Search Results - "YLA‐HERTTUALA, SEPPO"

Angiogenic gene therapy in cardiovascular diseases: dream or vision? by Ylä-Herttuala, Seppo, Bridges, Charles, Katz, Michael G, Korpisalo, Petra

“…Chronic cardiovascular diseases are significant health problems. Although current treatment strategies have tremendously improved disease management, up to 30%…”
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Gene Therapy of Critical Limb Ischemia Enters Clinical Use by Ylä-Herttuala, Seppo

“…Current treatments are based on endovascular operations and bypass surgery, but these operations are not always possible in elderly subjects. [...]there is a…”
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EphrinB2/EphB4 signaling regulates non‐sprouting angiogenesis by VEGF by Groppa, Elena, Brkic, Sime, Uccelli, Andrea, Wirth, Galina, Korpisalo‐Pirinen, Petra, Filippova, Maria, Dasen, Boris, Sacchi, Veronica, Muraro, Manuele Giuseppe, Trani, Marianna, Reginato, Silvia, Gianni‐Barrera, Roberto, Ylä‐Herttuala, Seppo, Banfi, Andrea

“…Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis, whose best‐understood mechanism is sprouting. However, therapeutic VEGF…”
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Biology of vascular endothelial growth factors by Roy, Himadri, Bhardwaj, Shalini, Ylä-Herttuala, Seppo

“…Angiogenesis is the process by which new blood vessels are formed from existing vessels. The vascular endothelial growth factors (VEGFs) are considered as key…”
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Optimized Protocol for Accurate Titration of Adeno-Associated Virus Vectors by Suoranta, Tuisku, Laham-Karam, Nihay, Ylä-Herttuala, Seppo

“…Adeno-associated virus (AAV) is currently the most popular gene delivery vector for gene therapy. However, variability in titration methods between different…”
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Cardiac Lymphatics – A New Avenue for Therapeutics? by Vuorio, Taina, Tirronen, Annakaisa, Ylä-Herttuala, Seppo

“…Recent progress in lymphatic vessel biology and in novel imaging techniques has established the importance of the lymphatic vasculature as part of the…”
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Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): a randomised, open-label, phase 3 trial by Westphal, Manfred, Prof, Ylä-Herttuala, Seppo, Prof, Martin, John, MD, Warnke, Peter, MD, Menei, Philippe, MD, Eckland, David, FRCP, Kinley, Judith, PhD, Kay, Richard, PhD, Ram, Zvi, Prof

“…Summary Background Besides the use of temozolomide and radiotherapy for patients with favourable methylation status, little progress has been made in the…”
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High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer by Sopo, Minna, Sallinen, Hanna, Hämäläinen, Kirsi, Kivelä, Annukka, Ylä-Herttuala, Seppo, Kosma, Veli-Matti, Keski-Nisula, Leea, Anttila, Maarit

“…Antiangiogenic therapy, although part of standard treatment in ovarian cancer, has variable efficacy. Furthermore, little is known about the prognostic…”
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The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction: the BAMI trial by Mathur, Anthony, Fernández-Avilés, Francisco, Bartunek, Jozef, Belmans, Ann, Crea, Filippo, Dowlut, Sheik, Galiñanes, Manuel, Good, Marie-Claire, Hartikainen, Juha, Hauskeller, Christine, Janssens, Stefan, Kala, Petr, Kastrup, Jens, Martin, John, Menasché, Philippe, Sanz-Ruiz, Ricardo, Ylä-Herttuala, Seppo, Zeiher, Andreas

“…Abstract Aims  Bone marrow-derived mononuclear cell (BM-MNC) therapy may improve myocardial recovery in patients following acute myocardial infarction (AMI),…”
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Changes in nuclear and cytoplasmic microRNA distribution in response to hypoxic stress by Turunen, Tiia A., Roberts, Thomas C., Laitinen, Pia, Väänänen, Mari-Anna, Korhonen, Paula, Malm, Tarja, Ylä-Herttuala, Seppo, Turunen, Mikko P.

