Search Results - "YASUKAWA, Hideo"

Omentin Prevents Myocardial Ischemic Injury Through AMP-Activated Protein Kinase- and Akt-Dependent Mechanisms by Kataoka, Yoshiyuki, MD, Shibata, Rei, MD, PhD, Ohashi, Koji, MD, PhD, Kambara, Takahiro, MD, Enomoto, Takashi, MS, Uemura, Yusuke, MD, Ogura, Yasuhiro, MD, PhD, Yuasa, Daisuke, MD, Matsuo, Kazuhiro, MD, Nagata, Takanobu, MD, Oba, Toyoharu, MD, Yasukawa, Hideo, MD, PhD, Numaguchi, Yasushi, MD, PhD, Sone, Takahito, MD, PhD, Murohara, Toyoaki, MD, PhD, Ouchi, Noriyuki, MD, PhD

“…Objectives This study examined the impact of omentin on myocardial injury in a mouse model of ischemia/reperfusion (I/R) and explored its underlying…”
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ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells by Morita, Rimpei, Suzuki, Mayu, Kasahara, Hidenori, Shimizu, Nana, Shichita, Takashi, Sekiya, Takashi, Kimura, Akihiro, Sasaki, Ken-ichiro, Yasukawa, Hideo, Yoshimura, Akihiko

“…Transplantation of endothelial cells (ECs) is a promising therapeutic approach for ischemic disorders. In addition, the generation of ECs has become…”
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Endogenous interleukin-22 prevents cardiac rupture after myocardial infarction in mice by Yamamoto, Mai, Yasukawa, Hideo, Takahashi, Jinya, Nohara, Shoichiro, Sasaki, Tomoko, Shibao, Kodai, Akagaki, Daiki, Okabe, Kota, Yanai, Toshiyuki, Shibata, Tatsuhiro, Fukumoto, Yoshihiro

“…Myocardial infarction (MI) can result in fatal myocardial rupture or heart failure due to adverse remodeling and dysfunction of the left ventricle. Although…”
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SOCS3 deficiency in cardiomyocytes elevates sensitivity of ischemic preconditioning that synergistically ameliorates myocardial ischemia reperfusion injury by Nohara, Shoichiro, Yamamoto, Mai, Yasukawa, Hideo, Nagata, Takanobu, Takahashi, Jinya, Shimozono, Koutatsu, Yanai, Toshiyuki, Sasaki, Tomoko, Okabe, Kota, Shibata, Tatsuhiro, Akagaki, Daiki, Mawatari, Kazutoshi, Fukumoto, Yoshihiro

“…Ischemic preconditioning (IPC) is the most powerful endogenous cardioprotective form of cellular adaptation. However, the inhibitory or augmenting mechanism…”
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Renal Nerve-Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning by Oba, Toyoharu, Yasukawa, Hideo, Nagata, Takanobu, Kyogoku, Sachiko, Minami, Tomoko, Nishihara, Michihide, Ohshima, Hideki, Mawatari, Kazutoshi, Nohara, Shoichiro, Takahashi, Jinya, Sugi, Yusuke, Igata, Sachiyo, Iwamoto, Yoshiko, Kai, Hisashi, Matsuoka, Hidehiro, Takano, Makoto, Aoki, Hiroki, Fukumoto, Yoshihiro, Imaizumi, Tsutomu

“…Background:Remote ischemic preconditioning (RIPC) induced by transient limb ischemia is a powerful innate mechanism of cardioprotection against ischemia…”
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Negative Regulation of Cytokine Signaling Pathways by Yasukawa, Hideo, Sasaki, Atsuo, Yoshimura, Akihiko

“…The Janus family of protein tyrosine kinases (JAKs) and STAT transcription factors regulate cellular processes involved in cell growth, differentiation, and…”
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Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity by Yoshimura, Akihiko, Mori, Hiroyuki, Hanada, Reiko, Hanada, Toshikatsu, Aki, Daisuke, Mashima, Ryuichi, Nishinakamura, Hitomi, Torisu, Takehiro, Chien, Kenneth R, Yasukawa, Hideo

