Search Results - "YOUNG, David A"

Characterization of the Cartilage DNA Methylome in Knee and Hip Osteoarthritis by Rushton, Michael D., Reynard, Louise N., Barter, Matt J., Refaie, Ramsay, Rankin, Kenneth S., Young, David A., Loughlin, John

“…Objective The aim of this study was to characterize the genome‐wide DNA methylation profile of chondrocytes from knee and hip cartilage obtained from patients…”
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Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases by Hui, Wang, Litherland, Gary J, Elias, Martina S, Kitson, Gareth I, Cawston, Tim E, Rowan, Andrew D, Young, David A

“…To investigate the effect of leptin on cartilage destruction. Collagen release was assessed in bovine cartilage explant cultures, while collagenolytic and…”
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Genome‐Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR‐140‐5p by Barter, Matt J., Tselepi, Maria, Gómez, Rodolfo, Woods, Steven, Hui, Wang, Smith, Graham R., Shanley, Daryl P., Clark, Ian M., Young, David A.

“…microRNAs (miRNAs) are abundantly expressed in development where they are critical determinants of cell differentiation and phenotype. Accordingly miRNAs are…”
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The expression and function of microRNAs in chondrogenesis and osteoarthritis by Swingler, Tracey E., Wheeler, Guy, Carmont, Virginia, Elliott, Hannah R., Barter, Matthew J., Abu-Elmagd, Muhammad, Donell, Simon T., Boot-Handford, Raymond P., Hajihosseini, Mohammad K., Münsterberg, Andrea, Dalmay, Tamas, Young, David A., Clark, Ian M.

“…Objective To use an in vitro model of chondrogenesis to identify microRNAs (miRNAs) with a functional role in cartilage homeostasis. Methods The expression of…”
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HDAC6 regulates NF-κB signalling to control chondrocyte IL-1-induced MMP and inflammatory gene expression by Barter, Matt J., Butcher, Andrew, Wang, Hui, Tsompani, Dimitra, Galler, Martin, Rumsby, Ellen L., Culley, Kirsty L., Clark, Ian M., Young, David A.

“…Elevated pro-inflammatory signalling coupled with catabolic metalloproteinase expression is a common feature of arthritis, leading to cartilage damage,…”
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Simulation Testing of Pediatric Rapid Response Teams: Can Simulation Be Used to Determine the Best Team Structure? by Young, David A., MD, MEd, MBA, FAAP, CHSE

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Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation by Reynard, Louise N., Bui, Catherine, Canty-Laird, Elizabeth G., Young, David A., Loughlin, John

“…GDF5 is involved in synovial joint development, maintenance and repair, and the rs143383 C/T single nucleotide polymorphism (SNP) located in the 5′UTR of GDF5…”
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cAMP response element‐binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis by Bui, Catherine, Barter, Matt J., Scott, Jenny L., Xu, Yaobo, Galler, Martin, Reynard, Louise N., Rowan, Andrew D., Young, David A.

“…ABSTRACT Osteoarthritis is a degenerative joint disease characterized by a progressive and irreversible loss of the articular cartilage, due in main part to…”
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Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis models by Gilbert, Sophie J, Soul, Jamie, Hao, Yao, Lin, Hua, Piróg, Katarzyna A, Coxhead, Jonathan, Patel, Krutik, Barter, Matt J, Young, David A, Blain, Emma J

“…Animal models of post-traumatic osteoarthritis (PTOA) recapitulate the pathological changes observed in human PTOA. Here, skeletally mature C57Bl6 mice were…”
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Correlation of Infinium HumanMethylation450K and MethylationEPIC BeadChip arrays in cartilage by Cheung, Kathleen, Burgers, Marjolein J, Young, David A, Cockell, Simon, Reynard, Louise N

“…DNA methylation of CpG sites is commonly measured using Illumina Infinium BeadChip platforms. The Infinium MethylationEPIC array has replaced the Infinium…”
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The identification of trans-acting factors that regulate the expression of GDF5 via the osteoarthritis susceptibility SNP rs143383 by Syddall, Catherine M, Reynard, Louise N, Young, David A, Loughlin, John

