Search Results - "YANG, Teddy"

Neutralization of PD-L2 is Essential for Overcoming Immune Checkpoint Blockade Resistance in Ovarian Cancer by Miao, Yu Rebecca, Thakkar, Kaushik N, Qian, Jin, Kariolis, Mihalis S, Huang, Wei, Nandagopal, Saravanan, Yang, Teddy Tat Chi, Diep, Anh N, Cherf, Gerald Maxwell, Xu, Yu, Moon, Eui Jung, Xiao, Yiren, Alemany, Haizea, Li, Tiane, Yu, Wenhua, Wei, Bo, Rankin, Erinn B, Giaccia, Amato J

“…Ovarian cancer represents a major clinical hurdle for immune checkpoint blockade (ICB), with reported low patient response rates. We found that the immune…”
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Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos by Gonzalez-Sandoval, Adriana, Towbin, Benjamin D., Kalck, Veronique, Cabianca, Daphne S., Gaidatzis, Dimos, Hauer, Michael H., Geng, Liqing, Wang, Li, Yang, Teddy, Wang, Xinghao, Zhao, Kehao, Gasser, Susan M.

“…Interphase chromatin is organized in distinct nuclear sub-compartments, reflecting its degree of compaction and transcriptional status. In Caenorhabditis…”
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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation by Qi, Wei, Chan, HoMan, Tenga, Lin, Li, Ling, Chuai, Shannon, Zhang, Ruipeng, Zeng, Jue, Li, Min, Fan, Hong, Lin, Ying, Gu, Justin, Ardayfio, Ophelia, Zhang, Ji-Hu, Yan, Xiaoxia, Fang, Jialuo, Mi, Yuan, Zhang, Man, Zhou, Tao, Feng, Grace, Chen, Zijun, Li, Guobin, Yang, Teddy, Zhao, Kehao, Liu, Xianghui, Yu, Zhengtian, Lu, Chris X., Atadja, Peter, Li, En

“…Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component of the Polycomb repressive complex 2 (PRC2), which represses gene expression by…”
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Regulation of Transcription Factor NFAT by ADP-Ribosylation by Olabisi, Opeyemi A., Soto-Nieves, Noemi, Nieves, Edward, Yang, Teddy T. C., Yang, XiaoYong, Yu, Raymond Y. L., Suk, Hee Yun, Macian, Fernando, Chow, Chi-Wing

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Development and characterization of a novel human CD137 agonistic antibody with anti‐tumor activity and a good safety profile in non‐human primates by Gao, Yingying, Yang, Teddy, Liu, Hu, Song, Ningning, Dai, Chaohui, Ding, Yu

“…CD137 (4‐1BB, TNFRSF9), an inducible T‐cell costimulatory receptor, is expressed on activated T cells, activated NK cells, Treg cells, and several innate…”
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Development of a fully human anti‐GITR antibody with potent antitumor activity using H2L2 mice by Tong, Qiuli, Liu, Hu, Qi, Qianqian, Dai, Chaohui, Yang, Teddy, Qian, Feng

“…Glucocorticoid‐induced TNF receptor‐related (GITR) can act as a co‐stimulatory receptor, representing a potential target for safely enhancing immunotherapy…”
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High-throughput optofluidic screening of single B cells identifies novel cross-reactive antibodies as inhibitors of uPAR with antibody-dependent effector functions by Lourenço, André Luiz, Chuo, Shih-Wei, Bohn, Markus F, Hann, Byron, Khan, Shireen, Yevalekar, Neha, Patel, Nitin, Yang, Teddy, Xu, Lina, Lv, Dandan, Drakas, Robert, Lively, Sarah, Craik, Charles S

“…The urokinase-type plasminogen activator receptor (uPAR) is an essential regulator for cell signaling in tumor cell proliferation, adhesion, and metastasis…”
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NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma by ZHENG HUANG, HAIPING WU, GU, Justin, MAN ZHANG, YANG, Teddy, KEHAO ZHAO, YANYAN YU, JINGQUAN DAI, WEI YI, SHAOLIAN ZHOU, QIAN LI, JING WU, SHANNON CHUAI, JUN LIU, XU WU, CHAN, Homan, LU, Chris, ATADJA, Peter, EN LI, YAN WANG, MIN HU, FIONA XU, FENG YAN, ENGLUND, Nathan, ZHAOFU WANG, HAILONG ZHANG, MING FANG, YOUZHEN WANG

“…Histone lysine methyltransferase NSD2 (WHSC1/MMSET) is overexpressed frequently in multiple myeloma due to the t(4;14) translocation associated with 15% to 20%…”
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Preclinical efficacy and toxicity studies of a highly specific chimeric anti‐CD47 antibody by Xu, Zhiqiang, Gao, Jing, Yao, Jingyun, Yang, Teddy, Wang, Dongxu, Dai, Chaohui, Ding, Yu

“…Cluster of differentiation 47 (CD47) is a widely expressed self‐protection transmembrane protein that functions as a critical negative regulator to induce…”
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Integration of Protein Kinases mTOR and Extracellular Signal-Regulated Kinase 5 in Regulating Nucleocytoplasmic Localization of NFATc4 by Yang, Teddy T. C., Yu, Raymond Y. L., Agadir, Anissa, Gao, Guo-Jian, Campos-Gonzalez, Roberto, Tournier, Cathy, Chow, Chi-Wing

