Search Results - "YOUNKIN, Steven G"

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids by Zhao, Jing, Fu, Yuan, Yamazaki, Yu, Ren, Yingxue, Davis, Mary D., Liu, Chia-Chen, Lu, Wenyan, Wang, Xue, Chen, Kai, Cherukuri, Yesesri, Jia, Lin, Martens, Yuka A., Job, Lucy, Shue, Francis, Nguyen, Thanh Thanh, Younkin, Steven G., Graff-Radford, Neill R., Wszolek, Zbigniew K., Brafman, David A., Asmann, Yan W., Ertekin-Taner, Nilüfer, Kanekiyo, Takahisa, Bu, Guojun

“…APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer’s disease (AD). To address the underlying mechanism, we develop cerebral…”
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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci by De Jager, Philip L, Srivastava, Gyan, Lunnon, Katie, Burgess, Jeremy, Schalkwyk, Leonard C, Yu, Lei, Eaton, Matthew L, Keenan, Brendan T, Ernst, Jason, McCabe, Cristin, Tang, Anna, Raj, Towfique, Replogle, Joseph, Brodeur, Wendy, Gabriel, Stacey, Chai, High S, Younkin, Curtis, Younkin, Steven G, Zou, Fanggeng, Szyf, Moshe, Epstein, Charles B, Schneider, Julie A, Bernstein, Bradley E, Meissner, Alex, Ertekin-Taner, Nilufer, Chibnik, Lori B, Kellis, Manolis, Mill, Jonathan, Bennett, David A

“…Aging can lead to cognitive decline associated with neural pathology and Alzheimer's disease (AD). Here the authors scan the methylation status of CpGs across…”
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Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight by Ebbert, Mark T W, Jensen, Tanner D, Jansen-West, Karen, Sens, Jonathon P, Reddy, Joseph S, Ridge, Perry G, Kauwe, John S K, Belzil, Veronique, Pregent, Luc, Carrasquillo, Minerva M, Keene, Dirk, Larson, Eric, Crane, Paul, Asmann, Yan W, Ertekin-Taner, Nilufer, Younkin, Steven G, Ross, Owen A, Rademakers, Rosa, Petrucelli, Leonard, Fryer, John D

“…The human genome contains "dark" gene regions that cannot be adequately assembled or aligned using standard short-read sequencing technologies, preventing…”
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Innate immunity receptor CD36 promotes cerebral amyloid angiopathy by Park, Laibaik, Zhou, Joan, Zhou, Ping, Pistick, Rose, Jamal, Sleiman El, Younkin, Linda, Pierce, Joseph, Arreguin, Andrea, Anrather, Josef, Younkin, Steven G., Carlson, George A., McEwen, Bruce S., ladecola, Costantino

“…Deposition of amyloid-β (Aβ) in cerebral arteries, known as cerebral amyloid angiopathy (CAA), occurs both in the setting of Alzheimer's disease and…”
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Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases by Allen, Mariet, Carrasquillo, Minerva M., Funk, Cory, Heavner, Benjamin D., Zou, Fanggeng, Younkin, Curtis S., Burgess, Jeremy D., Chai, High-Seng, Crook, Julia, Eddy, James A., Li, Hongdong, Logsdon, Ben, Peters, Mette A., Dang, Kristen K., Wang, Xue, Serie, Daniel, Wang, Chen, Nguyen, Thuy, Lincoln, Sarah, Malphrus, Kimberly, Bisceglio, Gina, Li, Ma, Golde, Todd E., Mangravite, Lara M., Asmann, Yan, Price, Nathan D., Petersen, Ronald C., Graff-Radford, Neill R., Dickson, Dennis W., Younkin, Steven G., Ertekin-Taner, Nilüfer

