Search Results - "YOSHIFUJI, Hajime"

Pathophysiology of large vessel vasculitis and utility of interleukin-6 inhibition therapy by Yoshifuji, Hajime

“…Takayasu arteritis (TAK) and giant cell arteritis (GCA) affect mainly large- and medium-sized arteries. In refractory cases, vascular remodeling progresses and…”
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Glucocorticoids in the treatment of IgG4-related disease—Prospects for new international treatment guidelines by Yoshifuji, Hajime, Umehara, Hisanori

“…ABSTRACT Immunoglobulin G4-related disease (IgG4-RD) is a chronic fibro-inflammatory disease that may cause dysfunction in various organs. Worldwide…”
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Long-term efficacy and safety of tocilizumab in refractory Takayasu arteritis: final results of the randomized controlled phase 3 TAKT study by Nakaoka, Yoshikazu, Isobe, Mitsuaki, Tanaka, Yoshiya, Ishii, Tomonori, Ooka, Seido, Niiro, Hiroaki, Tamura, Naoto, Banno, Shogo, Yoshifuji, Hajime, Sakata, Yasushi, Kawakami, Atsushi, Atsumi, Tatsuya, Furuta, Shunsuke, Kohsaka, Hitoshi, Suzuki, Katsuya, Hara, Ryoki, Maejima, Yasuhiro, Tsukamoto, Hiroshi, Takasaki, Yoshinari, Yamashita, Katsuhisa, Okada, Norihiro, Yamakido, Shinji, Takei, Syuji, Yokota, Shumpei, Nishimoto, Norihiro

“…Abstract Objective To investigate the long-term efficacy and safety of the IL-6 receptor antibody tocilizumab in patients with Takayasu arteritis (TAK)…”
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Organ Damage and Quality of Life in Takayasu Arteritis　― Evidence From a National Registry Analysis by Yoshifuji, Hajime, Nakaoka, Yoshikazu, Uchida, Haruhito A., Sugihara, Takahiko, Watanabe, Yoshiko, Funakoshi, Sohei, Isobe, Mitsuaki, Harigai, Masayoshi, Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis (JPVAS)

“…Background: Takayasu arteritis, affecting primarily young women, damages large arteries and organs. We examined the impact of disease duration and sex on organ…”
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A susceptibility locus in the IL12B but not LILRA3 region is associated with vascular damage in Takayasu arteritis by Kadoba, Keiichiro, Watanabe, Ryu, Iwasaki, Takeshi, Nakajima, Toshiki, Kitagori, Koji, Akizuki, Shuji, Murakami, Kosaku, Nakashima, Ran, Hashimoto, Motomu, Tanaka, Masao, Ohmura, Koichiro, Morinobu, Akio, Terao, Chikashi, Yoshifuji, Hajime

“…HLA-B*52 is an established genetic factor in Takayasu arteritis (TAK). Recently, single nucleotide polymorphisms (SNPs) in IL12B (rs6871626) and LILRA3…”
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Roles of cytotoxic lymphocytes and MIC/LILR families in pathophysiology of Takayasu arteritis by Yoshifuji, Hajime, Terao, Chikashi

“…Takayasu arteritis (TAK) affects the aorta and its primary branches, mainly in young women. In its advanced stages, it can cause severe complications, such as…”
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TAFRO syndrome is associated with anti-SSA/Ro60 antibodies, in contrast to idiopathic castleman disease by Shirakashi, Mirei, Nishida, Yuri, Nakashima, Ran, Fujimoto, Masakazu, Hiwa, Ryosuke, Tsuji, Hideaki, Kitagori, Koji, Akizuki, Shuji, Morinobu, Akio, Yoshifuji, Hajime

“…TAFRO syndrome is an acute systemic inflammatory disease characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis/renal dysfunction, and…”
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Recent advances in Takayasu arteritis by Terao, Chikashi, Yoshifuji, Hajime, Mimori, Tsuneyo

“…Takayasu arteritis (TAK) is a relatively rare systemic vasculitis mainly affecting the aorta and its large branches. While patients with TAK are more…”
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The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody by Nakashima, Ran, Imura, Yoshitaka, Kobayashi, Shio, Yukawa, Naoichiro, Yoshifuji, Hajime, Nojima, Takaki, Kawabata, Daisuke, Ohmura, Koichiro, Usui, Takashi, Fujii, Takao, Okawa, Katsuya, Mimori, Tsuneyo

