Search Results - "YUTAKA TOMITA"

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys by Nagai, Yuji, Miyakawa, Naohisa, Takuwa, Hiroyuki, Hori, Yukiko, Oyama, Kei, Ji, Bin, Takahashi, Manami, Huang, Xi-Ping, Slocum, Samuel T., DiBerto, Jeffrey F., Xiong, Yan, Urushihata, Takuya, Hirabayashi, Toshiyuki, Fujimoto, Atsushi, Mimura, Koki, English, Justin G., Liu, Jing, Inoue, Ken-ichi, Kumata, Katsushi, Seki, Chie, Ono, Maiko, Shimojo, Masafumi, Zhang, Ming-Rong, Tomita, Yutaka, Nakahara, Jin, Suhara, Tetsuya, Takada, Masahiko, Higuchi, Makoto, Jin, Jian, Roth, Bryan L., Minamimoto, Takafumi

“…The chemogenetic technology designer receptors exclusively activated by designer drugs (DREADDs) afford remotely reversible control of cellular signaling,…”
Get full text

Differential pial and penetrating arterial responses examined by optogenetic activation of astrocytes and neurons by Hatakeyama, Nao, Unekawa, Miyuki, Murata, Juri, Tomita, Yutaka, Suzuki, Norihiro, Nakahara, Jin, Takuwa, Hiroyuki, Kanno, Iwao, Matsui, Ko, Tanaka, Kenji F, Masamoto, Kazuto

“…A variety of brain cells participates in neurovascular coupling by transmitting and modulating vasoactive signals. The present study aimed to probe cell…”
Get full text

Close association between spreading depolarization and development of infarction under experimental ischemia in anesthetized male mice by Unekawa, Miyuki, Tomita, Yutaka, Masamoto, Kazuto, Kanno, Iwao, Nakahara, Jin, Izawa, Yoshikane

“…[Display omitted] •No infarct was detected in mice without SD during experimental ischemia.•The infarct size tended to be larger in repeated SD-occurred…”
Get full text

MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice by Takado, Yuhei, Takuwa, Hiroyuki, Sampei, Kazuaki, Urushihata, Takuya, Takahashi, Manami, Shimojo, Masafumi, Uchida, Shoko, Nitta, Nobuhiro, Shibata, Sayaka, Nagashima, Keisuke, Ochi, Yoshihiro, Ono, Maiko, Maeda, Jun, Tomita, Yutaka, Sahara, Naruhiko, Near, Jamie, Aoki, Ichio, Shibata, Kazuhisa, Higuchi, Makoto

“…To assess if magnetic resonance spectroscopy (MRS)-measured Glutamate (Glu) and GABA reflect excitatory and inhibitory neural activities, respectively, we…”
Get full text

Optical manipulation of local cerebral blood flow in the deep brain of freely moving mice by Abe, Yoshifumi, Kwon, Soojin, Oishi, Mitsuhiro, Unekawa, Miyuki, Takata, Norio, Seki, Fumiko, Koyama, Ryuta, Abe, Manabu, Sakimura, Kenji, Masamoto, Kazuto, Tomita, Yutaka, Okano, Hideyuki, Mushiake, Hajime, Tanaka, Kenji F.

“…An artificial tool for manipulating local cerebral blood flow (CBF) is necessary for understanding how CBF controls brain function. Here, we generate vascular…”
Get full text

Dynamic diameter response of intraparenchymal penetrating arteries during cortical spreading depression and elimination of vasoreactivity to hypercapnia in anesthetized mice by Unekawa, Miyuki, Tomita, Yutaka, Masamoto, Kazuto, Toriumi, Haruki, Osada, Takashi, Kanno, Iwao, Suzuki, Norihiro

“…Cortical spreading depression (CSD) induces marked hyperemia with a transient decrease of regional cerebral blood flow (rCBF), followed by sustained oligemia…”
Get full text

