Search Results - "YAW DEBRAH, Alexander"

Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production by HOERAUF, Achim, MAND, Sabine, FISCHER, Kerstin, KRUPPA, Thomas, MARFO-DEBREKYEI, Yeboah, YAW DEBRAH, Alexander, PFARR, Kenneth M, ADJEI, Ohene, BÜTTNER, Dietrich W

“…Chemotherapy of onchocerciasis by doxycycline, which targets symbiotic Wolbachia endobacteria, has been shown to result in a long-term sterility of adult…”
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Reference intervals for selected haematological and biochemical parameters among apparently healthy adults in different eco-geographical zones in Ghana by Abbam, Gabriel, Tandoh, Samuel, Tetteh, Mary, Afrifah, David Amoah, Annani-Akollor, Max Efui, Owiredu, Eddie-Williams, Gyasi, Charles, Adu-Gyamfi, Constance, Sackey, Benedict, Debrah, Alexander Yaw, Addai-Mensah, Otchere

“…Due to the influence of gender, race/genetics, age, lifestyle habits and geography on the references intervals (RIs), the Clinical and Laboratory Standards…”
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Doxycycline Improves Filarial Lymphedema Independent of Active Filarial Infection: A Randomized Controlled Trial by Mand, Sabine, Debrah, Alexander Yaw, Klarmann, Ute, Batsa, Linda, Marfo-Debrekyei, Yeboah, Kwarteng, Alexander, Specht, Sabine, Belda-Domene, Aurea, Fimmers, Rolf, Taylor, Mark, Adjei, Ohene, Hoerauf, Achim

“…Background. The aim of this study was to determine whether improvement of filarial lymphedema (LE) by doxycycline is restricted to patients with ongoing…”
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Occurrence of Lymphatic Filariasis infection after 15 years of mass drug administration in two hotspot districts in the Upper East Region of Ghana by Adu Mensah, Derrick, Debrah, Linda Batsa, Gyamfi, Peter Akosah, Rahamani, Abu Abudu, Opoku, Vera Serwaa, Boateng, John, Obeng, Prince, Osei-Mensah, Jubin, Kroidl, Inge, Klarmann-Schulz, Ute, Hoerauf, Achim, Debrah, Alexander Yaw

“…BACKGROUNDLymphatic filariasis (LF) causes chronic morbidity, which usually manifests as lymphedema or hydrocele. Mass drug administration (MDA) began in…”
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Association of haemato-biochemical indices and blood composite ratios with microfilaridermia in Onchocerciasis patients by Debrah, Linda Batsa, Gyasi, Charles, Ahiadorme, Monica, Rahamani, Abu Abudu, Opoku, Vera Serwaa, Obeng, Prince, Osei-Mensah, Jubin, Obeng, Michael Agyemang, Mensah, Derrick Adu, Debrah, Alexander Yaw

“…Onchocerciasis causes chronic systemic inflammation. Several studies have used markers such as haemato-biochemical indices to predict the occurrence of…”
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Plasminogen Activator Inhibitor-1 in poorly controlled vs well controlled Type-2 Diabetes Mellitus patients: A case-control study in a district hospital in Ghana by Nkansah, Charles, Addai-Mensah, Otchere, Mensah, Kofi, Owusu, Michael, Ephraim, Richard K D, Adu, Patrick, Osei-Boakye, Felix, Appiah, Samuel K, Serwaa, Dorcas, Derigubah, Charles A, Debrah, Alexander Yaw

“…Hypofibrinolysis resulting from the up-regulation of plasminogen activator inhibitor-1 (PAI-1) usually occurs in patients with type 2 diabetes mellitus (T2DM),…”
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Seroprevalence and Risk Factors of Toxoplasma gondii Infection among Pregnant Women in Kumasi: A Cross-Sectional Study at a District-Level Hospital, Ghana by Singh, Bhavana, Debrah, Linda Batsa, Acheampong, Godfred, Debrah, Alexander Yaw