“…Previous genome-wide association studies (GWAS), conducted by our group and others, have identified loci that harbor risk variants for neurodegenerative…”
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Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases by Allen, Mariet, Wang, Xue, Burgess, Jeremy D., Watzlawik, Jens, Serie, Daniel J., Younkin, Curtis S., Nguyen, Thuy, Malphrus, Kimberly G., Lincoln, Sarah, Carrasquillo, Minerva M., Ho, Charlotte, Chakrabarty, Paramita, Strickland, Samantha, Murray, Melissa E., Swarup, Vivek, Geschwind, Daniel H., Seyfried, Nicholas T., Dammer, Eric B., Lah, James J., Levey, Allan I., Golde, Todd E., Funk, Cory, Li, Hongdong, Price, Nathan D., Petersen, Ronald C., Graff-Radford, Neill R., Younkin, Steven G., Dickson, Dennis W., Crook, Julia R., Asmann, Yan W., Ertekin-Taner, Nilüfer

“…Comparative transcriptome analyses in Alzheimer's disease (AD) and other neurodegenerative proteinopathies can uncover both shared and distinct disease…”
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Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β by Park, Laibaik, Wang, Gang, Zhou, Ping, Zhou, Joan, Pitstick, Rose, Previti, Mary Lou, Younkin, Linda, Younkin, Steven G., Van Nostrand, William E., Cho, Sunghee, Anrather, Josef, Carlson, George A., Iadecola, Costantino, Südhof, Thomas C.

“…Increasing evidence indicates that cerebrovascular dysfunction plays a pathogenic role in Alzheimer's dementia (AD). Amyloid-β (Aβ), a peptide central to the…”
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Alzheimer's disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions by Wang, Xue, Allen, Mariet, İş, Özkan, Reddy, Joseph S, Tutor-New, Frederick Q, Castanedes Casey, Monica, Carrasquillo, Minerva M, Oatman, Stephanie R, Min, Yuhao, Asmann, Yan W, Funk, Cory, Nguyen, Thuy, Ho, Charlotte Cg, Malphrus, Kimberly G, Seyfried, Nicholas T, Levey, Allan I, Younkin, Steven G, Murray, Melissa E, Dickson, Dennis W, Price, Nathan D, Golde, Todd E, Ertekin-Taner, Nilüfer

“…Vast numbers of differentially expressed genes and perturbed networks have been identified in Alzheimer's disease (AD), however, neither disease nor brain…”
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Uncoupling of endothelial nitric oxide synthase in cerebral vasculature of Tg2576 mice by Santhanam, Anantha Vijay R., d'Uscio, Livius V., He, Tongrong, Das, Pritam, Younkin, Steven G., Katusic, Zvonimir S.

“…In this study, we tested the hypothesis that reduced bioavailability of tetrahydrobiopterin (BH4) is a major mechanism responsible for pathogenesis of…”
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Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease by Jankowsky, Joanna L, Melnikova, Tatiana, Fadale, Daniel J, Xu, Guilian M, Slunt, Hilda H, Gonzales, Victoria, Younkin, Linda H, Younkin, Steven G, Borchelt, David R, Savonenko, Alena V

“…Epidemiological studies suggest that individuals with greater education or more cognitively demanding occupations have diminished risk of developing dementia…”
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Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study by Simino, Jeannette, Wang, Zhiying, Bressler, Jan, Chouraki, Vincent, Yang, Qiong, Younkin, Steven G, Seshadri, Sudha, Fornage, Myriam, Boerwinkle, Eric, Mosley, Jr, Thomas H

“…We performed single-variant and gene-based association analyses of plasma amyloid-β (aβ) concentrations using whole exome sequence from 1,414 African and…”
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Impact of variant-level batch effects on identification of genetic risk factors in large sequencing studies by Wickland, Daniel P, Ren, Yingxue, Sinnwell, Jason P, Reddy, Joseph S, Pottier, Cyril, Sarangi, Vivekananda, Carrasquillo, Minerva M, Ross, Owen A, Younkin, Steven G, Ertekin-Taner, Nilüfer, Rademakers, Rosa, Hudson, Matthew E, Mainzer, Liudmila Sergeevna, Biernacka, Joanna M, Asmann, Yan W

