Search Results - "YASHIN, Anatoli I"

Quantification of biological aging in young adults by Belsky, Daniel W, Avshalom Caspi, Renate Houts, Harvey J. Cohen, David L. Corcoran, Andrea Danese, HonaLee Harrington, Salomon Israel, Morgan E. Levine, Jonathan D. Schaefer, Karen Sugden, Ben Williams, Anatoli I. Yashin, Richie Poulton, Terrie E. Moffitt

“…Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population…”
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Cumulative Deficits Better Characterize Susceptibility to Death in Elderly People than Phenotypic Frailty: Lessons from the Cardiovascular Health Study by Kulminski, Alexander M., Ukraintseva, Svetlana V., Kulminskaya, Irina V., Arbeev, Konstantin G., Land, Kenneth, Yashin, Anatoli I.

“…OBJECTIVES: To compare how well frailty measures based on a phenotypic frailty approach proposed in the Cardiovascular Health Study (CHS) and a cumulative…”
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Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan by Kulminski, Alexander M, Arbeev, Konstantin G, Culminskaya, Irina, Arbeeva, Liubov, Ukraintseva, Svetlana V, Stallard, Eric, Christensen, Kaare, Schupf, Nicole, Province, Michael A, Yashin, Anatoli I

“…Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics…”
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Cumulative Index of Health Deficiencies as a Characteristic of Long Life by Kulminski, Alexander M., Ukraintseva, Svetlana V., Akushevich, Igor V., Arbeev, Konstantin G., Yashin, Anatoli I.

“…OBJECTIVES: To describe the accumulation of aging‐associated health disorders using a cumulative measure known as a frailty index (FI) and to evaluate its…”
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Body Mass Index and Nine-Year Mortality in Disabled and Nondisabled Older U.S. Individuals by Kulminski, Alexander M., Arbeev, Konstantin G., Kulminskaya, Irina V., Ukraintseva, Svetlana V., Land, Kenneth, Akushevich, Igor, Yashin, Anatoli I.

“…OBJECTIVES: To investigate the relationship between body mass index (BMI) and 9‐year mortality in older (≥65) Americans with and without disability. DESIGN:…”
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Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans by Wu, Deqing, Cypser, James R., Yashin, Anatoli I., Johnson, Thomas E.

“…Exposure to mild heat-stress (heat-shock) can significantly increase the life expectancy of the nematode Caenorhabditis elegans. A single heat-shock early in…”
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Biodemographic Trajectories of Longevity by Vaupel, James W., Carey, James R., Christensen, Kaare, Johnson, Thomas E., Yashin, Anatoli I., Holm, Niels V., Iachine, Ivan A., Kannisto, Väinö, Khazaeli, Aziz A., Liedo, Pablo, Longo, Valter D., Zeng, Yi, Manton, Kenneth G., Curtsinger, James W.

“…Old-age survival has increased substantially since 1950. Death rates decelerate with age for insects, worms, and yeast, as well as humans. This evidence of…”
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Insights on aging and exceptional longevity from longitudinal data: novel findings from the Framingham Heart Study by Yashin, Anatoli I, Akushevich, Igor V, Arbeev, Konstantin G, Akushevich, Lucy, Ukraintseva, Svetlana V, Kulminski, Aliaksandr

“…Age trajectories of physiological indices contain important information about aging-related changes in the human organism and therefore may help us understand…”
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Health and function of participants in the Long Life Family Study: A comparison with other cohorts by Newman, Anne B, Glynn, Nancy W, Taylor, Christopher A, Sebastiani, Paola, Perls, Thomas T, Mayeux, Richard, Christensen, Kaare, Zmuda, Joseph M, Barral, Sandra, Lee, Joseph H, Simonsick, Eleanor M, Walston, Jeremy D, Yashin, Anatoli I, Hadley, Evan

“…Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine…”
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Central and Peripheral Effects of Insulin/IGF-1 Signaling in Aging and Cancer: Antidiabetic Drugs as Geroprotectors and Anticarcinogens by ANISIMOV, VLADIMIR N., BERSTEIN, LEV M., POPOVICH, IRINA G., ZABEZHINSKI, MARK A., EGORMIN, PETER A., TYNDYK, MARGARITA L., ANIKIN, IVAN V., SEMENCHENKO, ANNA V., YASHIN, ANATOLI I.

