Search Results - "YUN TSO, J"

Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo by Richmond, Jillian M, Strassner, James P, Zapata, Jr, Lucio, Garg, Madhuri, Riding, Rebecca L, Refat, Maggi A, Fan, Xueli, Azzolino, Vincent, Tovar-Garza, Andrea, Tsurushita, Naoya, Pandya, Amit G, Tso, J Yun, Harris, John E

“…Vitiligo is an autoimmune disease of the skin mediated by CD8 T cells that kill melanocytes and create white spots. Skin lesions in vitiligo frequently return…”
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CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection by Mathews, David V, Dong, Ying, Higginbotham, Laura B, Kim, Steven C, Breeden, Cynthia P, Stobert, Elizabeth A, Jenkins, Joseph, Tso, J Yun, Larsen, Christian P, Adams, Andrew B

“…Interrupting T cell costimulatory signals as a strategy to control undesired immune responses, such as occur in autoimmunity or transplantation, has the…”
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Engineered Human IgG Antibodies with Longer Serum Half-lives in Primates by Hinton, Paul R., Johlfs, Mary G., Xiong, Joanna M., Hanestad, Kelly, Ong, Kelly C., Bullock, Chuck, Keller, Stephen, Tang, Meina Tao, Tso, J. Yun, Vásquez, Max, Tsurushita, Naoya

“…The neonatal Fc receptor (FcRn) plays an important role in regulating the serum half-lives of IgG antibodies. A correlation has been established between the…”
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Blockade of CD122 on memory T cells in the skin suppresses sclerodermatous graft-versus-host disease by Kubota, Noriko, Tanaka, Ryota, Ichimura, Yuki, Konishi, Risa, Tso, J.Yun, Tsurushita, Naoya, Nomura, Toshifumi, Okiyama, Naoko

“…Antigen-stimulated naïve T cells differentiate into effector and memory T cells, of which resident memory T (TRM) cells reside permanently in organ tissues…”
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Derivation and characterization of cholesterol-independent non-GS NS0 cell lines for production of recombinant antibodies by Hartman, Taymar E., Sar, Nalin, Genereux, Kimberly, Barritt, Diana S., He, Yimin, Burky, John E., Wesson, Mark C., Tso, J. Yun, Tsurushita, Naoya, Zhou, Weichang, Sauer, Paul W.

“…Presented is an antibody production platform based on the fed‐batch culture of recombinant NS0‐derived cell lines. NS0 host cells, obtained from the European…”
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CD122 blockade restores immunological tolerance in autoimmune type 1 diabetes via multiple mechanisms by Yuan, Xiaomei, Dong, Yi, Tsurushita, Naoya, Tso, J Yun, Fu, Wenxian

“…Signaling through IL-2/IL-15Rβ (CD122) is essential for the differentiation and function of T cells and NK cells. A mAb against CD122 has been implicated to…”
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Mitochondria control of cell death induced by anti-HLA-DR antibodies by BAINS, S. K, MONE, A, YUN TSO, J, LUCAS, D, BYRD, J. C, WEINER, G. J, GREEN, J. M

“…We have previously reported that crosslinking HLA-DR directly induces programmed cell death of malignant B cells. The present study further characterizes the…”
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Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15 by Tieu, Roger, Zeng, Qiang, Zhao, Daqiang, Zhang, Gang, Feizi, Neda, Manandhar, Priyanka, Williams, Amanda L, Popp, Benjamin, Wood-Trageser, Michelle A, Demetris, Anthony J, Tso, J Yun, Johnson, Aaron J, Kane, Lawrence P, Abou-Daya, Khodor I, Shlomchik, Warren D, Oberbarnscheidt, Martin H, Lakkis, Fadi G

“…Our understanding of tissue-resident memory T (T ) cell biology has been largely developed from acute infection models in which antigen is cleared and…”
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Hu1D10 induces apoptosis concurrent with activation of the AKT survival pathway in human chronic lymphocytic leukemia cells by Mone, Andrew P., Huang, Peng, Pelicano, Helene, Cheney, Carolyn M., Green, Jennifer M., Tso, J. Yun, Johnson, Amy J., Jefferson, Sara, Lin, Thomas S., Byrd, John C.

