Search Results - "YEO, KWEE POO"

Age‐related bone loss is associated with FGF21 but not IGFBP1 in healthy adults by Lee, Shuen Yee, Fam, Kai Deng, Chia, Kar Ling, Yap, Margaret M. C., Goh, Jorming, Yeo, Kwee Poo, Yap, Eric P. H., Chotirmall, Sanjay H., Lim, Chin Leong

“…What is the central question of this study? Fibroblast growth factor 21 (FGF21) plays important therapeutic roles in metabolic diseases but is associated with…”
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Pharmacokinetics and tolerability of duloxetine following oral administration to healthy chinese subjects by TIANMEI, Si, PAT KNADLER, Mary, LIM, Ming T, KWEE POO YEO, LEYAN TENG, SHU LIANG, PAN, Alan X, LOBO, Evelyn D

“…The objectives of the study were to characterise the pharmacokinetics and assess the tolerability of duloxetine in healthy Chinese subjects after single and…”
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Fibroblast Growth Factor 21 Mediates the Associations between Exercise, Aging, and Glucose Regulation by LEE, SHUEN YEE, BURNS, STEPHEN F., NG, KENNETH K. C., STENSEL, DAVID J., ZHONG, LIANG, TAN, FRANKIE H. Y., CHIA, KAR LING, FAM, KAI DENG, YAP, MARGARET M. C., YEO, KWEE POO, YAP, ERIC P. H., LIM, CHIN LEONG

“…INTRODUCTIONAging increases the prevalence of glucose intolerance, but exercise improves glucose homeostasis. The fibroblast growth factor 21…”
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Open‐label, randomized study comparing basal insulin peglispro and insulin glargine, in combination with oral antihyperglycemic medications, in insulin‐naïve Asian patients with type 2 diabetes by Hirose, Takahisa, Cai, Zhihong, Yeo, Kwee Poo, Imori, Makoto, Ohwaki, Kenji, Imaoka, Takeshi

“…Introduction The present phase 3, randomized, open‐label study compared the efficacy and safety of basal insulin peglispro with insulin glargine after 26 weeks…”
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Effects of chronic renal failure on the pharmacokinetics of ruboxistaurin and its active metabolite 338522 by WISE, Stephen, YUEN, Eunice, CHAN, Clark, YEO KWEE POO, TENG, Lorraine, LAU, Titus, VOELKER, James

“…Ruboxistaurin, a specific inhibitor of the beta(1) and beta(2) isoforms of protein kinase C, is currently in clinical development for the treatment of several…”
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A least-squares approach to analyzing life-stress relationship in step-stress accelerated life tests by Teng, Siew-Leng, Yeo, Kwee-Poo

“…A new approach is proposed for the data analysis of failure-censored step-stress accelerated life tests with exponential failures, following an assumed…”
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Planning step-stress life-test with a target acceleration-factor by YEO, K.-P, TANG, L.-C

“…A sequential approach is presented to plan a multiple-steps step-stress accelerated life test (SSALT) with type-I censoring so as to achieve a pre-specified…”
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Pharmacokinetics, Pharmacodynamics, Tolerability, and Safety of Exenatide in Japanese Patients With Type 2 Diabetes Mellitus by Kothare, Prajakti A., Linnebjerg, Helle, Isaka, Yoshitaka, Uenaka, Kazunori, Yamamura, Ayuko, Yeo, Kwee Poo, de la Peña, Amparo, Teng, Choo Hua, Mace, Kenneth, Fineman, Mark, Shigeta, Hirofumi, Sakata, Yukikuni, Irie, Shin

“…In this single‐blind, parallel, placebo‐controlled study, the pharmacokinetics, pharmacodynamics, tolerability, and safety of subcutaneous exenatide were…”
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Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers by Skinner, Michael H., Kuan, Han‐Yi, Pan, Alan, Sathirakul, Korbtham, Knadler, Mary Pat, Gonzales, Celedon R., Yeo, Kwee Poo, Reddy, Shobha, Lim, Maggie, Ayan‐Oshodi, Mosun, Wise, Stephen D.

