Search Results - "YOUNG, Mary Anne"

Clinical applications of polygenic breast cancer risk: a critical review and perspectives of an emerging field by Yanes, Tatiane, Young, Mary-Anne, Meiser, Bettina, James, Paul A

“…Polygenic factors are estimated to account for an additional 18% of the familial relative risk of breast cancer, with those at the highest level of polygenic…”
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Knowledge, views and expectations for cancer polygenic risk testing in clinical practice: A cross‐sectional survey of health professionals by Smit, Amelia K., Sharman, Ashleigh R., Espinoza, David, Wallingford, Courtney, Young, Mary‐Anne, Dunlop, Kate, Tiller, Jane, Newson, Ainsley J., Meiser, Bettina, Cust, Anne E., Yanes, Tatiane

“…Polygenic risk scores (PRS) are becoming increasingly available in clinical practice to evaluate cancer risk. However, little is known about health…”
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Impacts of Rotational Grazing on Soil Carbon in Native Grass-Based Pastures in Southern Australia by Sanderman, Jonathan, Reseigh, Jodie, Wurst, Michael, Young, Mary-Anne, Austin, Jenet

“…Rotational grazing management strategies have been promoted as a way to improve the sustainability of native grass-based pasture systems. From disturbance…”
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Education in youth‐friendly genetic counseling by Holland, Lucy, Young, Mary‐Anne, Lewin, Jeremy, Pearce, Angela, Thompson, Kate

“…Genetic counselors have long recognized the challenges of working with adolescents and young adults (AYA) and their families. In 2010, a framework of…”
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Pharmacogenomic testing: perception of clinical utility, enablers and barriers to adoption in Australian hospitals by Pearce, Angela, Terrill, Bronwyn, Alffenaar, Jan‐Willem, Patanwala, Asad E., Kummerfeld, Sarah, Day, Richard, Young, Mary‐Anne, Stocker, Sophie L.

“…Background Despite healthcare professionals (HCP) endorsing the clinical utility of pharmacogenomics testing, use in clinical practice is limited. Aims To…”
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Systematic review of the uptake and outcomes from returning secondary findings to adult participants in research genomic testing by Mitchell, Lucas A, Jivani, Karishma, Young, Mary-Anne, Jacobs, Chris, Willis, Amanda M

“…The increasing use of genomic sequencing in research means secondary findings (SF) is more frequently detected and becoming a more pressing issue for…”
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Uptake of polygenic risk information among women at increased risk of breast cancer by Yanes, Tatiane, Meiser, Bettina, Kaur, Rajneesh, Scheepers‐Joynt, Maatje, McInerny, Simone, Taylor, Shelby, Barlow‐Stewart, Kristine, Antill, Yoland, Salmon, Lucinda, Smyth, Courtney, Young, Mary‐Anne, James, Paul A.

“…Polygenic risk scores (PRSs) are increasingly being implemented to assess breast cancer risk. This study aimed to assess and determine factors associated with…”
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Finding the five‐year window: A qualitative study examining young women's decision‐making and experience of using tamoxifen to reduce BRCA1/2 breast cancer risk by Forrest, Laura E., Forbes Shepherd, Rowan, Young, Mary‐Anne, Keogh, Louise A., James, Paul A.

“…Objective Tamoxifen has been demonstrated to reduce breast cancer risk in high‐risk, premenopausal women. Yet, very few young women with hereditary breast and…”
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Professional regulation for Australasian genetic counselors by Hoskins, Cass, Gaff, Clara, McEwen, Alison, Macciocca, Ivan, Pearn, Amy, Shalhoub, Carolyn, Salvemini, Hayley, Berkman, Jennifer, Riley, Kate E., Williams, Rachel, Milward, Michael, Young, Mary‐Anne

“…As a result of the ongoing global expansion of genetic counseling, the need to formalize a system of professional regulation for genetic counselors was…”
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Development and evaluation of a novel educational program for providers on the use of polygenic risk scores by Yanes, Tatiane, Wallingford, Courtney K., Young, Mary-Anne, McInerney-Leo, Aideen M., Willis, Amanda M., McKnight, Lauren, Terrill, Bronwyn, McInerny, Simone, Forrest, Laura E., Cicciarelli, Linda, Williams, Rachel, Keane, Holly, James, Paul A.

