Search Results - "Yabuuchi, Tetsuya"

The Modified Mosher’s Method and the Sulfoximine Method by Kusumi, Takenori, Ooi, Takashi, Ohkubo, Yumi, Yabuuchi, Tetsuya

“…This article describes the application of the modified Mosher’s method to a variety of natural products possessing a secondary alcohol for determining their…”
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Phenylglycine Methyl Ester, a Useful Tool for Absolute Configuration Determination of Various Chiral Carboxylic Acids by Yabuuchi, Tetsuya, Kusumi, Takenori

“…A new chiral anisotropic reagent, phenylglycine methyl ester (PGME), developed for the elucidation of the absolute configuration of chiral α,α-disubstituted…”
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NMR Spectroscopic Determination of the Absolute Configuration of Chiral Sulfoxides via N-(Methoxyphenylacetyl)sulfoximines by Yabuuchi, Tetsuya, Kusumi, Takenori

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Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation by Nishikawa-Shimono, Rie, Kuwabara, Motoi, Fujisaki, Sho, Matsuda, Daisuke, Endo, Mayumi, Kamitani, Masafumi, Futamura, Aya, Nomura, Yusaku, Yamaguchi-Sasaki, Toru, Yabuuchi, Tetsuya, Yamaguchi, Chitose, Tanaka-Yamamoto, Nozomi, Satake, Shunya, Abe-Sato, Kumi, Funayama, Kosuke, Sakata, Mayumi, Takahashi, Shinji, Hirano, Koga, Fukunaga, Takuya, Uozumi, Yoriko, Kato, Sayaka, Tamura, Yunoshin, Nakamori, Tomoaki, Mima, Masashi, Mishima-Tsumagari, Chiemi, Nozawa, Dai, Imai, Yudai, Asami, Taiji

“…[Display omitted] •HTS of our internal compound library led to the discovery of two hit compounds.•The two hit compounds were merged to provide a lead with…”
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A Convenient One-Pot Synthesis of Quaternary α-Methoxy- and α-Hydroxycarboxylic Acids by YABUUCHI, Tetsuya, KUSUMI, Takenori

“…Several α-methoxy- and α-hydroxycarboxylic acids have been synthesized by a new one-pot synthesis using ketones, tribromomethane, and potassium hydroxide in…”
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Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors by Oka, Yusuke, Yabuuchi, Tetsuya, Fujii, Yasuyuki, Ohtake, Hidenori, Wakahara, Shunichi, Matsumoto, Kayo, Endo, Mayumi, Tamura, Yunoshin, Sekiguchi, Yoshinori

“…Novel 2-aminothiazole-oxazoles were synthesized and evaluated as phosphoinositide 3-kinase γ (PI3Kγ) inhibitors. A novel series of 2-aminothiazole-oxazoles was…”
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Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases by Oka, Yusuke, Yabuuchi, Tetsuya, Oi, Takahiro, Kuroda, Shoichi, Fujii, Yasuyuki, Ohtake, Hidenori, Inoue, Tomoyuki, Wakahara, Shunichi, Kimura, Kayo, Fujita, Kiyoko, Endo, Mayumi, Taguchi, Kyoko, Sekiguchi, Yoshinori

“…Class I phosphoinositide 3-kinases (PI3Ks), particularly PI3Kγ, have become attractive drug targets for inflammatory and autoimmune disorders such as…”
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A CONVENIENT SYNTHESIS OF 2-MERCAPTO-OXAZOLES VIA β-KETOAZIDE AND ITS APPLICATION TO A KEY INTERMEDIATE OF PI3Kγ INHIBITORS by Oka, Yusuke, Yabuuchi, Tetsuya, Sekiguchi, Yoshinori

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Application of phenylglycine methyl ester (PGME) to determination of the absolute configuration of carboxylic acids having phenylalkyl group by Yabuuchi, Tetsuya, Ooi, Takashi, Kusumi, Takenori

“…(R)‐ and (S)‐phenylglycine methyl ester (PGME) was applied to elucidate the absolute configuration of a series of aliphatic carboxylic acids, 2a and 2b (n =…”
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5-(1,3-Benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazole derivatives as potent and selective transforming growth factor-β type I receptor inhibitors by Amada, Hideaki, Sekiguchi, Yoshinori, Ono, Naoya, Koami, Takeshi, Takayama, Tetsuo, Yabuuchi, Tetsuya, Katakai, Hironori, Ikeda, Akiko, Aoki, Mari, Naruse, Takumi, Wada, Reiko, Nozoe, Akiko, Sato, Masakazu

