Search Results - "YOUNG KWANG CHAE"

Targeting Epidermal Growth Factor Receptor in Triple Negative Breast Cancer: New Discoveries and Practical Insights for Drug Development by Costa, Ricardo, Shah, Ami N, Santa-Maria, Cesar A, Cruz, Marcelo R, Mahalingam, Devalingam, Carneiro, Benedito A, Kwang Chae, Young, Cristofanilli, Massimo, Gradishar, William J, Giles, Francis J

“…Highlights • EGFR is commonly expressed in triple negative breast cancer. • Monoclonal antibodies targeting EGFR failed to show significant activity. •…”
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Role of Human Aquaporin 5 In Colorectal Carcinogenesis by Kang, Sung Koo, Chae, Young Kwang, Woo, Janghee, Kim, Myoung Sook, Park, Jong Chul, Lee, Juna, Soria, Jean Charles, Jang, Se Jin, Sidransky, David, Moon, Chulso

“…While overexpression of several aquaporins (AQPs) has been reported in different types of human cancer, the role of AQPs in carcinogenesis has not been clearly…”
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Efficacy of Immune Checkpoint Inhibitors against Advanced or Metastatic Neuroendocrine Neoplasms: A Systematic Review and Meta-Analysis by Park, Eun-Joo, Park, Hyo-Jung, Kim, Kyung-Won, Suh, Chong-Hyun, Yoo, Changhoon, Chae, Young-Kwang, Tirumani, Sree Harsha, Ramaiya, Nikhil H

“…We performed a systematic review and meta-analysis of the treatment efficacy of immune checkpoint inhibitors (ICIs) in advanced/metastatic neuroendocrine…”
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Phase 1 study of the combination of vemurafenib, carboplatin, and paclitaxel in patients with BRAF‐mutated melanoma and other advanced malignancies by Bhatty, Minny, Kato, Shumei, Piha‐Paul, Sarina A., Naing, Aung, Subbiah, Vivek, Huang, Helen J., Karp, Daniel D., Tsimberidou, Apostolia M., Zinner, Ralph G., Hwu, Wen‐Jen, Javle, Milind, Patel, Sapna P., Hu, Mimi I., Varadhachary, Gauri R., Conley, Anthony P., Ramzanali, Nishma M., Holley, Veronica R., Kurzrock, Razelle, Meric‐Bernstam, Funda, Kwang Chae, Young, Kim, Kevin B., Falchook, Gerald S., Janku, Filip

“…Background BRAF inhibitors are effective against selected BRAFV600‐mutated tumors. Preclinical data suggest that BRAF inhibition in conjunction with…”
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Developmental therapeutics for inflammatory breast cancer: Biology and translational directions by Costa, Ricardo, Santa-Maria, Cesar A, Rossi, Giovanna, Carneiro, Benedito A, Chae, Young Kwang, Gradishar, William J, Giles, Francis J, Cristofanilli, Massimo

“…Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer, which accounts for approximately 3% of cases of breast malignancies. Diagnosis…”
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Detection of Minimal Residual Disease Using ctDNA in Lung Cancer: Current Evidence and Future Directions by Chae, Young Kwang, Oh, Michael S

“…Advances in DNA sequencing methods have significantly expanded the potential clinical applications of analyzing circulating tumor DNA (ctDNA). This genetic…”
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Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC) by Chae, Young Kwang, Chang, Sangmin, Ko, Taeyeong, Anker, Jonathan, Agte, Sarita, Iams, Wade, Choi, Wooyoung M., Lee, Kyoungmin, Cruz, Marcelo

“…Epithelial-mesenchymal transition (EMT) is able to drive metastasis during progression of multiple cancer types, including non-small cell lung cancer (NSCLC)…”
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Relation Between Common Allergic Symptoms and Coronary Heart Disease Among NHANES III Participants by Kim, Jongoh, MD, Purushottam, Bhaskar, MD, Chae, Young Kwang, MD, Chebrolu, Lakshmi, MD, Amanullah, Aman, MD, PhD

“…We investigated whether there is an increased risk of coronary heart diseases (CHD) in those with common allergic symptoms using the NHANES III, which is a…”
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Dose-related Effect of Statins in Venous Thrombosis Risk Reduction by Khemasuwan, Danai, MD, Chae, Young Kwang, MD, MPH, MBA, Gupta, Shikha, MD, Carpio, Alejandra, MD, Yun, Jeong Hyun, MD, MPH, Neagu, Stefan, MD, Lucca, Anabella B., MD, Valsecchi, Matias E., MD, MSc, Mora, Jorge I., MD

“…Abstract Background Atherosclerosis and venous thromboembolism share similar pathophysiology based on common inflammatory mediators. The dose-related effect of…”
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Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1–2 trials by Doebele, Robert C, Drilon, Alexander, Paz-Ares, Luis, Siena, Salvatore, Shaw, Alice T, Farago, Anna F, Blakely, Collin M, Seto, Takashi, Cho, Byung Chul, Tosi, Diego, Besse, Benjamin, Chawla, Sant P, Bazhenova, Lyudmila, Krauss, John C, Chae, Young Kwang, Barve, Minal, Garrido-Laguna, Ignacio, Liu, Stephen V, Conkling, Paul, John, Thomas, Fakih, Marwan, Sigal, Darren, Loong, Herbert H, Buchschacher, Gary L, Garrido, Pilar, Nieva, Jorge, Steuer, Conor, Overbeck, Tobias R, Bowles, Daniel W, Fox, Elizabeth, Riehl, Todd, Chow-Maneval, Edna, Simmons, Brian, Cui, Na, Johnson, Ann, Eng, Susan, Wilson, Timothy R, Demetri, George D

