Search Results - "YOUZHEN WANG"

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED by Qi, Wei, Zhao, Kehao, Gu, Justin, Huang, Ying, Wang, Youzhen, Zhang, Hailong, Zhang, Man, Zhang, Jeff, Yu, Zhengtian, Li, Ling, Teng, Lin, Chuai, Shannon, Zhang, Chao, Zhao, Mengxi, Chan, HoMan, Chen, Zijun, Fang, Douglas, Fei, Qi, Feng, Leying, Feng, Lijian, Gao, Yuan, Ge, Hui, Ge, Xinjian, Li, Guobin, Lingel, Andreas, Lin, Ying, Liu, Yueqin, Luo, Fangjun, Shi, Minlong, Wang, Long, Wang, Zhaofu, Yu, Yanyan, Zeng, Jue, Zeng, Chenhui, Zhang, Lijun, Zhang, Qiong, Zhou, Shaolian, Oyang, Counde, Atadja, Peter, Li, En

“…H3K27me3 binding to the EED pocket of the Polycomb repressive complex 2 (PRC2) is required to activate PRC2. An allosteric small-molecule inhibitor of PRC2 was…”
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Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia by Moujalled, Donia M., Pomilio, Giovanna, Ghiurau, Corina, Ivey, Adam, Salmon, Jessica, Rijal, Sewa, Macraild, Sarah, Zhang, Lan, Teh, Tse-Chieh, Tiong, Ing-Soo, Lan, Ping, Chanrion, Maia, Claperon, Audrey, Rocchetti, Francesca, Zichi, Adrien, Kraus-Berthier, Laurence, Wang, Youzhen, Halilovic, Ensar, Morris, Erick, Colland, Frédéric, Segal, David, Huang, David, Roberts, Andrew W., Maragno, Ana Leticia, Lessene, Guillaume, Geneste, Olivier, Wei, Andrew H.

“…Improving outcomes in acute myeloid leukemia (AML) remains a major clinical challenge. Overexpression of pro-survival BCL-2 family members rendering…”
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BH3 profiling as pharmacodynamic biomarker for the activity of BH3 mimetics by Pan, Rongqing Aaron, Wang, Youzhen, Qiu, Shumei, Villalobos-Ortiz, Mariana, Ryan, Jeremy, Morris, Erick, Halilovic, Ensar, Letai, Anthony

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Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC by Zeng, Hao, Castillo-Cabrera, Johnny, Manser, Mika, Lu, Bo, Yang, Zinger, Strande, Vaik, Begue, Damien, Zamponi, Raffaella, Qiu, Shumei, Sigoillot, Frederic, Wang, Qiong, Lindeman, Alicia, Reece-Hoyes, John S, Russ, Carsten, Bonenfant, Debora, Jiang, Xiaomo, Wang, Youzhen, Cong, Feng

“…EGFR-mutant NSCLCs frequently respond to EGFR tyrosine kinase inhibitors (TKIs). However, the responses are not durable, and the magnitude of tumor regression…”
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FGFR-Mediated Reactivation of MAPK Signaling Attenuates Antitumor Effects of Imatinib in Gastrointestinal Stromal Tumors by Li, Fang, Huynh, Hung, Li, Xiaoyan, Ruddy, David A, Wang, Youzhen, Ong, Richard, Chow, Pierce, Qiu, Shumei, Tam, Angela, Rakiec, Daniel P, Schlegel, Robert, Monahan, John E, Huang, Alan

“…Activating mutations in either KIT or PDGFRA are present in approximately 90% of gastrointestinal stromal tumors (GIST). Although treatment with the KIT and…”
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FGF401 and vinorelbine synergistically mediate antitumor activity and vascular normalization in FGF19-dependent hepatocellular carcinoma by Huynh, Hung, Prawira, Aldo, Le, Thi Bich Uyen, Vu, Thanh Chung, Hao, Huai-Xiang, Huang, Alan, Wang, Youzhen, Porta, Diana Graus

