Search Results - "YURONG LAI"

Scientific Contributions to Drug Metabolism by Dr. Edward T. Morgan, the Recipient of the Bernard B. Brodie Award in Drug Metabolism and Disposition in 2024-Editorial by Xiao-Bo, Zhong, Yurong, Lai

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Organic Anion Transporter 2: An Enigmatic Human Solute Carrier by Shen, Hong, Lai, Yurong, Rodrigues, A David

“…As a member of the solute carrier 22A (SLC22A) family, organic anion transporter 2 (OAT2; SLC22A7) is emerging as an important drug transporter because of its…”
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Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion by Lai, Yurong

“…Increasing challenges include the application of in vitro/in vivo models for prediction of safety and pharmacokinetic profiles for the compounds entering drug…”
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Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug‐Drug Interaction Evaluation: Perspectives From the International Transporter Consortium by Chu, Xiaoyan, Liao, Mingxiang, Shen, Hong, Yoshida, Kenta, Zur, Arik A., Arya, Vikram, Galetin, Aleksandra, Giacomini, Kathleen M., Hanna, Imad, Kusuhara, Hiroyuki, Lai, Yurong, Rodrigues, David, Sugiyama, Yuichi, Zamek‐Gliszczynski, Maciej J., Zhang, Lei

“…Drug transporters can govern the absorption, distribution, metabolism, and excretion of substrate drugs and endogenous substances. Investigations to examine…”
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Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug–Drug Interactions by Karlgren, Maria, Vildhede, Anna, Norinder, Ulf, Wisniewski, Jacek R, Kimoto, Emi, Lai, Yurong, Haglund, Ulf, Artursson, Per

“…The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug–drug…”
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Protein Abundance of Clinically Relevant Multidrug Transporters along the Entire Length of the Human Intestine by Drozdzik, Marek, Gröer, Christian, Penski, Jette, Lapczuk, Joanna, Ostrowski, Marek, Lai, Yurong, Prasad, Bhagwat, Unadkat, Jashvant D, Siegmund, Werner, Oswald, Stefan

“…Intestinal transporters are crucial determinants in the oral absorption of many drugs. We therefore studied the mRNA expression (N = 33) and absolute protein…”
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Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities by Zhang, Donglu, Hop, Cornelis E C A, Patilea-Vrana, Gabriela, Gampa, Gautham, Seneviratne, Herana Kamal, Unadkat, Jashvant D, Kenny, Jane R, Nagapudi, Karthik, Di, Li, Zhou, Lian, Zak, Mark, Wright, Matthew R, Bumpus, Namandjé N, Zang, Richard, Liu, Xingrong, Lai, Yurong, Khojasteh, S Cyrus

“…The well accepted "free drug hypothesis" for small-molecule drugs assumes that only the free (unbound) drug concentration at the therapeutic target can elicit…”
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Editorial: Clinical trials in drug metabolism and transport: 2022 by Lai, Yurong, Yanev, Stanislav, Liu, Zhihao

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Toward a Consensus on Applying Quantitative Liquid Chromatography‐Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper by Prasad, Bhagwat, Achour, Brahim, Artursson, Per, Hop, Cornelis E.C.A., Lai, Yurong, Smith, Philip C., Barber, Jill, Wisniewski, Jacek R., Spellman, Daniel, Uchida, Yasuo, Zientek, Michael A., Unadkat, Jashvant D., Rostami‐Hodjegan, Amin

“…Quantitative translation of information on drug absorption, disposition, receptor engagement, and drug–drug interactions from bench to bedside requires models…”
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Hepatic uptake of atorvastatin: influence of variability in transporter expression on uptake clearance and drug-drug interactions by Vildhede, Anna, Karlgren, Maria, Svedberg, Elin K, Wisniewski, Jacek R, Lai, Yurong, Norén, Agneta, Artursson, Per

“…Differences in the expression and function of the organic anion transporting polypeptide (OATP) transporters contribute to interindividual variability in…”
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Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood–Brain Barrier Measured by Quantitative Targeted Proteomics by Billington, Sarah, Salphati, Laurent, Hop, Cornelis E. C. A., Chu, Xiaoyan, Evers, Raymond, Burdette, Doug, Rowbottom, Christopher, Lai, Yurong, Xiao, Guangqing, Humphreys, W. Griffith, Nguyen, Tot Bui, Prasad, Bhagwat, Unadkat, Jashvant D.