“…Leptin is an adipocyte-derived hormone that plays a key role in energy homeostasis, yet resistance to leptin is a feature of most cases of obesity in humans…”
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Cardiac-Specific Deletion of SOCS-3 Prevents Development of Left Ventricular Remodeling After Acute Myocardial Infarction by Oba, Toyoharu, MD, Yasukawa, Hideo, MD, PhD, Hoshijima, Masahiko, MD, PhD, Sasaki, Ken-ichiro, MD, PhD, Futamata, Nobuyoshi, MD, Fukui, Daisuke, MD, Mawatari, Kazutoshi, MD, Nagata, Takanobu, MD, Kyogoku, Sachiko, MD, Ohshima, Hideki, MD, Minami, Tomoko, MD, Nakamura, Keiichiro, MD, PhD, Kang, Dongchon, MD, PhD, Yajima, Toshitaka, MD, PhD, Knowlton, Kirk U., MD, Imaizumi, Tsutomu, MD, PhD

“…Objectives The study investigated the role of myocardial suppressor of cytokine signaling-3 (SOCS3), an intrinsic negative feedback regulator of the janus…”
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Interleukin-22 Directly Activates Myocardial STAT3 (Signal Transducer and Activator of Transcription-3) Signaling Pathway and Prevents Myocardial Ischemia Reperfusion Injury by Takahashi, Jinya, Yamamoto, Mai, Yasukawa, Hideo, Nohara, Shoichiro, Nagata, Takanobu, Shimozono, Koutatsu, Yanai, Toshiyuki, Sasaki, Tomoko, Okabe, Kota, Shibata, Tatsuhiro, Mawatari, Kazutoshi, Kakuma, Tatsuyuki, Aoki, Hiroki, Fukumoto, Yoshihiro

“…BACKGROUND Interleukin (IL)-22, a member of the IL-10 cytokine family, is the only known cytokine that is secreted by immune cells but does not target immune…”
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IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages by Yoshimura, Akihiko, Yasukawa, Hideo, Ohishi, Masanobu, Mori, Hiroyuki, Murakami, Masaaki, Chinen, Takatoshi, Aki, Daisuke, Hanada, Toshikatsu, Takeda, Kiyoshi, Akira, Shizuo, Hoshijima, Masahiko, Hirano, Toshio, Chien, Kenneth R

“…Whereas interleukin-6 (IL-6) is a proinflammatory cytokine, IL-10 is an anti-inflammatory cytokine. Although signal transducer and activator of transcription 3…”
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Multidisciplinary Team-Based Palliative Care for Heart Failure and Food Intake at the End of Life by Shibata, Tatsuhiro, Mawatari, Kazutoshi, Nakashima, Naoko, Shimozono, Koutatsu, Ushijima, Kouko, Yamaji, Yumiko, Tetsuka, Kumi, Murakami, Miki, Okabe, Kouta, Yanai, Toshiyuki, Nohara, Shoichiro, Takahashi, Jinya, Aoki, Hiroki, Yasukawa, Hideo, Fukumoto, Yoshihiro

“…Traditionally, patients with end-stage heart failure (HF) have rarely been involved in end-of-life care (EOLC) discussions in Japan. The purpose of this study…”
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Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules by Nagata, Takanobu, Yasukawa, Hideo, Kyogoku, Sachiko, Oba, Toyoharu, Takahashi, Jinya, Nohara, Shoichiro, Minami, Tomoko, Mawatari, Kazutoshi, Sugi, Yusuke, Shimozono, Koutatsu, Pradervand, Sylvain, Hoshijima, Masahiko, Aoki, Hiroki, Fukumoto, Yoshihiro, Imaizumi, Tsutomu

“…Myocardial ischemia reperfusion injury (IRI) adversely affects cardiac performance and the prognosis of patients with acute myocardial infarction. Although…”
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Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias by Hara, Munetsugu, Takahashi, Tomoyuki, Mitsumasu, Chiaki, Igata, Sachiyo, Takano, Makoto, Minami, Tomoko, Yasukawa, Hideo, Okayama, Satoko, Nakamura, Keiichiro, Okabe, Yasunori, Tanaka, Eiichiro, Takemura, Genzou, Kosai, Ken-ichiro, Yamashita, Yushiro, Matsuishi, Toyojiro

