Search Results - "YUANXUE HUANG"

SPIB and BATF provide alternate determinants of IRF4 occupancy in diffuse large B-cell lymphoma linked to disease heterogeneity by Care, Matthew A, Cocco, Mario, Laye, Jon P, Barnes, Nicholas, Huang, Yuanxue, Wang, Ming, Barrans, Sharon, Du, Ming, Jack, Andrew, Westhead, David R, Doody, Gina M, Tooze, Reuben M

“…Interferon regulatory factor 4 (IRF4) is central to the transcriptional network of activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL), an…”
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BCR and TLR signaling pathways are recurrently targeted by genetic changes in splenic marginal zone lymphomas by QINGGUO YAN, YUANXUE HUANG, WATKINS, A. James, KOCIALKOWSKI, Sylvia, NAIYAN ZENG, HAMOUDI, Rifat A, ISAACSON, Peter G, DE LEVAL, Laurence, WOTHERSPOON, Andrew, DU, Ming-Qing

“…The genetics and pathogenesis of splenic marginal zone lymphoma are poorly understood. The lymphoma lacks chromosome translocation, and approximately 30% of…”
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Variable Responses of MYC Translocation Positive Lymphoma Cell Lines To Different Combinations of Novel Agents: Impact of BCL2 Family Protein Expression by Deng, Wenhan, Clipson, Alexandra, Liu, Hongxiang, Huang, Yuanxue, Dobson, Rachel, Wang, Ming, Johnson, Peter, Du, Ming-Qing

“…Several newly developed drugs including JQ1 (BET inhibitor), ABT199 (BCL2 inhibitor), and bortezomib (proteasome inhibitor) may offer novel therapeutic…”
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A practical strategy for the routine use of BIOMED‐2 PCR assays for detection of B‐ and T‐cell clonality in diagnostic haematopathology by Liu, Hongxiang, Bench, Anthony J., Bacon, Chris M., Payne, Karen, Huang, Yuanxue, Scott, Mike A., Erber, Wendy N., Grant, John W., Du, Ming‐Qing

“…Summary BIOMED‐2 polymerase chain reaction (PCR) assays for clonality analysis of immunoglobulin (IG) and T‐cell receptor (TCR) gene rearrangements were…”
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An integrated genomic and expression analysis of 7q deletion in splenic marginal zone lymphoma by Watkins, A James, Hamoudi, Rifat A, Zeng, Naiyan, Yan, Qingguo, Huang, Yuanxue, Liu, Hongxiang, Zhang, Jianzhong, Braggio, Esteban, Fonseca, Rafael, de Leval, Laurence, Isaacson, Peter G, Wotherspoon, Andrew, McPhail, Ellen D, Dogan, Ahmet, Du, Ming-Qing

“…Splenic marginal zone lymphoma (SMZL) is an indolent B-cell lymphoproliferative disorder characterised by 7q32 deletion, but the target genes of this deletion…”
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Distinct involvement of NF‐κB regulators by somatic mutation in ocular adnexal malt lymphoma by Yan, Qingguo, Wang, Ming, Moody, Sarah, Xue, Xuemin, Huang, Yuanxue, Bi, Yingwen, Du, Ming‐Qing

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Somatic Mutation Screening Using Archival Formalin-Fixed, Paraffin-Embedded Tissues by Fluidigm Multiplex PCR and Illumina Sequencing by Wang, Ming, Escudero-Ibarz, Leire, Moody, Sarah, Zeng, Naiyan, Clipson, Alexandra, Huang, Yuanxue, Xue, Xuemin, Grigoropoulos, Nicholas F, Barrans, Sharon, Worrillow, Lisa, Forshew, Tim, Su, Jing, Firth, Andrew, Martin, Howard, Jack, Andrew, Brugger, Kim, Du, Ming-Qing

