Search Results - "Yadagiri, Ganesh"
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Modified solid lipid nanoparticles encapsulated with Amphotericin B and Paromomycin: an effective oral combination against experimental murine visceral leishmaniasis
Published in Scientific reports (22-07-2020)“…The development of an effective oral therapeutics is an immediate need for the control and elimination of visceral leishmaniasis (VL). We exemplify the…”
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An intranasal vaccine comprising SARS-CoV-2 spike receptor-binding domain protein entrapped in mannose-conjugated chitosan nanoparticle provides protection in hamsters
Published in Scientific reports (26-07-2023)“…We developed a novel intranasal SARS-CoV-2 subunit vaccine called NARUVAX-C19/Nano based on the spike protein receptor-binding domain (RBD) entrapped in…”
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Immunotherapy and immunochemotherapy in combating visceral leishmaniasis
Published in Frontiers in medicine (17-05-2023)“…Visceral leishmaniasis (VL), a vector-borne disease, is caused by an obligate intramacrophage, kinetoplastid protozoan parasite of the genus . Globally, VL is…”
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Current challenges and nanotechnology-based pharmaceutical strategies for the treatment and control of malaria
Published in Parasite epidemiology and control (01-05-2022)“…Malaria is one of the prevalent tropical diseases caused by the parasitic protozoan of the genus Plasmodium spp. With an estimated 228 million cases, it is a…”
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Recuperating Biopharmaceutical Aspects of Amphotericin B and Paromomycin Using a Chitosan Functionalized Nanocarrier via Oral Route for Enhanced Anti-leishmanial Activity
Published in Frontiers in cellular and infection microbiology (15-10-2020)“…The design and development of new pharmaceutical formulations for the existing anti-leishmanial is a new strategic alternate to improve efficacy and safety…”
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An Orf-Virus (ORFV)-Based Vector Expressing a Consensus H1 Hemagglutinin Provides Protection against Diverse Swine Influenza Viruses
Published in Viruses (01-04-2023)“…Influenza A viruses (IAV-S) belonging to the H1 subtype are endemic in swine worldwide. Antigenic drift and antigenic shift lead to a substantial antigenic…”
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Evaluation of Efficacy of Surface Coated versus Encapsulated Influenza Antigens in Mannose-Chitosan Nanoparticle-Based Intranasal Vaccine in Swine
Published in Vaccines (Basel) (01-06-2024)“…This study focuses on the development and characterization of an intranasal vaccine platform using adjuvanted nanoparticulate delivery of swine influenza A…”
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Characterization of the Efficacy of a Split Swine Influenza A Virus Nasal Vaccine Formulated with a Nanoparticle/STING Agonist Combination Adjuvant in Conventional Pigs
Published in Vaccines (Basel) (01-11-2023)“…Swine influenza A viruses (SwIAVs) are pathogens of both veterinary and medical significance. Intranasal (IN) vaccination has the potential to reduce flu…”
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Intradermal Vaccination against Influenza with a STING-Targeted Nanoparticle Combination Adjuvant Induces Superior Cross-Protective Humoral Immunity in Swine Compared with Intranasal and Intramuscular Immunization
Published in Vaccines (Basel) (01-11-2023)“…The development of cross-protective vaccines against the zoonotic swine influenza A virus (swIAV), a potential pandemic-causing agent, continues to be an…”
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Evaluation of Safety and Antileishmanial Efficacy of Amine Functionalized Carbon-Based Composite Nanoparticle Appended With Amphotericin B: An in vitro and Preclinical Study
Published in Frontiers in chemistry (03-07-2020)“…Visceral leishmaniasis (VL) has been a major health concern in the developing world, primarily affecting impoverished people. It is caused by a protozoan…”
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Numerical Investigation: Effect of Stator Vanes on Turbocharger Turbine Performance
Published in International Journal of Rotating Machinery (01-01-2014)“…With reduced turbo lag and better transient response, the introduction of VTG stator guide vanes improved turbocharger performance at all the engine operating…”
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Enkephalins as a therapeutic intervention for visceral leishmaniasis
Published in Medical hypotheses (01-11-2020)“…Visceral leishmaniasis (VL) is a neglected tropical disease with high incidence of mortality and morbidity. The emergence of drug resistant parasites, severe…”
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Carboxymethyl chitosan modified lipid nanoformulations as a highly efficacious and biocompatible oral anti-leishmanial drug carrier system
Published in International journal of biological macromolecules (15-04-2022)“…Herein, carboxymethyl chitosan (CMC) grafted lipid nanoformulations were facilely prepared by thin-film hydration method as a highly efficient biocompatible…”
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Improvising anti-leishmanial activity of amphotericin B and paromomycin using co-delivery in d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) tailored nano-lipid carrier system
Published in Chemistry and physics of lipids (01-09-2020)“…•We aimed to design, develop and evaluate (in-vitro) a novel d-α-tocopheryl polyethylene glycol 1000 succinate modified amphotericin B (AmB) and paromomycin…”
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Human Infant Fecal Microbiota Differentially Influences the Mucosal Immune Pathways Upon Influenza Infection in a Humanized Gnotobiotic Pig Model
Published in Current microbiology (01-09-2024)“…In this study, we evaluated the impact of human gut microbiota on the immune pathways in the respiratory tract using a gnotobiotic (Gn) piglet model. We…”
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Coalition of Biological Agent (Melatonin) With Chemotherapeutic Agent (Amphotericin B) for Combating Visceral Leishmaniasis via Oral Administration of Modified Solid Lipid Nanoparticles
Published in ACS biomaterials science & engineering (12-06-2023)“…In this study, 2-hydroxypropyl-β-cyclodextrin (HPβCD) grafted solid lipid nanoparticle (SLN)-based bioconjugate was synthesized and used for administering a…”
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Current understanding and future directions of cruciferous vegetables and their phytochemicals to combat neurological diseases
Published in Phytotherapy research (01-03-2024)“…Neurological disorders incidences are increasing drastically due to complex pathophysiology, and the nonavailability of disease‐modifying agents. Several…”
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In vitro anti-leishmanial effects of garlic extract on Leishmania major: A Systematic Review
Published in Medical laboratory journal (01-05-2024)“…Background: Leishmaniasis is a vector-borne parasitic disease caused by an obligate intracellular protozoan. Despite the significant frequency of cutaneous…”
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Sensible graphene oxide differentiates macrophages and Leishmania : a bio-nano interplay in attenuating intracellular parasite
Published in RSC advances (22-07-2020)“…is an obligate intracellular protozoan parasite, which resides in human macrophage vacuoles that are referred to as parasitophorus vacuoles. Amphotericin B…”
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