Search Results - "YOUNG, Lei"

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  1. 1

    Enzymatic assembly of DNA molecules up to several hundred kilobases by Gibson, Daniel G, Young, Lei, Chuang, Ray-Yuan, Venter, J Craig, Hutchison, Clyde A, Smith, Hamilton O

    Published in Nature methods (01-05-2009)
    “…We describe an isothermal, single-reaction method for assembling multiple overlapping DNA molecules by the concerted action of a 5′ exonuclease, a DNA…”
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    RecA mediates MgpB and MgpC phase and antigenic variation in Mycoplasma genitalium, but plays a minor role in DNA repair by Burgos, Raul, Wood, Gwendolyn E., Young, Lei, Glass, John I., Totten, Patricia A.

    Published in Molecular microbiology (01-08-2012)
    “…Summary Mycoplasma genitalium, a sexually transmitted human pathogen, encodes MgpB and MgpC adhesins that undergo phase and antigenic variation through…”
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    Unusual Bacterioplankton Community Structure in Ultra-Oligotrophic Crater Lake by Urbach, Ena, Vergin, Kevin L., Young, Lei, Morse, Ariel, Larson, Gary L., Giovannoni, Stephen J.

    Published in Limnology and oceanography (01-05-2001)
    “…The bacterioplankton assemblage in Crater Lake, Oregon (U.S.A.), is different from communities found in other oxygenated lakes, as demonstrated by four small…”
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  6. 6

    Development of a murine prostatespecific 2-in-1 inducible bicistronic expression vector by YOUNG, Lei, QIHAN DONG

    Published in Biotechnology letters (01-06-2005)
    “…Transgenic research often suffers from the lack of strong tissue specific promoters and the lack of suitable antibodies for transgene detection. We have now…”
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    Journal Article
  7. 7

    Cloning of TC-1 (C8orf4), a Novel Gene Found to Be Overexpressed in Thyroid Cancer by Chua, Elizabeth L., Young, Lei, Wu, Wan Man, Turtle, John R., Dong, Qihan

    Published in Genomics (San Diego, Calif.) (01-11-2000)
    “…A novel gene highly expressed in thyroid cancer, designated TC-1 (thyroid cancer-1), was cloned from suppression subtractive hybridization between papillary…”
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  9. 9

    Two‐step total gene synthesis method by Young, Lei, Dong, Qihan

    Published in Nucleic acids research (2004)
    “…In the post‐genomic era, the ability to synthesize any arbitrary DNA sequence is increasingly in demand. A bottleneck in current gene synthesis technologies is…”
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  10. 10

    Assembly of Large, High G+C Bacterial DNA Fragments in Yeast by Noskov, Vladimir N, Karas, Bogumil J, Young, Lei, Chuang, Ray-Yuan, Gibson, Daniel G, Lin, Ying-Chi, Stam, Jason, Yonemoto, Isaac T, Suzuki, Yo, Andrews-Pfannkoch, Cynthia, Glass, John I, Smith, Hamilton O, Hutchison, Clyde A, Venter, J. Craig, Weyman, Philip D

    Published in ACS synthetic biology (20-07-2012)
    “…The ability to assemble large pieces of prokaryotic DNA by yeast recombination has great application in synthetic biology, but cloning large pieces of high G+C…”
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  11. 11

    Development of a murine prostate-specific 2-in-1 inducible bicistronic expression vector by Young, Lei, Dong, Qihan

    Published in Biotechnology letters (01-06-2005)
    “…Transgenic research often suffers from the lack of strong tissue specific promoters and the lack of suitable antibodies for transgene detection. We have now…”
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    Journal Article
  12. 12

    Probasin Promoter-driven Expression of ID1 Is not Sufficient for Carcinogenesis in Rodent Prostate by Salomon, Robert, Young, Lei, MacLeod, Duncan, Yu, Xiao-Ling, Dong, Qihan

    “…Inhibitor of DNA-binding-1 (ID1) negatively regulates cell differentiation and senescence, and enhances cellular proliferation and angiogenesis. Elevated…”
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  13. 13

    TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer by SUNDE, Margaret, MCGRATH, Kristine C. Y, YOUNG, Lei, MATTHEWS, Jacqueline M, CHUA, Elizabeth L, MACKAY, Joel P, DEATH, Alison K

    Published in Cancer research (Chicago, Ill.) (15-04-2004)
    “…A novel gene, thyroid cancer 1 (TC-1), was found recently to be overexpressed in thyroid cancer. TC-1 shows no homology to any of the known thyroid…”
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    Ornithine Decarboxylase (ODC) Expression Pattern in Human Prostate Tissues and ODC Transgenic Mice by Young, Lei, Salomon, Robert, Au, Wendy, Allan, Charles, Russell, Peter, Dong, Qihan

    “…Ornithine decarboxylase (ODC) is the key enzyme in the polyamine synthesis pathway and is overexpressed in a variety of cancers. We have performed a detailed…”
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  16. 16

    Targeted amplification of mutant strands for efficient site-directed mutagenesis and mutant screening by Young, Lei, Dong, Qihan

    “…Site-directed mutagenesis is an invaluable tool for functional studies and genetic engineering. However, most current protocols require the target DNA to be…”
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  17. 17

    TAMS technology for simple and efficient in vitro site‐directed mutagenesis and mutant screening by Young, Lei, Dong, Qihan

    Published in Nucleic acids research (01-02-2003)
    “…Site‐directed mutagenesis is an invaluable tool for functional studies and genetic engineering. However, most current protocols require the target DNA to be…”
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  18. 18

    Molecular cloning and characterization of a novel androgen repressible gene expressed in the prostate epithelium by Singh, Jaskirat, Young, Lei, Handelsman, David J., Dong, Qihan

    Published in Gene (28-03-2005)
    “…Prostate cancer deaths are due to functional escape of prostate cancer cells from their original androgen-dependent growth. To better understand the origin and…”
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    Prostate Epithelial Expression of a Novel Androgen Target Gene by Singh, Jaskirat, Young, Lei, Handelsman, David J, Dong, Qihan

    Published in Journal of andrology (01-09-2002)
    “…ABSTRACT To better understand the role of androgens in prostate development and disease it is important to characterize androgen‐regulated genes in the…”
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  20. 20

    Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma by Lee, Danbi, Lyu, Heather, Chung, Young-Hwa, Kim, Jeong A, Mathews, Priya, Jaffee, Elizabeth, Zheng, Lei, Yu, Eunsil, Lee, Young Joo, Ryu, Soo Hyung

    Published in World journal of gastroenterology : WJG (21-06-2016)
    “…AIM: To determine the genomic changes in hepatitis B virus(HBV) and evaluate their role in the development of hepatocellular carcinoma(HCC) in patients…”
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