“…High-throughput somatic mutation screening using FFPE tissues is a major challenge because of a lack of established methods and validated variant calling…”
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Primary effusion lymphoma: genomic profiling revealed amplification of SELPLG and CORO1C encoding for proteins important for cell migration by Luan, Shi-Lu, Boulanger, Emmanuelle, Ye, Hongtao, Chanudet, Estelle, Johnson, Nicola, Hamoudi, Rifat A, Bacon, Chris M, Liu, Hongxiang, Huang, Yuanxue, Said, Jonathan, Chu, Peiguo, Clemen, Christoph S, Cesarman, Ethel, Chadburn, Amy, Isaacson, Peter G, Du, Ming-Qing

“…Primary effusion lymphoma (PEL) is associated with Kaposi sarcoma herpesvirus (KSHV) but its pathogenesis is poorly understood. Many KSHV-associated products…”
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BIOMED‐2 PCR assays for IGK gene rearrangements are essential for B‐cell clonality analysis in follicular lymphoma by Payne, Karen, Wright, Penny, Grant, John W., Huang, Yuanxue, Hamoudi, Rifat, Bacon, Chris M., Du, Ming‐Qing, Liu, Hongxiang

“…Summary B‐cell clonality analysis is commonly performed by polymerase chain reaction (PCR) targeting the IGH genes although a high false‐negative rate is…”
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A20 inactivation in ocular adnexal MALT lymphoma by BI, Yingwen, NAIYAN ZENG, RONGJIA CHEN, XIONGZENG ZHU, DU, Ming-Qing, CHANUDET, Estelle, YUANXUE HUANG, HAMOUDI, Rifat A, HONGXIANG LIU, GEHONG DONG, JAMES WATKINS, A, LEY, Steven C, LIFEN ZOU

“…Recent studies showed A20 inactivation by deletion, mutation and promoter methylation in ocular adnexal mucosa-associated lymphoid tissue lymphoma. However,…”
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Splenic marginal zone lymphoma: characterization of 7q deletion and its value in diagnosis by Watkins, A. James, Huang, Yuanxue, Ye, Hongtao, Chanudet, Estelle, Johnson, Nicola, Hamoudi, Rifat, Liu, Hongxiang, Dong, Gehong, Attygalle, Ayoma, McPhail, Ellen D, Law, Mark E, Isaacson, Peter G, de Leval, Laurence, Wotherspoon, Andrew, Du, Ming-Qing

“…The diagnosis of splenic marginal zone lymphoma (SMZL) is frequently a challenge, due to its lack of specific histological features and immunophenotypic…”
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The prognosis of MYC translocation positive diffuse large B‐cell lymphoma depends on the second hit by Clipson, Alexandra, Barrans, Sharon, Zeng, Naiyan, Crouch, Simon, Grigoropoulos, Nicholas F, Liu, Hongxiang, Kocialkowski, Sylvia, Wang, Ming, Huang, Yuanxue, Worrillow, Lisa, Goodlad, John, Buxton, Jenny, Neat, Michael, Fields, Paul, Wilkins, Bridget, Grant, John W, Wright, Penny, EI‐Daly, Hesham, Follows, George A, Roman, Eve, Watkins, A James, Johnson, Peter W M, Jack, Andrew, Du, Ming‐Qing

“…A proportion of MYC translocation positive diffuse large B‐cell lymphomas (DLBCL) harbour a BCL2 and/or BCL6 translocation, known as double‐hit DLBCL, and are…”
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The Lymphoma-associated Fusion Tyrosine Kinase ITK-SYK Requires Pleckstrin Homology Domain-mediated Membrane Localization for Activation and Cellular Transformation by Rigby, Sue, Huang, Yuanxue, Streubel, Berthold, Chott, Andreas, Du, Ming-Qing, Turner, Suzanne D., Bacon, Chris M.

