Search Results - "YOKOYAMA, Masaru"

Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells by Haga, Kei, Fujimoto, Akira, Takai-Todaka, Reiko, Miki, Motohiro, Doan, Yen Hai, Murakami, Kosuke, Yokoyama, Masaru, Murata, Kazuyoshi, Nakanishi, Akira, Katayama, Kazuhiko

“…Norovirus is the leading cause of acute gastroenteritis worldwide. Since the discovery of human norovirus (HuNoV), an efficient and reproducible norovirus…”
Get full text

Deletion of a 197-Amino-Acid Region in the N-Terminal Domain of Spike Protein Attenuates Porcine Epidemic Diarrhea Virus in Piglets by Hou, Yixuan, Lin, Chun-Ming, Yokoyama, Masaru, Yount, Boyd L, Marthaler, Douglas, Douglas, Arianna L, Ghimire, Shristi, Qin, Yibin, Baric, Ralph S, Saif, Linda J, Wang, Qiuhong

“…We previously isolated a porcine epidemic diarrhea virus (PEDV) strain, PC177, by blind serial passaging of the intestinal contents of a diarrheic piglet in…”
Get full text

Dynamic rotation of the protruding domain enhances the infectivity of norovirus by Song, Chihong, Takai-Todaka, Reiko, Miki, Motohiro, Haga, Kei, Fujimoto, Akira, Ishiyama, Ryoka, Oikawa, Kazuki, Yokoyama, Masaru, Miyazaki, Naoyuki, Iwasaki, Kenji, Murakami, Kosuke, Katayama, Kazuhiko, Murata, Kazuyoshi

“…Norovirus is the major cause of epidemic nonbacterial gastroenteritis worldwide. Lack of structural information on infection and replication mechanisms hampers…”
Get full text

Late-Stage Derivatization of Oleanolic Acid-Based Anti-HIV-1 Compounds by Takeuchi, Reon, Fujimoto, Junko, Taguchi, Yoshinori, Ide, Ryuji, Kyan, Ryuji, Sato, Kohei, Mase, Nobuyuki, Yokoyama, Masaru, Harada, Shigeyoshi, Narumi, Tetsuo

“…A 12-keto-type oleanolic acid derivative (4) has been identified as a potent anti-human immunodeficiency virus type-1 (HIV-1) compound that demonstrates…”
Get full text

Loxapine inhibits replication of hepatitis A virus in vitro and in vivo by targeting viral protein 2C by Matsuda, Mami, Hirai-Yuki, Asuka, Kotani, Osamu, Kataoka, Michiyo, Zheng, Xin, Yamane, Daisuke, Yokoyama, Masaru, Ishii, Koji, Muramatsu, Masamichi, Suzuki, Ryosuke

“…No antiviral drugs currently are available for treatment of infection by hepatitis A virus (HAV), a causative agent of acute hepatitis, a potentially…”
Get full text

PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation by Miyakawa, Kei, Matsunaga, Satoko, Yokoyama, Masaru, Nomaguchi, Masako, Kimura, Yayoi, Nishi, Mayuko, Kimura, Hirokazu, Sato, Hironori, Hirano, Hisashi, Tamura, Tomohiko, Akari, Hirofumi, Miura, Tomoyuki, Adachi, Akio, Sawasaki, Tatsuya, Yamamoto, Naoki, Ryo, Akihide

“…Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1. Although Vpx is phosphorylated, it…”
Get full text

Allosteric Regulation of HIV-1 Capsid Structure for Gag Assembly, Virion Production, and Viral Infectivity by a Disordered Interdomain Linker by Koma, Takaaki, Kotani, Osamu, Miyakawa, Kei, Ryo, Akihide, Yokoyama, Masaru, Doi, Naoya, Adachi, Akio, Sato, Hironori, Nomaguchi, Masako

“…The retroviral Gag capsid (Gag-CA) interdomain linker is an unstructured peptide segment connecting structured N-terminal and C-terminal domains. Although the…”
Get full text

Cis -Allosteric Regulation of HIV-1 Reverse Transcriptase by Integrase by Masuda, Takao, Kotani, Osamu, Yokoyama, Masaru, Abe, Yuya, Kawai, Gota, Sato, Hironori

“…Reverse transcriptase (RT) and integrase (IN) are encoded tandemly in the genes of retroviruses. We reported recently that HIV-1 RT and IN need to be supplied…”
Get full text

Genetic regions affecting the replication and pathogenicity of dengue virus type 2 by Samune, Yoshihiro, Saito, Akatsuki, Sasaki, Tadahiro, Koketsu, Ritsuko, Srimark, Narinee, Phadungsombat, Juthamas, Yokoyama, Masaru, Kotani, Osamu, Sato, Hironori, Yamanaka, Atsushi, Haga, Saori, Okamoto, Toru, Kurosu, Takeshi, Nakayama, Emi E, Shioda, Tatsuo

“…Dengue is a mosquito-borne disease that has spread to over 100 countries. Its symptoms vary from the relatively mild acute febrile illness called dengue fever…”
Get full text

Structural dynamics of HIV-1 envelope Gp120 outer domain with V3 loop by Yokoyama, Masaru, Naganawa, Satoshi, Yoshimura, Kazuhisa, Matsushita, Shuzo, Sato, Hironori

“…The net charge of the hypervariable V3 loop on the HIV-1 envelope gp120 outer domain plays a key role in modulating viral phenotype. However, the molecular…”
Get full text

Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins by Kobayakawa, Takuya, Yokoyama, Masaru, Tsuji, Kohei, Boku, Sayaka, Kurakami, Masaki, Fujino, Masayuki, Ishii, Takahiro, Miura, Yutaro, Nishimura, Soshi, Shinohara, Kouki, Yamamoto, Kenichi, Bolah, Peter, Kotani, Osamu, Murakami, Tsutomu, Sato, Hironori, Tamamura, Hirokazu

