Search Results - "YOUWEN XU"

[11C]HCN Radiochemistry: Recent Progress and Future Perspectives by Xu, Youwen, Qu, Wenchao

“…Positron emission tomography (PET) is a unique non‐invasive imaging tool for studying in vivo biological processes. It utilizes short‐lived positron emitter…”
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Imaging metabotropic glutamate receptor system: Application of positron emission tomography technology in drug development by Xu, Youwen, Li, Zizhong

“…The diversity seen in the mode of pharmacology and the numerous glutamate receptor subtypes have previously complicated drug development efforts. Nonetheless,…”
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Effects of Modafinil on Dopamine and Dopamine Transporters in the Male Human Brain: Clinical Implications by Volkow, Nora D, Fowler, Joanna S, Logan, Jean, Alexoff, David, Zhu, Wei, Telang, Frank, Wang, Gene-Jack, Jayne, Millard, Hooker, Jacob M, Wong, Christopher, Hubbard, Barbara, Carter, Pauline, Warner, Donald, King, Payton, Shea, Colleen, Xu, Youwen, Muench, Lisa, Apelskog-Torres, Karen

“…CONTEXT Modafinil, a wake-promoting drug used to treat narcolepsy, is increasingly being used as a cognitive enhancer. Although initially launched as distinct…”
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ARID1A Variations in Cholangiocarcinoma: Clinical Significances and Molecular Mechanisms by Zhao, Shankun, Xu, Youwen, Wu, Weizhou, Wang, Pan, Wang, Yichao, Jiang, Hao, Zhu, Jie

“…Cholangiocarcinoma (CCA), a high mortality malignant carcinoma characterized by advanced disease and frequent recurrence, constitutes a major challenge for…”
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Robust biological nitrogen fixation in a model grass–bacterial association by Pankievicz, Vânia C. S., Amaral, Fernanda P., Santos, Karina F. D. N., Agtuca, Beverly, Xu, Youwen, Schueller, Michael J., Arisi, Ana Carolina M., Steffens, Maria. B.R., Souza, Emanuel M., Pedrosa, Fábio O., Stacey, Gary, Ferrieri, Richard A.

“…Summary Nitrogen‐fixing rhizobacteria can promote plant growth; however, it is controversial whether biological nitrogen fixation (BNF) from associative…”
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LINC00473 promotes hepatocellular carcinoma progression via acting as a ceRNA for microRNA-195 and increasing HMGA2 expression by Mo, Jinggang, Li, Bo, Zhou, Yong, Xu, Youwen, Jiang, Hao, Cheng, Xingjing, Wu, Xiaoyu, Zhang, Yaqiong

“…•LINC00473 was highly expressed in HCC cell lines.•Down-regulation of LINC00473 retarded HCC cell progression in vitro and in vivo.•LINC00473 targeted…”
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Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans by Hooker, Jacob M., Xu, Youwen, Schiffer, Wynne, Shea, Colleen, Carter, Pauline, Fowler, Joanna S.

“…Salvia divinorum, a mint plant originally used by the Mazatecs of Oaxaca, Mexico in spiritual rituals has gained popularity, in smoked form, as a legal…”
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Reversible Inhibitors of Monoamine Oxidase-A (RIMAs): Robust, Reversible Inhibition of Human Brain MAO-A by CX157 by FOWLER, Joanna S, LOGAN, Jean, WANG, Gene-Jack, TELANG, Frank, HUBBARD, Barbara, JAYNE, Millard, KING, Payton, CARTER, Pauline, CARTER, Scott, YOUWEN XU, SHEA, Colleen, MUENCH, Lisa, AZZARO, Albert J, ALEXOFF, David, SHUMAY, Elena, SCHUELLER, Michael, WARNER, Donald, APELSKOG-TORRES, Karen, FIELDING, Robert M, WEI ZHU, POSHUSTA, Amy K, BURCH, Daniel, BRAND, Barry, FREE, James, ASGHARNEJAD, Mahnaz

“…Reversible inhibitors of monoamine oxidase-A (RIMA) inhibit the breakdown of three major neurotransmitters, serotonin, norepinephrine and dopamine, offering a…”
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Correction: Alcohol ADME in Primates Studied with Positron Emission Tomography by Li, Zizhong, Xu, Youwen, Warner, Don, Volkow, Nora D.

“…The correct version of the table is available here: thumbnail Download: * PPT PowerPoint slide * PNG larger image * TIFF original image In addition, there were…”
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Blockade of the brain histamine H3 receptor by JNJ-39220675: preclinical PET studies with [11C]GSK189254 in anesthetized baboon by Logan, Jean, Carruthers, Nicholas I., Letavic, Michael A., Sands, Steven, Jiang, Xiaohui, Shea, Colleen, Muench, Lisa, Xu, Youwen, Carter, Pauline, King, Payton, Fowler, Joanna S.

