Search Results - "YUEXIA LIANG"

Estimation of gross calorific value of coal based on the cubist regression model by Chen, Junlin, He, Yuli, Liang, Yuexia, Wang, Wenjia, Duan, Xiong

“…The gross calorific value (GCV) of coal is an important parameter for evaluating coal quality, and regression analysis methods can be used to predict GCV. In…”
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Carboxylesterase catalyzed 18O-labeling of carboxylic acid and its potential application in LC-MS/MS based quantification of drug metabolites by Yu, Zaikuan J., Roesner, Joseph M., Lutz, Ryan, Liang, Yuexia, Baker, James, Smith, Dustin M., Fan, Peter W.

“…LC-MS quantification of drug metabolites is sometimes impeded by the availability of internal standards that often requires customized synthesis and/or…”
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Molecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus vaccine by Zhou, Xingdong, Wang, Hui, Ji, Qun, Du, Mingjuan, Liang, Yuexia, Li, Huanhuan, Li, Fan, Shang, Hang, Zhu, Xiujuan, Wang, Wei, Jiang, Lichun, Stepanov, Alexey V., Ma, Tianyu, Gong, Nanxin, Jia, Xiaodong, Gabibov, Alexander G., Lou, Zhiyong, Lu, Yinying, Guo, Yu, Zhang, Hongkai, Yang, Xiaoming

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Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses by Tucker, Thomas J, Sisko, John T, Tynebor, Robert M, Williams, Theresa M, Felock, Peter J, Flynn, Jessica A, Lai, Ming-Tain, Liang, Yuexia, McGaughey, Georgia, Liu, Meiquing, Miller, Mike, Moyer, Gregory, Munshi, Vandna, Perlow-Poehnelt, Rebecca, Prasad, Sridhar, Reid, John C, Sanchez, Rosa, Torrent, Maricel, Vacca, Joseph P, Wan, Bang-Lin, Yan, Youwei

“…Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have been shown to be a key component of highly active antiretroviral therapy (HAART). The use of…”
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Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase by Gomez, Robert, Jolly, Samson, Williams, Theresa, Tucker, Thomas, Tynebor, Robert, Vacca, Joe, McGaughey, Georgia, Lai, Ming-Tain, Felock, Peter, Munshi, Vandna, DeStefano, Daniel, Touch, Sinoeun, Miller, Mike, Yan, Youwei, Sanchez, Rosa, Liang, Yuexia, Paton, Brenda, Wan, Bang-Lin, Anthony, Neville

“…Pyridone inhibitors of non-nucleoside reverse transcriptase (NNRTI) with improved potency are reported. Next generation NNRTIs are sought which possess both…”
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Biaryl Ethers as Novel Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Key Mutant Viruses by Su, Dai-Shi, Lim, John J, Tinney, Elizabeth, Wan, Bang-Lin, Young, Mary Beth, Anderson, Kenneth D, Rudd, Deanne, Munshi, Vandna, Bahnck, Carolyn, Felock, Peter J, Lu, Meiquing, Lai, Ming-Tain, Touch, Sinoeun, Moyer, Gregory, DiStefano, Daniel J, Flynn, Jessica A, Liang, Yuexia, Sanchez, Rosa, Perlow-Poehnelt, Rebecca, Miller, Mike, Vacca, Joe P, Williams, Theresa M, Anthony, Neville J

“…Biaryl ethers were recently reported as potent NNRTIs. Herein we disclose a detailed SAR study that led to the biaryl ether 6. This compound possessed…”
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The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations by Tucker, Thomas J., Saggar, Sandeep, Sisko, John T., Tynebor, Robert M., Williams, Theresa M., Felock, Peter J., Flynn, Jessica A., Lai, Ming-Tain, Liang, Yuexia, McGaughey, Georgia, Liu, Meiquing, Miller, Mike, Moyer, Gregory, Munshi, Vandna, Perlow-Poehnelt, Rebecca, Prasad, Sridhar, Sanchez, Rosa, Torrent, Maricel, Vacca, Joseph P., Wan, Bang-Lin, Yan, Youwei