“…MicroRNAs (miRNAs) are small non-coding RNAs that have well-characterized roles in cytoplasmic gene regulation, where they act by binding to mRNA transcripts…”
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Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer by Sopo, Minna, Anttila, Maarit, Hämäläinen, Kirsi, Kivelä, Annukka, Ylä-Herttuala, Seppo, Kosma, Veli-Matti, Keski-Nisula, Leea, Sallinen, Hanna

“…In many malignancies including ovarian cancer, different angiogenic factors have been related to poor prognosis. However, data on their relations to each other…”
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Baculovirus: an Insect-derived Vector for Diverse Gene Transfer Applications by Airenne, Kari J, Hu, Yu-Chen, Kost, Thomas A, Smith, Richard H, Kotin, Robert M, Ono, Chikako, Matsuura, Yoshiharu, Wang, Shu, Ylä-Herttuala, Seppo

“…Insect-derived baculoviruses have emerged as versatile and safe workhorses of biotechnology. Baculovirus expression vectors (BEVs) have been applied widely for…”
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Functional roles of the membrane-associated AAV protein MAAP by Galibert, Lionel, Hyvönen, Amira, Eriksson, Reetta A. E., Mattola, Salla, Aho, Vesa, Salminen, Sami, Albers, Justin D., Peltola, Sanna K., Weman, Saija, Nieminen, Tiina, Ylä-Herttuala, Seppo, Lesch, Hanna P., Vihinen-Ranta, Maija, Airenne, Kari J.

“…With a limited coding capacity of 4.7 kb, adeno-associated virus (AAV) genome has evolved over-lapping genes to maximise the usage of its genome. An example is…”
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Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction by Vuorio, Taina, Ylä-Herttuala, Elias, Laakkonen, Johanna P., Laidinen, Svetlana, Liimatainen, Timo, Ylä-Herttuala, Seppo

“…Heart has a wide lymphatic network but the importance of cardiac lymphatic system in heart diseases has remained unclear. Vascular Endothelial Growth Factor…”
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Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease by Kanninen, Katja, Heikkinen, Riikka, Malm, Tarja, Rolova, Taisia, Kuhmonen, Susanna, Leinonen, Hanna, Ylä-Herttuala, Seppo, Tanila, Heikki, Levonen, Anna-Liisa, Koistinaho, Milla, Koistinaho, Jari

“…The amyloid hypothesis of Alzheimer's disease (AD) postulates that amyloid-β (Aβ) deposition and neurotoxicity play a causative role in AD; oxidative injury is…”
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Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success by Dragneva, Galina, Korpisalo, Petra, Ylä-Herttuala, Seppo

“…Angiogenic therapy, which involves the use of an exogenous stimulus to promote blood vessel growth, is an attractive approach for the treatment of ischemic…”
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Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth by Purhonen, Susanna, Palm, Jarmo, Rossi, Derrick, Kaskenpää, Nina, Rajantie, Iiro, Ylä-Herttuala, Seppo, Alitalo, Kari, Weissman, Irving L, Salven, Petri

“…The mechanisms by which bone marrow (BM)-derived stem cells might contribute to angiogenesis and the origin of neovascular endothelial cells (ECs) are…”
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Adenoviral Gene Therapy Vectors in Clinical Use—Basic Aspects with a Special Reference to Replication-Competent Adenovirus Formation and Its Impact on Clinical Safety by Leikas, Aleksi J., Ylä-Herttuala, Seppo, Hartikainen, Juha E. K.

“…Adenoviral vectors are commonly used in clinical gene therapy. Apart from oncolytic adenoviruses, vector replication is highly undesired as it may pose a…”
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Lymphatic Vessel Insufficiency in Hypercholesterolemic Mice Alters Lipoprotein Levels and Promotes Atherogenesis by Vuorio, Taina, Nurmi, Harri, Moulton, Karen, Kurkipuro, Jere, Robciuc, Marius R, Öhman, Miina, Heinonen, Suvi E, Samaranayake, Haritha, Heikura, Tommi, Alitalo, Kari, Ylä-Herttuala, Seppo

“…OBJECTIVE—Lymphatic vessels collect extravasated fluid and proteins from tissues to blood circulation as well as play an essential role in lipid metabolism by…”
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Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell-Cell Junctions and Lung Metastasis by HOLOPAINEN, Tanja, SAHARINEN, Pipsa, TAMMELA, Tuomas, BENJAMIN, Laura E, YLÄ-HERTTUALA, Seppo, CHING CHING LEOW, GOU YOUNG KOH, ALITALO, Kari, D'AMICO, Gabriela, LAMPINEN, Anita, EKLUND, Lauri, SORMUNEN, Raija, ANISIMOV, Andrey, ZARKADA, Georgia, LOHELA, Marja, HELOTERÄ, Hanna

“…Angiopoietin-2 (Ang2), a ligand for endothelial TEK (Tie2) tyrosine kinase receptor, is induced in hypoxic endothelial cells of tumors, where it promotes tumor…”
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