“…Objectives. Various autoantibodies are detected in the sera of PM/DM patients. Some of them are specific to PM/DM patients and closely associated with clinical…”
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Gastrointestinal manifestation of immunoglobulin G4-related disease: clarification through a multicenter survey by Notohara, Kenji, Kamisawa, Terumi, Uchida, Kazushige, Zen, Yoh, Kawano, Mitsuhiro, Kasashima, Satomi, Sato, Yasuharu, Shiokawa, Masahiro, Uehara, Takeshi, Yoshifuji, Hajime, Hayashi, Hiroko, Inoue, Koichi, Iwasaki, Keisuke, Kawano, Hiroo, Matsubayashi, Hiroyuki, Moritani, Yukitoshi, Murakawa, Katsuhiko, Oka, Yoshio, Tateno, Masatoshi, Okazaki, Kazuichi, Chiba, Tsutomu

“…Background Several reports on immunoglobulin (Ig)G4-related disease (IgG4-RD) with gastrointestinal involvement (IgG4-related gastrointestinal disease;…”
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Long-term outcomes of refractory Takayasu arteritis patients treated with biologics including ustekinumab by Gon, Yoshie, Yoshifuji, Hajime, Nakajima, Toshiki, Murakami, Kosaku, Nakashima, Ran, Ohmura, Koichiro, Mimori, Tsuneyo, Terao, Chikashi

“…Biologics have been used to treat refractory Takayasu arteritis (TAK), but their efficacy and safety have not been sufficiently evaluated. We extracted…”
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Expression of S100A8 protein on B cells is associated with disease activity in patients with systemic lupus erythematosus by Kitagori, Koji, Oku, Takuma, Wakabayashi, Masaki, Nakajima, Tomoya, Nakashima, Ran, Murakami, Kosaku, Hirayama, Yoshitaka, Ishihama, Yasushi, Ohmura, Koichiro, Morinobu, Akio, Mimori, Tsuneyo, Yoshifuji, Hajime

“…Systemic lupus erythematosus (SLE) is an intractable disease characterized by autoantibody production and autoreactive B and T cell proliferation. Although…”
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Anti-integrin αvβ6 antibody in Takayasu arteritis patients with or without ulcerative colitis by Ishikawa, Yuki, Yoshida, Hiroyuki, Yoshifuji, Hajime, Ohmura, Koichiro, Origuchi, Tomoki, Ishii, Tomonori, Mimori, Tsuneyo, Morinobu, Akio, Shiokawa, Masahiro, Terao, Chikashi

“…It has been well documented that Takayasu arteritis (TAK) and ulcerative colitis (UC) coexist in the same patients. characterizes the co-occurrence, which is…”
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Brief Report: Takayasu Arteritis and Ulcerative Colitis: High Rate of Co‐Occurrence and Genetic Overlap by Terao, Chikashi, Matsumura, Takayoshi, Yoshifuji, Hajime, Kirino, Yohei, Maejima, Yasuhiro, Nakaoka, Yoshikazu, Takahashi, Meiko, Amiya, Eisuke, Tamura, Natsuko, Nakajima, Toshiki, Origuchi, Tomoki, Horita, Tetsuya, Matsukura, Mitsuru, Kochi, Yuta, Ogimoto, Akiyoshi, Yamamoto, Motohisa, Takahashi, Hiroki, Nakayamada, Shingo, Saito, Kazuyoshi, Wada, Yoko, Narita, Ichiei, Kawaguchi, Yasushi, Yamanaka, Hisashi, Ohmura, Koichiro, Atsumi, Tatsuya, Tanemoto, Kazuo, Miyata, Tetsuro, Kuwana, Masataka, Komuro, Issei, Tabara, Yasuharu, Ueda, Atsuhisa, Isobe, Mitsuaki, Mimori, Tsuneyo, Matsuda, Fumihiko

