Search Results - "YANG, JAY"

Virtual resolutions of monomial ideals on toric varieties by Yang, Jay

“…We use cellular resolutions of monomial ideals to prove an analog of Hilbert's syzygy theorem for virtual resolutions of monomial ideals on smooth toric…”
Get full text

Research trends of post disaster reconstruction: The past and the future by Yi, Honglei, Yang, Jay

“…Natural disasters can have adverse effect on human lives. To raise the awareness of research and better combat future events, it is important to identify…”
Get full text

bioTCIs: Middle-to-Macro Biomolecular Targeted Covalent Inhibitors Possessing Both Semi-Permanent Drug Action and Stringent Target Specificity as Potential Antibody Replacements by Yang, Jay, Tabuchi, Yudai, Katsuki, Riku, Taki, Masumi

“…Monoclonal antibody therapies targeting immuno-modulatory targets such as checkpoint proteins, chemokines, and cytokines have made significant impact in…”
Get full text

Relative Nuclease Resistance of a DNA Aptamer Covalently Conjugated to a Target Protein by Tabuchi, Yudai, Yang, Jay, Taki, Masumi

“…A major obstacle to the therapeutic application of an aptamer is its susceptibility to nuclease digestion. Here, we confirmed the acquisition of relative…”
Get full text

Long Non-coding RNAs: an Emerging Powerhouse in the Battle between Life and Death of Tumor Cells by Xiong, Xing-dong, Ren, Xingcong, Cai, Meng-yun, Yang, Jay W, Liu, Xinguang, Yang, Jin-Ming

“…Abstract Long non-coding RNAs (lncRNAs) represent a class of non-protein coding transcripts longer than 200 nucleotides that have aptitude for regulating gene…”
Get full text

Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms by Steensma, David P., Wermke, Martin, Klimek, Virginia M., Greenberg, Peter L., Font, Patricia, Komrokji, Rami S., Yang, Jay, Brunner, Andrew M., Carraway, Hetty E., Ades, Lionel, Al-Kali, Aref, Alonso-Dominguez, Juan M., Alfonso-Piérola, Ana, Coombs, Catherine C., Deeg, H. Joachim, Flinn, Ian, Foran, James M., Garcia-Manero, Guillermo, Maris, Michael B., McMasters, Malgorzata, Micol, Jean-Baptiste, De Oteyza, Jaime Perez, Thol, Felicitas, Wang, Eunice S., Watts, Justin M., Taylor, Justin, Stone, Richard, Gourineni, Vikram, Marino, Alyssa J., Yao, Huilan, Destenaves, Benoit, Yuan, Xiaobin, Yu, Kun, Dar, Sara, Ohanjanian, Lernik, Kuida, Keisuke, Xiao, Jianjun, Scholz, Catherine, Gualberto, Antonio, Platzbecker, Uwe

“…We conducted a phase I clinical trial of H3B-8800, an oral small molecule that binds Splicing Factor 3B1 (SF3B1), in patients with MDS, CMML, or AML. Among 84…”
Get full text

Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser by Kupitz, Christopher, Basu, Shibom, Grotjohann, Ingo, Fromme, Raimund, Zatsepin, Nadia A., Rendek, Kimberly N., Hunter, Mark S., Shoeman, Robert L., White, Thomas A., Wang, Dingjie, James, Daniel, Yang, Jay-How, Cobb, Danielle E., Reeder, Brenda, Sierra, Raymond G., Liu, Haiguang, Barty, Anton, Aquila, Andrew L., Deponte, Daniel, Kirian, Richard A., Bari, Sadia, Bergkamp, Jesse J., Beyerlein, Kenneth R., Bogan, Michael J., Caleman, Carl, Chao, Tzu-Chiao, Conrad, Chelsie E., Davis, Katherine M., Fleckenstein, Holger, Galli, Lorenzo, Hau-Riege, Stefan P., Kassemeyer, Stephan, Laksmono, Hartawan, Liang, Mengning, Lomb, Lukas, Marchesini, Stefano, Martin, Andrew V., Messerschmidt, Marc, Milathianaki, Despina, Nass, Karol, Ros, Alexandra, Roy-Chowdhury, Shatabdi, Schmidt, Kevin, Seibert, Marvin, Steinbrener, Jan, Stellato, Francesco, Yan, Lifen, Yoon, Chunhong, Moore, Thomas A., Moore, Ana L., Pushkar, Yulia, Williams, Garth J., Boutet, Sébastien, Doak, R. Bruce, Weierstall, Uwe, Frank, Matthias, Chapman, Henry N., Spence, John C. H., Fromme, Petra