“…Genetic studies have shifted to sequencing-based rare variants discovery after decades of success in identifying common disease variants by Genome-Wide…”
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Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience by Ridge, Perry G, Karch, Celeste M, Hsu, Simon, Arano, Ivan, Teerlink, Craig C, Ebbert, Mark T W, Gonzalez Murcia, Josue D, Farnham, James M, Damato, Anna R, Allen, Mariet, Wang, Xue, Harari, Oscar, Fernandez, Victoria M, Guerreiro, Rita, Bras, Jose, Hardy, John, Munger, Ronald, Norton, Maria, Sassi, Celeste, Singleton, Andrew, Younkin, Steven G, Dickson, Dennis W, Golde, Todd E, Price, Nathan D, Ertekin-Taner, Nilüfer, Cruchaga, Carlos, Goate, Alison M, Corcoran, Christopher, Tschanz, JoAnn, Cannon-Albright, Lisa A, Kauwe, John S K

“…While age and the APOE ε4 allele are major risk factors for Alzheimer's disease (AD), a small percentage of individuals with these risk factors exhibit AD…”
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Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids by Zhao, Jing, Fu, Yuan, Yamazaki, Yu, Ren, Yingxue, Davis, Mary D., Liu, Chia-Chen, Lu, Wenyan, Wang, Xue, Chen, Kai, Cherukuri, Yesesri, Jia, Lin, Martens, Yuka A., Job, Lucy, Shue, Francis, Nguyen, Thanh Thanh, Younkin, Steven G., Graff-Radford, Neill R., Wszolek, Zbigniew K., Brafman, David A., Asmann, Yan W., Ertekin-Taner, Nilüfer, Kanekiyo, Takahisa, Bu, Guojun

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Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains by Wahrle, Suzanne, Das, Pritam, Nyborg, Andrew C., McLendon, Chris, Shoji, Mikio, Kawarabayashi, Takeshi, Younkin, Linda H., Younkin, Steven G., Golde, Todd E.

“…Buoyant membrane fractions containing presenilin 1 (PS1), an essential component of the γ-secretase complex, and APP CTFβ, a γ-secretase substrate, can be…”
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Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein by Niwa, Kiyoshi, Kazama, Ken, Younkin, Linda, Younkin, Steven G, Carlson, George A, Iadecola, Costantino

“…The amyloid-beta (A beta) peptide, which is derived from the amyloid precursor protein (APP), is involved in the pathogenesis of Alzheimer's dementia and…”
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Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease by Chung, Jaeyoon, Zhang, Xiaoling, Allen, Mariet, Wang, Xue, Ma, Yiyi, Beecham, Gary, Montine, Thomas J, Younkin, Steven G, Dickson, Dennis W, Golde, Todd E, Price, Nathan D, Ertekin-Taner, Nilüfer, Lunetta, Kathryn L, Mez, Jesse, Mayeux, Richard, Haines, Jonathan L, Pericak-Vance, Margaret A, Schellenberg, Gerard, Jun, Gyungah R, Farrer, Lindsay A

“…Simultaneous consideration of two neuropathological traits related to Alzheimer's disease (AD) has not been attempted in a genome-wide association study. We…”
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Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees by Ertekin-Taner, Nilufer, Graff-Radford, Neill, Younkin, Linda H., Eckman, Christopher, Baker, Matthew, Adamson, Jennifer, Ronald, James, Blangero, John, Hutton, Michael, Younkin, Steven G.

“…Plasma Aβ42 (amyloid β42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree…”
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Investigation of 15 of the top candidate genes for late-onset Alzheimer’s disease by Belbin, Olivia, Carrasquillo, Minerva M., Crump, Michael, Culley, Oliver J., Hunter, Talisha A., Ma, Li, Bisceglio, Gina, Zou, Fanggeng, Allen, Mariet, Dickson, Dennis W., Graff-Radford, Neill R., Petersen, Ronald C., Morgan, Kevin, Younkin, Steven G.

“…The 12 genome-wide association studies (GWAS) published to-date for late-onset Alzheimer’s disease (LOAD) have identified over 40 candidate LOAD risk…”
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The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice by Wen, Paul H., Hof, Patrick R., Chen, Xiaoping, Gluck, Karen, Austin, Gregory, Younkin, Steven G., Younkin, Linda H., DeGasperi, Rita, Gama Sosa, Miguel A., Robakis, Nikolaos K., Haroutunian, Vahram, Elder, Gregory A.

“…The functions of presenilin 1 (PS1) and how PS1 mutations cause familial Alzheimer's disease (FAD) are incompletely understood. PS1 expression is essential for…”
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