Search Results - "YAYON, Avner"

Enhanced chondrogenic phenotype of primary bovine articular chondrocytes in Fibrin-Hyaluronan hydrogel by multi-axial mechanical loading and FGF18 by Antunes, Bernardo P., Vainieri, M. Letizia, Alini, Mauro, Monsonego-Ornan, Efrat, Grad, Sibylle, Yayon, Avner

“…Current treatments for cartilage lesions are often associated with fibrocartilage formation and donor site morbidity. Mechanical and biochemical stimuli play…”
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Fibrin-Hyaluronic Acid Hydrogel (RegenoGel) with Fibroblast Growth Factor-18 for In Vitro 3D Culture of Human and Bovine Nucleus Pulposus Cells by Häckel, Sonja, Zolfaghar, Mona, Du, Jie, Hoppe, Sven, Benneker, Lorin M, Garstka, Nathalie, Peroglio, Marianna, Alini, Mauro, Grad, Sibylle, Yayon, Avner, Li, Zhen

“…We investigated the effects of a fibrin-hyaluronic acid hydrogel (FBG-HA) and fibroblast growth factor 18 (FGF-18) for nucleus pulposus (NP) regeneration…”
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Heterodimeric BMP‐2/7 for nucleus pulposus regeneration—In vitro and ex vivo studies by Li, Zhen, Lang, Gernot, Karfeld‐Sulzer, Lindsay S., Mader, Kerstin T., Richards, R. Geoff, Weber, Franz E., Sammon, Chris, Sacks, Hagit, Yayon, Avner, Alini, Mauro, Grad, Sibylle

“…ABSTRACT Intervertebral disc (IVD) degeneration is the leading trigger of low back pain, which causes disability and leads to enormous healthcare toll…”
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A placebo-controlled study comparing the efficacy of intra-articular injections of hyaluronic acid and a novel hyaluronic acid-platelet-rich plasma conjugate in a canine model of osteoarthritis by Lee, Mun-Ik, Kim, Jun-Hyung, Kwak, Ho-Hyun, Woo, Heung-Myong, Han, Jeong-Hee, Yayon, Avner, Jung, Yun-Chan, Cho, Jin-Man, Kang, Byung-Jae

“…The objective of this study was to assess the efficacy of intra-articular injections of hyaluronic acid (HA) and a novel, on-site conjugate of HA with…”
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Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization by Schlessinger, Joseph, Plotnikov, Alexander N., Ibrahimi, Omar A., Eliseenkova, Anna V., Yeh, Brian K., Yayon, Avner, Linhardt, Robert J., Mohammadi, Moosa

“…The crystal structure of a dimeric 2:2:2 FGF:FGFR:heparin ternary complex at 3 Å resolution has been determined. Within each 1:1 FGF:FGFR complex, heparin…”
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Distinct Fibroblast Growth Factor (FGF)/FGF Receptor Signaling Pairs Initiate Diverse Cellular Responses in the Oligodendrocyte Lineage by Fortin, Dale, Rom, Eran, Sun, Haijun, Yayon, Avner, Bansal, Rashmi

“…Fibroblast growth factors (FGFs) have been implicated in numerous cellular processes, including proliferation, migration, differentiation, and survival…”
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Mechanical Stress Inhibits Early Stages of Endogenous Cell Migration: A Pilot Study in an Ex Vivo Osteochondral Model by Vainieri, Maria L, Alini, Mauro, Yayon, Avner, van Osch, Gerjo J V M, Grad, Sibylle

“…Cell migration has a central role in osteochondral defect repair initiation and biomaterial-mediated regeneration. New advancements to reestablish tissue…”
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Fibroblast Growth Factor 4 and Its Novel Splice Isoform Have Opposing Effects on the Maintenance of Human Embryonic Stem Cell Self‐Renewal by Mayshar, Yoav, Rom, Eran, Chumakov, Irina, Kronman, Achia, Yayon, Avner, Benvenisty, Nissim

“…Human embryonic stem cells (HESCs) are unique in their capacity to self‐renew while remaining pluripotent. This undifferentiated state must be actively…”
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Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential by Thümmler, Katja, Rom, Eran, Zeis, Thomas, Lindner, Maren, Brunner, Sarah, Cole, John J, Arseni, Diana, Mücklisch, Steve, Edgar, Julia M, Schaeren-Wiemers, Nicole, Yayon, Avner, Linington, Christopher

“…Fibroblast growth factor (FGF) signaling contributes to failure of remyelination in multiple sclerosis, but targeting this therapeutically is complicated by…”
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Biomimetic fibrin-hyaluronan hydrogels for nucleus pulposus regeneration by Li, Zhen, Kaplan, Keren Mevorat, Wertzel, Abraham, Peroglio, Marianna, Amit, Boaz, Alini, Mauro, Grad, Sibylle, Yayon, Avner

