Search Results - "YANDELL, D. W"

p53 Gene Mutations and Protein Accumulation in Human Ovarian Cancer by Kupryjanczyk, Jolanta, Thor, Ann D., Beauchamp, Roberta, Merritt, Victor, Edgerton, Susan M., Bell, Debra A., Yandell, David W.

“…Mutations of the p53 gene on chromosome 17p are a common genetic change in the malignant progression of many cancers. We have analyzed 38 malignant tumors of…”
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Frequent Inactivation of the Retinoblastoma Anti-Oncogene is Restricted to a Subset of Human Tumor Cells by Horowitz, Jonathan M., Park, Sang-Ho, Bogenmann, Emil, Cheng, Jeng-Chung, Yandell, David W., Kaye, Frederick J., Minna, John D., Dryja, Thaddeus P., Weinberg, Robert A.

“…We have used polyclonal anti-synthetic peptide serum to study the role of retinoblastoma gene (RB) inactivation in a variety of human tumor cell lines. Our…”
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Chromosome 17p Deletions and p53 Gene Mutations Associated with the Formation of Malignant Neurofibrosarcomas in von Recklinghausen Neurofibromatosis by Menon, A. G., Anderson, K. M., Riccardi, V. M., Chung, R. Y., Whaley, J. M., Yandell, D. W., Farmer, G. E., Freiman, R. N., Lee, J. K., Li, F. P., Barker, D. F., Ledbetter, D. H., Kleider, A., Martuza, R. L., Gusella, J. F., Seizinger, B. R.

“…von Recklinghausen neurofibromatosis (NF1) is a common hereditary disorder characterized by neural crest-derived tumors, particularly benign neurofibromas…”
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Detection of DNA sequence polymorphisms by enzymatic amplification and direct genomic sequencing by YANDELL, D. W, DRYJA, T. P

“…The discovery of RFLPs and their utilization as genetic markers has revolutionized research in human molecular genetics. However, only a fraction of the DNA…”
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Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene by SAKAI, T, TOGUCHIDA, J, OHTANI, N, YANDELL, D. W, RAPAPORT, J. M, DRYJA, T. P

“…Inactivation of the retinoblastoma gene appears to have a fundamental role in the genesis of retinoblastoma, osteosarcoma, and other malignant tumors. The gene…”
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A point mutation of the rhodopsin gene in one form of retinitis pigmentosa by Dryja, Thaddeus P, McGee, Terri L, Reichel, Elias, Hahn, Lauri B, Cowley, Glenn S, Yandell, David W, Sandberg, Michael A, Berson, Eliot L

“…The gene for autosomal dominant retinitis pigmentosa in a large pedigree of Irish origin has recently been found to be linked to an anonymous polymorphic…”
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The retinoblastoma gene is involved in malignant progression of astrocytomas by Henson, J W, Schnitker, B L, Correa, K M, von Deimling, A, Fassbender, F, Xu, H J, Benedict, W F, Yandell, D W, Louis, D N

“…Loss of chromosome 13q occurs in up to 50% of human astrocytomas, suggesting the presence of an astrocytoma tumor suppressor gene on that chromosome. To…”
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Prevalence and Spectrum of Germline Mutations of the p53 Gene among Patients with Sarcoma by Toguchida, Junya, Yamaguchi, Toshikazu, Dayton, Siri H, Beaughamp, Roberta L, Herrera, Guillermo E, Ishizaki, Kanji, Yamamuro, Takao, Meyers, Paul A, Little, John B, Sasaki, Masao S, Weichselbaum, Ralph R, Yandell, David W

“…HEREDITARY mutations of tumor-suppressor genes have been correlated with a genetic predisposition to cancer, and several such genes have been linked to…”
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Role of mutational heterogeneity of the p53 gene in hepatocellular carcinoma by NISHIDA, N, FUKUDA, Y, KOKURYU, H, TOGUCHIDA, J, YANDELL, D. W, IKENEGA, M, IMURA, H, ISHIZAKI, K