“…The 1D10 antigen is the target for Hu1D10 (apolizumab), a humanized HLA-DR β-chain–specific antibody that is currently in clinical trials for hematologic…”
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IL-2Rα-Directed monoclonal antibodies provide effective therapy in a murine model of adult T-cell leukemia by a mechanism other than blockade of IL-2/IL-2Rα interaction by PHILLIPS, Kathleen E, HERRING, Bert, WILSON, Latresia A, RICKFORD, Marc S, MEILI ZHANG, GOLDMAN, Carolyn K, YUN TSO, J, WALDMANN, Thomas A

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Human IgG2 variants of chimeric anti-CD3 are nonmitogenic to T cells by Cole, MS, Anasetti, C, Tso, JY

“…The mouse anti-human CD3 mAb OKT3 is a potent immunosuppressive agent used for the treatment of acute transplant rejection. OKT3 therapy is associated with…”
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HuM291(nuvion), a humanized Fc receptor-nonbinding antibody against CD3, anergizes peripheral blood T cells as partial agonist of the T cell receptor by CHAU, Luan A, YUN TSO, J, MELROSE, Jennifer, MADRENAS, Joaquin

“…Humanized Fc receptor (FcR)-nonbinding antibodies against CD3 are promising immunosuppressive agents that may overcome both the neutralizing response to and…”
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A recombinant, membrane-acting immunotoxin by CHOVNICK, A, SCHNEIDER, W. P, YUN TSO, J, QUEEN, C, CHUNG NAN CHANG

“…The anti-Tac antibody is known to bind to the p55 chain of the human interleukin 2 receptor. An immunotoxin was produced by genetically linking Clostridium…”
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Formation of a bispecific antibody by the use of leucine zippers by Kostelny, SA, Cole, MS, Tso, JY

“…A new method is described for the production of bispecific F(ab')2 heterodimers using leucine zippers. Two heterodimer-forming "zipper" peptides derived from…”
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A bispecific antibody prolongs survival in mice bearing lung metastases of syngeneic mammary adenocarcinoma by Bakács, T, Lee, J, Moreno, M B, Zacharchuk, C M, Cole, M S, Tso, J Y, Paik, C H, Ward, J M, Segal, D M

“…In the present study we tested whether T cells retargeted with a bispecific antibody (bsAb) could block the growth of lung metastases of syngeneic mammary…”
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Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene by Tso, J. Yun, Sun, Xiao-Hong, Kao, Teh-hui, Reece, Kimberly S., Wu, Ray

“…Full length cDns encoding the glycolyti enzme glyceraldehyde-3-phosphate dehyrogense (GAPDH)fron rat man have been in both genomes based on genmic blot…”
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Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus by Bommhardt, U, Cole, M S, Tso, J Y, Zamoyska, R

“…Differentiation of thymocytes into mature single-positive T cells is an ordered process involving sequential interactions between T cell receptor (TCR),…”
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Restoration of Immune Tolerance in Type 1 Diabetes by Modulating Interleukin-2 Receptor Signaling by Yuan, Xiaomei, Dong, Yi, Tso, J. Yun, Fu, Wenxian

“…Type 1 diabetes (T1D) is an organ-specific autoimmune disease, characterized by the destruction of insulin-producing beta cells in pancreatic islets. A variety…”
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CD122 signaling in CD8^sup +^ memory T cells drives costimulation-independent rejection by Mathews, David V, Dong, Ying, Higginbotham, Laura B, Kim, Steven C, Breeden, Cynthia P, Stobert, Elizabeth A, Jenkins, Joseph, Tso, J Yun, Larsen, Christian P, Adams, Andrew B

“…Interrupting T cell costimulatory signals as a strategy to control undesired immune responses, such as occur in autoimmunity or transplantation, has the…”
Get full text

CD122 signaling in [CD8.sup.+] memory T cells drives costimulation-independent rejection by Mathews, David V, Dong, Ying, Higginbotham, Laura B, Kim, Steven C, Breeden, Cynthia P, Stobert, Elizabeth A, Jenkins, Joseph, Tso, J. Yun, Larsen, Christian P, Adams, Andrew B

“…Interrupting T cell costimulatory signals as a strategy to control undesired immune responses, such as occur in autoimmunity or transplantation, has the…”
Get full text