic and UV are required for comparable ROS induction in melanocytes.•Both cell…”
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Canine Subcutaneous Mast Cell Tumor: Characterization and Prognostic Indices by Thompson, J. J., Pearl, D. L., Yager, J. A., Best, S. J., Coomber, B. L., Foster, R. A.

“…Histologic grading schemes for canine cutaneous mast cell tumors (MCTs) were not developed for subcutaneous MCTs. Despite this, subcutaneous MCTs are currently…”
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Comparative effectiveness of antiretroviral drug classes for the treatment of HIV infection in patients with high viral loads: a multicentre retrospective cohort study by Adams, JL, Murray, M, Patel, N, Sawkin, MT, Boardman, RC, Pham, C, Kaur, H, Patel, D, Yager, JL, Pontiggia, L, Baxter, J

“…Objectives We aimed to compare the effectiveness of antiretroviral therapy (ART) classes for achieving HIV RNA suppression to < 50 HIV‐1 RNA copies/mL within…”
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Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following subchronic exposure to arsenate in drinking water by Kenyon, E.M., Hughes, M.F., Adair, B.M., Highfill, J.H., Crecelius, E.A., Clewell, H.J., Yager, J.W.

“…The relationship of exposure and tissue concentration of parent chemical and metabolites over prolonged exposure is a critical issue for chronic toxicities…”
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GM-CSF increases mucosal and systemic immunogenicity of an H1N1 influenza DNA vaccine administered into the epidermis of non-human primates by Loudon, Peter T, Yager, Eric J, Lynch, Debbie T, Narendran, Amithi, Stagnar, Cristy, Franchini, Anthony M, Fuller, James T, White, Phil A, Nyuandi, Julia, Wiley, Clayton A, Murphey-Corb, Michael, Fuller, Deborah H

“…The recent H5N1 avian and H1N1 swine-origin influenza virus outbreaks reaffirm that the threat of a world-wide influenza pandemic is both real and…”
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Maternal serum proteome changes between the first and third trimester of pregnancy in rural Southern Nepal by Scholl, P.F, Cole, R.N, Ruczinski, I, Gucek, M, Diez, R, Rennie, A, Nathasingh, C, Schulze, K, Christian, P, Yager, J.D, Groopman, J.D, West, K.P

“…Abstract Characterization of normal changes in the serum proteome during pregnancy may enhance understanding of maternal physiology and lead to the development…”
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Molecular mechanisms of estrogen carcinogenesis by Yager, J D, Liehr, J G

“…In western society, the causes of several cancers--including breast, endometrium, ovary, liver, and prostate--have been linked to inappropriate and/or…”
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Antibody-dependent enhancement and COVID-19: Moving toward acquittal by Yager, Eric J.

“…•Immunoglobulins represent an effective therapeutic option for the treatment of COVID-19.•Experimental findings of ADE with related coronaviruses provoked…”
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Brain biocompatibility and microglia response towards engineered self-assembling (RADA)4 nanoscaffolds by Koss, K.M., Churchward, M.A., Nguyen, A.T., Yager, J.Y., Todd, K.G., Unsworth, L.D.

“…[Display omitted] (RADA)4-based nanoscaffolds have many inherent properties making them amenable to tissue engineering applications: ease of synthesis, ease of…”
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Concentration- and Time-dependent Genomic Changes in the Mouse Urinary Bladder Following Exposure to Arsenate in Drinking Water for up to 12 Weeks by Clewell, H. J., Thomas, R. S., Kenyon, E. M., Hughes, M. F., Adair, B. M., Gentry, P. R., Yager, J. W.

“…Inorganic arsenic (Asi) is a known human bladder carcinogen. The objective of this study was to examine the concentration dependence of the genomic response to…”
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Therapeutic DNA vaccine induces broad T cell responses in the gut and sustained protection from viral rebound and AIDS in SIV-infected rhesus macaques by Fuller, Deborah Heydenburg, Rajakumar, Premeela, Che, Jenny W, Narendran, Amithi, Nyaundi, Julia, Michael, Heather, Yager, Eric J, Stagnar, Cristy, Wahlberg, Brendon, Taber, Rachel, Haynes, Joel R, Cook, Fiona C, Ertl, Peter, Tite, John, Amedee, Angela M, Murphey-Corb, Michael

“…Immunotherapies that induce durable immune control of chronic HIV infection may eliminate the need for life-long dependence on drugs. We investigated a DNA…”
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Canine Subcutaneous Mast Cell Tumors: Cellular Proliferation and KIT Expression as Prognostic Indices by Thompson, J. J., Yager, J. A., Best, S. J., Pearl, D. L., Coomber, B. L., Torres, R. N., Kiupel, M., Foster, R. A.

“…Molecular assays are widely used to prognosticate canine cutaneous mast cell tumors (MCT). There is limited information about these prognostic assays used on…”
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Comparison of Frequencies of Drug-Drug Interactions between Sofosbuvir/Ledipasvir and Ombitasvir/Dasabuvir/Paritaprevir/Ritonavir +/− Ribavirin among HIV/HCV Coinfected Patients by Schriever, C, Ahmed, A, Delehanty, K.R, Yager, J, Farrow, G, Kashtan, R, Lodise, T, Patel, N

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