Search Results - "YOUNT, Nannette Y"

Emerging Themes and Therapeutic Prospects for Anti-Infective Peptides by YOUNT, Nannette Y, YEAMAN, Michael R

“…Pathogens resistant to most conventional anti-infectives are a harbinger of the need to discover and develop novel anti-infective agents and strategies…”
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Mechanisms of Antimicrobial Peptide Action and Resistance by Yeaman, Michael R, Yount, Nannette Y

“…Antimicrobial peptides have been isolated and characterized from tissues and organisms representing virtually every kingdom and phylum, ranging from…”
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The Archetypal Gamma-Core Motif of Antimicrobial Cys-Rich Peptides Inhibits H + -ATPases in Target Pathogens by Andrés, María T, Yount, Nannette Y, Acosta-Zaldívar, Maikel, Yeaman, Michael R, Fierro, José F

“…Human lactoferrin (hLf) is an innate host defense protein that inhibits microbial H -ATPases. This protein includes an ancestral structural motif (i.e., γ-core…”
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The Hyr1 protein from the fungus Candida albicans is a cross kingdom immunotherapeutic target for Acinetobacter bacterial infection by Uppuluri, Priya, Lin, Lin, Alqarihi, Abdullah, Luo, Guanpingsheng, Youssef, Eman G, Alkhazraji, Sondus, Yount, Nannette Y, Ibrahim, Belal A, Bolaris, Michael Anthony, Edwards, Jr, John E, Swidergall, Marc, Filler, Scott G, Yeaman, Michael R, Ibrahim, Ashraf S

“…Different pathogens share similar medical settings and rely on similar virulence strategies to cause infections. We have previously applied 3-D computational…”
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Multidimensional Signatures in Antimicrobial Peptides by Yount, Nannette Y., Yeaman, Michael R., Kaback, H. Ronald

“…Conventional analyses distinguish between antimicrobial peptides by differences in amino acid sequence. Yet structural paradigms common to broader classes of…”
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Advances in antimicrobial peptide immunobiology by Yount, Nannette Y., Bayer, Arnold S., Xiong, Yan Q., Yeaman, Michael R.

“…Antimicrobial peptides are ancient components of the innate immune system and have been isolated from organisms spanning the phylogenetic spectrum. Over an…”
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Discovery of Novel Type II Bacteriocins Using a New High-Dimensional Bioinformatic Algorithm by Yount, Nannette Y, Weaver, David C, de Anda, Jaime, Lee, Ernest Y, Lee, Michelle W, Wong, Gerard C L, Yeaman, Michael R

“…Antimicrobial compounds first arose in prokaryotes by necessity for competitive self-defense. In this light, prokaryotes invented the first host defense…”
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Monoclonal IgM Antibodies Targeting Candida albicans Hyr1 Provide Cross-Kingdom Protection Against Gram-Negative Bacteria by Youssef, Eman G, Zhang, Lina, Alkhazraji, Sondus, Gebremariam, Teclegiorgis, Singh, Shakti, Yount, Nannette Y, Yeaman, Michael R, Uppuluri, Priya, Ibrahim, Ashraf S

“…Recent years have seen an unprecedented rise in the incidence of multidrug-resistant (MDR) Gram-negative bacteria (GNBs) such as and species. In view of the…”
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Selective Reciprocity in Antimicrobial Activity versus Cytotoxicity of hBD-2 and Crotamine by Yount, Nannette Y., Kupferwasser, Deborah, Spisni, Alberto, Dutz, Stephen M., Ramjan, Zachary H., Sharma, Shantanu, Waring, Alan J., Yeaman, Michael R., Kaback, H. Ronald

“…Recent discoveries suggest cysteine-stabilized toxins and antimicrobial peptides have structure-activity parallels derived by common ancestry. Here, human…”
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Modular determinants of antimicrobial activity in platelet factor-4 family kinocidins by Yeaman, Michael R., Yount, Nannette Y., Waring, Alan J., Gank, Kimberly D., Kupferwasser, Deborah, Wiese, Robert, Bayer, Arnold S., Welch, William H.

