Search Results - "YOUNG, Leonie"

Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities by Cosgrove, Nicola, Varešlija, Damir, Keelan, Stephen, Elangovan, Ashuvinee, Atkinson, Jennifer M., Cocchiglia, Sinéad, Bane, Fiona T., Singh, Vikrant, Furney, Simon, Hu, Chunling, Carter, Jodi M., Hart, Steven N., Yadav, Siddhartha, Goetz, Matthew P., Hill, Arnold D. K., Oesterreich, Steffi, Lee, Adrian V., Couch, Fergus J., Young, Leonie S.

“…The molecular events and transcriptional plasticity driving brain metastasis in clinically relevant breast tumor subtypes has not been determined. Here we…”
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Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines by Valiente, Manuel, Van Swearingen, Amanda E D, Anders, Carey K, Bairoch, Amos, Boire, Adrienne, Bos, Paula D, Cittelly, Diana M, Erez, Neta, Ferraro, Gino B, Fukumura, Dai, Gril, Brunilde, Herlyn, Meenhard, Holmen, Sheri L, Jain, Rakesh K, Joyce, Johanna A, Lorger, Mihaela, Massague, Joan, Neman, Josh, Sibson, Nicola R, Steeg, Patricia S, Thorsen, Frits, Young, Leonie S, Varešlija, Damir, Vultur, Adina, Weis-Garcia, Frances, Winkler, Frank

“…Spread of cancer to the brain remains an unmet clinical need in spite of the increasing number of cases among patients with lung, breast cancer, and melanoma…”
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Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable Targets by Varešlija, Damir, Priedigkeit, Nolan, Fagan, Ailís, Purcell, Siobhan, Cosgrove, Nicola, O'Halloran, Philip J, Ward, Elspeth, Cocchiglia, Sinéad, Hartmaier, Ryan, Castro, Carlos A, Zhu, Li, Tseng, George C, Lucas, Peter C, Puhalla, Shannon L, Brufsky, Adam M, Hamilton, Ronald L, Mathew, Aju, Leone, Jose P, Basudan, Ahmed, Hudson, Lance, Dwyer, Róisín, Das, Sudipto, O'Connor, Darran P, Buckley, Patrick G, Farrell, Michael, Hill, Arnold D K, Oesterreich, Steffi, Lee, Adrian V, Young, Leonie S

“…Breast cancer brain metastases (BrMs) are defined by complex adaptations to both adjuvant treatment regimens and the brain microenvironment. Consequences of…”
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CD44 increases the efficiency of distant metastasis of breast cancer by McFarlane, Suzanne, Coulter, Jonathan A, Tibbits, Paul, O'Grady, Anthony, McFarlane, Cheryl, Montgomery, Nicola, Hill, Ashleigh, McCarthy, Helen O, Young, Leonie S, Kay, Elaine W, Isacke, Clare M, Waugh, David J J

“…Metastasis is the predominant cause of death from cancer yet we have few biomarkers to predict patients at increased risk of metastasis and are unable to…”
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Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer by Pathiraja, Thushangi N, Nayak, Shweta R, Xi, Yuanxin, Jiang, Shiming, Garee, Jason P, Edwards, Dean P, Lee, Adrian V, Chen, Jian, Shea, Martin J, Santen, Richard J, Gannon, Frank, Kangaspeska, Sara, Jelinek, Jaroslav, Issa, Jean-Pierre J, Richer, Jennifer K, Elias, Anthony, McIlroy, Marie, Young, Leonie S, Davidson, Nancy E, Schiff, Rachel, Li, Wei, Oesterreich, Steffi

“…Resistance to aromatase inhibitors (AIs) is a major clinical problem in the treatment of estrogen receptor (ER)-positive breast cancer. In two breast cancer…”
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Steroid Ligands, the Forgotten Triggers of Nuclear Receptor Action; Implications for Acquired Resistance to Endocrine Therapy by Bleach, Rachel, Madden, Stephen F, Hawley, James, Charmsaz, Sara, Selli, Cigdem, Sheehan, Katherine M, Young, Leonie S, Sims, Andrew H, Souček, Pavel, Hill, Arnold D, McIlroy, Marie

