Search Results - "Yadav, Dharmendra B."

The discovery of potent small molecule activators of human STING by Pryde, David C., Middya, Sandip, Banerjee, Monali, Shrivastava, Ritesh, Basu, Sourav, Ghosh, Rajib, Yadav, Dharmendra B., Surya, Arjun

“…The adaptor protein STING plays a major role in innate immune sensing of cytosolic nucleic acids, by triggering a robust interferon response. Despite the…”
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G10 is a direct activator of human STING by Banerjee, Monali, Middya, Sandip, Shrivastava, Ritesh, Basu, Sourav, Ghosh, Rajib, Pryde, David C, Yadav, Dharmendra B, Surya, Arjun

“…The cGAS/STING pathway initiates an innate immune response when DNA is detected in the cytosol. DNA bound cGAS synthesizes cyclic dinucleotides which bind and…”
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The discovery of potent small molecule cyclic urea activators of STING by Basu, Sourav, Middya, Sandip, Banerjee, Monali, Ghosh, Rajib, Pryde, David C., Yadav, Dharmendra B., Shrivastava, Ritesh, Surya, Arjun

“…STING mediates innate immune responses that are triggered by the presence of cytosolic DNA. Activation of STING to boost antigen recognition is a therapeutic…”
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Synthesis of Diverse 6-Oxa-allocolchicinoids by a Suzuki-Miyaura Coupling, Acid-Catalyzed Intramolecular Transacetali­zation Strategy by Yadav, Dharmendra B., Taleli, Lebusetsa, van der Westhuyzen, Alet E., Fernandes, Manuel A., Dragoun, Maxim, Prokop, Aram, Schmalz, Hans-Günther, de Koning, Charles B., van Otterlo, Willem A. L.

“…The synthesis of allocolchicine analogues is of importance as these compounds have been found to possess promising anticancer activity by affecting tubulin…”
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Synthesis and biological evaluation of novel 1,4-naphthoquinone derivatives as antibacterial and antiviral agents by Tandon, Vishnu K., Yadav, Dharmendra B., Singh, Ravindra V., Vaish, Meenu, Chaturvedi, Ashok K., Shukla, Praveen K.

“…The synthesis, and antibacterial and antiviral activities of 5– 24 are described. A series of 1,4-naphthoquinone derivatives were synthesized and evaluated for…”
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6-Substituted imidazo[1,2- a]pyridines: Synthesis and biological activity against colon cancer cell lines HT-29 and Caco-2 by Dahan-Farkas, Nurit, Langley, Candice, Rousseau, Amanda L., Yadav, Dharmendra B., Davids, Hajierah, de Koning, Charles B.

“…A range of 6-substituted imidazo[1,2- a]pyridines were synthesized using a multicomponent coupling reaction. Most of these compounds were found to exhibit…”
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6,7‐Benzotropolone Syntheses Based on Ring‐Closing Metatheses and Four‐Electron Oxidations by Kreibich, Michael, Gemander, Manuel, Peter, David, Yadav, Dharmendra B., de Koning, Charles B., Fernandes, Manuel A., Green, Ivan R., van Otterlo, Willem A. L., Brückner, Reinhard

“…Four homoallyl ortho‐vinylaryl ketones (10a‐d) – 1,8‐dienes of sorts – were prepared by several approaches. In the presence of 1–2 mol‐% Grubbs‐II catalyst,…”
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Design, synthesis, and biological evaluation of 1,2,3-trisubstituted-1,4-dihydrobenzo[ g]quinoxaline-5,10-diones and related compounds as antifungal and antibacterial agents by Tandon, Vishnu K., Yadav, Dharmendra B., Maurya, Hardesh K., Chaturvedi, Ashok K., Shukla, Praveen K.

