Search Results - "YUFEI XIANG"

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? by Liu, Bingwen, Li, Min, Zhou, Zhiguang, Guan, Xuan, Xiang, Yufei

“…The emergent outbreak of coronavirus disease 2019 (COVID-19) has caused a global pandemic. Acute respiratory distress syndrome (ARDS) and multiorgan…”
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Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2 by Xiang, Yufei, Nambulli, Sham, Xiao, Zhengyun, Liu, Heng, Sang, Zhe, Duprex, W Paul, Schneidman-Duhovny, Dina, Zhang, Cheng, Shi, Yi

“…Cost-effective, efficacious therapeutics are urgently needed to combat the COVID-19 pandemic. In this study, we used camelid immunization and proteomics to…”
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Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes by Sun, Dapeng, Sang, Zhe, Kim, Yong Joon, Xiang, Yufei, Cohen, Tomer, Belford, Anna K., Huet, Alexis, Conway, James F., Sun, Ji, Taylor, Derek J., Schneidman-Duhovny, Dina, Zhang, Cheng, Huang, Wei, Shi, Yi

“…Interventions against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently needed. Stable and potent nanobodies (Nbs) that…”
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Altered Peripheral B-Lymphocyte Subsets in Type 1 Diabetes and Latent Autoimmune Diabetes in Adults by Deng, Chao, Xiang, Yufei, Tan, Tingting, Ren, Zhihui, Cao, Chuqing, Huang, Gan, Wen, Li, Zhou, Zhiguang

“…B lymphocytes play an important role in the immunopathogenesis of autoimmune diabetes. We hypothesized that the altered B-cell subset phenotype is associated…”
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ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB by Teng, Yaqun, Yadav, Tribhuwan, Duan, Meihan, Tan, Jun, Xiang, Yufei, Gao, Boya, Xu, Jianquan, Liang, Zhuobin, Liu, Yang, Nakajima, Satoshi, Shi, Yi, Levine, Arthur S., Zou, Lee, Lan, Li

“…Actively transcribed regions of the genome are protected by transcription-coupled DNA repair mechanisms, including transcription-coupled homologous…”
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Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study): A Nationwide, Multicenter, Clinic-Based Cross-Sectional Study by ZHIGUANG ZHOU, YUFEI XIANG, LESLIE, R. David, LINONG JI, WEIPING JIA, GUANG NING, GAN HUANG, LIN YANG, JIAN LIN, ZHENQI LIU, HAGOPIAN, William A

“…Adult non-insulin requiring diabetes includes latent autoimmune diabetes of adults (LADA), distinguished from type 2 diabetes by the presence of islet…”
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Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses by Nambulli, Sham, Xiang, Yufei, Tilston-Lunel, Natasha L, Rennick, Linda J, Sang, Zhe, Klimstra, William B, Reed, Douglas S, Crossland, Nicholas A, Shi, Yi, Duprex, W Paul

“…Globally, there is an urgency to develop effective, low-cost therapeutic interventions for coronavirus disease 2019 (COVID-19). We previously generated the…”
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Variable frequencies of peripheral T-lymphocyte subsets in the diabetes spectrum from type 1 diabetes through latent autoimmune diabetes in adults (LADA) to type 2 diabetes by Tan, Tingting, Xiang, Yufei, Deng, Chao, Cao, Chuqing, Ren, Zhihui, Huang, Gan, Zhou, Zhiguang

“…T lymphocytes are key players in the pathogenesis of autoimmune diabetes. We recruited subjects with T1D (n=81), LADA (n=82), T2D (n=95) and NGT (n=218) and…”
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Roles of TRPM channels in glioma by Chen, Zhigang, Xie, Han, Liu, Jun, Zhao, JiaJia, Huang, Ruixiang, Xiang, Yufei, Wu, Haoyuan, Tian, Dasheng, Bian, Erbao, Xiong, Zhang

“…Gliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one of the most aggressive and deadly tumor of the central…”
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Characterization of immune checkpoint inhibitor-associated fulminant type 1 diabetes associated with autoantibody status and ethnic origin by Qiu, Junlin, Luo, Shuoming, Yin, Wenfeng, Guo, Keyu, Xiang, Yufei, Li, Xia, Liu, Zhenqi, Zhou, Zhiguang

“…ObjectiveFulminant type 1 diabetes may uniquely occur as a fatal adverse event during immune checkpoint inhibitor (ICI) therapy. We investigated the clinical…”
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Super-enhancers complexes zoom in transcription in cancer by Wang, MengTing, Chen, QingYang, Wang, ShuJie, Xie, Han, Liu, Jun, Huang, RuiXiang, Xiang, YuFei, Jiang, YanYi, Tian, DaSheng, Bian, ErBao

“…Super-enhancers (SEs) consist of multiple typical enhancers enriched at high density with transcription factors, histone-modifying enzymes and cofactors…”
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Integrative proteomics identifies thousands of distinct, multi-epitope, and high-affinity nanobodies by Xiang, Yufei, Sang, Zhe, Bitton, Lirane, Xu, Jianquan, Liu, Yang, Schneidman-Duhovny, Dina, Shi, Yi