“…To develop a biomimetic polymeric injectable hydrogel that can support nucleus pulposus (NP) regeneration. Natural polymer-based hydrogels were synthesized…”
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A novel approach for knee osteoarthritis using high molecular weight hyaluronic acid conjugated to plasma fibrinogen – interim findings of a double-blind clinical study by Kandel, Leonid, Agar, Gabriel, Elkayam, Ori, Sharipov, Aybek, Slevin, Omer, Rivkin, Gurion, Dahan, Moshe, Aloush, Valerie, Pyeser, Amos B., Brin, Yaron, Beer, Yiftah, Yayon, Avner

“…Osteoarthritis (OA) is a widespread degenerative joint disease leading to progressive loss of function and pain. Available treatments do not provide long-term…”
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Insights into the Molecular Basis for Fibroblast Growth Factor Receptor Autoinhibition and Ligand-Binding Promiscuity by Olsen, Shaun K., Ibrahimi, Omar A., Raucci, Angela, Zhang, Fuming, Eliseenkova, Anna V., Yayon, Avner, Basilico, Claudio, Linhardt, Robert J., Schlessinger, Joseph, Mohammadi, Moosa

“…The prototypical fibroblast growth factor receptor (FGFR) extracellular domain consists of three Ig domains (D1-D3) of which the two membrane-proximal D2 and…”
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Complexity of FGF receptors: genetic basis for structural diversity and functional specificity by Givol, D, Yayon, A

“…Since 1989, the receptors for fibroblast growth factors (FGFs) were cloned and characterized as a subgroup of the family of receptor tyrosine kinases. Four FGF…”
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Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis by Chen, L, Adar, R, Yang, X, Monsonego, E O, Li, C, Hauschka, P V, Yayon, A, Deng, C X

“…Missense mutations in fibroblast growth factor receptor 3 (FGFR3) result in several human skeletal dysplasias, including the most common form of dwarfism,…”
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Human Combinatorial Fab Library Yielding Specific and Functional Antibodies against the Human Fibroblast Growth Factor Receptor 3 by Rauchenberger, Robert, Borges, Eric, Thomassen-Wolf, Elisabeth, Rom, Eran, Adar, Rivka, Yaniv, Yael, Malka, Michael, Chumakov, Irina, Kotzer, Sarit, Resnitzky, Dalia, Knappik, Achim, Reiffert, Silke, Prassler, Josef, Jury, Karin, Waldherr, Dirk, Bauer, Susanne, Kretzschmar, Titus, Yayon, Avner, Rothe, Christine

“…The human combinatorial antibody library Fab 1 (HuCAL®-Fab 1) was generated by transferring the heavy and light chain variable regions from the previously…”
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A Mouse Model for Achondroplasia Produced by Targeting Fibroblast Growth Factor Receptor 3 by Wang, Yingcai, Spatz, Michal K., Kannan, Karuppiah, Hayk, Hovhannisyan, Avivi, Aaron, Gorivodsky, Marat, Pines, Mark, Yayon, Avner, Lonai, Peter, Givol, David

“…Achondroplasia, the most common form of dwarfism in man, is a dominant genetic disorder caused by a point mutation (G380R) in the transmembrane region of…”
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Differential Activation of Cysteine‐Substitution Mutants of Fibroblast Growth Factor Receptor 3 Is Determined by Cysteine Localization by Adar, Rivka, Monsonego‐Ornan, Efrat, David, Pe'er, Yayon, Avner

“…Various human skeletal disorders are thought to be caused by mutations in fibroblast growth factor receptor 3 (FGFR3). These result in chronic FGFR3…”
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Developmental Localization of the Splicing Alternatives of Fibroblast Growth Factor Receptor-2 (FGFR2) by Orr-Urtreger, Avi, Bedford, Mark T., Burakova, Tatjana, Arman, Esther, Zimmer, Yitzhak, Yayon, Avner, Givol, David, Lonai, Peter

“…The gene for fibroblast growth factor receptor-2 (FGFR2) encodes two splice variants designated here as keratinocyte growth factor (KGFR) and bek. Their…”
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Fibroblast growth factor receptor-3 as a therapeutic target for Achondroplasia--genetic short limbed dwarfism by Aviezer, David, Golembo, Myriam, Yayon, Avner

“…Achondroplasia, the most common form of human dwarfism is a sporadic autosomal dominant condition that occurs in approximately 1:20,000 births. The major…”
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Induction of Mdm2 and enhancement of cell survival by bFGF by SHAULIAN, E, RESNITZKY, D, SHIFMAN, O, BLANDINO, G, AMSTERDAM, A, YAYON, A, OREN, M

“…Basic fibroblast growth factor (bFGF) can exert mitogenic and viability-promoting effects in a wide range of biological systems. The biochemical activities…”
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