Search Results - "YODER, Kristine"

Host Double Strand Break Repair Generates HIV-1 Strains Resistant to CRISPR/Cas9 by Yoder, Kristine E., Bundschuh, Ralf

“…CRISPR/Cas9 genome editing has been proposed as a therapeutic treatment for HIV-1 infection. CRISPR/Cas9 induced double strand breaks (DSBs) targeted to the…”
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DNA strand breaks and gaps target retroviral intasome binding and integration by Senavirathne, Gayan, London, James, Gardner, Anne, Fishel, Richard, Yoder, Kristine E.

“…Retrovirus integration into a host genome is essential for productive infections. The integration strand transfer reaction is catalyzed by a nucleoprotein…”
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CRISPR/Cas9 Genome Editing to Disable the Latent HIV-1 Provirus by Panfil, Amanda R, London, James A, Green, Patrick L, Yoder, Kristine E

“…HIV-1 infection can be successfully controlled with anti-retroviral therapy (ART), but is not cured. A reservoir of cells harboring transcriptionally silent…”
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CRISPR Genome Editing Applied to the Pathogenic Retrovirus HTLV-1 by Panfil, Amanda R, Green, Patrick L, Yoder, Kristine E

“…CRISPR editing of retroviral proviruses has been limited to HIV-1. We propose human T-cell leukemia virus type 1 (HTLV-1) as an excellent model to advance…”
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Expression and purification of nuclease-free protocatechuate 3,4-dioxygenase for prolonged single-molecule fluorescence imaging by Senavirathne, Gayan, Lopez, Miguel A., Messer, Ryan, Fishel, Richard, Yoder, Kristine E.

“…Single-molecule (SM) microscopy is a powerful tool capable of visualizing individual molecules and events in real time. SM imaging may rely on proteins or…”
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Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration by Jones, Nathan D., Lopez Jr, Miguel A., Hanne, Jeungphill, Peake, Mitchell B., Lee, Jong-Bong, Fishel, Richard, Yoder, Kristine E.

“…Retroviruses must integrate their linear viral cDNA into the host genome for a productive infection. Integration is catalysed by the retrovirus-encoded…”
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Nucleosome DNA unwrapping does not affect prototype foamy virus integration efficiency or site selection by Mackler, Randi M, Jones, Nathan D, Gardner, Anne M, Lopez, Jr, Miguel A, Howard, Cecil J, Fishel, Richard, Yoder, Kristine E

“…Eukaryotic DNA binding proteins must access genomic DNA that is packaged into chromatin in vivo. During a productive infection, retroviral integrases (IN) must…”
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Retroviral prototype foamy virus intasome binding to a nucleosome target does not determine integration efficiency by Kotlar, Randi M., Jones, Nathan D., Senavirathne, Gayan, Gardner, Anne M., Messer, Ryan K., Tan, Yow Yong, Rabe, Anthony J., Fishel, Richard, Yoder, Kristine E.

“…Retroviral integrases must navigate host DNA packaged as chromatin during integration of the viral genome. Prototype foamy virus (PFV) integrase (IN) forms a…”
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The base excision repair pathway is required for efficient lentivirus integration by Yoder, Kristine E, Espeseth, Amy, Wang, Xiao-hong, Fang, Qingming, Russo, Maria Teresa, Lloyd, R Stephen, Hazuda, Daria, Sobol, Robert W, Fishel, Richard

“…An siRNA screen has identified several proteins throughout the base excision repair (BER) pathway of oxidative DNA damage as important for efficient HIV…”
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Strategies for Targeting Retroviral Integration for Safer Gene Therapy: Advances and Challenges by Yoder, Kristine E, Rabe, Anthony J, Fishel, Richard, Larue, Ross C