“…The design and synthesis of novel diaryl ether NNRTIs with high levels of antiviral potency is reported. Using a combination of traditional Medicinal…”
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Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants by Su, Dai-Shi, Lim, John J., Tinney, Elizabeth, Wan, Bang-Lin, Young, Mary Beth, Anderson, Kenneth D., Rudd, Deanne, Munshi, Vandna, Bahnck, Carolyn, Felock, Peter J., Lu, Meiqing, Lai, Ming-Tain, Touch, Sinoeun, Moyer, Gregory, DiStefano, Daniel J., Flynn, Jessica A., Liang, Yuexia, Sanchez, Rosa, Prasad, Sridhar, Yan, Youwei, Perlow-Poehnelt, Rebecca, Torrent, Maricel, Miller, Mike, Vacca, Joe P., Williams, Theresa M., Anthony, Neville J.

“…Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are key elements of multidrug regimens, called HAART (Highly Active Antiretroviral Therapy), that are…”
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Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: Aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif by Su, Dai-Shi, Lim, John J., Tinney, Elizabeth, Tucker, Thomas J., Saggar, Sandeep, Sisko, John T., Wan, Bang-Lin, Young, Mary Beth, Anderson, Kenneth D., Rudd, Deanne, Munshi, Vandna, Bahnck, Carolyn, Felock, Peter J., Lu, Meiquing, Lai, Ming-Tain, Touch, Sinoeun, Moyer, Gregory, DiStefano, Daniel J., Flynn, Jessica A., Liang, Yuexia, Sanchez, Rosa, Perlow-Poehnelt, Rebecca, Miller, Mike, Vacca, Joe P., Williams, Theresa M., Anthony, Neville J.

“…Biaryl ethers were recently reported as potent NNRTIs. Herein, we disclose a detailed effort to modify the previously reported compound 1. We have designed and…”
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Ginsenoside Re reduces Aβ production by activating PPARγ to inhibit BACE1 in N2a/APP695 cells by Cao, Guoqiong, Su, Ping, Zhang, Shuai, Guo, Limin, Zhang, Haijing, Liang, Yuexia, Qin, Chunxia, Zhang, Wensheng

“…Alzheimer's disease (AD) is a neurodegenerative disease characterized by β-amyloid protein (Aβ) deposition. Reducing the Aβ load may be a new perspective for…”
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Population pharmacokinetic modeling for enterohepatic recirculation in Rhesus monkey by Shou, Magang, Lu, Wei, Kari, Prasad H., Xiang, Cathie, Liang, Yuexia, Lu, Ping, Cui, Dan, Emary, W. Bart, Michel, Kimberly B., Adelsberger, Jennifer K., Brunner, Janice E., Rodrigues, A. David

“…Enterohepatic recirculation (EHR) occurs via biliary excretion and intestinal reabsorption of a drug. Drug recycling through EHR can lead to a change in…”
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Quantitation of geometric isomers of a phosphodiesterase inhibitor in rat and monkey plasma using liquid chromatography–tandem mass spectrometry by Liang, Yuexia, Zhang, Rena, Adarayan, Emily, Adamson, Gary, Zhao, Jamie J., Kassahun, Kelem, Emary, W. Bart

“…Quantitation of geometric isomers of a phosphodiesterase inhibitor was required to determine the extent of interconversion following dosing of a single isomer…”
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16S rRNA and transcriptome analysis of the FOS-mediated alleviation of Aeromonas hydrophila-induced intestinal damage in Megalobrama amblycephala by Jiang, Dongxue, Li, Shengnan, Liang, Yuexia, Xu, Ruiyi, Qi, Qian, Wang, Bingke, Zhang, Chunnuan

“…This study was conducted to elucidate the effects of FOS that alleviate Aeromonas hydrophila-induced intestinal damage. The results showed that A. hydrophila…”
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Berberine modulates amyloid-β peptide generation by activating AMP-activated protein kinase by Zhang, Haijing, Zhao, Chunhui, Cao, Guoqiong, Guo, Limin, Zhang, Shuai, Liang, Yuexia, Qin, Chunxia, Su, Ping, Li, Hang, Zhang, Wensheng

