Search Results - "YOUNT, Boyd"

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence by Menachery, Vineet D, Yount, Boyd L, Debbink, Kari, Agnihothram, Sudhakar, Gralinski, Lisa E, Plante, Jessica A, Graham, Rachel L, Scobey, Trevor, Ge, Xing-Yi, Donaldson, Eric F, Randell, Scott H, Lanzavecchia, Antonio, Marasco, Wayne A, Shi, Zhengli-Li, Baric, Ralph S

“…Ralph Baric, Vineet Menachery and colleagues characterize a SARS-like coronavirus circulating in Chinese horseshoe bats to determine its potential to infect…”
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SARS-like WIV1-CoV poised for human emergence by Menachery, Vineet D., Yount, Boyd L., Sims, Amy C., Debbink, Kari, Agnihothram, Sudhakar S., Gralinski, Lisa E., Graham, Rachel L., Scobey, Trevor, Plante, Jessica A., Royal, Scott R., Swanstrom, Jesica, Sheahan, Timothy P., Pickles, Raymond J., Corti, Davide, Randell, Scott H., Lanzavecchia, Antonio, Marasco, Wayne A., Baric, Ralph S.

“…Outbreaks from zoonotic sources represent a threat to both human disease as well as the global economy. Despite a wealth of metagenomics studies,methods to…”
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A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures by Dinnon, Kenneth H., Leist, Sarah R., Schäfer, Alexandra, Edwards, Caitlin E., Martinez, David R., Montgomery, Stephanie A., West, Ande, Yount, Boyd L., Hou, Yixuan J., Adams, Lily E., Gully, Kendra L., Brown, Ariane J., Huang, Emily, Bryant, Matthew D., Choong, Ingrid C., Glenn, Jeffrey S., Gralinski, Lisa E., Sheahan, Timothy P., Baric, Ralph S.

“…Coronaviruses are prone to transmission to new host species, as recently demonstrated by the spread to humans of severe acute respiratory syndrome coronavirus…”
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Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection by Menachery, Vineet D, Dinnon, 3rd, Kenneth H, Yount, Jr, Boyd L, McAnarney, Eileen T, Gralinski, Lisa E, Hale, Andrew, Graham, Rachel L, Scobey, Trevor, Anthony, Simon J, Wang, Lingshu, Graham, Barney, Randell, Scott H, Lipkin, W Ian, Baric, Ralph S

“…Traditionally, the emergence of coronaviruses (CoVs) has been attributed to a gain in receptor binding in a new host. Our previous work with severe acute…”
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Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity by Menachery, Vineet D, Yount, Jr, Boyd L, Josset, Laurence, Gralinski, Lisa E, Scobey, Trevor, Agnihothram, Sudhakar, Katze, Michael G, Baric, Ralph S

“…The sudden emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and, more recently, Middle Eastern respiratory syndrome CoV (MERS-CoV)…”
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Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry by Shang, Jian, Wan, Yushun, Liu, Chang, Yount, Boyd, Gully, Kendra, Yang, Yang, Auerbach, Ashley, Peng, Guiqing, Baric, Ralph, Li, Fang

“…Coronaviruses recognize a variety of receptors using different domains of their envelope-anchored spike protein. How these diverse receptor recognition…”
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MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis by Menachery, Vineet D, Mitchell, Hugh D, Cockrell, Adam S, Gralinski, Lisa E, Yount, Jr, Boyd L, Graham, Rachel L, McAnarney, Eileen T, Douglas, Madeline G, Scobey, Trevor, Beall, Anne, Dinnon, 3rd, Kenneth, Kocher, Jacob F, Hale, Andrew E, Stratton, Kelly G, Waters, Katrina M, Baric, Ralph S

“…While dispensable for viral replication, coronavirus (CoV) accessory open reading frame (ORF) proteins often play critical roles during infection and…”
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Human dengue virus serotype 2 neutralizing antibodies target two distinct quaternary epitopes by Gallichotte, Emily N, Baric, Thomas J, Yount, Jr, Boyd L, Widman, Douglas G, Durbin, Anna, Whitehead, Steve, Baric, Ralph S, de Silva, Aravinda M

“…Dengue virus (DENV) infection causes dengue fever, dengue hemorrhagic fever and dengue shock syndrome. It is estimated that a third of the world's population…”
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Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection by Edwards, Caitlin E., Yount, Boyd L., Graham, Rachel L., Leist, Sarah R., Hou, Yixuan J., Dinnon, Kenneth H., Sims, Amy C., Swanstrom, Jesica, Gully, Kendra, Scobey, Trevor D., Cooley, Michelle R., Currie, Caroline G., Randell, Scott H., Baric, Ralph S.

