Search Results - "YI, Kyung H"

Fine tuning the immune response through B7-H3 and B7-H4 by Yi, Kyung H, Chen, Lieping

“…B7-H3 and B7-H4 belong to a new class of immune regulatory molecules, which primarily execute their functions in peripheral tissues to fine tune immune…”
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PIK3CA and AKT1 Mutations Have Distinct Effects on Sensitivity to Targeted Pathway Inhibitors in an Isogenic Luminal Breast Cancer Model System by BEAVER, Julia A, GUSTIN, John P, YI, Kyung H, RAJPUROHIT, Anandita, THOMAS, Matthew, GILBERT, Samuel F, MARC ROSEN, D, PARK, Ben Ho, LAURING, Josh

“…Activating mutations in the phosphoinositide-3-kinase (PI3K)/AKT/mTOR pathway are present in the majority of breast cancers and therefore are a major focus of…”
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Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine by Yi, Kyung H, Axtmayer, Jossette, Gustin, John P, Rajpurohit, Anandita, Lauring, Josh

“…The phosphatidylinositol 3-kinase (PI3-kinase)-Akt-mTOR pathway is mutated at high frequency in human breast cancer, and this pathway is the focus of active…”
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Recurrent AKT mutations in human cancers: functional consequences and effects on drug sensitivity by Yi, Kyung H, Lauring, Josh

“…Precision oncology trials based on tumor gene sequencing depend on robust knowledge about the phenotypic consequences of the genetic variants identified in…”
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Engineering targeted chromosomal amplifications in human breast epithelial cells by Springer, Simeon, Yi, Kyung H., Park, Jeenah, Rajpurohit, Anandita, Price, Amanda J., Lauring, Josh

“…Chromosomal amplifications are among the most common genetic alterations found in human cancers. However, experimental systems to study the processes that lead…”
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Adoptively transferred tumor-specific T cells stimulated Ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo by YI, Kyung H, NECHUSHTAN, Hovav, BOWERS, William J, WALKER, Gail R, YU ZHANG, PHAM, Dien G, PODACK, Eckhard R, FEDEROFF, Howard J, TOLBA, Khaled A, ROSENBLATT, Joseph D

“…4-1BB is a T-cell costimulatory receptor which binds its ligand 4-1BBL, resulting in prolonged T cell survival. We studied the antitumor effects of adoptively…”
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Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction by Nechushtan, Hovav, Pham, Dien, Zhang, Yu, Morgensztern, Daniel, Yi, Kyung H., Shin, Seung-Uon, Federoff, Howard J., Bowers, William J., Tolba, Khaled A., Rosenblatt, Joseph D.

“…Treatment of cancer with cytotoxic agents may induce lymphopenia. Adoptively transferred T cells have been reported to display enhanced anti-tumor efficacy in…”
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Fine tuning the immune response through B7-H3 and B7-H4: Mechanisms of Costimulation by YI, Kyung H, LIEPING CHEN

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