“…ITK-SYK, a novel fusion tyrosine kinase (FTK) resulting from a recurrent t(5;9)(q33;q22), was recently identified in a poorly understood subset of peripheral…”
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Richter transformation: clonal identity does not indicate a linear disease progression by Liu, Hongxiang, Yan, Qingguo, Nuako-Bandoh, Betty, Grigoropoulos, Nick, Huang, Yuanxue, Follows, George, Grant, John, Lawton, Hilary, Wright, Penny, Du, Ming-Qing

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Angioimmunoblastic T‐cell lymphoma contains multiple clonal T‐cell populations derived from a common TET2 mutant progenitor cell by Yao, Wen‐Qing, Wu, Fangtian, Zhang, Wenyan, Chuang, Shih‐Sung, Thompson, Joe S, Chen, Zi, Zhang, Shao‐Wei, Clipson, Alexandra, Wang, Ming, Liu, Hongxiang, Bibawi, Hani, Huang, Yuanxue, Campos, Luis, Grant, John W, Wright, Penny, EI‐Daly, Hesham, Rásó‐Barnett, Lívia, Farkas, Lorant, Follows, George A, Gao, Zifen, Attygalle, Ayoma D, Ashton‐Key, Margaret, Liu, Weiping, Du, Ming‐Qing

“…Angioimmunoblastic T‐cell lymphoma (AITL) is a neoplastic proliferation of T follicular helper cells with clinical and histological presentations suggesting a…”
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Contribution of immunoglobulin lambda light chain gene rearrangement analysis in the diagnosis of B‐cell neoplasms by Paterson, Anna L., El‐Daly, Hesham, Raso‐Barnett, Livia, Du, Ming‐Qing, Giger, Olivier, Soilleux, Elizabeth, Roberts, Thomas, Huang, Yuanxue, Bibawi, Hani, Matharu, Baljinder, Bench, Anthony, Scott, Mike A., Liu, Hongxiang

“…Summary Identification of clonal IGH, IGK and IGL gene rearrangements offers diagnostic adjunct in suspected B‐cell neoplasms. However, many centres omit IGL…”
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TNFAIP3 abnormalities in MALT lymphoma with autoimmunity by Chanudet, Estelle, Huang, Yuanxue, Zeng, Naiyan, Streubel, Berthold, Chott, Andreas, Raderer, Markus, Du, Ming‐Qing

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A comparison of methods for EGFR mutation testing in non-small cell lung cancer by Young, Elizabeth C, Owens, Martina M, Adebiyi, Idowu, Bedenham, Tina, Butler, Rachel, Callaway, Jonathan, Cranston, Treena, Crosby, Charlene, Cree, Ian A, Dutton, Laura, Faulkes, Catherine, Faulkner, Claire, Howard, Emma, Knight, Julia, Huang, Yuanxue, Lavender, Louise, Lazarou, Lazarus P, Liu, Hongxiang, Mair, Debbie, Milano, Antonio, Sandell, Stacey, Skinner, Alison, Wallace, Andrew, Williams, Maggie, Spivey, Vicky, Goodall, John, Frampton, Jonathan, Ellard, Sian

“…EGFR mutation testing of tumor samples is routinely performed to predict sensitivity to treatment with tyrosine kinase inhibitors for patients with non-small…”
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Application of a multi‐gene next‐generation sequencing panel to a non‐invasive oesophageal cell‐sampling device to diagnose dysplastic Barrett's oesophagus by Katz‐Summercorn, Annalise, Anand, Shubha, Ingledew, Sophie, Huang, Yuanxue, Roberts, Thomas, Galeano‐Dalmau, Nuria, O'Donovan, Maria, Liu, Hongxiang, Fitzgerald, Rebecca C

“…The early detection and endoscopic treatment of patients with the dysplastic stage of Barrett's oesophagus is a key to preventing progression to oesophageal…”
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A rare case of gastric MALT lymphoma resistant to multiple treatment regimens by Dong, Gehong, Huang, Yuanxue, Yan, Qingguo, Chanudet, Estelle, Ye, Hongtao, Liu, Hongxiang, Isaacson, Peter G, Rodriguez-Justo, Manuel, Du, Ming-Qing

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