Search Results - "YOUNG, Neal S"

VEXAS syndrome by Grayson, Peter C., Patel, Bhavisha A., Young, Neal S.

“…VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a monogenic disease of adulthood caused by somatic mutations in UBA1 in…”
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How I treat acquired aplastic anemia by Scheinberg, Phillip, Young, Neal S.

“…Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation,…”
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Current concepts in the pathophysiology and treatment of aplastic anemia by Young, Neal S

“…Historically viewed in isolation as an odd, rare, and invariably fatal blood disease, aplastic anemia is now of substantial interest for its immune…”
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Human Parvoviruses by Qiu, Jianming, Söderlund-Venermo, Maria, Young, Neal S

“…Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For…”
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Bone marrow failure and the telomeropathies by Townsley, Danielle M., Dumitriu, Bogdan, Young, Neal S.

“…Our understanding of the pathophysiology of aplastic anemia is undergoing significant revision, with implications for diagnosis and treatment. Constitutional…”
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Current concepts in the pathophysiology and treatment of aplastic anemia by Young, Neal S., Calado, Rodrigo T., Scheinberg, Phillip

“…Aplastic anemia, an unusual hematologic disease, is the paradigm of the human bone marrow failure syndromes. Almost universally fatal just a few decades ago,…”
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Aging and Hematopoiesis by Groarke, Emma M., MD, Young, Neal S., MD

“…In hematopoiesis, mature blood cells, granulocytes, erythrocytes, and megakaryocytes originate from hematopoietic stem cells. With age, changes in…”
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Aplastic Anemia by Young, Neal S

“…Once a uniformly fatal disease, aplastic anemia is now curable with allogeneic transplantation in 80% of children and 40% of adults, and immunosuppression with…”
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Telomere maintenance and human bone marrow failure by Calado, Rodrigo T., Young, Neal S.

“…Acquired and congenital aplastic anemias recently have been linked molecularly and pathophysiologically by abnormal telomere maintenance. Telomeres are…”
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CAISC: A software to integrate copy number variations and single nucleotide mutations for genetic heterogeneity profiling and subclone detection by single-cell RNA sequencing by Kannan, Jeerthi, Mathews, Liza, Wu, Zhijie, Young, Neal S, Gao, Shouguo

“…Although both copy number variations (CNVs) and single nucleotide variations (SNVs) detected by single-cell RNA sequencing (scRNA-seq) are used to study…”
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Ibrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: a phase 2, single-arm trial by Farooqui, Mohammed Z H, DO, Valdez, Janet, PA, Martyr, Sabrina, MD, Aue, Georg, MD, Saba, Nakhle, MD, Niemann, Carsten U, MD, Herman, Sarah E M, PhD, Tian, Xin, PhD, Marti, Gerald, MD, Soto, Susan, MSN, Hughes, Thomas E, PharmD, Jones, Jade, MD, Lipsky, Andrew, MD, Pittaluga, Stefania, MD, Stetler-Stevenson, Maryalice, MD, Yuan, Constance, MD, Lee, Yuh Shan, MD, Pedersen, Lone B, Geisler, Christian H, Prof, Calvo, Katherine R, MD, Arthur, Diane C, MD, Maric, Irina, MD, Childs, Richard, MD, Young, Neal S, MD, Wiestner, Adrian, Dr

“…Summary Background Patients with chronic lymphocytic leukaemia (CLL) with TP53 aberrations respond poorly to first-line chemoimmunotherapy, resulting in early…”
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Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells by Gao, Shouguo, Wu, Zhijie, Arnold, Bradley, Diamond, Carrie, Batchu, Sai, Giudice, Valentina, Alemu, Lemlem, Raffo, Diego Quinones, Feng, Xingmin, Kajigaya, Sachiko, Barrett, John, Ito, Sawa, Young, Neal S.

