Search Results - "YOU, M"

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis by Liu, Xiaoguang, Nie, Litong, Zhang, Yilei, Yan, Yuelong, Wang, Chao, Colic, Medina, Olszewski, Kellen, Horbath, Amber, Chen, Xiong, Lei, Guang, Mao, Chao, Wu, Shiqi, Zhuang, Li, Poyurovsky, Masha V., James You, M., Hart, Traver, Billadeau, Daniel D., Chen, Junjie, Gan, Boyi

“…SLC7A11-mediated cystine uptake suppresses ferroptosis yet promotes cell death under glucose starvation; the nature of the latter cell death remains unknown…”
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Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer by Liu, Xiaoguang, Olszewski, Kellen, Zhang, Yilei, Lim, Esther W., Shi, Jiejun, Zhang, Xiaoshan, Zhang, Jie, Lee, Hyemin, Koppula, Pranavi, Lei, Guang, Zhuang, Li, You, M. James, Fang, Bingliang, Li, Wei, Metallo, Christian M., Poyurovsky, Masha V., Gan, Boyi

“…SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival. Here we show that this comes at a significant cost for cancer…”
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SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells by Yan, Yuelong, Teng, Hongqi, Hang, Qinglei, Kondiparthi, Lavanya, Lei, Guang, Horbath, Amber, Liu, Xiaoguang, Mao, Chao, Wu, Shiqi, Zhuang, Li, James You, M., Poyurovsky, Masha V., Ma, Li, Olszewski, Kellen, Gan, Boyi

“…The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT) protects cancer cells from oxidative stress and is overexpressed in many…”
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A targetable LIFR−NF-κB−LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis by Yao, Fan, Deng, Yalan, Zhao, Yang, Mei, Ying, Zhang, Yilei, Liu, Xiaoguang, Martinez, Consuelo, Su, Xiaohua, Rosato, Roberto R., Teng, Hongqi, Hang, Qinglei, Yap, Shannon, Chen, Dahu, Wang, Yumeng, Chen, Mei-Ju May, Zhang, Mutian, Liang, Han, Xie, Dong, Chen, Xin, Zhu, Hao, Chang, Jenny C., You, M. James, Sun, Yutong, Gan, Boyi, Ma, Li

“…The growing knowledge of ferroptosis has suggested the role and therapeutic potential of ferroptosis in cancer, but has not been translated into effective…”
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Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety by Nguyen, Nhung Thi, Huang, Kai, Zeng, Hongxiang, Jing, Ji, Wang, Rui, Fang, Shaohai, Chen, Joyce, Liu, Xin, Huang, Zixian, You, M. James, Rao, Anjana, Huang, Yun, Han, Gang, Zhou, Yubin

“…Chimeric antigen receptor (CAR) T cell-based immunotherapy, approved by the US Food and Drug Administration, has shown curative potential in patients with…”
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AEL transformed from post-ET myelofibrosis with a sinusoidal pattern, JAK2 mutation, and biallelic TP53 inactivation by Wei, Qing, You, M. James

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Effect of surface roughness on pool boiling heat transfer at a heated surface having moderate wettability by Kim, Jinsub, Jun, Seongchul, Laksnarain, Ram, You, Seung M.

“…•Roughness effect on nucleate boiling is formulated using the Rohsenow correlation.•Surface roughness highly affects the CHF through capillary wicking.•CHF…”
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Plant Genomics-Advancing Our Understanding of Plants by You, Frank M

“…Plant genomics has made significant progress in recent years, enabling researchers to identify genes and genomic regions responsible for plant growth,…”
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The pathologic diagnosis of mantle cell lymphoma by Li, Shaoying, Xu, Jie, You, M James

“…Mantle cell lymphoma (MCL) is a mature B-cell non-Hodgkin lymphoma usually characterized by t(11;14) (q13;q32), or CCND1 translocation and Cyclin D1 over…”
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Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth by Wang, Lei, Xiong, Hua, Wu, Fengxia, Zhang, Yingjie, Wang, Ji, Zhao, Liyan, Guo, Xiaolan, Chang, Li-Ju, Zhang, Yong, You, M. James, Koochekpour, Shahriar, Saleem, Mohammad, Huang, Haojie, Lu, Junxuan, Deng, Yibin