“…For in vitro to in vivo extrapolation (IVIVE) of brain distribution of drugs that are transported at the human blood–brain barrier (BBB), it is important to…”
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Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype by Prasad, Bhagwat, Lai, Yurong, Lin, Yvonne, Unadkat, Jashvant D

“…Breast cancer resistance protein (BCRP), an efflux transporter expressed at the bile canalicular membrane, is responsible for the biliary clearance of many…”
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Induction of Human Intestinal and Hepatic Organic Anion Transporting Polypeptides: Where Is the Evidence for Its Relevance in Drug-Drug Interactions? by Rodrigues, A David, Lai, Yurong, Shen, Hong, Varma, Manthena V S, Rowland, Andrew, Oswald, Stefan

“…Organic anion transporting polypeptides (OATPs), expressed in human liver (OATP1B1, OATP1B3, and OATP2B1) and intestine (OATP2B1), govern the pharmacokinetics…”
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Transporter Gene Regulation in Sandwich Cultured Human Hepatocytes Through the Activation of Constitutive Androstane Receptor (CAR) or Aryl Hydrocarbon Receptor (AhR) by Niu, Congrong, Smith, Bill, Lai, Yurong

“…The induction potentials of ligand-activated nuclear receptors on metabolizing enzyme genes are routinely tested for new chemical entities. However,…”
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Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data by Jones, Hannah M, Barton, Hugh A, Lai, Yurong, Bi, Yi-An, Kimoto, Emi, Kempshall, Sarah, Tate, Sonya C, El-Kattan, Ayman, Houston, J Brian, Galetin, Aleksandra, Fenner, Katherine S

“…With efforts to reduce cytochrome P450-mediated clearance (CL) during the early stages of drug discovery, transporter-mediated CL mechanisms are becoming more…”
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Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study by Prasad, Bhagwat, Bhatt, Deepak Kumar, Johnson, Katherine, Chapa, Revathi, Chu, Xiaoyan, Salphati, Laurent, Xiao, Guangqing, Lee, Caroline, Hop, Cornelis E C A, Mathias, Anita, Lai, Yurong, Liao, Mingxiang, Humphreys, William G, Kumer, Sean C, Unadkat, Jashvant D

“…To predict the impact of liver cirrhosis on hepatic drug clearance using physiologically based pharmacokinetic (PBPK) modeling, we compared the protein…”
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Pleiotropic effects of rifampicin as a mixed-mode perpetrator drug assessed simultaneously using multiple endogenous biomarkers in dogs by Liu, Renmeng, Ma, Bin, Mok, Marilyn, Murray, Bernard, Subramanian, Raju, Lai, Yurong

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Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications by Zamek‐Gliszczynski, Maciej J., Patel, Mitesh, Yang, Xinning, Lutz, Justin D., Chu, Xiaoyan, Brouwer, Kim L. R., Lai, Yurong, Lee, Caroline A., Neuhoff, Sibylle, Paine, Mary F., Sugiyama, Yuichi, Taskar, Kunal S., Galetin, Aleksandra

“…There is an increasing interest in transporter induction (i.e., decreased systemic drug exposure due to increased efflux‐limited absorption or…”
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Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump by Rodrigues, A David, Lai, Yurong, Cvijic, Mary Ellen, Elkin, Lisa L, Zvyaga, Tatyana, Soars, Matthew G

“…The bile salt export pump (BSEP) is located on the canalicular plasma membrane of hepatocytes and plays an important role in the biliary clearance of bile…”
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Positron Emission Tomography Imaging of [11C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A by Billington, Sarah, Shoner, Steven, Lee, Scott, Clark‐Snustad, Kindra, Pennington, Matthew, Lewis, David, Muzi, Mark, Rene, Shirley, Lee, Jean, Nguyen, Tot Bui, Kumar, Vineet, Ishida, Kazuya, Chen, Laigao, Chu, Xiaoyan, Lai, Yurong, Salphati, Laurent, Hop, Cornelis E.C.A., Xiao, Guangqing, Liao, Mingxiang, Unadkat, Jashvant D.

“…Using positron emission tomography imaging, we determined the hepatic concentrations and hepatobiliary transport of [11C]rosuvastatin (RSV; i.v. injection) in…”
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