Search Results - "YOKOTA, TAMOTSU"

SGLT2 Inhibitors as a Therapeutic Option for Diabetic Nephropathy by Kawanami, Daiji, Matoba, Keiichiro, Takeda, Yusuke, Nagai, Yosuke, Akamine, Tomoyo, Yokota, Tamotsu, Sango, Kazunori, Utsunomiya, Kazunori

“…Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD) worldwide. Glycemic and blood pressure (BP) control are important but not…”
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Endothelial Dysfunction in Diabetes by Takeda, Yusuke, Matoba, Keiichiro, Sekiguchi, Kensuke, Nagai, Yosuke, Yokota, Tamotsu, Utsunomiya, Kazunori, Nishimura, Rimei

“…Diabetes is a worldwide health issue closely associated with cardiovascular events. Given the pandemic of obesity, the identification of the basic…”
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The Physiology, Pathology, and Therapeutic Interventions for ROCK Isoforms in Diabetic Kidney Disease by Matoba, Keiichiro, Takeda, Yusuke, Nagai, Yosuke, Sekiguchi, Kensuke, Yokota, Tamotsu, Utsunomiya, Kazunori, Nishimura, Rimei

“…Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase that was originally identified as RhoA interacting protein. A diverse…”
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ROCK2 Regulates Monocyte Migration and Cell to Cell Adhesion in Vascular Endothelial Cells by Takeda, Yusuke, Matoba, Keiichiro, Kawanami, Daiji, Nagai, Yosuke, Akamine, Tomoyo, Ishizawa, Sho, Kanazawa, Yasushi, Yokota, Tamotsu, Utsunomiya, Kazunori

“…The small GTPase Rho and its downstream effector, Rho-kinase (ROCK), regulate various cellular functions, including organization of the actin cytoskeleton,…”
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Rho-Kinase Blockade Attenuates Podocyte Apoptosis by Inhibiting the Notch Signaling Pathway in Diabetic Nephropathy by Matoba, Keiichiro, Kawanami, Daiji, Nagai, Yosuke, Takeda, Yusuke, Akamine, Tomoyo, Ishizawa, Sho, Kanazawa, Yasushi, Yokota, Tamotsu, Utsunomiya, Kazunori

“…Podocyte apoptosis is a key process in the onset of diabetic nephropathy. A significant body of evidence shows that the Notch signaling pathway plays a central…”
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Renal ROCK Activation and Its Pharmacological Inhibition in Patients With Diabetes by Matoba, Keiichiro, Sekiguchi, Kensuke, Nagai, Yosuke, Takeda, Yusuke, Takahashi, Hiroshi, Yokota, Tamotsu, Utsunomiya, Kazunori, Nishimura, Rimei

“…Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase with essential roles in cytoskeletal functions. Substantial evidence…”
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Targeting Redox Imbalance as an Approach for Diabetic Kidney Disease by Matoba, Keiichiro, Takeda, Yusuke, Nagai, Yosuke, Yokota, Tamotsu, Utsunomiya, Kazunori, Nishimura, Rimei

“…Diabetic kidney disease (DKD) is a worldwide public health problem. It is the leading cause of end-stage renal disease and is associated with increased…”
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The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats by Gojo, Atsushi, Utsunomiya, Kazunori, Taniguchi, Kanta, Yokota, Tamotsu, Ishizawa, Shoh, Kanazawa, Yasushi, Kurata, Hideaki, Tajima, Naoko

“…This study aimed to investigate the effect of the Rho-kinase inhibitor fasudil on the development of diabetic nephropathy and clarify a contribution of the…”
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ROCK2-induced metabolic rewiring in diabetic podocytopathy by Matoba, Keiichiro, Takeda, Yusuke, Nagai, Yosuke, Sekiguchi, Kensuke, Ukichi, Rikako, Takahashi, Hiroshi, Aizawa, Daisuke, Ikegami, Masahiro, Tachibana, Toshiaki, Kawanami, Daiji, Kanazawa, Yasushi, Yokota, Tamotsu, Utsunomiya, Kazunori, Nishimura, Rimei

“…Loss of podocytes is a common feature of diabetic renal injury and a key contributor to the development of albuminuria. We found that podocyte Rho associated…”
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Deletion of podocyte Rho-associated, coiled-coil-containing protein kinase 2 protects mice from focal segmental glomerulosclerosis by Matoba, Keiichiro, Nagai, Yosuke, Sekiguchi, Kensuke, Ohashi, Shinji, Mitsuyoshi, Etsuko, Shimoda, Masayuki, Tachibana, Toshiaki, Kawanami, Daiji, Yokota, Tamotsu, Utsunomiya, Kazunori, Nishimura, Rimei

“…Focal segmental glomerulosclerosis (FSGS) shares podocyte damage as an essential pathological finding. Several mechanisms underlying podocyte injury have been…”
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Effect of One-Week Salt Restriction on Blood Pressure Variability in Hypertensive Patients with Type 2 Diabetes by Iuchi, Hiroyuki, Sakamoto, Masaya, Suzuki, Hirofumi, Kayama, Yosuke, Ohashi, Kennosuke, Hayashi, Takeshi, Ishizawa, Sho, Yokota, Tamotsu, Tojo, Katsuyoshi, Yoshimura, Michihiro, Utsunomiya, Kazunori