“…Rationale The preclinical characterization of a series of aryloxypyridine amides has identified JNJ-39220675…”
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Alcohol ADME in primates studied with positron emission tomography by Li, Zizhong, Xu, Youwen, Warner, Don, Volkow, Nora D

“…The sensitivity to the intoxicating effects of alcohol as well as its adverse medical consequences differ markedly among individuals, which reflects in part…”
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In Vivo Imaging of Brain Aromatase in Female Baboons: [11C]Vorozole Kinetics and Effect of the Menstrual Cycle by Pareto, Deborah, Biegon, Anat, Alexoff, David, Carter, Pauline, Shea, Coreen, Muench, Lisa, Xu, Youwen, Fowler, Joanna S., Kim, Sunny W., Logan, Jean

“…The aim of this work was to quantify the brain distribution of the enzyme aromatase in the female baboon with positron emission tomography and the tracer…”
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Evaluation of 6-([18 F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain by Reid, Alicia E, Hooker, Jacob, Shumay, Elena, Logan, Jean, Shea, Colleen, Kim, Sung Won, Collins, Shanika, Xu, Youwen, Volkow, Nora, Fowler, Joanna S

“…Abstract Introduction Histone deacetylases (HDACs) are enzymes involved in epigenetic modifications that shift the balance toward chromatin condensation and…”
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Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec) by Kil, Kun-Eek, Ding, Yu-Shin, Lin, Kuo-Shyan, Alexoff, David, Kim, Sung Won, Shea, Colleen, Xu, Youwen, Muench, Lisa, Fowler, Joanna S

“…Abstract Introduction Imatinib mesylate (Gleevec) is a well known drug for treating chronic myeloid leukemia and gastrointestinal stromal tumors. Its active…”
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Evaluation of [ 11C]metergoline as a PET radiotracer for 5HTR in nonhuman primates by Hooker, Jacob M., Kim, Sung Won, Reibel, Achim T., Alexoff, David, Xu, Youwen, Shea, Colleen

“…Metergoline, a serotonin receptor antagonist, was labeled with carbon-11 in order to evaluate its pharmacokinetics and distribution in non-human primates using…”
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Characterisation of [11C]PR04.MZ in Papio anubis baboon: A selective high-affinity radioligand for quantitative imaging of the dopamine transporter by Riss, Patrick J., Hooker, Jacob M., Shea, Colleen, Xu, Youwen, Carter, Pauline, Warner, Donald, Ferrari, Valentina, Kim, Sung-Won, Aigbirhio, Franklin I., Fowler, Joanna S., Roesch, Frank

“…Automatted radiosynthesis of [11C]PR04.MZ and evaluation of the radiotracer in non-human primates is described…”
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Evaluation of a new norepinephrine transporter PET ligand in baboons, both in brain and peripheral organs by Ding, Yu-Shin, Lin, Kuo-Shyan, Garza, Victor, Carter, Pauline, Alexoff, David, Logan, Jean, Shea, Colleen, Xu, Youwen, King, Payton

“…Reboxetine is a specific norepinephrine transporter (NET) inhibitor and has been marketed in several countries as a racemic mixture of the (R,R) and (S,S)…”
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Reinvestigation of the synthesis and evaluation of [ N -methyl-11 C]vorozole, a radiotracer targeting cytochrome P450 aromatase by Kim, Sung Won, Biegon, Anat, Katsamanis, Zachary E, Ehrlich, Carolin W, Hooker, Jacob M, Shea, Colleen, Muench, Lisa, Xu, Youwen, King, Payton, Carter, Pauline, Alexoff, David L, Fowler, Joanna S

“…Abstract Introduction We reinvestigated the synthesis of [ N -methyl-11 C]vorozole, a radiotracer for aromatase, and discovered the presence of an N -methyl…”
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The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects by Volkow, Nora D., Wang, Gene-Jack, Fowler, Joanna S., Learned-Coughlin, Susan, Yang, Julia, Logan, Jean, Schlyer, David, Gatley, John S., Wong, Christopher, Zhu, Wei, Pappas, Naomi, Schueller, Michael, Jayne, Millard, Carter, Pauline, Warner, Donald, Ding, Yu-Shin, Shea, Colleen, Xu, Youwen

“…(2S,3S)-2-(3-Chlorophenyl)-3,5,5,-trimethyl-2-morpholinol hydrochloride (radafaxine) is a new antidepressant that blocks dopamine transporters (DAT). A concern…”
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Low Monoamine Oxidase B in Peripheral Organs in Smokers by Fowler, Joanna S., Logan, Jean, Wang, Gene-Jack, Volkow, Nora D., Telang, Frank, Zhu, Wei, Franceschi, Dinko, Pappas, Naomi, Ferrieri, Richard, Shea, Colleen, Garza, Victor, Xu, Youwen, Schlyer, David, Gatley, S. John, Ding, Yu-Shin, Alexoff, David, Warner, Donald, Netusil, Noelwah, Carter, Pauline, Jayne, Millard, King, Payton, Vaska, Paul

“…One of the major mechanisms for terminating the actions of catecholamines and vasoactive dietary amines is oxidation by monoamine oxidase (MAO). Smokers have…”
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