“…Objective Takayasu arteritis (TAK) is a systemic vasculitis affecting large arteries and large branches of the aorta. Ulcerative colitis (UC) is a prevalent…”
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Associated factors of poor treatment outcomes in patients with giant cell arteritis: clinical implication of large vessel lesions by Sugihara, Takahiko, Hasegawa, Hitoshi, Uchida, Haruhito A, Yoshifuji, Hajime, Watanabe, Yoshiko, Amiya, Eisuke, Maejima, Yasuhiro, Konishi, Masanori, Murakawa, Yohko, Ogawa, Noriyoshi, Furuta, Shunsuke, Katsumata, Yasuhiro, Komagata, Yoshinori, Naniwa, Taio, Okazaki, Takahiro, Tanaka, Yoshiya, Takeuchi, Tsutomu, Nakaoka, Yoshikazu, Arimura, Yoshihiro, Harigai, Masayoshi, Isobe, Mitsuaki

“…Relapses frequently occur in giant cell arteritis (GCA), and long-term glucocorticoid therapy is required. The identification of associated factors with poor…”
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Neutrophils are essential as a source of IL-17 in the effector phase of arthritis by Katayama, Masaki, Ohmura, Koichiro, Yukawa, Naoichiro, Terao, Chikashi, Hashimoto, Motomu, Yoshifuji, Hajime, Kawabata, Daisuke, Fujii, Takao, Iwakura, Yoichiro, Mimori, Tsuneyo

“…Th17 has been shown to have a pivotal role in the development of arthritis. However, the role of IL-17 in the T cell-independent effector phase has not fully…”
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Two Susceptibility Loci to Takayasu Arteritis Reveal a Synergistic Role of the IL12B and HLA-B Regions in a Japanese Population by Terao, Chikashi, Yoshifuji, Hajime, Kimura, Akinori, Matsumura, Takayoshi, Ohmura, Koichiro, Takahashi, Meiko, Shimizu, Masakazu, Kawaguchi, Takahisa, Chen, Zhiyong, Naruse, Taeko K., Sato-Otsubo, Aiko, Ebana, Yusuke, Maejima, Yasuhiro, Kinoshita, Hideyuki, Murakami, Kosaku, Kawabata, Daisuke, Wada, Yoko, Narita, Ichiei, Tazaki, Junichi, Kawaguchi, Yasushi, Yamanaka, Hisashi, Yurugi, Kimiko, Miura, Yasuo, Maekawa, Taira, Ogawa, Seishi, Komuro, Issei, Nagai, Ryozo, Yamada, Ryo, Tabara, Yasuharu, Isobe, Mitsuaki, Mimori, Tsuneyo, Matsuda, Fumihiko

“…Takayasu arteritis (TAK) is an autoimmune systemic vasculitis of unknown etiology. Although previous studies have revealed that HLA-B∗52:01 has an effect on…”
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Biomarkers and Autoantibodies of Interstitial Lung Disease with Idiopathic Inflammatory Myopathies by Yoshifuji, Hajime

“…Various autoantibodies are seen in idiopathic inflammatory myopathies. Among myositis-specific antibodies, anti-aminoacyl-tRNA synthetase and anti-melanoma…”
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Increase of MZB1 in B cells in systemic lupus erythematosus: proteomic analysis of biopsied lymph nodes by Miyagawa-Hayashino, Aya, Yoshifuji, Hajime, Kitagori, Koji, Ito, Shinji, Oku, Takuma, Hirayama, Yoshitaka, Salah, Adeeb, Nakajima, Toshiki, Kiso, Kaori, Yamada, Norishige, Haga, Hironori, Tsuruyama, Tatsuaki

“…Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease in which dysregulation of B cells has been recognized. Here, we searched for potential…”
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Serum soluble interleukin-2 receptor as a biomarker in immunoglobulin G4-related disease by Handa, Tomohiro, Matsui, Shoko, Yoshifuji, Hajime, Kodama, Yuzo, Yamamoto, Hiroshi, Minamoto, Seijiro, Waseda, Yuko, Sato, Yasuharu, Kubo, Keishi, Mimori, Tsuneyo, Chiba, Tsutomu, Hirai, Toyohiro, Mishima, Michiaki

“…Objectives: Serum soluble interleukin-2 (IL-2) receptor (sIL-2R) might reflect disease activity in immunoglobulin G4-related disease (IgG4-RD). We aimed to…”
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