Efficiency and Stability of Step-To Gait in Slow Walking by Hirayama, Kento, Otaka, Yohei, Kurayama, Taichi, Takahashi, Toru, Tomita, Yutaka, Inoue, Seigo, Honaga, Kaoru, Kondo, Kunitsugu, Osu, Rieko

“…As humans, we constantly change our movement strategies to adapt to changes in physical functions and the external environment. We have to walk very slowly in…”
Get full text

In Vivo Imaging of the Mouse Neurovascular Unit Under Chronic Cerebral Hypoperfusion by Yata, Kenichiro, Nishimura, Yuhei, Unekawa, Miyuki, Tomita, Yutaka, Suzuki, Norihiro, Tanaka, Toshio, Mizoguchi, Akira, Tomimoto, Hidekazu

“…BACKGROUND AND PURPOSE—Proper brain function is maintained by an integrated system called the neurovascular unit (NVU) comprised cellular and acellular…”
Get full text

Dynamic alterations in the central glutamatergic status following food and glucose intake: in vivo multimodal assessments in humans and animal models by Kubota, Manabu, Kimura, Yasuyuki, Shimojo, Masafumi, Takado, Yuhei, Duarte, Joao MN, Takuwa, Hiroyuki, Seki, Chie, Shimada, Hitoshi, Shinotoh, Hitoshi, Takahata, Keisuke, Kitamura, Soichiro, Moriguchi, Sho, Tagai, Kenji, Obata, Takayuki, Nakahara, Jin, Tomita, Yutaka, Tokunaga, Masaki, Maeda, Jun, Kawamura, Kazunori, Zhang, Ming-Rong, Ichise, Masanori, Suhara, Tetsuya, Higuchi, Makoto

“…Fluctuations of neuronal activities in the brain may underlie relatively slow components of neurofunctional alterations, which can be modulated by food intake…”
Get full text

A genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains by Shimojo, Masafumi, Ono, Maiko, Takuwa, Hiroyuki, Mimura, Koki, Nagai, Yuji, Fujinaga, Masayuki, Kikuchi, Tatsuya, Okada, Maki, Seki, Chie, Tokunaga, Masaki, Maeda, Jun, Takado, Yuhei, Takahashi, Manami, Minamihisamatsu, Takeharu, Zhang, Ming‐Rong, Tomita, Yutaka, Suzuki, Norihiro, Maximov, Anton, Suhara, Tetsuya, Minamimoto, Takafumi, Sahara, Naruhiko, Higuchi, Makoto

“…Positron emission tomography (PET) allows biomolecular tracking but PET monitoring of brain networks has been hampered by a lack of suitable reporters. Here,…”
Get full text

RBC velocities in single capillaries of mouse and rat brains are the same, despite 10-fold difference in body size by Unekawa, Miyuki, Tomita, Minoru, Tomita, Yutaka, Toriumi, Haruki, Miyaki, Koichi, Suzuki, Norihiro

“…Abstract Employing high-speed camera laser-scanning confocal microscopy with RBC-tracking software, we previously showed that RBC velocities in…”
Get full text

CD4+CD62L+ cells: A monitoring marker of fingolimod dosage in multiple sclerosis by Tanaka, Masami, Kinoshita, Masako, Tomita, Yutaka, Tanaka, Keiko

“…Objectives Fingolimod (FTY) potentially inhibits the disease activity of multiple sclerosis (MS), but induces severe lymphocytopenia that might be related…”
Get full text

Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model by Kudo, Takehiro, Takuwa, Hiroyuki, Takahashi, Manami, Urushihata, Takuya, Shimojo, Masafumi, Sampei, Kazuaki, Yamanaka, Mitsugu, Tomita, Yutaka, Sahara, Naruhiko, Suhara, Tetsuya, Higuchi, Makoto

“…In Alzheimer’s disease (AD), network hyperexcitability is frequently observed and associated with subsequent cognitive impairment. Dysfunction of inhibitory…”
Get full text