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer…”
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The role of lipid‐related genes, aging‐related processes, and environment in healthspan by Kulminski, Alexander M., Culminskaya, Irina, Arbeev, Konstantin G., Ukraintseva, Svetlana V., Stallard, Eric, Arbeeva, Liubov, Yashin, Anatoli I.

“…Summary The inherent complexity of aging‐related traits can temper progress in unraveling the genetic origins of healthspan. We focus on two generations in the…”
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Dynamic Determinants of Longevity and Exceptional Health by Yashin, Anatoliy I., Arbeev, Konstantin G., Akushevich, Igor, Arbeeva, Liubov, Kravchenko, Julia, Il'yasova, Dora, Kulminski, Alexander M., Akushevich, Lucy, Culminskaya, Irina V., Wu, Deqing, Ukraintseva, Svetlana V.

“…It is well known from epidemiology that values of indices describing physiological state in a given age may influence human morbidity and mortality risks…”
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The Heritability of CHD Mortality in Danish Twins After Controlling for Smoking and BMI by Wienke, Andreas, Herskind, Anne M., Christensen, Kaare, Skytthe, Axel, Yashin, Anatoli I.

“…Cause-specific mortality data on Danish monozygotic and dizygotic twins are used to analyze heritability estimates of susceptibility to coronary heart disease…”
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Leukocyte Telomere Length Is Associated with Disability in Older U.S. Population by Risques, Rosa Ana, Arbeev, Konstantin G., Yashin, Anatoli I., Ukraintseva, Svetlana V., Martin, George M., Rabinovitch, Peter S., Oshima, Junko

“…OBJECTIVES: To determine whether mean leukocyte telomere length (LTL) serves as a biomarker of disability assessed according to activities of daily living…”
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Trade‐off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan by Kulminski, Alexander M., Culminskaya, Irina, Ukraintseva, Svetlana V., Arbeev, Konstantin G., Arbeeva, Liubov, Wu, Deqing, Akushevich, Igor, Land, Kenneth C., Yashin, Anatoli I.

“…Summary Progress in unraveling the genetic origins of healthy aging is tempered, in part, by a lack of replication of effects, which is often considered a…”
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Letter to the editor: Standardization of genetic association studies, pros and cons, reaffirmed by Kulminski, Alexander, Culminskaya, Irina, Yashin, Anatoli I

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Accelerated accumulation of health deficits as a characteristic of aging by Kulminski, Alexander, Ukraintseva, Svetlana V., Akushevich, Igor, Arbeev, Konstantin G., Land, Kenneth, Yashin, Anatoli I.

“…Cross-sectional analyses show that an index of aging-associated health/well-being deficits, called the “frailty index”, can characterize the aging process in…”
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Circulatory Diseases in the U.S. Elderly in the Linked National Long-Term Care Survey-Medicare Database: Population-Based Analysis of Incidence, Comorbidity, and Disability by Akushevich, Igor, Kravchenko, Julia, Ukraintseva, Svetlana, Arbeev, Konstantin, Yashin, Anatoli I.

“…Incidence rates of acute coronary heart disease (ACHD; including myocardial infarction and angina pectoris), stroke, and heart failure (HF) were studied for…”
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Stochastic model for analysis of longitudinal data on aging and mortality by Yashin, Anatoli I., Arbeev, Konstantin G., Akushevich, Igor, Kulminski, Aliaksandr, Akushevich, Lucy, Ukraintseva, Svetlana V.

“…Aging-related changes in a human organism follow dynamic regularities, which contribute to the observed age patterns of incidence and mortality curves. An…”
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Heritability Estimates of Endophenotypes of Long and Health Life: The Long Life Family Study by Matteini, Amy M., Fallin, M. Daniele, Kammerer, Candace M., Schupf, Nicole, Yashin, Anatoli I., Christensen, Kaare, Arbeev, Konstantin G., Barr, Graham, Mayeux, Richard, Newman, Anne B., Walston, Jeremy D.

“…Background. Identification of gene variants that contribute to exceptional survival may provide critical biologic information that informs optimal health…”
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