“…The capsid of human immunodeficiency virus type 1 (HIV-1) forms a conical structure by assembling oligomers of capsid (CA) proteins and is a virion shell that…”
Get full text

Identification of a Novel Cis-Acting Regulator of HIV-1 Genome Packaging by Sakuragi, Sayuri, Kotani, Osamu, Yokoyama, Masaru, Shioda, Tatsuo, Sato, Hironori, Sakuragi, Jun-Ichi

“…Human immunodeficiency virus type 1 (HIV-1) uptakes homo-dimerized viral RNA genome into its own particle. A cis-acting viral RNA segment responsible for this…”
Get full text

Low-molecular-weight anti-HIV-1 agents targeting HIV-1 capsid proteins by Kobayakawa, Takuya, Yokoyama, Masaru, Tsuji, Kohei, Fujino, Masayuki, Kurakami, Masaki, Onishi, Takato, Boku, Sayaka, Ishii, Takahiro, Miura, Yutaro, Shinohara, Kouki, Kishihara, Yuki, Ohashi, Nami, Kotani, Osamu, Murakami, Tsutomu, Sato, Hironori, Tamamura, Hirokazu

“…The HIV-1 capsid is a shell that encapsulates viral RNA, and forms a conical structure by assembling oligomers of capsid (CA) proteins. Since the CA proteins…”
Get full text

Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development by Chutiwitoonchai, Nopporn, Mano, Takafumi, Kakisaka, Michinori, Sato, Hirotaka, Kondoh, Yasumitsu, Osada, Hiroyuki, Kotani, Osamu, Yokoyama, Masaru, Sato, Hironori, Aida, Yoko

“…Abstract An anti-influenza compound, DP2392-E10 based on inhibition of the nuclear export function of the viral nucleoprotein-nuclear export signal 3 (NP-NES3)…”
Get full text

Molecular Dynamics Simulation of the Influenza A(H3N2) Hemagglutinin Trimer Reveals the Structural Basis for Adaptive Evolution of the Recent Epidemic Clade 3C.2a by Yokoyama, Masaru, Fujisaki, Seiichiro, Shirakura, Masayuki, Watanabe, Shinji, Odagiri, Takato, Ito, Kimito, Sato, Hironori

“…Influenza A(H3N2) has been a major cause of seasonal influenza in humans since 1968, and has evolved by antigenic drift under the constantly changing human…”
Get full text

An influenza HA stalk reactive polymeric IgA antibody exhibits anti-viral function regulated by binary interaction between HA and the antibody by Sano, Kaori, Saito, Shinji, Suzuki, Tadaki, Kotani, Osamu, Ainai, Akira, van Riet, Elly, Tabata, Koshiro, Saito, Kumpei, Takahashi, Yoshimasa, Yokoyama, Masaru, Sato, Hironori, Maruno, Takahiro, Usami, Kaede, Uchiyama, Susumu, Ogawa-Goto, Kiyoko, Hasegawa, Hideki

“…IgA antibodies, which are secreted onto the mucosal surface as secretory IgA antibodies (SIgAs), play an important role in preventing influenza virus…”
Get full text

Concomitant Enhancement of HIV-1 Replication Potential and Neutralization-Resistance in Concert With Three Adaptive Mutations in Env V1/C2/C4 Domains by Doi, Naoya, Yokoyama, Masaru, Koma, Takaaki, Kotani, Osamu, Sato, Hironori, Adachi, Akio, Nomaguchi, Masako

“…HIV-1 Env protein functions in the entry process and is the target of neutralizing antibodies. Its intrinsically high mutation rate is certainly one of driving…”
Get full text

ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction by Miyakawa, Kei, Matsunaga, Satoko, Kanou, Kazuhiko, Matsuzawa, Atsushi, Morishita, Ryo, Kudoh, Ayumi, Shindo, Keisuke, Yokoyama, Masaru, Sato, Hironori, Kimura, Hirokazu, Tamura, Tomohiko, Yamamoto, Naoki, Ichijo, Hidenori, Takaori-Kondo, Akifumi, Ryo, Akihide

“…APOBEC3G (A3G) is an innate antiviral restriction factor that strongly inhibits the replication of human immunodeficiency virus type 1 (HIV-1). An HIV-1…”
Get full text

Increased HIV-1 sensitivity to neutralizing antibodies by mutations in the Env V3-coding region for resistance to CXCR4 antagonists by Hikichi, Yuta, Yokoyama, Masaru, Takemura, Taichiro, Fujino, Masayuki, Kumakura, Sei, Maeda, Yosuke, Yamamoto, Naoki, Sato, Hironori, Matano, Tetsuro, Murakami, Tsutomu

“…HIV-1 passage in cell culture in the presence of chemokine receptor antagonists can result in selection of viruses with env mutations that confer resistance to…”
Get full text

Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation by Matsumoto, Tadahiko, Shirakawa, Kotaro, Yokoyama, Masaru, Fukuda, Hirofumi, Sarca, Anamaria Daniela, Koyabu, Sukenao, Yamazaki, Hiroyuki, Kazuma, Yasuhiro, Matsui, Hiroyuki, Maruyama, Wataru, Nagata, Kayoko, Tanabe, Fumiko, Kobayashi, Masayuki, Shindo, Keisuke, Morishita, Ryo, Sato, Hironori, Takaori-Kondo, Akifumi

“…APOBEC3B cytidine deaminase (A3B) catalyzes cytosine into uracil in single-strand DNA and induces C-to-T mutations in genomic DNA of various types of tumors…”
Get full text