“…Zoonotic coronaviruses represent an ongoing threat, yet the myriads of circulating animal viruses complicate the identification of higher-risk isolates that…”
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Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice by Martinez, David R, Schäfer, Alexandra, Leist, Sarah R, De la Cruz, Gabriela, West, Ande, Atochina-Vasserman, Elena N, Lindesmith, Lisa C, Pardi, Norbert, Parks, Robert, Barr, Maggie, Li, Dapeng, Yount, Boyd, Saunders, Kevin O, Weissman, Drew, Haynes, Barton F, Montgomery, Stephanie A, Baric, Ralph S

“…The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003 and SARS-CoV-2 in 2019 highlights the need to develop universal vaccination…”
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Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice by Pruijssers, Andrea J., George, Amelia S., Schäfer, Alexandra, Leist, Sarah R., Gralinksi, Lisa E., Dinnon, Kenneth H., Yount, Boyd L., Agostini, Maria L., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., Gully, Kendra, Martinez, David R., Brown, Ariane J., Graham, Rachel L., Perry, Jason K., Du Pont, Venice, Pitts, Jared, Ma, Bin, Babusis, Darius, Murakami, Eisuke, Feng, Joy Y., Bilello, John P., Porter, Danielle P., Cihlar, Tomas, Baric, Ralph S., Denison, Mark R., Sheahan, Timothy P.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the novel viral disease COVID-19. With no approved therapies, this…”
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Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus by Scobey, Trevor, Yount, Boyd L., Sims, Amy C., Donaldson, Eric F., Agnihothram, Sudhakar S., Menachery, Vineet D., Graham, Rachel L., Swanstrom, Jesica, Bove, Peter F., Kim, Jeeho D., Grego, Sonia, Randell, Scott H., Baric, Ralph S.

“…Severe acute respiratory syndrome with high mortality rates (∼50%) is associated with a novel group 2c betacoronavirus designated Middle East respiratory…”
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Deletion of a 197-Amino-Acid Region in the N-Terminal Domain of Spike Protein Attenuates Porcine Epidemic Diarrhea Virus in Piglets by Hou, Yixuan, Lin, Chun-Ming, Yokoyama, Masaru, Yount, Boyd L, Marthaler, Douglas, Douglas, Arianna L, Ghimire, Shristi, Qin, Yibin, Baric, Ralph S, Saif, Linda J, Wang, Qiuhong

“…We previously isolated a porcine epidemic diarrhea virus (PEDV) strain, PC177, by blind serial passaging of the intestinal contents of a diarrheic piglet in…”
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Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines by Menachery, Vineet D, Gralinski, Lisa E, Mitchell, Hugh D, Dinnon, 3rd, Kenneth H, Leist, Sarah R, Yount, Jr, Boyd L, McAnarney, Eileen T, Graham, Rachel L, Waters, Katrina M, Baric, Ralph S

“…With an ongoing threat posed by circulating zoonotic strains, new strategies are required to prepare for the next emergent coronavirus (CoV). Previously,…”
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An Immunocompetent Mouse Model of Zika Virus Infection by Gorman, Matthew J., Caine, Elizabeth A., Zaitsev, Konstantin, Begley, Matthew C., Weger-Lucarelli, James, Uccellini, Melissa B., Tripathi, Shashank, Morrison, Juliet, Yount, Boyd L., Dinnon, Kenneth H., Rückert, Claudia, Young, Michael C., Zhu, Zhe, Robertson, Shelly J., McNally, Kristin L., Ye, Jing, Cao, Bin, Mysorekar, Indira U., Ebel, Gregory D., Baric, Ralph S., Best, Sonja M., Artyomov, Maxim N., Garcia-Sastre, Adolfo, Diamond, Michael S.

“…Progress toward understanding Zika virus (ZIKV) pathogenesis is hindered by lack of immunocompetent small animal models, in part because ZIKV fails to…”
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Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for the Rapid Response to Emerging Coronaviruses by Agnihothram, Sudhakar, Gopal, Robin, Yount, Boyd L., Donaldson, Eric F., Menachery, Vineet D., Graham, Rachel L., Scobey, Trevor D., Gralinski, Lisa E., Denison, Mark R., Zambon, Maria, Baric, Ralph S.

“…Background. Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012, causing severe acute respiratory disease and pneumonia, with 44% mortality…”
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Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus by Josset, Laurence, Menachery, Vineet D, Gralinski, Lisa E, Agnihothram, Sudhakar, Sova, Pavel, Carter, Victoria S, Yount, Boyd L, Graham, Rachel L, Baric, Ralph S, Katze, Michael G

“…A novel human coronavirus (HCoV-EMC) was recently identified in the Middle East as the causative agent of a severe acute respiratory syndrome (SARS) resembling…”
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Severe Acute Respiratory Syndrome Coronavirus ORF6 Antagonizes STAT1 Function by Sequestering Nuclear Import Factors on the Rough Endoplasmic Reticulum/Golgi Membrane by Frieman, Matthew, Yount, Boyd, Heise, Mark, Kopecky-Bromberg, Sarah A, Palese, Peter, Baric, Ralph S

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Evidence Supporting a Zoonotic Origin of Human Coronavirus Strain NL63 by HUYNH, Jeremy, SHIMENA LI, FRIEMAN, Matthew B, BARIC, Ralph S, DONALDSON, Eric F, YOUNT, Boyd, SMITH, Alexander, STURGES, Leslie, OLSEN, John C, NAGEL, Juliet, JOHNSON, Joshua B, AGNIHOTHRAM, Sudhakar, GATES, J. Edward

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Antagonism of dsRNA-Induced Innate Immune Pathways by NS4a and NS4b Accessory Proteins during MERS Coronavirus Infection by Comar, Courtney E, Goldstein, Stephen A, Li, Yize, Yount, Boyd, Baric, Ralph S, Weiss, Susan R

“…Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified in 2012 as a novel etiological agent of severe respiratory disease in humans. As…”
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