Search Results - "YU, Chul H"

Discovery of a potent and selective Aurora kinase inhibitor by Oslob, Johan D., Romanowski, Michael J., Allen, Darin A., Baskaran, Subramanian, Bui, Minna, Elling, Robert A., Flanagan, William M., Fung, Amy D., Hanan, Emily J., Harris, Shannon, Heumann, Stacey A., Hoch, Ute, Jacobs, Jeffrey W., Lam, Joni, Lawrence, Chris E., McDowell, Robert S., Nannini, Michelle A., Shen, Wang, Silverman, Jeffrey A., Sopko, Michelle M., Tangonan, Bradley T., Teague, Juli, Yoburn, Josh C., Yu, Chul H., Zhong, Min, Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard

“…The discovery of a novel series of Aurora kinase inhibitors is disclosed. This communication describes the discovery of a novel series of Aurora kinase…”
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Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye by Zhong, Min, Gadek, Thomas R, Bui, Minna, Shen, Wang, Burnier, John, Barr, Kenneth J, Hanan, Emily J, Oslob, Johan D, Yu, Chul H, Zhu, Jiang, Arkin, Michelle R, Evanchik, Marc J, Flanagan, W. Mike, Hoch, Ute, Hyde, Jennifer, Prabhu, Saileta, Silverman, Jeffrey A, Wright, Jasmin

“…LFA-1/ICAM-1 interaction is essential in support of inflammatory and specific T-cell regulated immune responses by mediating cell adhesion, leukocyte…”
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2-Aminobenzimidazoles as potent Aurora kinase inhibitors by Zhong, Min, Bui, Minna, Shen, Wang, Baskaran, Subramanian, Allen, Darin A., Elling, Robert A., Flanagan, W. Michael, Fung, Amy D., Hanan, Emily J., Harris, Shannon O., Heumann, Stacey A., Hoch, Ute, Ivy, Sheryl N., Jacobs, Jeffrey W., Lam, Stuart, Lee, Heman, McDowell, Robert S., Oslob, Johan D., Purkey, Hans E., Romanowski, Michael J., Silverman, Jeffrey A., Tangonan, Bradley T., Taverna, Pietro, Yang, Wenjin, Yoburn, Josh C., Yu, Chul H., Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard

“…This Letter describes the discovery and key structure–activity relationship (SAR) of a series of 2-aminobenzimidazoles as potent Aurora kinase inhibitors…”
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Structure–activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists by Zhong, Min, Hanan, Emily J., Shen, Wang, Bui, Minna, Arkin, Michelle R., Barr, Kenneth J., Evanchik, Marc J., Hoch, Ute, Hyde, Jennifer, Martell, Jose R., Oslob, Johan D., Paulvannan, Kumar, Prabhu, Saileta, Silverman, Jeffrey A., Wright, Jasmin, Yu, Chul H., Zhu, Jiang, Flanagan, W. Mike

“…Structure–activity relationship (SAR) of the α-amino acid residue and identification of (S)-2,3-diaminopropanoic acid (DAP) replacements of potent…”
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Water-soluble prodrugs of an Aurora kinase inhibitor by Oslob, Johan D., Heumann, Stacey A., Yu, Chul H., Allen, Darin A., Baskaran, Subramanian, Bui, Minna, Delarosa, Erlie, Fung, Amy D., Hashash, Ahmad, Hau, Jonathan, Ivy, Sheryl, Jacobs, Jeffrey W., Lew, Willard, Maung, Jack, McDowell, Robert S., Ritchie, Sean, Romanowski, Michael J., Silverman, Jeffrey A., Yang, Wenjin, Zhong, Min, Fuchs-Knotts, Tarra