“…Background and Objectives Duloxetine, a potent dual reuptake inhibitor of serotonin and norepinephrine currently undergoing clinical investigation for…”
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Dose selection using a semi-mechanistic integrated glucose-insulin-glucagon model: designing phase 2 trials for a novel oral glucokinase activator by Zhang, Xin, Schneck, Karen, Bue-Valleskey, Juliana, Yeo, Kwee Poo, Heathman, Michael, Sinha, Vikram

“…Selecting dosing regimens for phase 2 studies for a novel glucokinase activator LY2599506 is challenging due to the difficulty in modeling and assessing…”
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Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise by Lee, Shuen Yee, Burns, Stephen F, Ng, Kenneth K C, Stensel, David J, Zhong, Liang, Tan, Frankie H Y, Chia, Kar Ling, Fam, Kai Deng, Yap, Margaret M C, Yeo, Kwee Poo, Yap, Eric P H, Lim, Chin Leong

“…Fibroblast growth factor 21 (FGF21) and adiponectin increase the expression of genes involved in antioxidant pathways, but their roles in mediating oxidative…”
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Lack of effect of acute oral ingestion of vitamin C on oxidative stress, arterial stiffness or blood pressure in healthy subjects by Kelly, Ronan P, Poo Yeo, Kwee, Isaac, Helen B, Lee, Chung-Yung J, Huang, Shan Hong, Teng, Lorraine, Halliwell, Barry, Wise, Stephen D

“…Vitamin C is a potent antioxidant in vitro and has been reported to act as a vasodilator, possibly by increasing nitric oxide bioavailability. This study…”
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l-5-Hydroxytryptophan augments the neuroendocrine response to a SSRI by Lowe, Stephen L., Poo Yeo, Kwee, Teng, Leyan, Soon, Danny K.W., Pan, Alan, Wise, Stephen D., Peck, Richard W.

“…The objective of the study was to assess l-5-hydroxytryptophan's ( l-5HTP) augmentation effect on the neuroendocrine response to a SSRI (citalopram). A…”
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Olanzapine pharmacokinetics are similar in Chinese and Caucasian subjects by Sathirakul, Korbtham, Chan, Clark, Teng, Leyan, Bergstrom, Richard F., Yeo, Kwee Poo, Wise, Stephen D.

“…Aim  To compare the pharmacokinetic profiles and dose proportionality of olanzapine in Chinese and Caucasian subjects. Methods  Randomized, three‐period study…”
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Safety and efficacy of alamifovir in patients with chronic hepatitis B virus infection by Soon, Danny K.W., Lowe, Stephen L., Teng, Choo Hua, Yeo, Kwee Poo, McGill, James, Wise, Stephen D.

“…Alamifovir is a purine nucleotide analogue prodrug that shows potent activity against wild type and lamivudine resistant hepatitis B virus in preclinical…”
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Pharmacokinetics of ruboxistaurin are significantly altered by rifampicin‐mediated CYP3A4 induction by Yeo, Kwee Poo, Lowe, Stephen L., Lim, Ming Tung, Voelker, James R., Burkey, Jennifer L., Wise, Stephen D.

“…Aims The aim of this study was to evaluate the effect of rifampicin co‐administration on the pharmacokinetics of ruboxistaurin and its active metabolite,…”
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Clinical Pharmacokinetics of Alamifovir and Its Metabolites by CHAN, Clark, ABU-RADDAD, Eyas, WISE, Stephen D, GOLOR, Georg, WATANABE, Hikari, SASAKI, Akira, KWEE POO YEO, SOON, Danny, SINHA, Vikram P, FLANAGAN, Shawn D, HE, Minxia M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Single-dose pharmacokinetics and glucodynamics of the novel, long-acting basal insulin LY2605541 in healthy subjects by Sinha, Vikram P., Choi, Siak Leng, Soon, Danny Kwang Wei, Mace, Kenneth F., Yeo, Kwee Poo, Lim, Shufen T. H., Howey, Daniel C.

“…LY2605541 is a novel basal insulin analog with a prolonged duration of action. Two Phase I studies assessed LY2605541 pharmacokinetics (PK), glucodynamics…”
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18. Glucagon Receptor Antibody LY2786890 Reduced Glucose Levels in Type 2 Diabetes Mellitus Patients (106-LB) by Kelly, Ronan P., Garhyan, Parag, Reynolds, Vincent L., Martin, Jennifer A., Tang, Cheng Cai, Yeo, Kwee Poo, Hardy, Thomas A.

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L-5-Hydroxytryptophan augments the neuroendo crine response to a SSRI by LOWE, Stephen L, KWEE POO YEO, LEYAN TENG, SOON, Danny K. W, PAN, Alan, WISE, Stephen D, PECK, Richard W

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