“…There is strong epidemiologic evidence indicating that estrogens may not be the sole steroid drivers of breast cancer. We hypothesize that abundant adrenal…”
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Cleavage of the extracellular domain of junctional adhesion molecule-A is associated with resistance to anti-HER2 therapies in breast cancer settings by Leech, Astrid O, Vellanki, Sri HariKrishna, Rutherford, Emily J, Keogh, Aoife, Jahns, Hanne, Hudson, Lance, O'Donovan, Norma, Sabri, Siham, Abdulkarim, Bassam, Sheehan, Katherine M, Kay, Elaine W, Young, Leonie S, Hill, Arnold D K, Smith, Yvonne E, Hopkins, Ann M

“…Junctional adhesion molecule-A (JAM-A) is an adhesion molecule whose overexpression on breast tumor tissue has been associated with aggressive cancer…”
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Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK-directed activation of NF-κB by Periyasamy, Manikandan, Singh, Anup K., Gemma, Carolina, Farzan, Raed, Allsopp, Rebecca C., Shaw, Jacqueline A., Charmsaz, Sara, Young, Leonie S., Cunnea, Paula, Coombes, R. Charles, Győrffy, Balázs, Buluwela, Lakjaya, Ali, Simak

“…The mutagenic APOBEC3B (A3B) cytosine deaminase is frequently over-expressed in cancer and promotes tumour heterogeneity and therapy resistance. Hence,…”
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FiTAc-seq: fixed-tissue ChIP-seq for H3K27ac profiling and super-enhancer analysis of FFPE tissues by Font-Tello, Alba, Kesten, Nikolas, Xie, Yingtian, Taing, Len, Varešlija, Damir, Young, Leonie S., Hamid, Anis A., Van Allen, Eliezer M., Sweeney, Christopher J., Gjini, Evisa, Lako, Ana, Hodi, F. Steven, Bellmunt, Joaquim, Brown, Myles, Cejas, Paloma, Long, Henry W.

“…Fixed-tissue ChIP-seq for H3K27 acetylation (H3K27ac) profiling (FiTAc-seq) is an epigenetic method for profiling active enhancers and promoters in…”
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The AIB1 Oncogene Promotes Breast Cancer Metastasis by Activation of PEA3-Mediated Matrix Metalloproteinase 2 (MMP2) and MMP9 Expression by Qin, Li, Liao, Lan, Redmond, Aisling, Young, Leonie, Yuan, Yuhui, Chen, Hongwu, O'Malley, Bert W., Xu, Jianming

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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RET overexpression leads to increased brain metastatic competency in luminal breast cancer by Jagust, Petra, Powell, Aoibhin M, Ola, Mihaela, Watson, Louise, de Pablos-Aragoneses, Ana, García-Gómez, Pedro, Fallon, Ramón, Bane, Fiona, Heiland, Mona, Morris, Gareth, Cavanagh, Brenton, McGrath, Jason, Ottaviani, Daniela, Hegarty, Aisling, Cocchiglia, Sinéad, Sweeney, Kieron J, MacNally, Stephen, Brett, Francesca M, Cryan, Jane, Beausang, Alan, Morris, Patrick, Valiente, Manuel, Hill, Arnold D K, Varešlija, Damir, Young, Leonie S

“…Breast cancer brain metastasis is a rising occurrence, necessitating a better understanding of the mechanisms involved for effective management. Breast cancer…”
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Global Characterization of the SRC-1 Transcriptome Identifies ADAM22 as an ER-Independent Mediator of Endocrine-Resistant Breast Cancer by MCCARTAN, Damian, BOLGER, Jarlath C, YOUNG, Leonie S, FAGAN, Ailis, BYRNE, Christopher, YUAN HAO, LI QIN, MCLLROY, Marie, JIANMING XU, HILL, Arnold D, GAORA, Peadaro

“…The development of breast cancer resistance to endocrine therapy results from an increase in cellular plasticity that permits the emergence of a…”
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Correction to: Nongenomic oestrogen signalling in oestrogen receptor negative breast cancer cells: a role for the angiotensin II receptor AT1 by Lim, Kheng Tian, Cosgrave, Niamh, Hill, Arnold David, Young, Leonie S

“…After the publication of this work [1] errors were noticed in the total protein loading controls for Figs. 1C, 2B, 3B and 4B…”
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Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer by Browne, Alacoque L., Charmsaz, Sara, Varešlija, Damir, Fagan, Ailis, Cosgrove, Nicola, Cocchiglia, Sinéad, Purcell, Siobhan, Ward, Elspeth, Bane, Fiona, Hudson, Lance, Hill, Arnold D., Carroll, Jason S., Redmond, Aisling M., Young, Leonie S.