“…Retroviruses are obligate intracellular parasites that must integrate a copy of the viral genome into the host DNA. The integration reaction is performed by…”
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DNA Damage-Dependent Acetylation and Ubiquitination of H2AX Enhances Chromatin Dynamics by Ikura, Tsuyoshi, Tashiro, Satoshi, Kakino, Akemi, Shima, Hiroki, Jacob, Naduparambil, Amunugama, Ravindra, Yoder, Kristine, Izumi, Shunsuke, Kuraoka, Isao, Tanaka, Kiyoji, Kimura, Hiroshi, Ikura, Masae, Nishikubo, Shuichi, Ito, Takashi, Muto, Akihiko, Miyagawa, Kiyoshi, Takeda, Shunichi, Fishel, Richard, Igarashi, Kazuhiko, Kamiya, Kenji

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference by Bennett, Geoffrey R, Peters, Ryan, Wang, Xiao-hong, Hanne, Jeungphill, Sobol, Robert W, Bundschuh, Ralf, Fishel, Richard, Yoder, Kristine E

“…Host base excision repair (BER) proteins that repair oxidative damage enhance HIV infection. These proteins include the oxidative DNA damage glycosylases…”
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Prototype Foamy Virus Integrase Displays Unique Biochemical Activities among Retroviral Integrases by Rabe, Anthony J, Tan, Yow Yong, Larue, Ross C, Yoder, Kristine E

“…Integrases of different retroviruses assemble as functional complexes with varying multimers of the protein. Retroviral integrases require a divalent metal…”
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Removal of nuclease contamination during purification of recombinant prototype foamy virus integrase by Lopez, Miguel A., Mackler, Randi M., Yoder, Kristine E.

“…•A bacterial DNA nuclease co-purifies with recombinant retroviral integrase.•Integrase assays may be confounded by the contaminating nuclease.•The nuclease and…”
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Widespread nuclease contamination in commonly used oxygen-scavenging systems by Senavirathne, Gayan, Liu, Jiaquan, Lopez, Miguel A, Hanne, Jeungphill, Martin-Lopez, Juana, Lee, Jong-Bong, Yoder, Kristine E, Fishel, Richard

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Expression and Purification of Nuclease-Free Oxygen Scavenger Protocatechuate 3,4-Dioxygenase by Messer, Ryan K, Lopez, Jr, Miguel A, Senavirathne, Gayan, Yoder, Kristine E

“…Single molecule (SM) microscopy is used in the study of dynamic molecular interactions of fluorophore labeled biomolecules in real time. However, fluorophores…”
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Assembly and Purification of Prototype Foamy Virus Intasomes by Mackler, Randi M, Lopez, Jr, Miguel A, Yoder, Kristine E

“…A defining feature and necessary step of the retrovirus life cycle is the integration of the viral genome into the host genome. All retroviruses encode an…”
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Prototype foamy virus intasome aggregation is mediated by outer protein domains and prevented by protocatechuic acid by Jones, Nathan D., Mackler, Randi M., Lopez, Miguel A., Baltierra-Jasso, Laura E., Altman, Matthew P., Senavirathne, Gayan, Yoder, Kristine E.

“…The integrase (IN) enzyme of retrovirus prototype foamy virus (PFV) consists of four domains: amino terminal extension (NED), amino terminus (NTD), catalytic…”
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siRNA screening of a targeted library of DNA repair factors in HIV infection reveals a role for base excision repair in HIV integration by Espeseth, Amy S, Fishel, Rick, Hazuda, Daria, Huang, Qian, Xu, Min, Yoder, Kristine, Zhou, Honglin

“…Host DNA repair enzymes have long been assumed to play a role in HIV replication, and many different DNA repair factors have been associated with HIV. In order…”
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Detection and Removal of Nuclease Contamination During Purification of Recombinant Prototype Foamy Virus Integrase by Lopez, Jr, Miguel A, Mackler, Randi M, Altman, Matthew P, Yoder, Kristine E

“…The integrase (IN) protein of the retrovirus prototype foamy virus (PFV) is a model enzyme for studying the mechanism of retroviral integration. Compared to IN…”
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