“…T-cell large granular lymphocyte leukemia (T-LGLL) is a lymphoproliferative disease and bone marrow failure syndrome which responds to immunosuppressive…”
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Immunosuppressive Activity of Exosomes from Granulocytic Myeloid-Derived Suppressor Cells in a Murine Model of Immune Bone Marrow Failure by Manley, Ash Lee, Chen, Jichun, Fitzgerald, Wendy, Feng, Xingmin, Young, Neal S

“…We previously reported that granulocytic myeloid-derived suppressor cells (G-MDSCs) suppressed T-cell activation and attenuated bone marrow failure (BMF) in a…”
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Deep sequencing and flow cytometric characterization of expanded effector memory CD8 + CD57 + T cells frequently reveals T-cell receptor Vβ oligoclonality and CDR3 homology in acquired aplastic anemia by Giudice, Valentina, Feng, Xingmin, Lin, Zenghua, Hu, Wei, Zhang, Fanmao, Qiao, Wangmin, Ibanez, Maria Del Pilar Fernandez, Rios, Olga, Young, Neal S

“…Oligoclonal expansion of CD8 CD28 lymphocytes has been considered indirect evidence for a pathogenic immune response in acquired aplastic anemia. A subset of…”
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HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia by Zaimoku, Yoshitaka, Patel, Bhavisha A., Adams, Sharon D., Shalhoub, Ruba, Groarke, Emma M., Lee, Audrey Ai Chin, Kajigaya, Sachiko, Feng, Xingmin, Rios, Olga Julia, Eager, Holly, Alemu, Lemlem, Quinones Raffo, Diego, Wu, Colin O., Flegel, Willy A., Young, Neal S.

“…Immune aplastic anemia (AA) features somatic loss of HLA class I allele expression on bone marrow cells, consistent with a mechanism of escape from…”
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Predicting response of severe aplastic anemia to immunosuppression combined with eltrombopag by Zaimoku, Yoshitaka, Patel, Bhavisha A, Shalhoub, Ruba, Groarke, Emma M, Feng, Xingmin, Wu, Colin O, Young, Neal S

“…Pretreatment blood counts, particularly an absolute reticulocyte count ≥25×109/L, correlate with response to immunosuppressive therapy in severe aplastic…”
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Minimal role of interleukin 6 and toll-like receptor 2 and 4 in murine models of immune-mediated bone marrow failure by Solorzano, Sabrina, Kim, Jisoo, Chen, Jichun, Feng, Xingmin, Young, Neal S

“…Immune aplastic anemia (AA) results from T cell attack on hematopoietic cells, resulting in bone marrow hypocellularity and pancytopenia. Animal models have…”
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GATA2 deficiency-associated bone marrow disorder differs from idiopathic aplastic anemia by Ganapathi, Karthik A., Townsley, Danielle M., Hsu, Amy P., Arthur, Diane C., Zerbe, Christa S., Cuellar-Rodriguez, Jennifer, Hickstein, Dennis D., Rosenzweig, Sergio D., Braylan, Raul C., Young, Neal S., Holland, Steven M., Calvo, Katherine R.

“…Germ-line GATA2 gene mutations, leading to haploinsufficiency, have been identified in patients with familial myelodysplastic syndrome/acute myeloid leukemia,…”
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Long noncoding RNAs of single hematopoietic stem and progenitor cells in healthy and dysplastic human bone marrow by Wu, Zhijie, Gao, Shouguo, Zhao, Xin, Chen, Jinguo, Keyvanfar, Keyvan, Feng, Xingmin, Kajigaya, Sachiko, Young, Neal S

“…Long noncoding RNAs (lncRNAs) are regulators of cell differentiation and development. The lncRNA transcriptome in human hematopoietic stem and progenitor cells…”
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Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells by Calado, Rodrigo T., Yewdell, William T., Wilkerson, Keisha L., Regal, Joshua A., Kajigaya, Sachiko, Stratakis, Constantine A., Young, Neal S.

“…Androgens have been used in the treatment of bone marrow failure syndromes without a clear understanding of their mechanism of action. Blood counts of patients…”
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