“…Entrectinib is a potent inhibitor of tropomyosin receptor kinase (TRK) A, B, and C, which has been shown to have anti-tumour activity against NTRK gene…”
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Current landscape and future of dual anti-CTLA4 and PD-1/PD-L1 blockade immunotherapy in cancer; lessons learned from clinical trials with melanoma and non-small cell lung cancer (NSCLC) by Chae, Young Kwang, Arya, Ayush, Iams, Wade, Cruz, Marcelo R, Chandra, Sunandana, Choi, Jaehyuk, Giles, Francis

“…Immunotherapy is among the most rapidly evolving treatment strategies in oncology. The therapeutic potential of immune-checkpoint inhibitors is exemplified by…”
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Wnt/beta-catenin pathway: modulating anticancer immune response by Pai, Sachin Gopalkrishna, Carneiro, Benedito A, Mota, Jose Mauricio, Costa, Ricardo, Leite, Caio Abner, Barroso-Sousa, Romualdo, Kaplan, Jason Benjamin, Chae, Young Kwang, Giles, Francis Joseph

“…Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration,…”
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Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application by Chae, Young Kwang, Ranganath, Keerthi, Hammerman, Peter S, Vaklavas, Christos, Mohindra, Nisha, Kalyan, Aparna, Matsangou, Maria, Costa, Ricardo, Carneiro, Benedito, Villaflor, Victoria M, Cristofanilli, Massimo, Giles, Francis J

“…The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) is a tyrosine kinase signaling pathway that has a fundamental role in many biologic…”
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Repurposing metformin for cancer treatment: current clinical studies by Chae, Young Kwang, Arya, Ayush, Malecek, Mary-Kate, Shin, Daniel Sanghoon, Carneiro, Benedito, Chandra, Sunandana, Kaplan, Jason, Kalyan, Aparna, Altman, Jessica K, Platanias, Leonidas, Giles, Francis

“…In recent years, several studies have presented evidence suggesting a potential role for metformin in anti-cancer therapy. Preclinical studies have…”
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A phase II basket trial of Dual Anti–CTLA–4 and Anti–PD–1 Blockade in Rare Tumors (DART) SWOG S1609: High‐grade neuroendocrine neoplasm cohort by Patel, Sandip Pravin, Mayerson, Edward, Chae, Young Kwang, Strosberg, Jonathan, Wang, Jue, Konda, Bhavana, Hayward, Jourdain, McLeod, Christine M., Chen, Helen X., Sharon, Elad, Othus, Megan, Ryan, Christopher W., Plets, Melissa, Blanke, Charles D., Kurzrock, Razelle

“…Background The authors previously reported the results of the nonpancreatic neuroendocrine neoplasm cohort of the SWOG S1609 DART (Dual Anti–CTLA‐4 and…”
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Nivolumab in Metastatic Adrenocortical Carcinoma: Results of a Phase 2 Trial by Carneiro, Benedito A, Konda, Bhavana, Costa, Rubens B, Costa, Ricardo L B, Sagar, Vinay, Gursel, Demirkan B, Kirschner, Lawrence S, Chae, Young Kwang, Abdulkadir, Sarki A, Rademaker, Alfred, Mahalingam, Devalingam, Shah, Manisha H, Giles, Francis J

“…Systemic treatment of metastatic adrenocortical carcinoma (ACC) remains limited to chemotherapy and mitotane. Preliminary evidence suggesting that antitumor…”
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Concordance of Genomic Alterations by Next-Generation Sequencing in Tumor Tissue versus Circulating Tumor DNA in Breast Cancer by Chae, Young Kwang, Davis, Andrew A, Jain, Sarika, Santa-Maria, Cesar, Flaum, Lisa, Beaubier, Nike, Platanias, Leonidas C, Gradishar, William, Giles, Francis J, Cristofanilli, Massimo

“…While identifying genomic alterations in tumor tissue is the current gold-standard technique for molecular profiling, circulating tumor DNA (ctDNA) represents…”
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Analysis of Cell-Free DNA from 32,989 Advanced Cancers Reveals Novel Co-occurring Activating RET Alterations and Oncogenic Signaling Pathway Aberrations by Rich, Thereasa A, Reckamp, Karen L, Chae, Young Kwang, Doebele, Robert C, Iams, Wade T, Oh, Michael, Raymond, Victoria M, Lanman, Richard B, Riess, Jonathan W, Stinchcombe, Thomas E, Subbiah, Vivek, Trevarthen, David R, Fairclough, Stephen, Yen, Jennifer, Gautschi, Oliver

“…is an emerging oncogenic target showing promise in phase I/II clinical trials. An understudied aspect of -driven cancers is the extent to which co-occurring…”
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71 Tumors with higher heterogeneity were associated with superior survival outcome amongst stage I lung cancer patients with low tumor mutational burden (TMB) by Fridland, Stanislav, Chae, Young Kwang

“…BackgroundTumor mutational burden (TMB) has been shown to predict response to immune checkpoint inhibitors.1 Furthermore, the FDA has approved the use of TMB…”
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A Promoter Methylation Pattern in the N-Methyl-d-Aspartate Receptor 2B Gene Predicts Poor Prognosis in Esophageal Squamous Cell Carcinoma by MYOUNG SOOK KIM, YAMASHITA, Keishi, SIDRANSKY, David, YOUNG KWANG CHAE, TOKUMARU, Yutaka, XIAOFEI CHANG, ZAHURAK, Marianna, OSADA, Motonobu, HANNAH LUI PARK, CHUANG, Alice, CALIFANO, Joseph A

“…Purpose: To investigate whether the promoter methylation pattern in N -methyl- d -aspartate receptor 2B (NMDAR2B) is correlated with clinical features of human…”
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