“…In vitro and in vivo properties of prodrug derivatives of the Aurora kinase inhibitor SNS-314 are described. Compound 1 (SNS-314) is a potent and selective…”
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Synthesis and biological activity of selective pipecolic acid-based TNF-α converting enzyme (TACE) inhibitors by Letavic, Michael A., Axt, Matt Z., Barberia, John T., Carty, Thomas J., Danley, Dennis E., Geoghegan, Kieran F., Halim, Nadia S., Hoth, Lise R., Kamath, Ajith V., Laird, Ellen R., Lopresti-Morrow, Lori L., McClure, Kim F., Mitchell, Peter G., Natarajan, Vijayalakshmi, Noe, Mark C., Pandit, Jayvardhan, Reeves, Lisa, Schulte, Gayle K., Snow, Sheri L., Sweeney, Francis J., Tan, Douglas H., Yu, Chul H.

“…A series of novel, selective TNF-α converting enzyme inhibitors based on 4-hydroxy and 5-hydroxy pipecolate hydroxamic acid scaffolds is described. The potency…”
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Identification of nonpeptidic small-molecule inhibitors of interleukin-2 by Waal, Nathan D., Yang, Wenjin, Oslob, Johan D., Arkin, Michelle R., Hyde, Jennifer, Lu, Wanli, McDowell, Robert S., Yu, Chul H., Raimundo, Brian C.

“…The identification, design, and synthesis of a series of novel sulfamide- and urea-based small-molecule antagonists of the protein–protein interaction…”
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Integrating Fragment Assembly and Biophysical Methods in the Chemical Advancement of Small-Molecule Antagonists of IL-2:  An Approach for Inhibiting Protein−Protein Interactions by Raimundo, Brian C, Oslob, Johan D, Braisted, Andrew C, Hyde, Jennifer, McDowell, Robert S, Randal, Mike, Waal, Nathan D, Wilkinson, Jennifer, Yu, Chul H, Arkin, Michelle R

“…Fragment assembly has shown promise for discovering small-molecule antagonists for difficult targets, including protein−protein interactions. Here, we describe…”
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Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists by Zhong, Min, Shen, Wang, Barr, Kenneth J., Arbitrario, Jennifer P., Arkin, Michelle R., Bui, Minna, Chen, Teresa, Cunningham, Brian C., Evanchik, Marc J., Hanan, Emily J., Hoch, Ute, Huen, Karen, Hyde, Jennifer, Kumer, Jeffery L., Lac, Teresa, Lawrence, Chris E., Martell, Jose R., Oslob, Johan D., Paulvannan, Kumar, Prabhu, Saileta, Silverman, Jeffrey A., Wright, Jasmin, Yu, Chul H., Zhu, Jiang, Flanagan, W. Mike

“…The discovery of a novel series of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists is described. This…”
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Benzimidazolone p38 inhibitors by DOMBROSKI, Mark A, LETAVIC, Michael A, JORDAN, Crystal K, LABASI, Jeff M, MARTIN, William H, PEESE, Kevin M, STOCK, Ingrid A, SVENSSON, Linne, SWEENEY, Francis J, YU, Chul H, MCCLURE, Kim F, BARBERIA, John T, CARTY, Thomas J, CORTINA, Santo R, CSIKI, Csilla, DIPESA, Alan J, ELLIOTT, Nancy C, GABEL, Christopher A

“…The synthesis and in vitro p38 alpha activity of a novel series of benzimidazolone inhibitors is described. The p38 alpha SAR is consistent with a mode of…”
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Synthesis and biological activity of piperazine-Based dual MMP-13 and TNF-α converting enzyme inhibitors by Letavic, Michael A., Barberia, John T., Carty, Thomas J., Hardink, Joel R., Liras, Jennifer, Lopresti-Morrow, Lori L., Mitchell, Peter G., Noe, Mark C., Reeves, Lisa M., Snow, Sheri L., Stam, Ethan J., Sweeney, Francis J., Vaughn, Marcie L., Yu, Chul H.

“…A series of novel MMP-13 and TNF-α converting enzyme inhibitors based on piperazine 2-hydroxamic acid scaffolds are described. The TACE, MMP-1 and MMP-13…”
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