“…The antibody immune response is essential for the survival of mammals. However, we still lack a systematic understanding of the antibody repertoire. Here, we…”
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Impact of new variants on SARS-CoV-2 infectivity and neutralization: A molecular assessment of the alterations in the spike-host protein interactions by Cheng, Mary Hongying, Krieger, James M., Banerjee, Anupam, Xiang, Yufei, Kaynak, Burak, Shi, Yi, Arditi, Moshe, Bahar, Ivet

“…The emergence of SARS-CoV-2 variants necessitates rational assessment of their impact on the recognition and neutralization of the virus by the host cell. We…”
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Zinc transporter 8 autoantibody (ZnT8A) could help differentiate latent autoimmune diabetes in adults (LADA) from phenotypic type 2 diabetes mellitus by Huang, Gan, Xiang, Yufei, Pan, Lingling, Li, Xia, Luo, Shuoming, Zhou, Zhiguang

“…Background The ZnT8A is an independent marker for diagnosis of type 1 diabetes mellitus. We investigated the distribution and clinical features of ZnT8A…”
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Identification of autoimmune type 1 diabetes and multiple organ‐specific autoantibodies in adult‐onset non‐insulin‐requiring diabetes in China: A population‐based multicentre nationwide survey by Xiang, Yufei, Huang, Gan, Zhu, Yaxi, Zuo, Xuan, Liu, Xinyuan, Feng, Qiong, Li, Xia, Yang, Tubao, Lu, Juming, Shan, Zhongyan, Liu, Jie, Tian, Haoming, Ji, Qiuhe, Zhu, Dalong, Ge, Jiapu, Lin, Lixiang, Chen, Li, Guo, Xiaohui, Zhao, Zhigang, Li, Qiang, Weng, Jianping, Jia, Weiping, Liu, Zhenqi, Ji, Linong, Yang, Wenying, Leslie, Richard D., Zhou, Zhiguang

“…Aims To investigate the prevalence of adult‐onset autoimmune diabetes (ADM) and predisposition to autoimmune diseases by quantifying serum organ‐specific…”
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GAD65 Antibody Epitopes and Genetic Background in Latent Autoimmune Diabetes in Youth (LADY) by Peng, Yiman, Li, Xia, Xiang, Yufei, Yan, Xiang, Zhou, Houde, Tang, Xiaohan, Cheng, Jin, Niu, Xiaohong, Liu, Jing, Ji, Qiuhe, Ji, Linong, Huang, Gan, Zhou, Zhiguang

“…Epitope-specific GAD65Abs and gene assays help improve the value of risk stratification in autoimmune diabetes mellitus and protect islet function…”
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Exendin-4 protects mitochondria from reactive oxygen species induced apoptosis in pancreatic Beta cells by Li, Zhen, Zhou, Zhiguang, Huang, Gan, Hu, Fang, Xiang, Yufei, He, Lining

“…Mitochondrial oxidative stress is the basis for pancreatic β-cell apoptosis and a common pathway for numerous types of damage, including glucotoxicity and…”
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A resource of high-quality and versatile nanobodies for drug delivery by Shen, Zhuolun, Xiang, Yufei, Vergara, Sandra, Chen, Apeng, Xiao, Zhengyun, Santiago, Ulises, Jin, Changzhong, Sang, Zhe, Luo, Jiadi, Chen, Kong, Schneidman-Duhovny, Dina, Camacho, Carlos, Calero, Guillermo, Hu, Baoli, Shi, Yi

“…Therapeutic and diagnostic efficacies of small biomolecules and chemical compounds are hampered by suboptimal pharmacokinetics. Here, we developed a repertoire…”
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Heterogeneity of Altered Cytokine Levels Across the Clinical Spectrum of Diabetes in China by Xiang, Yufei, Zhou, Pengcheng, Li, Xiaojue, Huang, Gan, Liu, Zhenqi, Xu, Aimin, Leslie, R. David, Zhou, Zhiguang

“…OBJECTIVE: To determine the relationship between selected cytokines and diabetes in Chinese subjects. RESEARCH DESIGN AND METHODS: Adult patients with…”
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Combination therapy with saxagliptin and vitamin D for the preservation of β-cell function in adult-onset type 1 diabetes: a multi-center, randomized, controlled trial by Yan, Xiang, Li, Xia, Liu, Bingwen, Huang, Jiaqi, Xiang, Yufei, Hu, Yuhang, Tang, Xiaohan, Zhang, Ziwei, Huang, Gan, Xie, Zhiguo, Zhou, Houde, Liu, Zhenqi, Wang, Xiangbing, Leslie, Richard David, Zhou, Zhiguang

“…Disease modifying therapies aiming to preserve β-cell function in patients with adult-onset autoimmune type 1 diabetes are lacking. Here, we conducted a…”
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