Search Results - "YIRU GUO"

Echocardiography-guided percutaneous left ventricular intracavitary injection as a cell delivery approach in infarcted mice by Nong, Yibing, Guo, Yiru, Tomlin, Alex, Zhu, Xiaoping, Wysoczynski, Marcin, Li, Qianhong, Bolli, Roberto

“…In the field of cell therapy for heart disease, a new paradigm of repeated dosing of cells has recently emerged. However, the lack of a repeatable cell…”
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Single dose of synthetic microRNA-199a or microRNA-149 mimic does not improve cardiac function in a murine model of myocardial infarction by Nong, Yibing, Guo, Yiru, Gumpert, Anna, Li, Qianhong, Tomlin, Alex, Zhu, Xiaoping, Bolli, Roberto

“…Intramyocardial injection of synthetic microRNAs (miRs) has recently been reported to be beneficial after myocardial infarction (MI). We conducted a randomized…”
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TRPA1 channel contributes to myocardial ischemia-reperfusion injury by Conklin, Daniel J, Guo, Yiru, Nystoriak, Matthew A, Jagatheesan, Ganapathy, Obal, Detlef, Kilfoil, Peter J, Hoetker, Joseph David, Guo, Luping, Bolli, Roberto, Bhatnagar, Aruni

“…Myocardial ischemia-reperfusion (I/R) results in the generation of free radicals, accumulation of lipid peroxidation-derived unsaturated aldehydes, variable…”
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c-kit+ Cardiac stem cells alleviate post-myocardial infarction left ventricular dysfunction despite poor engraftment and negligible retention in the recipient heart by Hong, Kyung U, Guo, Yiru, Li, Qian-Hong, Cao, Pengxiao, Al-Maqtari, Tareq, Vajravelu, Bathri N, Du, Junjie, Book, Michael J, Zhu, Xiaoping, Nong, Yibing, Bhatnagar, Aruni, Bolli, Roberto

“…Although transplantation of c-kit+ cardiac stem cells (CSCs) has been shown to alleviate left ventricular (LV) dysfunction induced by myocardial infarction…”
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Stromal cell-derived factor-1α confers protection against myocardial ischemia/reperfusion injury : Role of the cardiac stromal cell-derived factor-1α-CXCR4 axis by XIAOFENG HU, SHUJING DAI, WU, Wen-Jian, WEI TAN, XIAOPING ZHU, JINGYAO MU, YIRU GUO, BOLLI, Roberto, ROKOSH, Gregg

“…Stromal cell-derived factor-1alpha (SDF-1alpha) binding to its cognate receptor, CXCR4, regulates a variety of cellular functions such as stem cell homing,…”
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Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice by Kang, Yi, Nasr, Marjan, Guo, Yiru, Uchida, Shizuka, Weirick, Tyler, Li, Hong, Kim, Jae, Moore, Joseph B., Muthusamy, Senthilkumar, Bolli, Roberto, Wysoczynski, Marcin

“…Although cardiac mesenchymal cell (CMC) therapy mitigates post-infarct cardiac dysfunction, the underlying mechanisms remain unidentified. It is acknowledged…”
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Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure by Abouleisa, Riham R.E., Salama, Abou Bakr M., Ou, Qinghui, Tang, Xian-Liang, Solanki, Mitesh, Guo, Yiru, Nong, Yibing, McNally, Lindsey, Lorkiewicz, Pawel K., Kassem, Kamal M., Ahern, Brooke M., Choudhary, Krishna, Thomas, Reuben, Huang, Yu, Juhardeen, Hamzah R., Siddique, Aisha, Ifthikar, Zainab, Hammad, Sally K., Elbaz, Ayman S., Ivey, Kathryn N., Conklin, Daniel J., Satin, Jonathan, Hill, Bradford G., Srivastava, Deepak, Bolli, Roberto, Mohamed, Tamer M.A.

“…The regenerative capacity of the heart after myocardial infarction is limited. Our previous study showed that ectopic introduction of 4 cell cycle factors (4F;…”
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Effects of Heme Oxygenase-1 on c-Kit-Positive Cardiac Cells by Li, Qianhong, Dasari, Chandrashekhar, Li, Ding, Arshia, Asma, Umer, Ahmed Muaaz, Abouzid, Mohamed Riad Abdelgawad, Guo, Yiru, Bolli, Roberto

“…Heme oxygenase-1 (HO-1) is one of the most powerful cytoprotective proteins known. The goal of this study was to explore the effects of HO-1 in c-kit-positive…”
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Inducible cardiac-specific overexpression of cyclooxygenase-2 (COX-2) confers resistance to ischemia/reperfusion injury by Guo, Yiru, Nong, Yibing, Tukaye, Deepali Nivas, Rokosh, Gregg, Du, Junjie, Zhu, Xiaoping, Book, Michael, Tomlin, Alex, Li, Qianhong, Bolli, Roberto

“…The role of cyclooxygenase-2 (COX-2) in cardiovascular biology remains controversial. Although COX-2 has been reported to mediate the protective actions of…”
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The Heme Oxygenase 1 Inducer (CoPP) Protects Human Cardiac Stem Cells against Apoptosis through Activation of the Extracellular Signal-regulated Kinase (ERK)/NRF2 Signaling Pathway and Cytokine Release by Cai, Chuanxi, Teng, Lei, Vu, Duc, He, Jia-Qiang, Guo, Yiru, Li, Qianghong, Tang, Xian-Liang, Rokosh, Gregg, Bhatnagar, Aruni, Bolli, Roberto

