Search Results - "YODOI, J."

Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation by Kadowaki, H, Nishitoh, H, Urano, F, Sadamitsu, C, Matsuzawa, A, Takeda, K, Masutani, H, Yodoi, J, Urano, Y, Nagano, T, Ichijo, H

“…Amyloid beta (Abeta) is a main component of senile plaques in Alzheimer's disease and induces neuronal cell death. Reactive oxygen species (ROS), nitric oxide…”
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The thioredoxin system in retroviral infection and apoptosis by Masutani, H, Ueda, S, Yodoi, J

“…Human thioredoxin (TRX) was first identified in human T-cell leukemia virus type I (HTLV-I)-positive T-cell lines and is associated with the pathophysiology of…”
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Transgenic mice overproducing human thioredoxin-1, an antioxidative and anti-apoptotic protein, prevents diabetic embryopathy by Kamimoto, Y, Sugiyama, T, Kihira, T, Zhang, L, Murabayashi, N, Umekawa, T, Nagao, K, Ma, N, Toyoda, N, Yodoi, J, Sagawa, N

“…Aims/hypothesis Experimental studies have suggested that apoptosis is involved in diabetic embryopathy through oxidative stress. However, the precise mechanism…”
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Pancreatic B-cell function is altered by oxidative stress induced by acute hyperglycaemia by Miyazaki, Y., Kawano, H., Yoshida, T., Miyamoto, S., Hokamaki, J., Nagayoshi, Y., Yamabe, H., Nakamura, H., Yodoi, J., Ogawa, H.

“…Aims  Type 2 diabetes is preceded by a symptom‐free period of impaired glucose tolerance (IGT). Pancreatic B‐cell function decreases as glucose intolerance…”
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Oxygen sensing and redox signaling: the role of thioredoxin in embryonic development and cardiac diseases by Kobayashi-Miura, M, Shioji, K, Hoshino, Y, Masutani, H, Nakamura, H, Yodoi, J

“…It is important to regulate the oxygen concentration and scavenge oxygen radicals throughout the life of animals. In mammalian embryos, proper oxygen…”
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Redox regulation of cell growth and cell death by Kwon, Yong-Won, Masutani, Hiroshi, Nakamura, Hajime, Ishii, Yasuyuki, Yodoi, Junji

“…Oxidative stress evokes various cellular events, including activation of transcription factors, apoptosis, and cell cycle arrest. Accumulating evidence shows…”
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Thioredoxin reduces C‐C chemokine‐induced chemotaxis of human eosinophils by Kobayashi, N., Yamada, Y., Ito, W., Ueki, S., Kayaba, H., Nakamura, H., Yodoi, J., Chihara, J.

“…Background:  Human thioredoxin (TRX) is one of redox‐active proteins that regulate reactive oxidative metabolisms. In recent study, we found that serum levels…”
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Thioredoxin-binding protein-2 (TBP-2 VDUP1 TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformation by Chen, Z, Lopez-Ramos, D A, Yoshihara, E, Maeda, Y, Masutani, H, Sugie, K, Maeda, M, Yodoi, J

“…Although glucocorticoid (GC) is widely used for treating hematopoietic malignancies including adult T-cell leukemia (ATL), the mechanism by which leukemic…”
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Extracellular thioredoxin levels are increased in patients with acute lung injury by Callister, M E, Burke-Gaffney, A, Quinlan, G J, Nicholson, A G, Florio, R, Nakamura, H, Yodoi, J, Evans, T W

“…Background: Acute lung injury (ALI) and its extreme manifestation the acute respiratory distress syndrome (ARDS) complicate a wide variety of serious medical…”
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Cytoprotective Effects of Geranylgeranylacetone against Retinal Photooxidative Damage by Tanito, Masaki, Kwon, Yong-Won, Kondo, Norihiko, Bai, Jie, Masutani, Hiroshi, Nakamura, Hajime, Fujii, Junichi, Ohira, Akihiro, Yodoi, Junji

“…Exposure to excessive light induces retinal photoreceptor cell damage, leading to development and progression of various retinal diseases. We tested the effect…”
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Nitric oxide induces thioredoxin-1 nuclear translocation: Possible association with the p21Ras survival pathway by Arai, Roberto J., Masutani, H., Yodoi, J., Debbas, V., Laurindo, Francisco R., Stern, A., Monteiro, Hugo P.