“…Methyl-CpG-binding protein 2 (MeCP2) is an epigenetic regulator of gene expression that is essential for normal brain development. Mutations in MeCP2 lead to…”
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Role of Macrophage Socs3 in the Pathogenesis of Aortic Dissection by Ohno‐Urabe, Satoko, Aoki, Hiroki, Nishihara, Michihide, Furusho, Aya, Hirakata, Saki, Nishida, Norifumi, Ito, Sohei, Hayashi, Makiko, Yasukawa, Hideo, Imaizumi, Tsutomu, Akashi, Hidetoshi, Tanaka, Hiroyuki, Fukumoto, Yoshihiro

“…Background Aortic dissection (AD) is a life‐threatening medical emergency caused by the abrupt destruction of the intimomedial layer of the aortic walls. Given…”
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Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction by Hiwatashi, Kiyokazu, Tamiya, Taiga, Hasegawa, Eiichi, Fukaya, Tomohiro, Hashimoto, Masayuki, Kakoi, Kyosuke, Kashiwagi, Ikko, Kimura, Akihiro, Inoue, Naoko, Morita, Rimpei, Yasukawa, Hideo, Yoshimura, Akihiko

“…Abstract Inflammation has been demonstrated to play important roles in tumorigenesis, tumor progression, and metastasis. STAT3 has been shown to be frequently…”
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Genetic Deletion of Socs3 in Smooth Muscle Cells Ameliorates Aortic Dissection in Mice by Hirakata, Saki, Aoki, Hiroki, Ohno-Urabe, Satoko, Nishihara, Michihide, Furusho, Aya, Nishida, Norifumi, Ito, Sohei, Hayashi, Makiko, Yasukawa, Hideo, Imaizumi, Tsutomu, Hiromatsu, Sinichi, Tanaka, Hiroyuki, Fukumoto, Yoshihiro

“…[Display omitted] •Stat3, a major signaling molecule for proinflammatory cytokines including IL-6, was activated both in inflammatory cells and in SMC in the…”
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Platelet P-selectin plays an important role in arterial thrombogenesis by forming large stable platelet-leukocyte aggregates by Yokoyama, Shinji, Ikeda, Hisao, Haramaki, Nobuya, Yasukawa, Hideo, Murohara, Toyoaki, Imaizumi, Tsutomu

“…We investigated the role of P-selectin in arterial thrombogenesis by forming large stable platelet-leukocyte aggregates. Plaque rupture followed by thrombus…”
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Alterations in Coxsackievirus and Adenovirus Receptor Confer Susceptibility to Ventricular Arrhythmia With an Ischemic Event by Yasukawa, Hideo, MD, PhD, Oba, Toyoharu, MD, PhD, Fukumoto, Yoshihiro, MD, PhD

“…In vitro binding analysis revealed interaction between CAR protein and the sodium channel Nav1.5. [...]expression studies using human MI samples combined with…”
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Absence of SOCS3 in the Cardiomyocyte Increases Mortality in a gp130-Dependent Manner Accompanied by Contractile Dysfunction and Ventricular Arrhythmias by YAJIMA, Toshitaka, MUROFUSHI, Yoshiteru, DALTON, Nancy D, YAJIMA, Tomoko, YASUKAWA, Hideo, PETERSON, Kirk L, KNOWLTON, Kirk U, HANBING ZHOU, PARK, Stanley, HOUSMAN, Jonathan, ZHONG, Zhao-Hua, NAKAMURA, Michinari, MACHIDA, Mitsuyo, HWANG, Kyung-Kuk, YUSU GU

“…Suppressor of cytokine signaling-3 (SOCS3) is a key negative-feedback regulator of the gp130 receptor that provides crucial signaling for cardiac hypertrophy…”
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The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2 by Kamizono, S, Hanada, T, Yasukawa, H, Minoguchi, S, Kato, R, Minoguchi, M, Hattori, K, Hatakeyama, S, Yada, M, Morita, S, Kitamura, T, Kato, H, Nakayama Ki, Yoshimura, A

“…Fusion of the TEL gene on 12p13 to the JAK2 tyrosine kinase gene on 9p24 has been found in human leukemia. TEL -mediated oligomerization of JAK2 results in…”
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