Search Results - "Yadav, Neelu"

Restoration of mitochondria function as a target for cancer therapy by Bhat, Tariq A., Kumar, Sandeep, Chaudhary, Ajay K., Yadav, Neelu, Chandra, Dhyan

“…•Mitochondria dysfunction is a key reason for therapy resistance in cancer.•Defective oxidative phosphorylation contributes to mitochondria dysfunction.•Heat…”
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A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60 by Kumar, Rahul, Chaudhary, Ajay K, Woytash, Jordan, Inigo, Joseph R, Gokhale, Abhiram A, Bshara, Wiam, Attwood, Kristopher, Wang, Jianmin, Spernyak, Joseph A, Rath, Eva, Yadav, Neelu, Haller, Dirk, Goodrich, David W, Tang, Dean G, Chandra, Dhyan

“…Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival…”
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A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer by Liu, Song, Kumari, Sangeeta, Hu, Qiang, Senapati, Dhirodatta, Venkadakrishnan, Varadha Balaji, Wang, Dan, DePriest, Adam D, Schlanger, Simon E, Ben-Salem, Salma, Valenzuela, Malyn May, Willard, Belinda, Mudambi, Shaila, Swetzig, Wendy M, Das, Gokul M, Shourideh, Mojgan, Koochekpour, Shahriah, Falzarano, Sara Moscovita, Magi-Galluzzi, Cristina, Yadav, Neelu, Chen, Xiwei, Lao, Changshi, Wang, Jianmin, Billaud, Jean-Noel, Heemers, Hannelore V

“…Standard treatment for metastatic prostate cancer (CaP) prevents ligand-activation of androgen receptor (AR). Despite initial remission, CaP progresses while…”
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Small Molecule Regulators of Protein Arginine Methyltransferases by Cheng, Donghang, Yadav, Neelu, King, Randall W, Swanson, Maurice S, Weinstein, Edward J, Bedford, Mark T

“…Here we report the identification of small molecules that specifically inhibit protein arginine N -methyltransferase (PRMT) activity. PRMTs are a family of…”
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CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells by O'Brien, Karen B, Alberich-Jordà, Meritxell, Yadav, Neelu, Kocher, Olivier, Diruscio, Annalisa, Ebralidze, Alexander, Levantini, Elena, Sng, Natasha J L, Bhasin, Manoj, Caron, Tyler, Kim, Daehoon, Steidl, Ulrich, Huang, Gang, Halmos, Balázs, Rodig, Scott J, Bedford, Mark T, Tenen, Daniel G, Kobayashi, Susumu

“…Coactivator-associated arginine methyltransferase I (CARM1; PRMT4) regulates gene expression by multiple mechanisms including methylation of histones and…”
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RhoA as a Mediator of Clinically Relevant Androgen Action in Prostate Cancer Cells by Schmidt, Lucy J, Duncan, Kelly, Yadav, Neelu, Regan, Kevin M, Verone, Alissa R, Lohse, Christine M, Pop, Elena A, Attwood, Kristopher, Wilding, Gregory, Mohler, James L, Sebo, Thomas J, Tindall, Donald J, Heemers, Hannelore V

“…Recently, we have identified serum response factor (SRF) as a mediator of clinically relevant androgen receptor (AR) action in prostate cancer (PCa). Genes…”
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The Novel Human Protein Arginine N-Methyltransferase PRMT6 Is a Nuclear Enzyme Displaying Unique Substrate Specificity by Frankel, Adam, Yadav, Neelu, Lee, Jaeho, Branscombe, Tina L., Clarke, Steven, Bedford, Mark T.

“…Protein arginine methylation is a prevalent posttranslational modification in eukaryotic cells that has been implicated in signal transduction, the metabolism…”
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Specific Protein Methylation Defects and Gene Expression Perturbations in Coactivator-Associated Arginine Methyltransferase 1-Deficient Mice by Yadav, Neelu, Lee, Jaeho, Kim, Jeesun, Shen, Jianjun, Mickey C. -T. Hu, Aldaz, C. Marcelo, Bedford, Mark T.