“…One of the major redox-regulating molecules with thiol reducing activity is thioredoxin-1 (TRX-1). TRX-1 is a multifunctional protein that exists in the…”
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Redox Regulation by Thioredoxin and Thioredoxin‐Binding Proteins by Nishiyama, Akira, Masutani, Hiroshi, Nakamura, Hajime, Nishinaka, Yumiko, Yodoi, Junji

“…Recent works have shown the importance of reduction/oxidation (redox) regulation in various biological phenomena. Thioredoxin is a 12‐kDa protein with…”
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Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of thioredoxin-binding protein-2 by AHSAN, M. K, MASUTANI, H, YAMAGUCHI, Y, KIM, Y.-C, NOSAKA, K, MATSUOKA, M, NISHINAKA, Y, MAEDA, M, YODOI, J

“…The transition from interleukin-2 (IL-2)-dependent to IL-2-independent growth is considered one of the key steps in the transformation of human T-cell leukemia…”
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Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation by WEI, S. Jack, BOTERO, Ana, HIROTA, Kiichi, BRADBURY, C. Matthew, MARKOVINA, Stephanie, LASZLO, Andrei, SPITZ, Douglas R, GOSWAMI, Prabhat C, YODOI, Junji, GIUS, David

“…Thioredoxin (TRX) is a cytoplasmic, redox-sensitive signaling factor believed to participate in the regulation of nuclear transcription factors mediating…”
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Overexpression of thioredoxin1 in transgenic mice suppresses development of diabetic nephropathy by Hamada, Yasuhiro, Miyata, Satoshi, Nii-Kono, Tomoko, Kitazawa, Riko, Kitazawa, Sohei, Higo, Satomi, Fukunaga, Michiru, Ueyama, Shigemitu, Nakamura, Hajime, Yodoi, Junji, Fukagawa, Masafumi, Kasuga, Masato

“…Background. Oxidative stress has been suggested to play an important role in the pathogenesis of diabetic nephropathy. In the present study, the effects of…”
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Regulatory roles of thioredoxin in oxidative stress-induced cellular responses by Nishinaka, Y, Masutani, H, Nakamura, H, Yodoi, J

“…Thioredoxin (TRX) is a small ubiquitous and multifunctional protein having a redox-active dithiol/disulfide within the conserved active site sequence…”
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Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system by Makino, Y, Okamoto, K, Yoshikawa, N, Aoshima, M, Hirota, K, Yodoi, J, Umesono, K, Makino, I, Tanaka, H

“…Adaptation to stress evokes a variety of biological responses, including activation of the hypothalamic-pituitary-adrenal (HPA) axis and synthesis of a panel…”
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Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity by Sasada, T, Iwata, S, Sato, N, Kitaoka, Y, Hirota, K, Nakamura, K, Nishiyama, A, Taniguchi, Y, Takabayashi, A, Yodoi, J

“…Thioredoxin is a small ubiquitous protein with multiple biological functions, including cellular defense mechanisms against oxidative stress. In the present…”
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Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II) by Sasada, Tetsuro, Nakamura, Hajime, Ueda, Shugo, Sato, Norihito, Kitaoka, Yuki, Gon, Yasuhiro, Takabayashi, Arimichi, Spyrou, Giannis, Holmgren, Arne, Yodoi, Junji

“…The thioredoxin (TRX) system, composed of nicotinamide adenine dinucleotide phosphate (reduced form), TRX, and TRX reductase (TRXR), has multiple biologic…”
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Lipid Peroxidation and Peroxynitrite in Retinal Ischemia-Reperfusion Injury by Shibuki, Hiroto, Katai, Naomichi, Yodoi, Junji, Uchida, Koji, Yoshimura, Nagahisa

“…To investigate whether lipid peroxides play a role in retinal cell death due to ischemia-reperfusion injury, whether recombinant human thioredoxin (rhTRX)…”
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