Change in brain activity through virtual reality-based brain-machine communication in a chronic tetraplegic subject with muscular dystrophy by Hashimoto, Yasunari, Ushiba, Junichi, Kimura, Akio, Liu, Meigen, Tomita, Yutaka

“…For severely paralyzed people, a brain-computer interface (BCI) provides a way of re-establishing communication. Although subjects with muscular dystrophy (MD)…”
Get full text

Spatiotemporal dynamics of red blood cells in capillaries in layer I of the cerebral cortex and changes in arterial diameter during cortical spreading depression and response to hypercapnia in anesthetized mice by Unekawa, Miyuki, Tomita, Yutaka, Toriumi, Haruki, Osada, Takashi, Masamoto, Kazuto, Kawaguchi, Hiroshi, Izawa, Yoshikane, Itoh, Yoshiaki, Kanno, Iwao, Suzuki, Norihiro, Nakahara, Jin

“…Objective Control of red blood cell velocity in capillaries is essential to meet local neuronal metabolic requirements, although changes of capillary diameter…”
Get full text

Pial Arteries Respond Earlier than Penetrating Arterioles to Neural Activation in the Somatosensory Cortex in Awake Mice Exposed to Chronic Hypoxia: An Additional Mechanism to Proximal Integration Signaling? by Sekiguchi, Yuta, Takuwa, Hiroyuki, Kawaguchi, Hiroshi, Kikuchi, Takahiro, Okada, Eiji, Kanno, Iwao, Ito, Hiroshi, Tomita, Yutaka, Itoh, Yoshiaki, Suzuki, Norihiro, Sudo, Ryo, Tanishita, Kazuo, Masamoto, Kazuto

“…The pial and penetrating arteries have a crucial role in regulating cerebral blood flow (CBF) to meet neural demand in the cortex. Here, we examined the…”
Get full text

Hyperperfusion Counteracted by Transient Rapid Vasoconstriction Followed by Long-Lasting Oligemia Induced by Cortical Spreading Depression in Anesthetized Mice by Unekawa, Miyuki, Tomita, Yutaka, Toriumi, Haruki, Osada, Takashi, Masamoto, Kazuto, Kawaguchi, Hiroshi, Itoh, Yoshiaki, Kanno, Iwao, Suzuki, Norihiro

“…Cortical spreading depression (CSD) involves mass depolarization of neurons and glial cells accompanied with changes in regional cerebral blood flow (rCBF) and…”
Get full text

Clinical features and varieties of non-motor fluctuations in Parkinson's disease: A Japanese multicenter study by Seki, Morinobu, Takahashi, Kazushi, Uematsu, Daisuke, Mihara, Ban, Morita, Yoko, Isozumi, Kazuo, Ohta, Kouichi, Muramatsu, Kazuhiro, Shirai, Toshitaka, Nogawa, Shigeru, Gotoh, Jun, Yamaguchi, Keiji, Tomita, Yutaka, Yasutomi, Daisuke, Nihei, Yoshihiro, Iwasawa, Satoko, Suzuki, Norihiro

“…Abstract Objective This multicenter cross-sectional study aimed to investigate the clinical features and varieties of non-motor fluctuation in Parkinson's…”
Get full text

Recovery Process of Standing Postural Control in Hemiplegia after Stroke by Yanohara, Ryuzo, Teranishi, Toshio, Tomita, Yutaka, Tanino, Genichi, Ueno, Yoshiya, Sonoda, Shigeru

“…[Purpose] The aim of this study was to investigate the recovery process of standing postural control in hemiplegia after stroke. [Subjects and Methods]…”
Get full text

INFLUENCE OF MIRROR THERAPY ON HUMAN MOTOR CORTEX by FUKUMURA, KENJI, SUGAWARA, KENICHI, TANABE, SHIGEO, USHIBA, JUNICHI, TOMITA, YUTAKA

“…This article investigates whether or not mirror therapy alters the neural mechanisms in human motor cortex. Six healthy volunteers participated. The study…”
Get full text