“…Hepatocellular carcinoma (HCC) is a lethal cancer with limited therapeutic options, and standard therapy with sorafenib provides only modest survival benefits…”
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NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma by ZHENG HUANG, HAIPING WU, GU, Justin, MAN ZHANG, YANG, Teddy, KEHAO ZHAO, YANYAN YU, JINGQUAN DAI, WEI YI, SHAOLIAN ZHOU, QIAN LI, JING WU, SHANNON CHUAI, JUN LIU, XU WU, CHAN, Homan, LU, Chris, ATADJA, Peter, EN LI, YAN WANG, MIN HU, FIONA XU, FENG YAN, ENGLUND, Nathan, ZHAOFU WANG, HAILONG ZHANG, MING FANG, YOUZHEN WANG

“…Histone lysine methyltransferase NSD2 (WHSC1/MMSET) is overexpressed frequently in multiple myeloma due to the t(4;14) translocation associated with 15% to 20%…”
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Effects of Combined Main Ditch and Field Ditch Control Measures on Crop Yield and Drainage Discharge in the Northern Huaihe River Plain, Anhui Province, China by Tang, Rong, Wang, Xiugui, Han, Xudong, Yan, Yihui, Huang, Shuang, Huang, Jiesheng, Shen, Tao, Wang, Youzhen, Liu, Jia

“…Open-ditch controlled drainage is an important water management measure used to reduce drought and waterlogging stress in many areas in the world. Such…”
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Partial hydrogenation of benzene to cyclohexene on a Ru-Zn/m-ZrO2 nanocomposite catalyst by Wang, Jianqiang, Wang, Youzhen, Xie, Songhai, Qiao, Minghua, Li, Hexing, Fan, Kangnian

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Cortical interneurons upregulate neurotrophins in vivo in response to targeted apoptotic degeneration of neighboring pyramidal neurons by YOUZHEN WANG, SHEEN, V. L, MACKLIS, J. D

“…Intercellular signals provided by growth and neurotrophic factors play a critical role during neurogenesis and as part of cellular repopulation strategies…”
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Vessel traffic flow forecasting with the combined model based on support vector machine by Haiyan, Wang, Youzhen, Wang

“…The research of vessel traffic flow prediction is important basis of waterway planning, design and vessel navigation management. Vessel traffic model is a…”
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A coupled regional-scale numerical model for hydrological processes and interactions between groundwater and surface water in a controlled drainage district by Han, Xudong, Zhu, Yan, Wang, Xiugui, Wang, Youzhen, Shen, Tao, Tang, Rong

“…•A novel regional-scale hydrological model for drainage districts is developed.•The spatiotemporal exchange between surface water and groundwater are…”
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LBY135, a novel anti-DR5 agonistic antibody induces tumor cell-specific cytotoxic activity in human colon tumor cell lines and xenografts by Li, Jing, Knee, Deborah A., Wang, Youzhen, Zhang, Qingxiu, Johnson, Jennifer A., Cheng, Jane, He, Helen, Miller, Christine, Li, Zhifang, Kowal, Colleen, Eckman III, Joseph, Tang, Betty, Yuan, Jing, Chen, Liqing, Deveraux, Quinn, Nasoff, Marc S., Stover, David

“…TRAIL (TNF‐related apoptosis‐inducing ligand) induces apoptosis on binding to DR4 and DR5 receptors on the surface of tumor cells. These receptors are of…”
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Dynamic BH3 Profiling As Pharmacodynamic Biomarker for the Activity of BH3 Mimetics by Pan, Rongqing, Wang, Youzhen, Qiu, Shumei, Ryan, Jeremy, Halilovic, Ensar

“…Pharmacodynamic (PD) biomarkers provide information about the pharmacologic effects of a drug on its target, i.e. to assess whether a given agent is engaging…”
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Neural Precursor Differentiation Following Transplantation into Neocortex Is Dependent on Intrinsic Developmental State and Receptor Competence by Sheen, Volney L., Arnold, Matthew W., Wang, Youzhen, Macklis, Jeffrey D.