“…Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by memory deficits and cognitive decline. Excessive amyloid-β (Aβ) peptide…”
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Protective effects of the fructooligosaccharide on the growth performance, biochemical indexes, and intestinal morphology of blunt snout bream (Megalobrama amblycephala) infected by Aeromonas hydrophila by Jiang, Dongxue, Li, Shengnan, Liang, Yuexia, Ma, Junqi, Wang, Bingke, Zhang, Chunnuan

“…  The purpose of the study was to investigate the effects of dietary fructooligosaccharide (FOS) on growth performance, biochemical indexes, intestinal…”
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Metabolite Bioanalysis in Drug Development: Recommendations from the IQ Consortium Metabolite Bioanalysis Working Group by Li, Wenkui, Vazvaei‐Smith, Faye, Dear, Gordon, Boer, Jason, Cuyckens, Filip, Fraier, Daniela, Liang, Yuexia, Lu, Ding, Mangus, Heidi, Moliner, Patricia, Pedersen, Mette Lund, Romeo, Andrea A., Spracklin, Douglas K., Wagner, David S., Winter, Serge, Xu, Xiaohui (Sophia)

“…The intent of this perspective is to share the recommendations of the International Consortium for Innovation and Quality in Pharmaceutical Development…”
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Characterisation of the absorption, distribution, metabolism, excretion and mass balance of doravirine, a non-nucleoside reverse transcriptase inhibitor in humans by Sanchez, Rosa I., Fillgrove, Kerry L., Yee, Ka Lai, Liang, Yuexia, Lu, Bing, Tatavarti, Aditya, Liu, Rachael, Anderson, Matt S., Behm, Martin O., Fan, Li, Li, Yun, Butterton, Joan R., Iwamoto, Marian, Khalilieh, Sauzanne G.

“…Absorption, distribution, metabolism and elimination of doravirine (MK-1439), a novel non-nucleoside reverse transcriptase inhibitor, were investigated. Two…”
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In vitro assessment of drug-drug interaction potential of boceprevir associated with drug metabolizing enzymes and transporters by Chu, Xiaoyan, Cai, Xiaoxin, Cui, Donghui, Tang, Cuyue, Ghosal, Anima, Chan, Grace, Green, Mitchell D, Kuo, Yuhsin, Liang, Yuexia, Maciolek, Cheri M, Palamanda, Jairam, Evers, Raymond, Prueksaritanont, Thomayant

“…The inhibitory effect of boceprevir (BOC), an inhibitor of hepatitis C virus nonstructural protein 3 protease was evaluated in vitro against a panel of…”
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Self-assembly of X-shaped antibody to combine the activity of IgG and IgA for enhanced tumor killing by Liang, Yuexia, Li, Xin, Peng, Fengping, Ye, Xiaohan, Wang, Wei, Cen, Tianyi, Li, Fan, Lu, Yue, Liu, Zhaoyun, Liu, Hui, Ding, Kai, Ye, Kai, Yu, Yang, Ma, Tianyu, Zhang, Sihe, Huang, Yi, Wang, Yuan, Yang, Xue, Fu, Rong, Zhang, Hongkai

“…IgA can induce activation of neutrophils which are the most abundant cell type in blood, but the development of IgA as therapeutic has been confounded by its…”
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Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator by Rudd, Michael T., Manley, Peter J., Hanney, Barbara, Meng, Zhaoyang, Shu, Youheng, de Leon, Pablo, Frie, Jessica L., Han, Yongxin, Wai, Jenny Miu-Chun, Yang, Zhi-Qiang, Perkins, James J., Hurzy, Danielle M., Manikowski, Jesse J., Zhu, Hong, Bungard, Christopher J., Converso, Antonella, Meissner, Robert S., Cosden, Mali L., Hayashi, Ikuo, Ma, Lei, O’Brien, Julie, Uebele, Victor N., Schachter, Joel B., Bhandari, Neetesh, Ward, Gwendolyn J., Fillgrove, Kerry L., Lu, Bing, Liang, Yuexia, Dubost, David C., Puri, Vanita, Eddins, Donnie M., Vardigan, Joshua D., Drolet, Robert E., Kern, Jonathan T., Uslaner, Jason M.

“…Glutamate plays a key role in cognition and mood, and it has been shown that inhibiting ionotropic glutamate receptors disrupts cognition, while enhancing…”
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