“…Background. This study investigated the prevalence and risk factors of Toxoplasma gondii infection among pregnant women in a district-level hospital in Ghana…”
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Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial by Klarmann-Schulz, Ute, Specht, Sabine, Debrah, Alexander Yaw, Batsa, Linda, Ayisi-Boateng, Nana Kwame, Osei-Mensah, Jubin, Mubarik, Yusif, Konadu, Peter, Ricchiuto, Arcangelo, Fimmers, Rolf, Arriens, Sandra, Dubben, Bettina, Ford, Louise, Taylor, Mark, Hoerauf, Achim

“…The search for new macrofilaricidal drugs against onchocerciasis that can be administered in shorter regimens than required for doxycycline (DOX, 200mg/d given…”
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Mhealth tools for community-based infectious disease surveillance in Africa: a scoping review protocol by Aku, Fortress Yayra, Amuasi, John Humphrey, Debrah, Linda Batsa, Opoku, Daniel, Gmanyami, Jonathan Mawutor, Hoerauf, Achim, Debrah, Alexander Yaw, Quentin, Wilm

“…IntroductionCountries in the WHO’s African region have found community-based surveillance useful in ensuring the effectiveness of the Integrated Disease…”
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Plasmodium falciparum histidine-rich protein 2 diversity in Ghana by Addai-Mensah, Otchere, Dinko, Bismarck, Noagbe, Mark, Ameke, Selassie Louis, Annani-Akollor, Max Efui, Owiredu, Eddie-Williams, Mensah, Kofi, Tackie, Richmond, Togbe, Eliezer, Agyare-Kwabi, Comfort, Gyasi, Charles, Adu-Gyamfi, Constance, Debrah, Alexander Yaw

“…In the absence of microscopy, Plasmodium falciparum histidine-rich proteins 2 (PfHRP2)-based rapid diagnostic tests (RDTs) are recommended for the diagnosis of…”
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A qPCR to quantify Wolbachia from few Onchocerca volvulus microfilariae as a surrogate for adult worm histology in clinical trials of antiwolbachial drugs by Schlabe, Stefan, Korir, Patricia, Lämmer, Christine, Landmann, Frederic, Dubben, Bettina, Koschel, Marianne, Albers, Anna, Debrah, Linda Batsa, Debrah, Alexander Yaw, Hübner, Marc P., Pfarr, Kenneth, Klarmann-Schulz, Ute, Hoerauf, Achim

“…The filarial nematode Onchocerca volvulus causes onchocerciasis (river blindness), a neglected tropical disease affecting 21 million people, mostly in…”
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Morbidity management and surveillance of lymphatic filariasis disease and acute dermatolymphangioadenitis attacks using a mobile phone-based tool by community health volunteers in Ghana by Debrah, Linda Batsa, Mohammed, Aliyu, Osei-Mensah, Jubin, Mubarik, Yusif, Agbenyega, Olivia, Ayisi-Boateng, Nana Kwame, Pfarr, Kenneth, Kuehlwein, Janina Melanie, Klarmann-Schulz, Ute, Hoerauf, Achim, Debrah, Alexander Yaw

“…Morbidity burden of lymphatic filariasis (LF) relies on the information from the Mass Drug Administration (MDA) programme where Community Health Volunteers…”
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PA-84 Dissecting the diagnostic performance of the alere filariasis test strip for the detection of active Wuchereria bancrofti infection and treatment success by Opoku, John, Batsa-Debrah, Linda, Schlabe, Stefan, Osei-Mensah, Jubin, Serwaa Opoku, Vera, Adu-Mensah, Derrick, Pfarr, Kenneth, Korir Jebett, Patricia, Wauschkuhn, Caroline, Hoerauf, Achim, Klarmann-Schulz, Ute, Yaw Debrah, Alexander

“…BackgroundAlthough the Alere Filariasis Test Strip (FTS) is recommended for surveillance and monitoring of Wuchereria bancrofti infection, the performance…”
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Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study by Hoerauf, Achim, Specht, Sabine, Büttner, Marcelle, Pfarr, Kenneth, Mand, Sabine, Fimmers, Rolf, Marfo-Debrekyei, Yeboah, Konadu, Peter, Debrah, Alexander Yaw, Bandi, Claudio, Brattig, Norbert, Albers, Anna, Larbi, John, Batsa, Linda, Adjei, Ohene, Büttner, Dietrich W.