“…The synthesis, antifungal, and antibacterial activities of 3– 23 are described. A series of ( S)- N-(3-chloro-1,4-naphthoquinon-2-yl)-α-amino acid ethyl esters…”
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Overcoming Compound Fluorescence in the FLiK Screening Assay with Red-Shifted Fluorophores by Schneider, Ralf, Gohla, Anne, Simard, Jeffrey R, Yadav, Dharmendra B, Fang, Zhizhou, van Otterlo, Willem A. L, Rauh, Daniel

“…In the attempt to discover novel chemical scaffolds that can modulate the activity of disease-associated enzymes, such as kinases, biochemical assays are…”
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Synthesis and biological evaluation of novel ( l)-α-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents by Tandon, Vishnu K., Yadav, Dharmendra B., Singh, Ravindra V., Chaturvedi, Ashok K., Shukla, Praveen K.

“…The synthesis, antifungal, and antibacterial activities of 3– 15 are described. A series of ( S)- N-(1,4-naphthoquinon-2-yl)-α-amino acid methyl esters 3– 9,…”
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Naphtho[2,3- b][1,4]-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: Synthesis and biological evaluation as potential antibacterial and antifungal agents by Tandon, Vishnu K., Maurya, Hardesh K., Yadav, Dharmendra B., Tripathi, Ashutosh, Kumar, Manish, Shukla, Praveen K.

“…The synthesis, antibacterial and antifungal activities of 2– 24 are described. A series of 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thio-alkanoate…”
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Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents by TANDON, Vishnu K, CHHOR, Rakeshwar B, SINGH, Ravindra V, RAI, Sanjay, YADAV, Dharmendra B

“…A series of 1,4-naphthoquinone derivatives were synthesized and tested for antifungal and antitumor activity against a number of fungal disease causative…”
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Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents by Tandon, Vishnu K., Singh, Ravindra V., Yadav, Dharmendra B.

“…The synthesis, antiviral, antifungal and anticancer activities of 4– 10 is described. The synthesis and evaluation of some 2-substituted-1,4-naphthoquinones 2,…”
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Application of an isomerization-ring-closing metathesis strategy to the synthesis of unsaturated seven-membered, benzo-fused heterocycles containing two heteroatoms by Yadav, Dharmendra B., Morgans, Garreth L., Aderibigbe, Blessing A., Madeley, Lee G., Fernandes, Manuel A., Michael, Joseph P., de Koning, Charles B., van Otterlo, Willem A.L.

“…An isomerization-RCM approach was utilized to synthesize a number of seven-membered benzo-fused heterocycles containing two heteroatoms ( N, O, N, S, and S,…”
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Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents by TANDON, Vishnu K, YADAV, Dharmendra B, CHATURVEDI, Ashok K, SHUKLA, Praveen K

“…A series of (1,4)-naphthoquinono [3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives 2-7 were synthesized and evaluated for antifungal,…”
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Formation of an unexpected rearrangement product using Grubbs’ second generation catalyst: 2-allyl-3,4-dihydro-2H-1,4-benzothiazines from diene precursors by Morgans, Garreth L., Yadav, Dharmendra B., Fernandes, Manuel A., de Koning, Charles B., Michael, Joseph P., van Otterlo, Willem A.L.

“…Application of sub-stoichiometric amounts of Grubbs’ second generation catalyst to bis-allyl substrates containing an allylsulfide group resulted in the…”
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G10 is a direct activator of human STING by Monali Banerjee, Sandip Middya, Ritesh Shrivastava, Sourav Basu, Rajib Ghosh, David C. Pryde, Dharmendra B. Yadav, Arjun Surya, Michael Nevels

“…The cGAS/STING pathway initiates an innate immune response when DNA is detected in the cytosol. DNA bound cGAS synthesizes cyclic dinucleotides which bind and…”
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Synthesis of (1,4)-naphthoquinono-[3,2- c]-1 H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents by Tandon, Vishnu K., Yadav, Dharmendra B., Chaturvedi, Ashok K., Shukla, Praveen K.

“…A series of (1,4)-naphthoquinono [3,2- c]-1 H-pyrazoles and their (1,4)-naphthohydroquinone derivatives 2– 7 were synthesized and evaluated for antifungal,…”
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