“…Femtosecond X-ray pulses were used to obtain diffraction data on photosystem II, revealing conformational changes as the complex transitions from the dark S 1…”
Get full text

Structural and biophysical properties of FopA, a major outer membrane protein of Francisella tularensis by Nagaratnam, Nirupa, Martin-Garcia, Jose M, Yang, Jay-How, Goode, Matthew R, Ketawala, Gihan, Craciunescu, Felicia M, Zook, James D, Sonowal, Manashi, Williams, Dewight, Grant, Thomas D, Fromme, Raimund, Hansen, Debra T, Fromme, Petra

“…Francisella tularensis is an extremely infectious pathogen and a category A bioterrorism agent. It causes the highly contagious zoonosis, Tularemia. Currently,…”
Get full text

APEX2- tagging of Sigma 1-receptor indicates subcellular protein topology with cytosolic N-terminus and ER luminal C-terminus by Mavylutov, Timur, Chen, Xi, Guo, Lianwang, Yang, Jay

Get full text

Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy by Carter, Jenna L., Hege, Katie, Yang, Jay, Kalpage, Hasini A., Su, Yongwei, Edwards, Holly, Hüttemann, Maik, Taub, Jeffrey W., Ge, Yubin

“…Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the second most common form of acute leukemia in children. Despite this,…”
Get full text

Structural basis of redox modulation on chloroplast ATP synthase by Yang, Jay-How, Williams, Dewight, Kandiah, Eaazhisai, Fromme, Petra, Chiu, Po-Lin

“…In higher plants, chloroplast ATP synthase has a unique redox switch on its γ subunit that modulates enzyme activity to limit ATP hydrolysis at night. To…”
Get full text

Antileukemic activity and mechanism of action of the novel PI3K and histone deacetylase dual inhibitor CUDC-907 in acute myeloid leukemia by Li, Xinyu, Su, Yongwei, Madlambayan, Gerard, Edwards, Holly, Polin, Lisa, Kushner, Juiwanna, Dzinic, Sijana H, White, Kathryn, Ma, Jun, Knight, Tristan, Wang, Guan, Wang, Yue, Yang, Jay, Taub, Jeffrey W, Lin, Hai, Ge, Yubin

“…Induction therapy for patients with acute myeloid leukemia (AML) has remained largely unchanged for over 40 years, while overall survival rates remain…”
Get full text

The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands by Mishra, Ashish K, Mavlyutov, Timur, Singh, Deo R, Biener, Gabriel, Yang, Jay, Oliver, Julie A, Ruoho, Arnold, Raicu, Valerică

“…The sigma-1 receptor (S1R) is a 223-amino-acid membrane protein that resides in the endoplasmic reticulum and the plasma membrane of some mammalian cells. The…”
Get more information

The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia by Li, Xinyu, Su, Yongwei, Hege, Katie, Madlambayan, Gerard, Edwards, Holly, Knight, Tristan, Polin, Lisa, Kushner, Juiwanna, Dzinic, Sijana H, White, Kathryn, Yang, Jay, Miller, Regan, Wang, Guan, Zhao, Lijing, Wang, Yue, Lin, Hai, Taub, Jeffrey W, Ge, Yubin

“…Venetoclax is a promising agent in the treatment of acute myeloid leukemia, though its antileukemic activity is limited to combination therapies. Mcl-1…”
Get full text

Macromolecular diffractive imaging using imperfect crystals by Ayyer, Kartik, Yefanov, Oleksandr M., Oberthür, Dominik, Roy-Chowdhury, Shatabdi, Galli, Lorenzo, Mariani, Valerio, Basu, Shibom, Coe, Jesse, Conrad, Chelsie E., Fromme, Raimund, Schaffer, Alexander, Dörner, Katerina, James, Daniel, Kupitz, Christopher, Metz, Markus, Nelson, Garrett, Xavier, Paulraj Lourdu, Beyerlein, Kenneth R., Schmidt, Marius, Sarrou, Iosifina, Spence, John C. H., Weierstall, Uwe, White, Thomas A., Yang, Jay-How, Zhao, Yun, Liang, Mengning, Aquila, Andrew, Hunter, Mark S., Robinson, Joseph S., Koglin, Jason E., Boutet, Sébastien, Fromme, Petra, Barty, Anton, Chapman, Henry N.

