Search Results - "Yadav, Dharmendra K."
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Biomedical and Antioxidant Potentialities in Chilli: Perspectives and Way Forward
Published in Molecules (Basel, Switzerland) (27-09-2022)“…Worldwide, since ages and nowadays, traditional medicine is well known, owing to its biodiversity, which immensely contributed to the advancement and…”
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2
Packet processing and data plane program verification: A survey with tools, techniques, and challenges
Published in International journal of communication systems (25-09-2023)“…Summary In today's era of fast‐growing network‐enabled devices combined, it increases the complexity of the network. This leads to the massive data packet…”
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SARS-CoV-2: Recent Variants and Clinical Efficacy of Antibody-Based Therapy
Published in Frontiers in cellular and infection microbiology (14-02-2022)“…Multiple variants of SARS-CoV-2 have emerged and are now prevalent at the global level. Currently designated variants of concern (VOCs) are B.1.1.7, B1.351,…”
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Molecular Targets for Malarial Chemotherapy: A Review
Published in Current topics in medicinal chemistry (01-01-2019)“…The malaria parasite resistance to the existing drugs is a serious problem to the currently used antimalarials and, thus, highlights the urgent need to develop…”
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Drug resistance reversal potential of multifunctional thieno[3,2-c]pyran via potentiation of antibiotics in MDR P. aeruginosa
Published in Biomedicine & pharmacotherapy (01-10-2021)“…We explored the antibacterial potential (alone and combination) against multidrug resistant (MDR) Pseudomonas aeruginosa isolates KG-P2 using synthesized…”
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6
Insight Into the Molecular Dynamic Simulation Studies of Reactive Oxygen Species in Native Skin Membrane
Published in Frontiers in pharmacology (27-06-2018)“…In recent years, the role of reactive oxygen species (ROS) in regulating cancer cell apoptosis, inflammation, cell ischemia, and cell signaling pathways has…”
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Carvacrol instigates intrinsic and extrinsic apoptosis with abrogation of cell cycle progression in cervical cancer cells: Inhibition of Hedgehog/GLI signaling cascade
Published in Frontiers in chemistry (11-01-2023)“…Recent times have seen a strong surge in therapeutically targeting the hedgehog (HH)/GLI signaling pathway in cervical cancer. HH signaling pathway is reported…”
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Studies of the benzopyran class of selective COX-2 inhibitors using 3D-QSAR and molecular docking
Published in Archives of pharmacal research (01-12-2018)“…The Gaussian-based 3D-QSAR studies for 58 selective COX-2 (cyclooxygenase-2) inhibitors belonging to benzopyran chemical class were performed. Partial least…”
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Antiviral Effects of Artemisinin and Its Derivatives against SARS-CoV-2 Main Protease: Computational Evidences and Interactions with ACE2 Allelic Variants
Published in Pharmaceuticals (Basel, Switzerland) (22-01-2022)“…Fighting against the emergent coronavirus disease (COVID-19) remains a big challenge at the front of the world communities. Recent research has outlined the…”
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Recent Advances in Pathophysiology, Drug Development and Future Perspectives of SARS-CoV-2
Published in Frontiers in cell and developmental biology (06-11-2020)“…The coronavirus (SARS-CoV-2) pandemic is a rapidly transmitting and highly pathogenic disease. The spike protein of SARS-CoV-2 binds to the surface of…”
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Frankincense oil-loaded nanoemulsion formulation of paclitaxel and erucin: A synergistic combination for ameliorating drug resistance in breast cancer: In vitro and in vivo study
Published in Frontiers in pharmacology (18-10-2022)“…Nanoformulation-based combinational drug delivery systems are well known to overcome drug resistance in cancer management. Among them, nanoemulsions are…”
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12
Identification of PARP12 Inhibitors By Virtual Screening and Molecular Dynamics Simulations
Published in Frontiers in pharmacology (09-08-2022)“…Poly [adenosine diphosphate (ADP)-ribose] polymerases (PARPs) are members of a family of 17 enzymes that performs several fundamental cellular processes…”
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13
Molecular docking and ADME studies of natural compounds of Agarwood oil for topical anti-inflammatory activity
Published in Current computer-aided drug design (01-09-2013)“…Aquilaria agallocha Roxb. family, Thymelaeaceae, is an evergreen plant of South-East Asia, commonly described as aloe wood or agarwood. Traditionally, the…”
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Biological Evaluation in Resistant Cancer Cells and Study of Mechanism of Action of Arylvinyl-1,2,4-Trioxanes
Published in Pharmaceuticals (Basel, Switzerland) (16-03-2022)“…1,2,4-trioxane is a pharmacophore, which possesses a wide spectrum of biological activities, including anticancer effects. In this study, the cytotoxic effect…”
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15
Development of Dementia in Type 2 Diabetes Patients: Mechanisms of Insulin Resistance and Antidiabetic Drug Development
Published in Cells (Basel, Switzerland) (25-11-2022)“…Dementia is reported to be common in those with type 2 diabetes mellitus. Type 2 diabetes contributes to common molecular mechanisms and an underlying…”
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QSAR, docking and ADMET studies of artemisinin derivatives for antimalarial activity targeting plasmepsin II, a hemoglobin-degrading enzyme from P. falciparum
Published in Current pharmaceutical design (01-12-2012)“…This work presents the development of quantitative structure activity relationship (QSAR) model to predict the antimalarial activity of artemisinin…”
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Microwave-assisted One-pot Efficient Synthesis of Functionalized 2-Oxo-2-phenylethylidenes-linked 2-Oxobenzo[1,4]oxazines and 2-Oxoquino[1,4]oxalines: Synthetic Applications, Antioxidant Activity, SAR and Cytotoxic Studies
Published in Acta chimica Slovenica (01-12-2017)“…A microwave-assisted, environmentally benign green protocol for the synthesis of functionalized (Z)-3-(2-oxo-2-phenylethylidene)-3,…”
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Molecular modeling based synthesis and evaluation of in vitro anticancer activity of indolyl chalcones
Published in Current topics in medicinal chemistry (01-01-2015)“…A series of twenty one chalcone derivatives having indole moiety were synthesized and were evaluated against four human cancer cell lines. Indolyl chalcones…”
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QSAR guided semi-synthesis and in-vitro validation of anticancer activity in ursolic acid derivatives
Published in Current topics in medicinal chemistry (01-04-2014)“…As a part of our anticancer drug discovery programme, QSAR models were developed for the prediction of anticancer activities of ursolic acid derivatives…”
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Drug Resistance Reversal Potential of Nanoparticles/Nanocomposites via Antibiotic's Potentiation in Multi Drug Resistant P. aeruginosa
Published in Nanomaterials (Basel, Switzerland) (30-12-2021)“…Bacteria employ numerous resistance mechanisms against structurally distinct drugs by the process of multidrug resistance. A study was planned to discover the…”
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