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Phosphorylation of NFATc4 by p38 Mitogen-Activated Protein Kinases by Yang, Teddy T. C., Xiong, Qiufang, Enslen, Hervé, Davis, Roger J., Chow, Chi-Wing

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Role of Transcription Factor NFAT in Glucose and Insulin Homeostasis by Yang, Teddy T. C., Suk, Hee Yun, Yang, XiaoYong, Olabisi, Opeyemi, Yu, Raymond Y. L., Durand, Jorge, Jelicks, Linda A., Kim, Ja-Young, Scherer, Philipp E., Wang, Yuhua, Feng, Yun, Rossetti, Luciano, Graef, Isabella A., Crabtree, Gerald R., Chow, Chi-Wing

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Ablation of Calcineurin Aβ Reveals Hyperlipidemia and Signaling Cross-talks with Phosphodiesterases by Suk, Hee Yun, Zhou, Chen, Yang, Teddy T.C., Zhu, Hong, Yu, Raymond Y.L., Olabisi, Opeyemi, Yang, XiaoYong, Brancho, Deborah, Kim, Ja-Young, Scherer, Philipp E., Frank, Philippe G., Lisanti, Michael P., Calvert, John W., Lefer, David J., Molkentin, Jeffery D., Ghigo, Alessandra, Hirsch, Emilio, Jin, Jianping, Chow, Chi-Wing

“…Insulin resistance, hyperlipidemia, and cardiovascular complications are common dysregulations of metabolic syndrome. Transplant patients treated with…”
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α-Tocopherol Decreases Superoxide Anion Release in Human Monocytes Under Hyperglycemic Conditions Via Inhibition of Protein Kinase C-α by SENTHIL KUMAR VENUGOPAL, DEVARAJ, Sridevi, YANG, Teddy, JIALAL, Ishwarlal

“…α-Tocopherol Decreases Superoxide Anion Release in Human Monocytes Under Hyperglycemic Conditions Via Inhibition of Protein Kinase C-α Senthil Kumar Venugopal…”
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CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma by Burington, Bart, Yue, Peng, Shi, Xiaoyan, Advani, Ranjana, Lau, Jeffrey T, Tan, Jenille, Stinson, Susanna, Stinson, Jeremy, Januario, Thomas, de Vos, Sven, Ansell, Stephen, Forero-Torres, Andres, Fedorowicz, Grazyna, Yang, Teddy T C, Elkins, Kristi, Du, Changchun, Mohan, Sankar, Yu, Nancy, Modrusan, Zora, Seshagiri, Somasekar, Yu, Shang-Fan, Pandita, Ajay, Koeppen, Hartmut, French, Dorothy, Polson, Andrew G, Offringa, Rienk, Whiting, Nancy, Ebens, Allen, Dornan, David

“…The primary function of B cells, critical components of the adaptive immune response, is to produce antibodies against foreign antigens, as well as to perform…”
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Recruitment of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Signaling Pathway to the NFATc4 Transcription Activation Complex by Yang, Teddy T. C., Xiong, Qiufang, Graef, Isabella A., Crabtree, Gerald R., Chow, Chi-Wing

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Evolutionarily Conserved Role of Calcineurin in Phosphodegron-Dependent Degradation of Phosphodiesterase 4D by Zhu, Hong, Suk, Hee Yun, Yu, Raymond Y. L., Brancho, Deborah, Olabisi, Opeyemi, Yang, Teddy T. C., Yang, XiaoYong, Zhang, Jialin, Moussaif, Mustapha, Durand, Jorge L., Jelicks, Linda A., Kim, Ja-Young, Scherer, Philipp E., Frank, Philippe G., Lisanti, Michael P., Calvert, John W., Duranski, Mark R., Lefer, David J., Huston, Elaine, Baillie, George S., Houslay, Miles D., Molkentin, Jeffrey D., Jin, Jianping, Chow, Chi-Wing

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Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition by Yang, Xiao Yong, Yang, Teddy T.C., Schubert, William, Factor, Stephen M., Chow, Chi-Wing

“…Thin spongy myocardium is critical at early embryonic stage [before embryonic day (E) 13.5 in mice] to allow diffusion of oxygen and nutrients to the…”
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Developing high-affinity decoy receptors to treat multiple myeloma and diffuse large B cell lymphoma by Miao, Yu Rebecca, Thakkar, Kaushik, Cenik, Can, Jiang, Dadi, Mizuno, Kazue, Jia, Chenjun, Li, Caiyun Grace, Zhao, Hongjuan, Diep, Anh, Xu, Yu, Zhang, Xin Eric, Yang, Teddy Tat Chi, Liedtke, Michaela, Abidi, Parveen, Leung, Wing-sze, Koong, Albert C., Giaccia, Amato J.

“…Disease relapse and treatment-induced immunotoxicity pose significant clinical challenges for patients with hematological cancers. Here, we reveal distinctive…”
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Characterization of 405B8H3(D‐E), a newly engineered high affinity chimeric LAG‐3 antibody with potent antitumor activity by Lan, Xiaoxuan, Yang, Teddy Tat Chi, Wang, Yinghui, Qu, Baoyuan, Rong, Shaofeng, Song, Ningning

“…Lymphocyte activation gene‐3 (LAG‐3) is a type I transmembrane protein with structural similarities to CD4. Overexpression of LAG‐3 enables cancer cells to…”
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