Search Results - "YUAN, Sarah Y"

Endothelial glycocalyx-associated molecules as potential serological markers for sepsis-associated encephalopathy: A systematic review and meta-analysis by Baby, Sheon, Reljic, Tea, Villalba, Nuria, Kumar, Ambuj, Yuan, Sarah Y

“…Sepsis-associated encephalopathy (SAE) is characterized by a diffuse cerebral dysfunction that accompanies sepsis in the absence of direct central nervous…”
Get full text

Endothelial microvesicles carrying Src-rich cargo impair adherens junction integrity and cytoskeleton homeostasis by Chatterjee, Victor, Yang, Xiaoyuan, Ma, Yonggang, Cha, Byeong, Meegan, Jamie E, Wu, Mack, Yuan, Sarah Y

“…Abstract Aims Microvesicles (MVs) conduct intercellular communication and impact diverse biological processes by transferring bioactive cargos to other cells…”
Get full text

The Endothelial Glycocalyx as a Double-Edged Sword in Microvascular Homeostasis and Pathogenesis by Villalba, Nuria, Baby, Sheon, Yuan, Sarah Y

“…Expressed on the endothelial cell (EC) surface of blood vessels, the glycocalyx (GCX), a mixture of carbohydrates attached to proteins, regulates the access of…”
Get full text

Thrombin-cleaved syndecan-3/-4 ectodomain fragments mediate endothelial barrier dysfunction by Jannaway, Melanie, Yang, Xiaoyuan, Meegan, Jamie E, Coleman, Danielle C, Yuan, Sarah Y

“…The endothelial glycocalyx constitutes part of the endothelial barrier but its degradation leaves endothelial cells exposed to transmigrating cells and…”
Get full text

Citrullinated histone 3 causes endothelial barrier dysfunction by Meegan, Jamie E., Yang, Xiaoyuan, Beard, Richard S., Jannaway, Melanie, Chatterjee, Victor, Taylor-Clark, Thomas E., Yuan, Sarah Y.

“…Circulating components of neutrophil extracellular traps (NETs), especially histones, are associated with tissue injury during inflammatory conditions like…”
Get full text

Site-specific opening of the blood-brain barrier by extracellular histones by Villalba, Nuria, Baby, Sheon, Cha, Byeong J, Yuan, Sarah Y

“…Increased extracellular histones in the bloodstream are known as a biomarker for vascular dysfunction associated with severe trauma or sepsis. There is limited…”
Get full text

Role of Neutrophil Extracellular Traps and Vesicles in Regulating Vascular Endothelial Permeability by Ma, Yonggang, Yang, Xiaoyuan, Chatterjee, Victor, Meegan, Jamie E, Beard, Jr, Richard S, Yuan, Sarah Y

“…The microvascular endothelium serves as the major barrier that controls the transport of blood constituents across the vessel wall. Barrier leakage occurs…”
Get full text

Myosin Light Chain Kinase Signaling in Endothelial Barrier Dysfunction by Rigor, Robert R., Shen, Qiang, Pivetti, Christopher D., Wu, Mack H., Yuan, Sarah Y.

“…Microvascular barrier dysfunction is a serious problem that occurs in many inflammatory conditions, including sepsis, trauma, ischemia–reperfusion injury,…”
Get full text

Sphingosine-1-Phosphate Reduces Hemorrhagic Shock and Resuscitation-Induced Microvascular Leakage by Protecting Endothelial Mitochondrial Integrity by Alves, Natascha G, Trujillo, Andrea N, Breslin, Jerome W, Yuan, Sarah Y

“…ABSTRACTExcessive microvascular permeability is a serious complication following hemorrhagic shock and resuscitation (HSR). S1P has been shown to ameliorate…”
Get full text

Nonmuscle Myosin Light-Chain Kinase Deficiency Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice via Reduced Endothelial Barrier Dysfunction and Monocyte Migration by CHONGXIU SUN, WU, Mack H, YUAN, Sarah Y

“…Endothelial dysfunction and monocyte migration are key events in the pathogenesis of atherosclerosis. Nonmuscle myosin light-chain kinase (nmMLCK), the…”
Get full text