“…The mutational spectrum of the p53 gene was analyzed in 53 hepatocellular carcinomas. Somatic mutations of the p53 gene were detected in 17 cases (32%). Among…”
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Loss of 17p, mutation of the p53 gene and overexpression of p53 protein in esophageal squamous cell carcinomas by WAGATA, T, SHIBAGAKI, I, IMAMURA, M, SHIMADA, Y, TOGUCHIDA, J, YANDELL, D. W, IKENAGA, M, TOBE, T, ISHIZAKI, K

“…We analyzed mutations of the p53 gene by single-strand conformation polymorphism analysis of polymerase chain reaction products and direct sequencing through…”
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Point Mutational Inactivation of the Retinoblastoma Antioncogene by Horowitz, Jonathan M., Yandell, David W., Park, Sang-Ho, Canning, Susan, Whyte, Peter, Buchkovich, Karen, Harlow, Ed, Weinberg, Robert A., Dryja, Thaddeus P.

“…The retinoblastoma (Rb) antioncogene encodes a nuclear phosphoprotein, p105-Rb, that forms protein complexes with the adenovirus E1A and SV40 large T…”
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Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas by ISHIKAWA, J, HONG-JI XU, YANDELL, D. W, MAEDA, S, KAMIDONO, S, BENEDICT, W. F, TAKAHASHI, R

“…The retinoblastoma (RB) gene was the first tumor suppressor gene isolated and its inactivation is associated with the pathogenesis of several types of human…”
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Accumulation of wild type p53 protein in human astrocytomas by RUBIO, M.-P, VON DEIMLING, A, YANDELL, D. W, WIESTLER, O. D, GUSELLA, J. F, LOUIS, D. N

“…We have previously described 10 astrocytomas with accumulation of p53 protein but no mutations in p53 exons 5-8, and we have suggested that they might…”
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Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling by Yandell, D W, Campbell, T A, Dayton, S H, Petersen, R, Walton, D, Little, J B, McConkie-Rosell, A, Buckley, E G, Dryja, T P

“…Mutations of the retinoblastoma gene, most of which cannot be detected by conventional Southern blotting, are known to cause both the nonhereditary and…”
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Frequent p53 gene mutations in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome 17p by NAKAI, H, MISAWA, S, TOGUCHIDA, J, YANDELL, D. W, ISHIZAKI, K

“…We investigated chromosome alterations and mutations of the p53 gene in 118 samples from 92 patients with chronic myelogenous leukemia in various clinical…”
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Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma by Kato, Mitsuo V., Shimizu, Takashi, Ishizaki, Kanji, Kaneko, Akihiro, Yandell, David W., Toguchida, Junya, Sasaki, Masao S.

“…Loss of heterozygosity (LOH) on chromosome 17 and mutations of the p53 gene were examined in 25 retinoblastomas (RB), consisting of three familial tumors, nine…”
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Structure and partial genomic sequence of the human retinoblastoma susceptibility gene by McGee, T L, Yandell, D W, Dryja, T P

“…This report describes the genomic organization of the human retinoblastoma susceptibility locus. This gene spans approximately 200 kb of DNA within human…”
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p53 gene analysis of ovarian borderline tumors and stage I carcinomas by Kupryjanczyk, Jolanta, Bell, Debra A, Dimeo, Dino, Beauchamp, Roberta, Thor, Ann D, Yandell, David W

“…Mutations of the p53 gene are common in human ovarian carcinomas; however, their role in the early development of ovarian cancer is unclear. Twelve ovarian…”
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p53 expression in ovarian borderline tumors and stage I carcinomas by Kupryjańczyk, J, Bell, D A, Yandell, D W, Scully, R E, Thor, A D

“…Seventy-nine ovarian serous and mucinous borderline tumors, 36 stage I carcinomas and 39 stage II-IV carcinomas were studied for p53 protein accumulation with…”
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Parental origin of mutations of the retinoblastoma gene by Dryja, Thaddeus P, Mukai, Shizuo, Petersen, Robert, Rapaport, Joyce M, Walton, David, Yandell, David W

“…Retinoblastoma and osteosarcoma arise from cells that have lost both functional copies of the retinoblastoma gene. Using the cloned retinoblastoma gene and…”
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