“…Intracoronary delivery of c-kit-positive human cardiac stem cells (hCSCs) is a promising approach to repair the infarcted heart, but it is severely limited by…”
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A highly sensitive and accurate method to quantify absolute numbers of c-kit+ cardiac stem cells following transplantation in mice by Hong, Kyung U., Li, Qian-Hong, Guo, Yiru, Patton, Nikita S., Moktar, Afsoon, Bhatnagar, Aruni, Bolli, Roberto

“…Although transplantation of c-kit+ cardiac stem cells (CSCs) alleviates post-myocardial infarction left ventricular dysfunction, there are no reliable methods…”
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Comparison of Repeated Doses of C-kit-Positive Cardiac Cells versus a Single Equivalent Combined Dose in a Murine Model of Chronic Ischemic Cardiomyopathy by Li, Qianhong, Guo, Yiru, Nong, Yibing, Tomlin, Alex, Gumpert, Anna, Zhu, Xiaoping, Hassan, Syed Adeel, Bolli, Roberto

“…Using a murine model of chronic ischemic cardiomyopathy caused by an old myocardial infarction (MI), we have previously found that three doses of 1 × 10 c-kit…”
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Myocardial Reparative Properties of Cardiac Mesenchymal Cells Isolated on the Basis of Adherence by Wysoczynski, Marcin, PhD, Guo, Yiru, MD, Moore, Joseph B., PhD, Muthusamy, Senthilkumar, PhD, Li, Qianhong, MD, PhD, Nasr, Marjan, MS, Li, Hong, PhD, Nong, Yibing, MD, Wu, Wenjian, MD, Tomlin, Alex A., BS, Zhu, Xiaoping, MD, Hunt, Gregory, BS, Gumpert, Anna M., PhD, Book, Michael J., MS, Khan, Abdur, MD, Tang, Xian-Liang, MD, Bolli, Roberto, MD

“…Abstract Background The authors previously reported that the c-kit–positive (c-kitPOS ) cells isolated from slowly adhering (SA) but not from rapidly adhering…”
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Intracoronary administration of cardiac stem cells in mice: a new, improved technique for cell therapy in murine models by Li, Qianhong, Guo, Yiru, Ou, Qinghui, Chen, Ning, Wu, Wen-Jian, Yuan, Fangping, O’Brien, Erin, Wang, Tao, Luo, Li, Hunt, Gregory N., Zhu, Xiaoping, Bolli, Roberto

“…A model of intracoronary stem cell delivery that enables transgenesis/gene targeting would be a powerful tool but is still lacking. To address this gap, we…”
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Cells Expressing Early Cardiac Markers Reside in the Bone Marrow and Are Mobilized Into the Peripheral Blood After Myocardial Infarction by Kucia, Magda, Dawn, Buddhadeb, Hunt, Greg, Guo, Yiru, Wysoczynski, Marcin, Majka, Marcin, Ratajczak, Janina, Rezzoug, Francine, Ildstad, Suzanne T, Bolli, Roberto, Ratajczak, Mariusz Z

“…The concept that bone marrow (BM)–derived cells participate in cardiac regeneration remains highly controversial and the identity of the specific cell type(s)…”
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A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning by Bolli, Roberto, Stein, Adam B, Guo, Yiru, Wang, Ou-Li, Rokosh, Gregg, Dawn, Buddhadeb, Molkentin, Jeffery D, Sanganalmath, Santosh K, Zhu, Yanqing, Xuan, Yu-Ting

“…Abstract Pharmacological studies have shown that signal transducers and activators of transcription (STATs) are necessary for the delayed cardioprotection of…”
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Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury by Zhao, Jingjing, Conklin, Daniel J, Guo, Yiru, Zhang, Xiang, Obal, Detlef, Guo, Luping, Jagatheesan, Ganapathy, Katragadda, Kartik, He, Liqing, Yin, Xinmin, Prodhan, Md Aminul Islam, Shah, Jasmit, Hoetker, David, Kumar, Amit, Kumar, Vijay, Wempe, Michael F, Bhatnagar, Aruni, Baba, Shahid P

“…BACKGROUND Myocardial ischemia reperfusion (I/R) injury is associated with complex pathophysiological changes characterized by pH imbalance, the accumulation…”
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Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium by Stein, Adam B, Bolli, Roberto, Dawn, Buddhadeb, Sanganalmath, Santosh K, Zhu, Yanqing, Wang, Ou-Li, Guo, Yiru, Motterlini, Roberto, Xuan, Yu-Ting

“…Abstract A growing body of evidence indicates that carbon monoxide (CO), once perceived merely as a poisonous gas, exerts antiapoptotic and cytoprotective…”
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Comparison of One and Three Intraventricular Injections of Cardiac Progenitor Cells in a Murine Model of Chronic Ischemic Cardiomyopathy by Guo, Yiru, Nong, Yibing, Li, Qianhong, Tomlin, Alex, Kahlon, Arunpreet, Gumpert, Anna, Slezak, Jan, Zhu, Xiaoping, Bolli, Roberto

“…Repeated doses of c-kit cardiac progenitor cells (CPCs) are superior to a single dose in improving LV function in rats with old myocardial infarction (MI)…”
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Cardiac Progenitor Cells and Bone Marrow-Derived Very Small Embryonic-Like Stem Cells for Cardiac Repair After Myocardial Infarction by Tang, Xian-Liang, Rokosh, D. Gregg, Guo, Yiru, Bolli, Roberto

“…Heart failure after myocardial infarction (MI) continues to be the most prevalent cause of morbidity and mortality worldwide. Although pharmaceutical agents…”
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