“…A series of 5-(1,3-benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazole derivatives was synthesized as transforming growth factor-β (TGF-β) type I…”
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Pyrrole derivatives as potent inhibitors of lymphocyte-specific kinase: Structure, synthesis, and SAR by Takayama, Tetsuo, Umemiya, Hiroki, Amada, Hideaki, Yabuuchi, Tetsuya, Shiozawa, Fumiyasu, Katakai, Hironori, Takaoka, Akiko, Yamaguchi, Akie, Endo, Mayumi, Sato, Masakazu

“…We have described the synthesis, enzyme inhibitory activity, structure–activity relationships, and proposed binding mode of a novel series of pyrrole…”
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Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase [gamma] inhibitors by Oka, Yusuke, Yabuuchi, Tetsuya, Fujii, Yasuyuki, Ohtake, Hidenori, Wakahara, Shunichi, Matsumoto, Kayo, Endo, Mayumi, Tamura, Yunoshin, Sekiguchi, Yoshinori

“…A novel series of 2-aminothiazole-oxazoles was designed and synthesized as part of efforts to develop potent phosphoinositide 3-kinase [gamma] (PI3K[gamma])…”
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5-(1,3-Benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazo le derivatives as potent and selective transforming growth factor-[beta] type I receptor inhibitors by Amada, Hideaki, Sekiguchi, Yoshinori, Ono, Naoya, Koami, Takeshi, Takayama, Tetsuo, Yabuuchi, Tetsuya, Katakai, Hironori, Ikeda, Akiko, Aoki, Mari, Naruse, Takumi, Wada, Reiko, Nozoe, Akiko, Sato, Masakazu

“…A series of 5-(1,3-benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazo l e derivatives was synthesized as transforming growth factor-[beta]…”
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Ring-fused pyrazole derivatives as potent inhibitors of lymphocyte-specific kinase (Lck): Structure, synthesis, and SAR by Takayama, Tetsuo, Umemiya, Hiroki, Amada, Hideaki, Yabuuchi, Tetsuya, Koami, Takeshi, Shiozawa, Fumiyasu, Oka, Yusuke, Takaoka, Akiko, Yamaguchi, Akie, Endo, Mayumi, Sato, Masakazu

“…We have identified a novel series of ring-fused pyrazole derivatives as lymphocyte-specific kinase (Lck) inhibitors. The most potent analogs exhibited good…”
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Resolution of 1- and 2-naphthylmethoxyacetic acids, NMR reagents for absolute configuration determination, by use of L-phenylalaninol by Arita, Shoko, Yabuuchi, Tetsuya, Kusumi, Takenori

“…Racemic 1‐ and 2‐naphthylmethoxyacetic acids (1NMA and 2NMA), the chiral anisotropic reagents used for absolute configuration determination of chiral secondary…”
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A Convenient One-Pot Synthesis of Quaternary [alpha]-Methoxy- and [alpha]-Hydroxycarboxylic Acids by YABUUCHI, Tetsuya, KUSUMI, Takenori

“…Several α-methoxy- and α-hydroxycarboxylic acids have been synthesized by a new one-pot synthesis using ketones, tribromomethane, and potassium hydroxide in…”
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Sesquiterpenes and Monoterpenes from the Bark of Inula macrophylla by SU, Bao-Ning, TAKAISHI, Yoshihisa, YABUUCHI, Tetsuya, KUSUMI, Takenori, TORI, Motoo, TAKAOKA, Shigeru, HONDA, Gisho, ITO, Michiho, TAKEDA, Yoshio, KODZHIMATOV, Olimjon K., ASHURMETOV, Ozodbek

“…Eleven new sesquiterpenes (1--11) and two thymol derivatives (12, 13), along with 12 known sesquiterpenes and monoterpenes, were isolated from the bark of…”
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The structures and absolute configurations of macrophyllic acids A–E, five new rearranged eudesmane sesquiterpene acids from the bark of Inula macrophylla by Su, Bao-Ning, Takaishi, Yoshihisa, Yabuuchi, Tetsuya, Kusumi, Takenori, Tori, Motoo, Takaoka, Shigeru

“…Macrophyllic acids A–E, five novel sesquiterpene acids with a new rearranged carbon skeleton, have been isolated from the bark of Inula macrophylla. Their…”
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Sesquiterpenes and Monoterpenes from the Bark of Inula m acrophylla by Su, Bao-Ning, Takaishi, Yoshihisa, Yabuuchi, Tetsuya, Kusumi, Takenori, Tori, Motoo, Takaoka, Shigeru, Honda, Gisho, Ito, Michiho, Takeda, Yoshio, Kodzhimatov, Olimjon K, Ashurmetov, Ozodbek

“…Eleven new sesquiterpenes (1−11) and two thymol derivatives (12, 13), along with 12 known sesquiterpenes and monoterpenes, were isolated from the bark of Inula…”
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