“…rs143383 is a C to T transition SNP located in the 5'untranslated region (5'UTR) of the growth differentiation factor 5 gene GDF5. The T allele of the SNP is…”
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DNA methylation analysis identifies key transcription factors involved in mesenchymal stem cell osteogenic differentiation by Gómez, Rodolfo, Barter, Matt J, Alonso-Pérez, Ana, Skelton, Andrew J, Proctor, Carole, Herrero-Beaumont, Gabriel, Young, David A

“…Knowledge about regulating transcription factors (TFs) for osteoblastogenesis from mesenchymal stem cells (MSCs) is limited. Therefore, we investigated the…”
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The role of microRNA-3085 in chondrocyte function by Le, Linh, Niu, Lingzi, Barter, Matthew J., Young, David A., Dalmay, Tamas, Clark, Ian M., Swingler, Tracey E.

“…MicroRNAs have been shown to play a role in cartilage development, homeostasis and breakdown during osteoarthritis. We previously identified miR-3085 in humans…”
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Class I Histone Deacetylase Inhibition Modulates Metalloproteinase Expression and Blocks Cytokine‐Induced Cartilage Degradation by Culley, Kirsty L., Hui, Wang, Barter, Matt J., Davidson, Rose K., Swingler, Tracey E., Destrument, Auriane P. M., Scott, Jenny L., Donell, Simon T., Fenwick, Steve, Rowan, Andrew D., Young, David A., Clark, Ian M.

“…Objective To examine the ability of a broad‐spectrum histone deacetylase (HDAC) inhibitor to protect cartilage in vivo, and to explore the effects of…”
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Recent advances in understanding the regulation of metalloproteinases [version 1; peer review: 2 approved] by Young, David A, Barter, Matt J, Wilkinson, David J

“…Metalloproteinases remain important players in arthritic disease, in part because members of this large enzymatic family, namely matrix metalloproteinase-1…”
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Dynamic chromatin accessibility landscape changes following interleukin-1 stimulation by Barter, Matt J, Cheung, Kathleen, Falk, Julia, Panagiotopoulos, Andreas C, Cosimini, Caitlin, O'Brien, Siobhan, Teja-Putri, Karina, Neill, Graham, Deehan, David J, Young, David A.

“…Dynamic modifications of chromatin allow rapid access of the gene regulatory machinery to condensed genomic regions facilitating subsequent gene expression…”
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Increased hippocampal excitability in miR-324-null mice by Hayman, Dan J., Modebadze, Tamara, Charlton, Sarah, Cheung, Kat, Soul, Jamie, Lin, Hua, Hao, Yao, Miles, Colin G., Tsompani, Dimitra, Jackson, Robert M., Briggs, Michael D., Piróg, Katarzyna A., Clark, Ian M., Barter, Matt J., Clowry, Gavin J., LeBeau, Fiona E. N., Young, David A.

“…MicroRNAs are non-coding RNAs that act to downregulate the expression of target genes by translational repression and degradation of messenger RNA molecules…”
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Assessing Density-Functional Theory for Equation-Of-State by Söderlind, Per, Young, David

“…The last decade has seen a continued development of better experimental techniques to measure equation-of-state (EOS) for various materials. These improvements…”
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A preliminary molecular phylogeny of shield-bearer moths (Lepidoptera: Adeloidea: Heliozelidae) highlights rich undescribed diversity by Milla, Liz, van Nieukerken, Erik J., Vijverberg, Ruben, Doorenweerd, Camiel, Wilcox, Stephen A., Halsey, Mike, Young, David A., Jones, Therésa M., Kallies, Axel, Hilton, Douglas J.

“…[Display omitted] •First molecular phylogeny of the shield-bearer moth family (Heliozelidae).•Five major clades suggested by molecular evidence.•Rich…”
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A negative feedback loop mediated by STAT3 limits human Th17 responses by Purvis, Harriet A, Anderson, Amy E, Young, David A, Isaacs, John D, Hilkens, Catharien M U

“…The transcription factor STAT3 is critically required for the differentiation of Th17 cells, a T cell subset involved in various chronic inflammatory diseases…”
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