Search Results - "YAOHUANG KE"

A humanized anti-VEGF rabbit monoclonal antibody inhibits angiogenesis and blocks tumor growth in xenograft models by Yu, Yanlan, Lee, Pierre, Ke, Yaohuang, Zhang, Yongke, Yu, Qiu, Lee, Jonathan, Li, Mingzhen, Song, Jialiang, Chen, Jungang, Dai, Jihong, Do Couto, Fernando Jose Rebelo, An, Zhiqiang, Zhu, Weimin, Yu, Guo-Liang

“…Rabbit antibodies have been widely used in research and diagnostics due to their high antigen specificity and affinity. Though these properties are also highly…”
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Reassessment of Id1 protein expression in human mammary, prostate, and bladder cancers using a monospecific rabbit monoclonal anti-Id1 antibody by PERK, Jonathan, GIL-BAZO, Ignacio, GERALD, William L, BROGI, Edi, BENEZRA, Robert, CHIN, Yvette, DE CANDIA, Paola, CHEN, John J. S, YUNTAO ZHAO, CHAO, Shirley, CHEONG, Wai, YAOHUANG KE, AL-AHMADIE, Hikmat

“…Id proteins are a class of dominant-negative antagonists of helix-loop-helix transcription factors and have been shown to control differentiation of a variety…”
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An mRNA Loop/Bulge in the Ferritin Iron-responsive Element Forms in Vivo and Was Detected by Radical Probing with Cu-1,10-phenantholine and Iron Regulatory Protein Footprinting by Ke, Yaohuang, Theil, Elizabeth C.

“…Messenger RNA (mRNA) regulatory elements often form helices specifically distorted by loops or bulges, which control protein synthesis rates in vitro. Do such…”
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Measuring affinity constants of 1450 monoclonal antibodies to peptide targets with a microarray-based label-free assay platform by Landry, J.P., Ke, Yaohuang, Yu, Guo-Liang, Zhu, X.D.

“…Monoclonal antibodies (mAbs) are major reagents for research and clinical diagnosis. For their inherently high specificities to intended antigen targets and…”
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Loops and Bulge/Loops in Iron-responsive Element Isoforms Influence Iron Regulatory Protein Binding by Ke, Yaohuang, Wu, Jingyang, Leibold, Elizabeth A., Walden, William E., Theil, Elizabeth C.

“…A family of noncoding mRNA sequences, iron-responsive elements (IREs), coordinately regulate several mRNAs through binding a family of mRNA-specific proteins,…”
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Discovering small molecule ligands of vascular endothelial growth factor that block VEGF-KDR binding using label-free microarray-based assays by Landry, James P, Fei, Yiyan, Zhu, Xiangdong, Ke, Yaohuang, Yu, Guoliang, Lee, Pierre

“…We present here a label-free microarray-based assay platform that we used to identify inhibitors of vascular endothelial growth factor (VEGF)-kinase-insertion…”
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Measuring Affinity Constants of 1,450 Monoclonal Antibodies to Peptide Targets with a Microarray-based Label-Free Assay Platform by Landry, J. P., Ke, Yaohuang, Yu, Guo-Liang, Zhu, X. D.

“…Monoclonal antibodies (mAbs) are major reagents for research and clinical diagnosis. For their inherently high specificities to intended antigen targets and…”
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Development of humanized rabbit monoclonal antibodies against vascular endothelial growth factor receptor 2 with potential antitumor effects by Yu, Yanlan, Lee, Pierre, Ke, Yaohuang, Zhang, Yongke, Chen, Jungang, Dai, Jihong, Li, Mingzhen, Zhu, Weimin, Yu, Guo-Liang

“…•Our study suggests that RabMAbs are highly relevant for therapeutic applications.•We generated a panel of 30 neutralization anti-KDR rabbit monoclonal…”
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Discovery of VEGF-KDR Binding Inhibitors by Screening Small-Molecule Microarrays with Label-Free Ellipsometric Scanners by Landry, James P., Fei, Yiyan, Zhu, Xiangdong, Ke, Yaohuang, Li, Y. Peter, Yu, Guoliang

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Overexpression of the transcription factor foxo4 is associated with rapid glucose clearance by Wang, Biao, Zhu, Jun, Mounzih, Khalid, Chehab, Eric F., Ke, Yaohuang, Chehab, Farid F.

“…Leptin treatment ameliorates lipoatrophic diabetes in animal models and humans. Transgenic mice overexpressing leptin (LepTg) are lipoatrophic but not diabetic…”
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Abstract 2451: A novel humanized anti-CD40 RabMAb exhibits potent efficacy in preclinical models by Zhang, Yongke, Dai, Jihong, Ke, Yaohuang, Li, Wenjun, Yu, Qiu, Li, Mingzhen, Feng, Lifeng, An, Zhiqiang, Yu, Guo-Liang, Zhu, Weimin

“…Abstract Monoclonal antibodies directed against B cell antigens have shown clinical benefits to hematologic malignancies. CD40 is a member of the TNFR…”
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Loops and bulge/loops in iron-responsive element isoforms influence iron regulatory protein binding. Fine-tuning of mRNA regulation? by Ke, Y, Wu, J, Leibold, E A, Walden, W E, Theil, E C

“…A family of noncoding mRNA sequences, iron-responsive elements (IREs), coordinately regulate several mRNAs through binding a family of mRNA-specific proteins,…”
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Internal Loop/Bulge and Hairpin Loop of the Iron-Responsive Element of Ferritin mRNA Contribute to Maximal Iron Regulatory Protein 2 Binding and Translational Regulation in the Iso-iron-responsive Element/Iso-iron Regulatory Protein Family by Ke, Yaohuang, Sierzputowska-Gracz, Hanna, Gdaniec, Zofia, Theil, Elizabeth C

“…Iron-responsive elements (IREs), a natural group of mRNA-specific sequences, bind iron regulatory proteins (IRPs) differentially and fold into hairpins [with a…”
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Overexpression of leptin in transgenic mice leads to decreased basal lipolysis, PKA activity, and perilipin levels by Ke, Yaohuang, Qiu, Jun, Ogus, Scott, Shen, Wen-Jun, Kraemer, Fredric B, Chehab, Farid F

“…Transgenic mice overexpressing leptin (LepTg) exhibit substantial reductions in adipose mass. Since the binding of leptin to its receptor activates the…”
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The influence of mRNA internal loop/bulges and C-bulges on IRE-dependent regulation of protein synthesis by Ke, Yaohuang

“…Interactions of iron responsive elements (IREs) in the noncoding regions of mRNAs with iron regulatory proteins (IRPs) are responsive to iron concentrations in…”
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