Search Results - "Yafawi, Rolla"

The contribution of lysosomotropism to autophagy perturbation by Ashoor, Roshan, Yafawi, Rolla, Jessen, Bart, Lu, Shuyan

“…Autophagy refers to the catabolic process in eukaryotic cells that delivers cytoplasmic material to lysosomes for degradation. This highly conserved process is…”
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Immunomodulatory Effect of the Topical Ophthalmic Janus Kinase Inhibitor Tofacitinib (CP-690,550) in Patients with Dry Eye Disease by Huang, Jing-Feng, PhD, Yafawi, Rolla, BSc, Zhang, Min, MS, McDowell, Michael, PhD, Rittenhouse, Kay D., PhD, Sace, Frederick, MS, Liew, Shiao Hui (Melissa), MB, BS, Cooper, Scott R., MBA, Pickering, Eve H., PhD

“…Objective To evaluate the immunomodulatory effect of topical ophthalmic tofacitinib (CP-690,550) after an 8-week treatment period in patients with dry eye…”
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Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia by Kashyap, Manoj K, Amaya-Chanaga, Carlos I, Kumar, Deepak, Simmons, Brett, Huser, Nanni, Gu, Yin, Hallin, Max, Lindquist, Kevin, Yafawi, Rolla, Choi, Michael Y, Amine, Ale-Ali, Rassenti, Laura Z, Zhang, Cathy, Liu, Shu-Hui, Smeal, Tod, Fantin, Valeria R, Kipps, Thomas J, Pernasetti, Flavia, Castro, Januario E

“…The CXCR4-CXCL12 axis plays an important role in the chronic lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has been reported…”
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A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies by Liu, Shu-Hui, Gu, Yin, Pascual, Bernadette, Yan, Zhengming, Hallin, Max, Zhang, Cathy, Fan, Conglin, Wang, Wenlian, Lam, Justine, Spilker, Mary E., Yafawi, Rolla, Blasi, Eileen, Simmons, Brett, Huser, Nanni, Ho, Wei-Hsien, Lindquist, Kevin, Tran, Thomas-Toan, Kudaravalli, Jyothirmayee, Ma, Jing-Tyan, Jimenez, Gretchen, Barman, Ishita, Brown, Colleen, Chin, Sherman Michael, Costa, Maria J., Shelton, David, Smeal, Tod, Fantin, Valeria R., Pernasetti, Flavia

“…The chemokine receptor CXCR4 is highly expressed and associated with poor prognosis in multiple malignancies. Upon engagement by its ligand, CXCL12, CXCR4…”
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Association of leukemic molecular profile with efficacy of inotuzumab ozogamicin in adults with relapsed/refractory ALL by Zhao, Yaqi, Laird, A. Douglas, Roberts, Kathryn G., Yafawi, Rolla, Kantarjian, Hagop, DeAngelo, Daniel J., Stelljes, Matthias, Liedtke, Michaela, Stock, Wendy, Gökbuget, Nicola, O’Brien, Susan, Jabbour, Elias, Cassaday, Ryan D., Loyd, Melanie R., Olsen, Scott, Neale, Geoffrey, Liu, Xueli, Vandendries, Erik, Advani, Anjali, Mullighan, Charles G.

“…•Responses to inotuzumab were observed in all leukemic subtypes, genomic alterations, and risk groups.•Inotuzumab demonstrated superior efficacy vs…”
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Abstract 2649: Fc-effector function activity of the CXCR4 IgG1 antibody PF-06747143: a novel clinical candidate for the treatment of hematologic malignancies by Pernasetti, Flavia, Liu, Shu-Hui, Yin, Gu, Pascual, Bernadette, Yan, Zhengming, Hallin, Max, Yafawi, Rolla, Zhang, Cathy, Fang, Connie, Wang, Wenlian, Lam, Justine, Spilker, Mary E., Blasi, Eileen, Simmons, Brett, Huser, Nanni, Ho, Wei-Hsien, Lindquist, Kevin, Tran, Thomas-Toan, Kudaravalli, Jyothirmayee, Ma, Jing-Tyan, Jimenez, Gretchen, Barman, Ishita, Brown, Colleen, Chin, Sherman-Michael, Costa, Maria, Shelton, David, Smeal, Tod, Fantin, Valeria R.

“…Abstract The chemokine receptor CXCR4 triggers signaling pathways that control cell migration to tissues where its ligand, CXCL12, is highly expressed,…”
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Abstract CT027: Exploration of association of leukemic molecular profile with efficacy in patients (pts) with relapsed/refractory acute lymphoblastic leukemia (ALL) treated with inotuzumab ozogamicin (InO) in the phase 3 INO-VATE trial by Zhao, Yaqi, Laird, A Douglas, Roberts, Kathryn, Yafawi, Rolla, Kantarjian, Hagop, DeAngelo, Daniel J., Stelljes, Matthias, Liedtke, Michaela, Stock, Wendy, Gökbuget, Nicola, O'Brien, Susan, Jabbour, Elias, Cassaday, Ryan D., Loyd, Melanie R., Olsen, Scott, Neale, Geoffrey, Liu, Xueli, Vandendries, Erik, Mullighan, Charles G., Advani, Anjali

“…Abstract Background: INO-VATE (NCT01564784) demonstrated higher rates of remission, MRD-negativity, and improved overall survival (hazard ratio 0.75, one-sided…”
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Assay development and validation of inflammatory markers in impression cytology specimens (144.19) by Yafawi, Rolla, Sace, Frederick, Huang, Jing-Feng, John-Baptiste, Annette

“…Abstract The principle of Impression Cytology (IC) utilizes a non-invasive technique to remove superficial layers of the ocular surface. The application of a…”
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Comparison of 3 Kidney Injury Multiplex Panels in Rats by John-Baptiste, Annette, Vitsky, Allison, Sace, Frederick, Zong, Qing, Ko, Mira, Yafawi, Rolla, Liu, Ling

“…Kidney injury biomarkers have been utilized by pharmaceutical companies as a means to assess the potential of candidate drugs to induce nephrotoxicity…”
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Limitations of an ocular surface inflammatory biomarker in impression cytology specimens by Yafawi, Rolla, Ko, Mira, Sace, Frederick P., John-Baptiste, Annette

“…Context: A number of ocular conditions, such as dry eye, are associated with inflammation on the surface of the eye leading to irritation and ocular pain. Many…”
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High Level Phosphatase Activity Revealed in Chronic Lymphocytic Leukemia Cells That Use Mutated Immunoglobulin Heavy Chain Variable Region Genes and Lack High-Level Expression of the Zeta-Associated Protein 70 (ZAP-70) by Fantl, Wendy J., Yafawi, Rolla L., Putta, Santosh K., Huang, Ying-Wen, Francis-Lang, Helen L., Laura, Rassenti Z., Cohen, Aileen Cleary, Kipps, Thomas J.

“…Signals propagated through the B cell receptor (BCR) guide the maturation and survival of B cells and might factor in the pathogenesis and progression of…”
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