Search Results - "Yadlapalli, Jai Shankar K."

A pharmacokinetic study of morphine‐6‐O‐sulfate in rat plasma and brain by Yadlapalli, Jai Shankar K., Albayati, Zaineb A. F., Breen, Philip J., Dobretsov, Maxim, Penthala, Narsimha R., Hendrickson, Howard P., Crooks, Peter A.

“…Morphine‐6‐O‐sulfate (M6S), a polar, zwitterionic sulfate ester of morphine, is a powerful and safe analgesic in several rat models of pain. A sensitive liquid…”
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Evaluation of morphine‐like effects of the mixed mu/delta agonist morphine‐6‐O‐sulfate in rats: Drug discrimination and physical dependence by Yadlapalli, Jai Shankar K., Bommagani, Shoban Babu, Mahelona, Ryan D., Wan, Anqi, Gannon, Brenda M., Penthala, Narsimha R., Dobretsov, Maxim, Crooks, Peter A., Fantegrossi, William E.

“…Morphine‐6‐O‐sulfate (M6S) is as a mixed‐action mu/delta (μ/δ) opioid receptor agonist with high potency and analgesic efficacy. These studies used assays of…”
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Evaluation of Analgesia, Tolerance, and the Mechanism of Action of Morphine-6- O -Sulfate Across Multiple Pain Modalities in Sprague-Dawley Rats by Yadlapalli, Jai Shankar K., Dogra, Navdeep, Walbaum, Anqi W., Wessinger, William D., Prather, Paul L., Crooks, Peter A., Dobretsov, Maxim

“…Morphine-6-O-sulfate (M6S) is a mixed μ/δ-opioid receptor (OR) agonist and potential alternative to morphine for treatment of chronic multimodal pain. To…”
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Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome? by Yadlapalli, Jai Shankar K., Dogra, Navdeep, Walbaum, Anqi W., Prather, Paul L., Crooks, Peter A., Dobretsov, Maxim

“…•Pinprick pain threshold was studied in a rat model of diabetes.•Diabetic animals developed either pinprick hypoalgesia or pinprick hyperalgesia.•The pain…”
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Antinociceptive effects of the 6-O-sulfate ester of morphine in normal and diabetic rats: Comparative role of mu- and delta-opioid receptors by Yadlapalli, Jai Shankar K., Ford, Benjamin M., Ketkar, Amit, Wan, Anqi, Penthala, Narasimha R., Eoff, Robert L., Prather, Paul L., Dobretsov, Maxim, Crooks, Peter A.

“…In vivo analysis of morphine- and M6S-induced (i.p.) antinociception was examined by hot water tail flick latency test in naive and diabetic rats. In vitro…”
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Preclinical assessment of utility of M6S for multimodal acute and chronic pain treatment in diabetic neuropathy by Yadlapalli, Jai Shankar K., Dogra, Navdeep, Walbaum, Anqi W., Prather, Paul L., Crooks, Peter A., Dobretsov, Maxim

“…Previous reports from our laboratory have established that morphine-6-O-sulfate (M6S) is a mixed μ/δ opioid receptor (OR) agonist and a potential improved…”
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Degenerative Tissue Responses to Space-like Radiation Doses in a Rodent Model of Simulated Microgravity by Chowdhury, Parimal, Akel, Nisreen, Jamshidi-Parsian, Azemat, Gaddy, Dana, Griffin, Robert J, Yadlapalli, Jai Shankar K, Dobretsov, Maxim

“…This study examines acute and degenerative tissue responses to space-like radiation doses in a rodent model of simulated microgravity. We have studied four…”
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Stability studies of potent opioid analgesic, morphine‐6‐O‐sulfate in various buffers and biological matrices by HPLC‐DAD analysis by Yadlapalli, Jai Shankar K., Albayati, Zaineb A.F., Penthala, Narasimha R., Hendrickson, Howard P., Crooks, Peter A.

“…The 6‐O‐sulfate ester of morphine (M6S) has previously been shown to be an analgesic with greater potency and fewer side effects than morphine. However, being…”
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Preclinical evaluation of the 6-O-sulfate ester of morphine for the treatment of multimodal acute and chronic pain by Yadlapalli, Jai Shankar K

“…Chronic pain is a huge economic burden and a devastating complication requiring therapeutic interventions. This dissertation evaluated the analgesic potency,…”
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Seeking Predictable Subject Characteristics That Influence Clinical Trial Discontinuation by Yadlapalli, Jai Shankar K.B., Martin, Irwin G.

“…Subject retention is one of the key factors that determine success of a clinical trial. Many researchers have focused on the issue of recruitment, and few have…”
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