Lung infection by Pseudomonas aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice by Villalba, Nuria, Ma, Yonggang, Gahan, Sarah A, Joly-Amado, Aurelie, Spence, Sam, Yang, Xiaoyuan, Nash, Kevin R, Yuan, Sarah Y

“…Severe lung infection can lead to brain dysfunction and neurobehavioral disorders. The mechanisms that regulate the lung-brain axis of inflammatory response to…”
Get full text

Molecular mechanisms of endothelial hyperpermeability: implications in inflammation by Kumar, Puneet, Shen, Qiang, Pivetti, Christopher D, Lee, Eugene S, Wu, Mack H, Yuan, Sarah Y

“…Endothelial hyperpermeability is a significant problem in vascular inflammation associated with trauma, ischaemia-reperfusion injury, sepsis, adult respiratory…”
Get more information

Gut Ischemia Reperfusion Injury Induces Lung Inflammation via Mesenteric Lymph-Mediated Neutrophil Activation by Ma, Yonggang, Zabell, Taylor, Creasy, Alexandra, Yang, Xiaoyuan, Chatterjee, Victor, Villalba, Nuria, Kistler, Erik B, Wu, Mack H, Yuan, Sarah Y

“…Gut ischemia/reperfusion (I/R) injury is a common clinical problem associated with significant mortality and morbidities that result from systemic inflammation…”
Get full text

Sphingosine‐1‐phosphate protects against brain microvascular endothelial junctional protein disorganization and barrier dysfunction caused by alcohol by Alves, Natascha G., Yuan, Sarah Y., Breslin, Jerome W.

“…Objective S1P has known endothelial barrier‐protective properties, but whether this extends to the BBB is unclear. We hypothesized that alcohol‐induced…”
Get full text

DHHC21 deficiency attenuates renal dysfunction during septic injury by Yang, Xiaoyuan, Zheng, Ethan, Ma, Yonggang, Chatterjee, Victor, Villalba, Nuria, Breslin, Jerome W., Liu, Ruisheng, Wu, Mack H., Yuan, Sarah Y.

“…Renal dysfunction is one of the most common complications of septic injury. One critical contributor to septic injury-induced renal dysfunction is renal…”
Get full text

Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome by Beard, Richard S., Yang, Xiaoyuan, Meegan, Jamie E., Overstreet, Jonathan W., Yang, Clement G.Y., Elliott, John A., Reynolds, Jason J., Cha, Byeong J., Pivetti, Christopher D., Mitchell, David A., Wu, Mack H., Deschenes, Robert J., Yuan, Sarah Y.

“…Endothelial dysfunction is a hallmark of systemic inflammatory response underlying multiple organ failure. Here we report a novel function of DHHC-containing…”
Get full text

A Disintegrin and Metalloproteinase 15 Contributes to Atherosclerosis by Mediating Endothelial Barrier Dysfunction via Src Family Kinase Activity by Sun, Chongxiu, Wu, Mack H, Lee, Eugene S, Yuan, Sarah Y

“…OBJECTIVE—Endothelium dysfunction is an initiating factor in atherosclerosis. A disintegrin and metalloproteinase 15 (ADAM 15) is a multidomain metalloprotease…”
Get full text

Protein Palmitoylation in Leukocyte Signaling and Function by Yang, Xiaoyuan, Chatterjee, Victor, Ma, Yonggang, Zheng, Ethan, Yuan, Sarah Y.

“…Palmitoylation is a post-translational modification (PTM) based on thioester-linkage between palmitic acid and the cysteine residue of a protein. This covalent…”
Get full text

A disintegrin and metalloproteinase 15-mediated glycocalyx shedding contributes to vascular leakage during inflammation by Yang, Xiaoyuan, Meegan, Jamie E, Jannaway, Melanie, Coleman, Danielle C, Yuan, Sarah Y

Get full text

MicroRNA-147b regulates vascular endothelial barrier function by targeting ADAM15 expression by Chatterjee, Victor, Beard, Jr, Richard S, Reynolds, Jason J, Haines, Ricci, Guo, Mingzhang, Rubin, Matthew, Guido, Jenny, Wu, Mack H, Yuan, Sarah Y

“…A disintegrin and metalloproteinase15 (ADAM15) has been shown to be upregulated and mediate endothelial hyperpermeability during inflammation and sepsis. This…”
Get full text