Search Results - "YOUNG, C. C"

Improved coarse‐grained model for studying sequence dependent phase separation of disordered proteins by Regy, Roshan Mammen, Thompson, Jacob, Kim, Young C., Mittal, Jeetain

“…We present improvements to the hydropathy scale (HPS) coarse‐grained (CG) model for simulating sequence‐specific behavior of intrinsically disordered proteins…”
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Relation between single-molecule properties and phase behavior of intrinsically disordered proteins by Dignon, Gregory L., Zheng, Wenwei, Best, Robert B., Kim, Young C., Mittal, Jeetain

“…Proteins that undergo liquid–liquid phase separation (LLPS) have been shown to play a critical role in many physiological functions through formation of…”
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Therapeutic host-directed strategies to improve outcome in tuberculosis by Young, C., Walzl, G., Du Plessis, N.

“…Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but has limited efficacy against pulmonary TB disease development and modest…”
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Targeting mutations in cancer by Waarts, Michael R, Stonestrom, Aaron J, Park, Young C, Levine, Ross L

“…Targeted therapies have come to play an increasingly important role in cancer therapy over the past two decades. This success has been made possible in large…”
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The MCM v3.3.1 degradation scheme for isoprene by Jenkin, M. E, Young, J. C, Rickard, A. R

“…The chemistry of isoprene degradation in the Master Chemical Mechanism (MCM) has been systematically refined and updated to reflect recent advances in…”
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Sequence determinants of protein phase behavior from a coarse-grained model by Dignon, Gregory L, Zheng, Wenwei, Kim, Young C, Best, Robert B, Mittal, Jeetain

“…Membraneless organelles important to intracellular compartmentalization have recently been shown to comprise assemblies of proteins which undergo liquid-liquid…”
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The prevalence and outcomes of frailty in older cancer patients: a systematic review by Handforth, C., Clegg, A., Young, C., Simpkins, S., Seymour, M.T., Selby, P.J., Young, J.

“…Frailty is a state of vulnerability to poor resolution of homeostasis following a stressor event, such as chemotherapy or cancer surgery. Better knowledge of…”
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Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function by Cerletti, Massimiliano, Jang, Young C., Finley, Lydia W.S., Haigis, Marcia C., Wagers, Amy J.

“…Calorie restriction (CR) extends life span and ameliorates age-related pathologies in most species studied, yet the mechanisms underlying these effects remain…”
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Molecular Details of Protein Condensates Probed by Microsecond Long Atomistic Simulations by Zheng, Wenwei, Dignon, Gregory L, Jovic, Nina, Xu, Xichen, Regy, Roshan M, Fawzi, Nicolas L, Kim, Young C, Best, Robert B, Mittal, Jeetain

“…The formation of membraneless organelles in cells commonly occurs via liquid–liquid phase separation (LLPS) and is in many cases driven by multivalent…”
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Coarse-Grained Models to Study Protein–DNA Interactions and Liquid–Liquid Phase Separation by Kapoor, Utkarsh, Kim, Young C., Mittal, Jeetain

“…Recent advances in coarse-grained (CG) computational models for DNA have enabled molecular-level insights into the behavior of DNA in complex multiscale…”
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Losing a Job: The Nonpecuniary Cost of Unemployment in the United States by Young, Cristobal

“…Drawing on the Panel Study of Income Dynamics, I track the subjective well-being of individuals as they enter and exit unemployment. Job loss is a salient…”
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Carbon Dioxide-Mediated C(sp3)–H Arylation of Amine Substrates by Kapoor, Mohit, Liu, Daniel, Young, Michael C

“…Elaborating amines via C–H functionalization has been an important area of research over the past decade but has generally relied on an added directing group…”
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A Raster-oriented Method for Creating Eclipse Maps by Wright, Ernie, Young, C. Alex

“…Abstract Traditional total solar eclipse maps based on 19th-century calculation methods do not take full advantage of important refinements recently made…”
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Limited roles of Piezo mechanosensing channels in articular cartilage development and osteoarthritis progression by Young, C., Kobayashi, T.

“…To investigate the role of Piezo1 and Piezo2 in surgically induced osteoarthritis (OA) in mice. Male conditional knockout (cKO) mice missing Piezo1 and Piezo2…”
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Sequence dependent phase separation of protein-polynucleotide mixtures elucidated using molecular simulations by Regy, Roshan Mammen, Dignon, Gregory L, Zheng, Wenwei, Kim, Young C, Mittal, Jeetain

“…Abstract Ribonucleoprotein (RNP) granules are membraneless organelles (MLOs), which majorly consist of RNA and RNA-binding proteins and are formed via…”
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Hydropathy Patterning Complements Charge Patterning to Describe Conformational Preferences of Disordered Proteins by Zheng, Wenwei, Dignon, Gregory, Brown, Matthew, Kim, Young C, Mittal, Jeetain

“…Understanding the conformational ensemble of an intrinsically disordered protein (IDP) is of great interest due to its relevance to critical intracellular…”
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Smoking, Mental Illness, and Public Health by Prochaska, Judith J, Das, Smita, Young-Wolff, Kelly C

“…Tobacco use remains the leading preventable cause of death worldwide. In particular, people with mental illness are disproportionately affected with high…”
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Temperature-Controlled Liquid–Liquid Phase Separation of Disordered Proteins by Dignon, Gregory L, Zheng, Wenwei, Kim, Young C, Mittal, Jeetain

“…The liquid–liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) is a commonly observed phenomenon within the cell, and such condensates…”
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Selective constraints on global plankton dispersal by Ward, Ben A., Cael, B. B., Collins, Sinead, Young, C. Robert

“…Marine microbial communities are highly interconnected assemblages of organisms shaped by ecological drift, natural selection, and dispersal. The relative…”
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The impact of oil price volatility on stock markets: Evidences from oil-importing countries by Joo, Young C., Park, Sung Y.

“…This study investigates the effects of oil price volatility on stock markets. We consider the stock returns of ten major oil-importing countries: China,…”
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