“…Mammalian platelets contain an array of antimicrobial peptides, termed platelet microbicidal proteins (PMPs). Human and rabbit PMPs include known chemokines,…”
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Peptide antimicrobials: cell wall as a bacterial target by Yount, Nannette Y., Yeaman, Michael R.

“…Endogenous host defense peptides (HDPs) are among the most ancient immune mediators, constituting a first line of defense against invading pathogens across the…”
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Platelet Antistaphylococcal Responses Occur through P2X₁ and P2Y₁₂ Receptor-Induced Activation and Kinocidin Release by Trier, Darin A, Gank, Kimberly D, Kupferwasser, Deborah, Yount, Nannette Y, French, William J, Michelson, Alan D, Kupferwasser, Leon I, Xiong, Yan Q, Bayer, Arnold S, Yeaman, Michael R

“…Platelets (PLTs) act in antimicrobial host defense by releasing PLT microbicidal proteins (PMPs) or PLT kinocidins (PKs). Receptors mediating staphylocidal…”
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Context mediates antimicrobial efficacy of kinocidin congener peptide RP-1 by Yount, Nannette Y, Cohen, Samuel E, Kupferwasser, Deborah, Waring, Alan J, Ruchala, Piotr, Sharma, Shantanu, Wasserman, Karlman, Jung, Chun-Ling, Yeaman, Michael R

“…Structure-mechanism relationships are key determinants of host defense peptide efficacy. These relationships are influenced by anatomic, physiologic and…”
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PACAP is a pathogen-inducible resident antimicrobial neuropeptide affording rapid and contextual molecular host defense of the brain by Lee, Ernest Y., Chan, Liana C., Wang, Huiyuan, Lieng, Juelline, Hung, Mandy, Srinivasan, Yashes, Wang, Jennifer, Waschek, James A., Ferguson, Andrew L., Lee, Kuo-Fen, Yount, Nannette Y., Yeaman, Michael R., Wong, Gerard C. L.

“…Defense of the central nervous system (CNS) against infection must be accomplished without generation of potentially injurious immune cell-mediated or…”
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Unifying themes in host defence effector polypeptides by Yeaman, Michael R, Yount, Nannette Y

“…It is said that nature is the greatest innovator, yet molecular conservation can be equally powerful. One key requirement for the survival of any host is its…”
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SSD1 Is Integral to Host Defense Peptide Resistance in Candida albicans by Gank, Kimberly D, Yeaman, Michael R, Kojima, Satoshi, Yount, Nannette Y, Park, Hyunsook, Edwards, Jr, John E, Filler, Scott G, Fu, Yue

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Unifying structural signature of eukaryotic α-helical host defense peptides by Yount, Nannette Y., Weaver, David C., Lee, Ernest Y., Lee, Michelle W., Wang, Huiyuan, Chan, Liana C., Wong, Gerard C. L., Yeaman, Michael R.

“…Diversity of α-helical host defense peptides (αHDPs) contributes to immunity against a broad spectrum of pathogens via multiple functions. Thus, resolving…”
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Platelet Microbicidal Protein 1: Structural Themes of a Multifunctional Antimicrobial Peptide by YOUNT, Nannette Y, GANK, Kimberly D, YAN QIONG XIONG, BAYER, Arnold S, PENDER, Thomas, WELCH, William H, YEAMAN, Michael R

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Structural congruence among membrane-active host defense polypeptides of diverse phylogeny by Yount, Nannette Y., Yeaman, Michael R.

“…A requisite for efficacious host defense against pathogens and predators has prioritized evolution of effector molecules thereof. A recent multidimensional…”
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α-Defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes by Yamamoto, Cindy M., Banaiee, Niaz, Yount, Nannette Y., Patel, Bindi, Selsted, Michael E.

“…α‐Defensins are antimicrobial peptides that contribute to innate‐immune functions of neutrophils and intestinal Paneth cells. Transcription of α‐defensin genes…”
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