“…Crystal lattice disorder, which gives rise to a continuous diffraction pattern, is exploited to determine the structure of the integral membrane protein…”
Get full text

Modular droplet injector for sample conservation providing new structural insight for the conformational heterogeneity in the disease-associated NQO1 enzyme by Doppler, Diandra, Sonker, Mukul, Egatz-Gomez, Ana, Grieco, Alice, Zaare, Sahba, Jernigan, Rebecca, Meza-Aguilar, Jose Domingo, Rabbani, Mohammad T, Manna, Abhik, Alvarez, Roberto C, Karpos, Konstantinos, Cruz Villarreal, Jorvani, Nelson, Garrett, Yang, Jay-How, Carrion, Jackson, Morin, Katherine, Ketawala, Gihan K, Pey, Angel L, Ruiz-Fresneda, Miguel Angel, Pacheco-Garcia, Juan Luis, Hermoso, Juan A, Nazari, Reza, Sierra, Raymond, Hunter, Mark S, Batyuk, Alexander, Kupitz, Christopher J, Sublett, Robert E, Lisova, Stella, Mariani, Valerio, Boutet, Sébastien, Fromme, Raimund, Grant, Thomas D, Botha, Sabine, Fromme, Petra, Kirian, Richard A, Martin-Garcia, Jose Manuel, Ros, Alexandra

“…Droplet injection strategies are a promising tool to reduce the large amount of sample consumed in serial femtosecond crystallography (SFX) measurements at…”
Get more information

Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo by Das, Archita, Sudhahar, Varadarajan, Chen, Gin-Fu, Kim, Ha Won, Youn, Seock-Won, Finney, Lydia, Vogt, Stefan, Yang, Jay, Kweon, Junghun, Surenkhuu, Bayasgalan, Ushio-Fukai, Masuko, Fukai, Tohru

“…Copper (Cu), an essential nutrient, promotes wound healing, however, target of Cu action and underlying mechanisms remain elusive. Cu chaperone Antioxidant-1…”
Get full text

Oxide-Relief and Zn-Diffusion 850-nm Vertical-Cavity Surface-Emitting Lasers With Extremely Low Energy-to-Data-Rate Ratios for 40 Gbit/s Operations by Jin-Wei Shi, Jhih-Cheng Yan, Jhih-Min Wun, Chen, J., Ying-Jay Yang

“…We demonstrate novel structures of a vertical-cavity surface-emitting laser (VCSEL) for high-speed (~40 Gbit/s) operation with ultralow power consumption…”
Get full text

Verification of very strong coupling in a semiconductor optical microcavity by Yang, Ming-Jay, Kim, Na Young, Yamamoto, Yoshihisa, Na, Neil

“…We study the very strong coupling effect in a semiconductor optical microcavity in which the exciton radius is dramatically modified due to the presence of…”
Get full text

Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography by Pandey, Suraj, Calvey, George, Katz, Andrea M, Malla, Tek Narsingh, Koua, Faisal H M, Martin-Garcia, Jose M, Poudyal, Ishwor, Yang, Jay-How, Vakili, Mohammad, Yefanov, Oleksandr, Zielinski, Kara A, Bajt, Sasa, Awel, Salah, Doerner, Katarina, Frank, Matthias, Gelisio, Luca, Jernigan, Rebecca, Kirkwood, Henry, Kloos, Marco, Koliyadu, Jayanath, Mariani, Valerio, Miller, Mitchell D, Mills, Grant, Nelson, Garrett, Olmos, Jr, Jose L, Sadri, Alireza, Sato, Tokushi, Tolstikova, Alexandra, Xu, Weijun, Ourmazd, Abbas, Spence, John C H, Schwander, Peter, Barty, Anton, Chapman, Henry N, Fromme, Petra, Mancuso, Adrian P, Phillips, Jr, George N, Bean, Richard, Pollack, Lois, Schmidt, Marius

“…Here, we illustrate what happens inside the catalytic cleft of an enzyme when substrate or ligand binds on single-millisecond timescales. The initial phase of…”
Get full text