Search Results - "YOKOTA, Sandra J"

Humanized mouse model of ovarian cancer recapitulates patient solid tumor progression, ascites formation, and metastasis by Bankert, Richard B, Balu-Iyer, Sathy V, Odunsi, Kunle, Shultz, Leonard D, Kelleher, Jr, Raymond J, Barnas, Jennifer L, Simpson-Abelson, Michelle, Parsons, Robert, Yokota, Sandra J

“…Ovarian cancer is the most common cause of death from gynecological cancer. Understanding the biology of this disease, particularly how tumor-associated…”
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Characterization of Human Lung Tumor-Associated Fibroblasts and Their Ability to Modulate the Activation of Tumor-Associated T Cells by Nazareth, Michael R, Broderick, Lori, Simpson-Abelson, Michelle R, Kelleher, Raymond J., Jr, Yokota, Sandra J, Bankert, Richard B

“…The tumor microenvironment of human non-small cell lung cancer (NSCLC) is composed largely of stromal cells, including fibroblasts, yet these cells have been…”
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T Cells and Stromal Fibroblasts in Human Tumor Microenvironments Represent Potential Therapeutic Targets by Barnas, Jennifer L., Simpson-Abelson, Michelle R., Yokota, Sandra J., Kelleher, Raymond J., Bankert, Richard B.

“…The immune system of cancer patients recognizes tumor-associated antigens expressed on solid tumors and these antigens are able to induce tumor-specific…”
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IL-12 delivered intratumorally by multilamellar liposomes reactivates memory T cells in human tumor microenvironments by Simpson-Abelson, Michelle R, Purohit, Vivek S, Pang, Wing Man, Iyer, Vandana, Odunsi, Kunle, Demmy, Todd L, Yokota, Sandra J, Loyall, Jenni L, Kelleher, Raymond J, Balu-Iyer, Sathy, Bankert, Richard B

“…Abstract Using a novel loading technique, IL-12 is reported here to be efficiently encapsulated within large multilamellar liposomes. The preclinical efficacy…”
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Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells by Broderick, Lori, Yokota, Sandra J, Reineke, Joshua, Mathiowitz, Edith, Stewart, Carleton C, Barcos, Maurice, Kelleher, Jr, Raymond J, Bankert, Richard B

“…The implantation of small pieces of human primary lung tumor biopsy tissue into SCID mice results in a viable s.c. xenograft in which the tissue architecture,…”
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Changes in ovarian tumor cell number, tumor vasculature, and T cell function monitored in vivo using a novel xenograft model by Yokota, Sandra J, Facciponte, John G, Kelleher, Jr, Raymond J, Shultz, Leonard D, Loyall, Jenni L, Parsons, Robert R, Odunsi, Kunle, Frelinger, John G, Lord, Edith M, Gerber, Scott A, Balu-Iyer, Sathy V, Bankert, Richard B

“…Despite an initial response to chemotherapy, most patients with ovarian cancer eventually progress and succumb to their disease. Understanding why effector T…”
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Antibody targeting of doxorubicin-loaded liposomes suppresses the growth and metastatic spread of established human lung tumor xenografts in severe combined immunodeficient mice by SUGANO, Masahiko, EGILMEZ, Nejat K, YOKOTA, Sandra J, CHEN, Fang-An, HARDING, Jennifer, SHI KUN HUANG, BANKERT, Richard B

“…Beta1 integrins, expressed on the cell surface of human non-small cell lung carcinomas, are used here as a target for the selective delivery of anti-cancer…”
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Response to Comment on “Characterization of Human Lung Tumor-Associated Fibroblasts and Their Ability to Modulate the Activation of Tumor-Associated T Cells” by Nazareth, Michael R., Broderick, Lori, Simpson-Abelson, Michelle R., Kelleher, Raymond J., Yokota, Sandra J., Bankert, Richard B.

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Long-Term Engraftment and Expansion of Tumor-Derived Memory T Cells Following the Implantation of Non-Disrupted Pieces of Human Lung Tumor into NOD-scid IL2Rγnull Mice by Simpson-Abelson, Michelle R., Sonnenberg, Gregory F., Takita, Hiroshi, Yokota, Sandra J., Conway, Thomas F., Kelleher, Raymond J., Shultz, Leonard D., Barcos, Maurice, Bankert, Richard B.

“…Abstract Non-disrupted pieces of primary human lung tumor implanted into NOD-scid IL2Rγnull mice consistently result in successful xenografts in which tissue…”
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Long-Term Engraftment and Expansion of Tumor-Derived Memory T Cells Following the Implantation of Non-Disrupted Pieces of Human Lung Tumor into NOD-scid IL2R gamma super(null) Mice by Simpson-Abelson, Michelle R, Sonnenberg, Gregory F, Takita, Hiroshi, Yokota, Sandra J, Conway, Thomas FJr, Kelleher, Raymond JJr, Shultz, Leonard D, Barcos, Maurice, Bankert, Richard B

“…Non-disrupted pieces of primary human lung tumor implanted into NOD-scid IL2R gamma super(null) mice consistently result in successful xenografts in which…”
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Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice by Simpson-Abelson, Michelle R, Sonnenberg, Gregory F, Takita, Hiroshi, Yokota, Sandra J, Conway, Jr, Thomas F, Kelleher, Jr, Raymond J, Shultz, Leonard D, Barcos, Maurice, Bankert, Richard B

“…Non-disrupted pieces of primary human lung tumor implanted into NOD-scid IL2Rgamma(null) mice consistently result in successful xenografts in which tissue…”
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Human CD4 super(+) Effector Memory T Cells Persisting in the Microenvironment of Lung Cancer Xenografts Are Activated by Local Delivery of IL-12 to Proliferate, Produce IFN- gamma , and Eradicate Tumor Cells by Broderick, Lori, Yokota, Sandra J, Reineke, Joshua, Mathiowitz, Edith, Stewart, Carleton C, Barcos, Maurice, Kelleher, Raymond J, Bankert, Richard B

“…The implantation of small pieces of human primary lung tumor biopsy tissue into SCID mice results in a viable s.c. xenograft in which the tissue architecture,…”
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Long-Term Engraftment and Expansion of Tumor-Derived Memory T Cells Following the Implantation of Non-Disrupted Pieces of Human Lung Tumor into NOD-scid IL2R{gamma}null Mice by Simpson-Abelson, Michelle R, Sonnenberg, Gregory F, Takita, Hiroshi, Yokota, Sandra J, Conway, Thomas F., Jr, Kelleher, Raymond J., Jr, Shultz, Leonard D, Barcos, Maurice, Bankert, Richard B

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Human CD4+ Effector Memory T Cells Persisting in the Microenvironment of Lung Cancer Xenografts Are Activated by Local Delivery of IL-12 to Proliferate, Produce IFN-{gamma}, and Eradicate Tumor Cells by Broderick, Lori, Yokota, Sandra J, Reineke, Joshua, Mathiowitz, Edith, Stewart, Carleton C, Barcos, Maurice, Kelleher, Raymond J., Jr, Bankert, Richard B

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The effect of free fatty acids on spectrin organization in lymphocytes by Stephen, F D, Yokota, S J, Repasky, E A

“…Previous studies have shown that cis unsaturated free fatty acids (uFFAs) are able to cause alterations in the normal distribution pattern of certain…”
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