“…This study aimed to develop an online educational program for using polygenic risk score (PRS) for breast and ovarian cancer risk assessments and to evaluate…”
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Influence of lived experience on risk perception among women who received a breast cancer polygenic risk score: ‘Another piece of the pie’ by Willis, Amanda M., Smith, Sian K., Meiser, Bettina, James, Paul A., Ballinger, Mandy L., Thomas, David M., Yanes, Tatiane, Young, Mary‐Anne

“…Polygenic risk scores (PRS) are personalized assessments of disease risk based on the cumulative effect of common low‐risk genetic variants. PRS have been…”
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Social media usage in family communication about genetic information: ‘I no longer speak with my sister but she needed to know’ by Leighton, Sarah, Forrest, Laura E., Young, Mary‐Anne, Delatycki, Martin B., Lynch, Elly

“…The use of social media has become a ubiquitous form of communication. Little is known about whether social media is used in families to assist with the…”
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Making Sense of SNPs: Women’s Understanding and Experiences of Receiving a Personalized Profile of Their Breast Cancer Risks by Young, Mary-Anne, Forrest, Laura Elenor, Rasmussen, Victoria-Mae, James, Paul, Mitchell, Gillian, Sawyer, Sarah Dilys, Reeve, Katrina, Hallowell, Nina

“…Genome wide association studies have identified a number of common genetic variants - single nucleotide polymorphisms (SNPs) – that combine to increase breast…”
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Polygenic risk in familial breast cancer: Changing the dynamics of communicating genetic risk by Gregory, Gillian, Das Gupta, Kuheli, Meiser, Bettina, Barlow‐Stewart, Kristine, Geelan‐Small, Peter, Kaur, Rajneesh, Scheepers‐Joynt, Maatje, McInerny, Simone, Taylor, Shelby, Antill, Yoland, Salmon, Lucinda, Smyth, Courtney, Young, Mary‐Anne, James, Paul A, Yanes, Tatiane

“…Hereditary breast cancer is associated with known genetic changes: either variants that affect function in a few rare genes or an ever‐increasing number of…”
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Men's experiences of recontact about a potential increased risk of prostate cancer due to Lynch Syndrome: “Just another straw on the stack” by Rasmussen, Victoria, Forbes Shepherd, Rowan, Forrest, Laura Elenor, James, Paul A., Young, Mary‐Anne

“…The practice of recontacting patients to provide new health information is becoming increasingly common in clinical genetics, despite the limited research to…”
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High frequency of germline TP53 mutations in a prospective adult-onset sarcoma cohort by Mitchell, Gillian, Ballinger, Mandy L, Wong, Stephen, Hewitt, Chelsee, James, Paul, Young, Mary-Anne, Cipponi, Arcadi, Pang, Tiffany, Goode, David L, Dobrovic, Alex, Thomas, David M

“…Sarcomas are a key feature of Li-Fraumeni and related syndromes (LFS/LFL), associated with germline TP53 mutations. Current penetrance estimates for TP53…”
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Psychosocial morbidity in TP53 mutation carriers: is whole-body cancer screening beneficial? by McBride, Kate A., Ballinger, Mandy L., Schlub, Timothy E., Young, Mary-Anne, Tattersall, Martin H. N., Kirk, Judy, Eeles, Ros, Killick, Emma, Walker, Leslie G., Shanley, Sue, Thomas, David M., Mitchell, Gillian

“…Germline TP53 mutation carriers are at high risk of developing a range of cancers. Effective cancer risk management is an important issue for these…”
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The PiGeOn project: protocol for a longitudinal study examining psychosocial, behavioural and ethical issues and outcomes in cancer tumour genomic profiling by Best, Megan, Newson, Ainsley J, Meiser, Bettina, Juraskova, Ilona, Goldstein, David, Tucker, Kathy, Ballinger, Mandy L, Hess, Dominique, Schlub, Timothy E, Biesecker, Barbara, Vines, Richard, Vines, Kate, Thomas, David, Young, Mary-Anne, Savard, Jacqueline, Jacobs, Chris, Butow, Phyllis

“…Genomic sequencing in cancer (both tumour and germline), and development of therapies targeted to tumour genetic status, hold great promise for improvement of…”
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Psychosocial and behavioral impact of breast cancer risk assessed by testing for common risk variants: protocol of a prospective study by Yanes, Tatiane, Meiser, Bettina, Young, Mary-Anne, Kaur, Rajneesh, Mitchell, Gillian, Barlow-Stewart, Kristine, Roscioli, Tony, Halliday, Jane, James, Paul

“…The 'common variant, common disease' model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or…”
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The PiGeOn project: protocol of a longitudinal study examining psychosocial and ethical issues and outcomes in germline genomic sequencing for cancer by Best, Megan, Newson, Ainsley J, Meiser, Bettina, Juraskova, Ilona, Goldstein, David, Tucker, Kathy, Ballinger, Mandy L, Hess, Dominique, Schlub, Timothy E, Biesecker, Barbara, Vines, Richard, Vines, Kate, Thomas, David, Young, Mary-Anne, Savard, Jacqueline, Jacobs, Chris, Butow, Phyllis

“…Advances in genomics offer promise for earlier detection or prevention of cancer, by personalisation of medical care tailored to an individual's genomic risk…”
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