“…Arginine methylation has been implicated in the regulation of gene expression. The coactivator-associated arginine methyltransferase 1 (CARM1/PRMT4) binds the…”
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Correction: A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer by Liu, Song, Kumari, Sangeeta, Hu, Qiang, Senapati, Dhirodatta, Venkadakrishnan, Varadha Balaji, Wang, Dan, DePriest, Adam D, Schlanger, Simon E, Ben-Salem, Salma, Valenzuela, Malyn May, Willard, Belinda, Mudambi, Shaila, Swetzig, Wendy M, Das, Gokul M, Shourideh, Mojgan, Koochekpour, Shahriah, Falzarano, Sara Moscovita, Magi-Galluzzi, Cristina, Yadav, Neelu, Chen, Xiwei, Lao, Changshi, Wang, Jianmin, Billaud, Jean-Noel, Heemers, Hannelore V

“…A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer. eLife 6:e28482. doi:…”
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Combination therapy induces unfolded protein response and cytoskeletal rearrangement leading to mitochondrial apoptosis in prostate cancer by Kumar, Sandeep, Chaudhary, Ajay K., Kumar, Rahul, O'Malley, Jordan, Dubrovska, Anna, Wang, Xinjiang, Yadav, Neelu, Goodrich, David W., Chandra, Dhyan

“…Development of therapeutic resistance is responsible for most prostate cancer (PCa) related mortality. Resistance has been attributed to an acquired or…”
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Loss of CARM1 Results in Hypomethylation of Thymocyte Cyclic AMP-regulated Phosphoprotein and Deregulated Early T Cell Development by Kim, Jeesun, Lee, Jaeho, Yadav, Neelu, Wu, Qi, Carter, Carla, Richard, Stéphane, Richie, Ellen, Bedford, Mark T.

“…The coactivator-associated arginine methyltransferase, CARM1, is a positive regulator of transcription. Using high density protein arrays, we have previously…”
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Recruitment of Rpd3 to the telomere depends on the protein arginine methyltransferase Hmt1 by Milliman, Eric J, Yadav, Neelu, Chen, Yin-Chu, Muddukrishna, Bhavana, Karunanithi, Sheelarani, Yu, Michael C

“…In the yeast Saccharomyces cerevisiae, the establishment and maintenance of silent chromatin at the telomere requires a delicate balance between opposing…”
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Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation by Zhang, Honghao, Gogada, Raghu, Yadav, Neelu, Lella, Ravi K, Badeaux, Mark, Ayres, Mary, Gandhi, Varsha, Tang, Dean G, Chandra, Dhyan

“…In the intrinsic death pathway, cytochrome C (CC) released from mitochondria to the cytosol triggers Apaf-1 apoptosome formation and subsequent caspase…”
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Mitochondrial DNA mutations and breast tumorigenesis by Yadav, Neelu, Chandra, Dhyan

“…Breast cancer is a heterogeneous disease and genetic factors play an important role in its genesis. Although mutations in tumor suppressors and oncogenes…”
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Mitochondrial and postmitochondrial survival signaling in cancer by Yadav, Neelu, Chandra, Dhyan

“…Cancer cells are resistant to conventional chemotherapy and radiotherapy, however, the molecular mechanisms of resistance to therapy remain unclear. Cellular…”
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Neem components as potential agents for cancer prevention and treatment by Hao, Fang, Kumar, Sandeep, Yadav, Neelu, Chandra, Dhyan

“…Azadirachta indica, also known as neem, is commonly found in many semi-tropical and tropical countries including India, Pakistan, and Bangladesh. The…”
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Utility of CA 125 in Determining the Response to Neoadjuvant Chemotherapy by Yadav, Neelu, Podder, Anirudha Rohit

“…Background CA-125 is the tumor marker for surface epithelial carcinoma of ovary, and it is used to determine the response to chemotherapy, relapse, and disease…”
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A Phase 1/1b Open-Label, Multicenter, Two-Part Study of SETD2 Inhibitor EZM0414 in Patients with Relapsed/Refractory Multiple Myeloma or Diffuse Large B-Cell Lymphoma by Richardson, Paul G., Niesvizky, Ruben, Yang, Jay, Yadav, Neelu, Hsu, Helen, Flowers, Christopher R.

“…Background: Multiple myeloma (MM) is a heterogeneous disease of monoclonal plasma cells. More than 40% of patients with MM harbor translocations of the…”
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Hsp60 and IL-8 axis promotes apoptosis resistance in cancer by Kumar, Sandeep, O’Malley, Jordan, Chaudhary, Ajay Kumar, Inigo, Joseph R., Yadav, Neelu, Kumar, Rahul, Chandra, Dhyan

“…Background Interleukin-8 (IL-8) and heat shock protein 60 (Hsp60) play crucial roles in cell survival and maintenance of cellular homoeostasis. However, cross…”
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Endoplasmic reticulum-mediated unfolded protein response and mitochondrial apoptosis in cancer by Bhat, Tariq A., Chaudhary, Ajay K., Kumar, Sandeep, O’Malley, Jordan, Inigo, Joseph R., Kumar, Rahul, Yadav, Neelu, Chandra, Dhyan

“…Abrogation of endoplasmic reticulum (ER) protein folding triggered by exogenous or endogenous factors, stimulates a cellular stress response, termed ER stress…”
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