“…Accumulating evidence suggests that codeletion of the tumor suppressor genes Pten and p53 plays a crucial role in the development of castration-resistant…”
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A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis by Rezaeian, Abdol-Hossein, Li, Chien-Feng, Wu, Ching-Yuan, Zhang, Xian, Delacerda, Jorge, You, M. James, Han, Fei, Cai, Zhen, Jeong, Yun Seong, Jin, Guoxiang, Phan, Liem, Chou, Ping-Chieh, Lee, Mong-Hong, Hung, Mien-Chie, Sarbassov, Dos, Lin, Hui-Kuan

“…The understanding of how hypoxia stabilizes and activates HIF1α in the nucleus with related oncogenic signals could revolutionize targeted therapy for cancers…”
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The Role of Tumor-Associated Macrophages in Leukemia by Li, Yueyang, You, M James, Yang, Yaling, Hu, Dongzhi, Tian, Chen

“…In addition to intrinsic factors, leukemia cell growth is influenced by the surrounding nonhematopoietic cells in the leukemic microenvironment, including…”
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DDX5 is a positive regulator of oncogenic NOTCH1 signaling in T cell acute lymphoblastic leukemia by Lin, S, Tian, L, Shen, H, Gu, Y, Li, J-L, Chen, Z, Sun, X, James You, M, Wu, L

“…Notch signaling is a highly conserved cell–cell communication pathway regulating normal development and tissue homeostasis. Aberrant Notch signaling represents…”
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Effect of surface roughness on pool boiling heat transfer of water on hydrophobic surfaces by Kim, Jin S., Girard, Adam, Jun, Seongchul, Lee, Jungho, You, Seung M.

“…•Study of surface roughness effect on pool boiling of water on hydrophobic surfaces.•Boiling heat transfer coefficients varied with surface roughness and…”
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Association Between High-Deductible Health Plans and Engagement in Routine Medical Care for Type 2 Diabetes in a Privately Insured Population: A Propensity Score-Matched Study by Wu, You M, Huang, Jie, Reed, Mary E

“…High-deductible health plans (HDHPs) are increasingly more common but can be challenging for patients to navigate and may negatively affect care engagement for…”
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miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion by Chen, Dahu, Sun, Yutong, Yuan, Yuan, Han, Zhenbo, Zhang, Peijing, Zhang, Jinsong, You, M James, Teruya-Feldstein, Julie, Wang, Min, Gupta, Sumeet, Hung, Mien-Chie, Liang, Han, Ma, Li

“…Whether epithelial-mesenchymal transition (EMT) is always linked to increased tumorigenicity is controversial. Through microRNA (miRNA) expression profiling of…”
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BETP degradation simultaneously targets acute myelogenous leukemic stem cells and the microenvironment by Piya, Sujan, Mu, Hong, Bhattacharya, Seemana, Lorenzi, Philip L, Davis, R. Eric, McQueen, Teresa, Ruvolo, Vivian, Baran, Natalia, Wang, Zhiqiang, Qian, Yimin, Crews, Craig M, Konopleva, Marina, Ishizawa, Jo, You, M. James, Kantarjian, Hagop, Andreeff, Michael, Borthakur, Gautam

“…The antileukemic effect of inhibiting bromodomain and extra-terminal domain-containing (BET-containing) proteins (BETPs) such as BRD4 has largely been largely…”
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EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis by Yang, Weiwei, Xia, Yan, Cao, Yu, Zheng, Yanhua, Bu, Wen, Zhang, Lin, You, M. James, Koh, Mei Yee, Cote, Gilbert, Aldape, Kenneth, Li, Yi, Verma, Inder M., Chiao, Paul J., Lu, Zhimin

“…Many types of human tumor cells have overexpressed pyruvate kinase M2 (PKM2). However, the mechanism underlying this increased PKM2 expression remains to be…”
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Disease Resistance Gene Analogs (RGAs) in Plants by Sekhwal, Manoj Kumar, Li, Pingchuan, Lam, Irene, Wang, Xiue, Cloutier, Sylvie, You, Frank M

“…Plants have developed effective mechanisms to recognize and respond to infections caused by pathogens. Plant resistance gene analogs (RGAs), as resistance (R)…”
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The value of quantitative CT texture analysis in differentiation of angiomyolipoma without visible fat from clear cell renal cell carcinoma on four-phase contrast-enhanced CT images by You, M.-W., Kim, N., Choi, H.J.

“…To investigate the diagnostic performance and usefulness of texture analysis in differentiating angiomyolipoma (AML) without visible fat from clear cell renal…”
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