“…Reconstruction of neocortical circuitry by transplantation of neural precursors, or by manipulation of endogenous precursors, may depend critically upon both…”
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High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response by Gao, Hui, Korn, Joshua M, Ferretti, Stéphane, Monahan, John E, Wang, Youzhen, Singh, Mallika, Zhang, Chao, Schnell, Christian, Yang, Guizhi, Zhang, Yun, Balbin, O Alejandro, Barbe, Stéphanie, Cai, Hongbo, Casey, Fergal, Chatterjee, Susmita, Chiang, Derek Y, Chuai, Shannon, Cogan, Shawn M, Collins, Scott D, Dammassa, Ernesta, Ebel, Nicolas, Embry, Millicent, Green, John, Kauffmann, Audrey, Kowal, Colleen, Leary, Rebecca J, Lehar, Joseph, Liang, Ying, Loo, Alice, Lorenzana, Edward, Robert McDonald, E, McLaughlin, Margaret E, Merkin, Jason, Meyer, Ronald, Naylor, Tara L, Patawaran, Montesa, Reddy, Anupama, Röelli, Claudia, Ruddy, David A, Salangsang, Fernando, Santacroce, Francesca, Singh, Angad P, Tang, Yan, Tinetto, Walter, Tobler, Sonja, Velazquez, Roberto, Venkatesan, Kavitha, Von Arx, Fabian, Wang, Hui Qin, Wang, Zongyao, Wiesmann, Marion, Wyss, Daniel, Xu, Fiona, Bitter, Hans, Atadja, Peter, Lees, Emma, Hofmann, Francesco, Li, En, Keen, Nicholas, Cozens, Robert, Jensen, Michael Rugaard, Pryer, Nancy K, Williams, Juliet A, Sellers, William R

“…The authors implement a collection of patient-derived xenograft tumors to test cancer drug responses. Profiling candidate therapeutics with limited cancer…”
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Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation by Baltschukat, Sabrina, Engstler, Barbara Schacher, Huang, Alan, Hao, Huai-Xiang, Tam, Angela, Wang, Hui Qin, Liang, Jinsheng, DiMare, Matthew T, Bhang, Hyo-Eun Carrie, Wang, Youzhen, Furet, Pascal, Sellers, William R, Hofmann, Francesco, Schoepfer, Joseph, Tiedt, Ralph

“…The selective MET inhibitor capmatinib is being investigated in multiple clinical trials, both as a single agent and in combination. Here, we describe the…”
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Achieving High-Performance Polymer-Wrapper-Free Aligned Carbon Nanotube Field-Effect Transistors Through Degradable Polymer Wrapping and Efficient Removal Techniques by Bai, Lan, Lin, Yanxia, Chen, Xingxing, Yin, Huimin, Jin, Chuanhong, Wang, Youzhen, Zhang, Zhiyong, Peng, Lian-Mao, Liang, Xuelei, Cao, Yu

“…Semiconducting carbon nanotubes (s-CNTs) have emerged as a promising alternative to traditional silicon for ultrascaled field-effect transistors (FETs), owing…”
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Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials by Fritsch, Christine, Huang, Alan, Chatenay-Rivauday, Christian, Schnell, Christian, Reddy, Anupama, Liu, Manway, Kauffmann, Audrey, Guthy, Daniel, Erdmann, Dirk, De Pover, Alain, Furet, Pascal, Gao, Hui, Ferretti, Stephane, Wang, Youzhen, Trappe, Joerg, Brachmann, Saskia M, Maira, Sauveur-Michel, Wilson, Christopher, Boehm, Markus, Garcia-Echeverria, Carlos, Chene, Patrick, Wiesmann, Marion, Cozens, Robert, Lehar, Joseph, Schlegel, Robert, Caravatti, Giorgio, Hofmann, Francesco, Sellers, William R

“…Somatic PIK3CA mutations are frequently found in solid tumors, raising the hypothesis that selective inhibition of PI3Kα may have robust efficacy in…”
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Glycerol tributylate (Triacylglycerol tributanoate) promoted the liver lipid metabolism by cultivating the intestinal flora of grass carp (Ctenopharyngodon idellus) by Ji, Yan, Hu, Bing, Wang, Youzhen, Dong, Guifang, Zhang, Chi, Yu, Denghang

“…To investigate the effects of glycerol tributyrin (TB) ( Triacylglycerol tributanoate ) on the regulation of liver lipid metabolism by intestinal flora of…”
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