“…Steroid receptor coactivator 1 (SRC-1) interacts with nuclear receptors and other transcription factors (TFs) to initiate transcriptional networks and regulate…”
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The function of steroid receptor coactivator-1 in normal tissues and cancer by Walsh, Claire A, Qin, Li, Tien, Jean Ching-Yi, Young, Leonie S, Xu, Jianming

“…In 1995, the steroid receptor coactivator-1 (SRC-1) was identified as the first authentic steroid receptor coactivator. Since then, the SRC proteins have…”
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Altered Steroid Milieu in AI-Resistant Breast Cancer Facilitates AR Mediated Gene-Expression Associated with Poor Response to Therapy by Creevey, Laura, Bleach, Rachel, Madden, Stephen F, Toomey, Sinead, Bane, Fiona T, Varešlija, Damir, Hill, Arnold D, Young, Leonie S, McIlroy, Marie

“…Divergent roles for androgen receptor (AR) in breast cancer have been reported. Following aromatase inhibitor (AI) treatment, the conversion of circulating…”
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A novel panel of differentially-expressed microRNAs in breast cancer brain metastasis may predict patient survival by Giannoudis, Athina, Clarke, Kim, Zakaria, Rasheed, Varešlija, Damir, Farahani, Mosavar, Rainbow, Lucille, Platt-Higgins, Angela, Ruthven, Stuart, Brougham, Katherine A., Rudland, Philip S., Jenkinson, Michael D., Young, Leonie S., Falciani, Francesco, Palmieri, Carlo

“…Breast cancer brain metastasis (BCBM) is an area of unmet clinical need. MicroRNAs (miRNAs) have been linked to the metastatic process in breast cancer (BC)…”
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Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype by Varešlija, Damir, Ward, Elspeth, Purcell, Siobhan P., Cosgrove, Nicola S., Cocchiglia, Sinéad, O’Halloran, Philip J., Charmsaz, Sara, Bane, Fiona T., Brett, Francesca M., Farrell, Michael, Cryan, Jane, Beausang, Alan, Hudson, Lance, Turnbul, Arran K., Dixon, J. Michael, Hill, Arnold D. K., Priedigkeit, Nolan, Oesterreich, Steffi, Lee, Adrian V., Sims, Andrew H., Redmond, Aisling M., Carroll, Jason S., Young, Leonie S.

“…Steroid regulated cancer cells use nuclear receptors and associated regulatory proteins to orchestrate transcriptional networks to drive disease progression…”
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ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis by Charmsaz, Sara, Doherty, Ben, Cocchiglia, Sinéad, Varešlija, Damir, Marino, Attilio, Cosgrove, Nicola, Marques, Ricardo, Priedigkeit, Nolan, Purcell, Siobhan, Bane, Fiona, Bolger, Jarlath, Byrne, Christopher, O'Halloran, Philip J, Brett, Francesca, Sheehan, Katherine, Brennan, Kieran, Hopkins, Ann M, Keelan, Stephen, Jagust, Petra, Madden, Stephen, Martinelli, Chiara, Battaglini, Matteo, Oesterreich, Steffi, Lee, Adrian V, Ciofani, Gianni, Hill, Arnold D K, Young, Leonie S

“…Metastatic breast cancer is a major cause of cancer-related deaths in woman. Brain metastasis is a common and devastating site of relapse for several breast…”
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Metastatic Progression with Resistance to Aromatase Inhibitors Is Driven by the Steroid Receptor Coactivator SRC-1 by MCBRYAN, Jean, THEISSEN, Sarah M, BYRNE, Christopher, HUGHES, Eamon, COCCHIGLIA, Sinead, SANDE, Stephen, O'HARA, Jane, TIBBITTS, Paul, HILL, Arnold D. K, YOUNG, Leonie S

“…Aromatase inhibitors (AI) are a standard-of-care treatment for postmenopausal, estrogen receptor-positive breast cancers. Although tumor recurrence on AI…”
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