“…Increased short-term blood pressure (BP) variability on 24-hour ambulatory BP monitoring (ABPM) is known to be a risk factor for cardiovascular events…”
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Fasudil inhibits ER stress-induced VCAM-1 expression by modulating unfolded protein response in endothelial cells by Kawanami, Daiji, Matoba, Keiichiro, Okada, Rina, Tsukamoto, Masami, Kinoshita, Jun, Ishizawa, Sho, Kanazawa, Yasushi, Yokota, Tamotsu, Utsunomiya, Kazunori

“…•Tunicamycin activates Rho/Rho-kinase signaling in endothelial cells.•Fasudil, a specific Rho-kinase inhibitor, lowers ER stress-mediated VCAM-1…”
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The Rho-kinase inhibitor fasudil restores normal motor nerve conduction velocity in diabetic rats by assuring the proper localization of adhesion-related molecules in myelinating Schwann cells by Kanazawa, Yasushi, Takahashi-Fujigasaki, Junko, Ishizawa, Sho, Takabayashi, Naoko, Ishibashi, Kumiko, Matoba, Keiichiro, Kawanami, Daiji, Yokota, Tamotsu, Tajima, Naoko, Utsunomiya, Kazunori

“…The Rho/Rho-kinase signaling pathway has been shown to be involved in the complications of diabetes. In this study, we found that fasudil, a specific…”
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Sphingosine-1-phosphate induces differentiation of cultured renal tubular epithelial cells under Rho kinase activation via the S1P2 receptor by Ishizawa, Sho, Takahashi-Fujigasaki, Junko, Kanazawa, Yasushi, Matoba, Keiichiro, Kawanami, Daiji, Yokota, Tamotsu, Iwamoto, Takeo, Tajima, Naoko, Manome, Yoshinobu, Utsunomiya, Kazunori

“…Background Sphingosine-1-phosphate (S1P) is reportedly involved in the pathogenesis of kidney disease; however, the precise role played by S1P in renal…”
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Interactions between serum vitamin D levels and vitamin D receptor gene FokI polymorphisms for renal function in patients with type 2 diabetes by Yokoyama, Keitaro, Nakashima, Akio, Urashima, Mitsuyoshi, Suga, Hiroaki, Mimura, Takeshi, Kimura, Yasuo, Kanazawa, Yasushi, Yokota, Tamotsu, Sakamoto, Masaya, Ishizawa, Sho, Nishimura, Rimei, Kurata, Hideaki, Tanno, Yudo, Tojo, Katsuyoshi, Kageyama, Shigeru, Ohkido, Ichiro, Utsunomiya, Kazunori, Hosoya, Tatsuo

“…We aimed to examine associations among serum 25-hydroxyvitamin D (25OHD) levels, 1,25-dihyroxyvitamin D (1,25OHD) levels, vitamin D receptor (VDR)…”
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Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C β2 Activation and Diabetes by WAY, Kerrie J, ISSHIKI, Keiji, KING, George L, SUZUMA, Kiyoshi, YOKOTA, Tamotsu, ZVAGELSKY, Dmitriy, SCHOEN, Frederick J, SANDUSKY, George E, PECHOUS, Penelope A, VLAHOS, Chris J, WAKASAKI, Hisao

“…Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C β2 Activation and Diabetes Kerrie J. Way 1 ,…”
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Role of Protein Kinase C on the Expression of Platelet-Derived Growth Factor and Endothelin-1 in the Retina of Diabetic Rats and Cultured Retinal Capillary Pericytes by YOKOTA, Tamotsu, MA, Ronald C, PARK, Joong-Yeol, ISSHIKI, Keiji, SOTIROPOULOS, Konstantinos B, RAUNIYAR, Ravi K, BORNFELDT, Karin E, KING, George L

“…Role of Protein Kinase C on the Expression of Platelet-Derived Growth Factor and Endothelin-1 in the Retina of Diabetic Rats and Cultured Retinal Capillary…”
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Involvement of the Rho/Rho kinase signaling pathway in platelet-derived growth factor BB-induced vascular endothelial growth factor expression in diabetic rat retina by Yokota, Tamotsu, Utsunomiya, Kazunori, Taniguchi, Kanta, Gojo, Atsushi, Kurata, Hideaki, Tajima, Naoko

“…To examine the role played by the Rho/Rho kinase pathway in the platelet-derived growth factor BB (PDGF-BB)-induced expression of vascular endothelial growth…”
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Association of Polymorphism of Estrogen Receptor-α Gene with Circulating Levels of Adiponectin in Postmenopausal Women with Type 2 Diabetes by Yoshihara, Rie, Utsunomiya, Kazunori, Gojo, Atsushi Gojo Atsushi, Ishizawa, Sho, Kanazawa, Yasushi, Matoba, Keiichiro, Taniguchi, Kanta, Yokota, Tamotsu, Kurata, Hideaki, Yokoyama, Jun-ichi, Urashima, Mitsuyoshi, Tajima, Naoko

“…Aim: Menopause is a risk factor for cardiovascular disease (CVD) in women because of the reduction in endogenous estrogen. Recently, single nucleotide…”
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Prospective randomized study for optimal insulin therapy in type 2 diabetic patients with secondary failure by Miyashita, Yumi, Nishimura, Rimei, Nemoto, Masami, Matsudaira, Toru, Kurata, Hideaki, Yokota, Tamotsu, Yokota, Kuninobu, Tojo, Katsuyoshi, Utsunomiya, Kazunori, Tajima, Naoko

“…The large clinical trials proved that Basal-Bolus (BB) insulin therapy was effective in the prevention of diabetic complications and their progression…”
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