“…In a randomized, placebo-controlled trial in Ghana, 67 onchocerciasis patients received 200-mg/day doxycycline for 4–6 weeks, followed by ivermectin (IVM)…”
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Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis by Debrah, Alexander Yaw, Mand, Sabine, Specht, Sabine, Marfo-Debrekyei, Yeboah, Batsa, Linda, Pfarr, Kenneth, Larbi, John, Lawson, Bernard, Taylor, Mark, Adjei, Ohene, Hoerauf, Achim

“…Lymphatic filariasis is a disease of considerable socioeconomic burden in the tropics. Presently used antifilarial drugs are able to strongly reduce…”
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Analysis of Mycobacterium ulcerans-specific T-cell cytokines for diagnosis of Buruli ulcer disease and as potential indicator for disease progression by Nausch, Norman, Antwi-Berko, Daniel, Mubarik, Yusif, Abass, Kabiru Mohammed, Owusu, Wellington, Owusu-Dabo, Ellis, Debrah, Linda Batsa, Debrah, Alexander Yaw, Jacobsen, Marc, Phillips, Richard O

“…Buruli ulcer disease (BUD), caused by Mycobacterium (M.) ulcerans, is the third most common mycobacterial disease after tuberculosis and leprosy. BUD causes…”
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Coagulation abnormalities in childhood acute lymphoblastic leukemia: assessing the impact of L-asparaginase therapy in Ghana by Osei-OWusu, William, Ntiamoah, David Ofosu, Akuffo, Gordon Asare, Mintaah, Selina, Owusu, Michael, Sackey, Benedict, Antwi-Boateng, Lilian, Abdul, Ganiwu, Annani-Akollor, Max, Owiredu, Eddie-Williams, Debrah, Alexander Yaw, Addai-Mensah, Otchere

“…Background Although the rate of childhood acute lymphoblastic leukemia (ALL) is increasing in Africa, there is a dearth of information on the disease and the…”
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Single nucleotide polymorphisms in the angiogenic and lymphangiogenic pathways are associated with lymphedema caused by Wuchereria bancrofti by Debrah, Linda Batsa, Albers, Anna, Debrah, Alexander Yaw, Brockschmidt, Felix F, Becker, Tim, Herold, Christine, Hofmann, Andrea, Osei-Mensah, Jubin, Mubarik, Yusif, Fröhlich, Holger, Hoerauf, Achim, Pfarr, Kenneth

“…Lymphedema (LE) is a chronic clinical manifestation of filarial nematode infections characterized by lymphatic dysfunction and subsequent accumulation of…”
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Increased HIV Incidence in Wuchereria bancrofti Microfilaria Positive Individuals in Tanzania by Mnkai, Jonathan, Ritter, Manuel, Maganga, Lucas, Maboko, Leonard, Olomi, Willyhelmina, Clowes, Petra, Minich, Jessica, Lelo, Agola Eric, Kariuki, Daniel, Debrah, Alexander Yaw, Geldmacher, Christof, Hoelscher, Michael, Saathoff, Elmar, Chachage, Mkunde, Pfarr, Kenneth, Hoerauf, Achim, Kroidl, Inge

“…Infections with are associated with reduced immunity against concomitant infections. Indeed, our previous study described a 2.3-fold increased HIV incidence…”
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Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulus by Specht, Sabine, Mand, Sabine, Marfo-Debrekyei, Yeboah, Debrah, Alexander Yaw, Konadu, Peter, Adjei, Ohene, Büttner, Dietrich W, Hoerauf, Achim

“…The microfilaricidal and temporarily sterilizing drug ivermectin is used for mass treatment of filarial infections. Filariae containing Wolbachia endobacteria…”
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