Search Results - "YANAGIHARA, Kazuyoshi"

Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts by Naito, Yutaka, Yamamoto, Yusuke, Sakamoto, Naoya, Shimomura, Iwao, Kogure, Akiko, Kumazaki, Minami, Yokoi, Akira, Yashiro, Masakazu, Kiyono, Tohru, Yanagihara, Kazuyoshi, Takahashi, Ryou-u, Hirakawa, Kosei, Yasui, Wataru, Ochiya, Takahiro

“…Cancer-associated fibroblasts (CAFs), one of the major components of a tumour microenvironment, comprise heterogeneous populations involved in tumour…”
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Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment by Umakoshi, Michinobu, Takahashi, So, Itoh, Go, Kuriyama, Sei, Sasaki, Yuto, Yanagihara, Kazuyoshi, Yashiro, Masakazu, Maeda, Daichi, Goto, Akiteru, Tanaka, Masamitsu

“…Tumor-derived extracellular vesicles (TEVs) secreted into the blood create a pre-metastatic niche in distant organs; however, it is unclear how TEVs are…”
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MicroRNA‐148a is downregulated in gastric cancer, targets MMP7, and indicates tumor invasiveness and poor prognosis by Sakamoto, Naoya, Naito, Yutaka, Oue, Naohide, Sentani, Kazuhiro, Uraoka, Naohiro, Zarni Oo, Htoo, Yanagihara, Kazuyoshi, Aoyagi, Kazuhiko, Sasaki, Hiroki, Yasui, Wataru

“…Gastric cancer (GC) develops through deregulation of gene expression and accumulation of epigenetic abnormalities, leading to tumor cell acquisition of…”
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Expression of asporin reprograms cancer cells to acquire resistance to oxidative stress by Sasaki, Yuto, Takagane, Kurara, Konno, Takumi, Itoh, Go, Kuriyama, Sei, Yanagihara, Kazuyoshi, Yashiro, Masakazu, Yamada, Satoru, Murakami, Shinya, Tanaka, Masamitsu

“…Asporin (ASPN), a small leucine‐rich proteoglycan expressed predominantly by cancer associated fibroblasts (CAFs), plays a pivotal role in tumor progression…”
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Cancer‐associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T‐cell suppression by Itoh, Go, Takagane, Kurara, Fukushi, Yuma, Kuriyama, Sei, Umakoshi, Michinobu, Goto, Akiteru, Yanagihara, Kazuyoshi, Yashiro, Masakazu, Tanaka, Masamitsu

“…In some tumors, a small number of cancer cells are scattered in a large fibrotic stroma. Here, we demonstrate a novel mechanism for expansion of pro‐tumor…”
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MicroRNA‐143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer by Naito, Yutaka, Sakamoto, Naoya, Oue, Naohide, Yashiro, Masakazu, Sentani, Kazuhiro, Yanagihara, Kazuyoshi, Hirakawa, Kosei, Yasui, Wataru

“…Gastric cancer (GC) is one of the most common malignancies worldwide. In particular, scirrhous type GC is highly metastatic and is characterized clinically by…”
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Drug-exposed cancer-associated fibroblasts facilitate gastric cancer cell progression following chemotherapy by Ishii, Takahiro, Suzuki, Ayako, Kuwata, Takeshi, Hisamitsu, Shoshi, Hashimoto, Hiroko, Ohara, Yuuki, Yanagihara, Kazuyoshi, Mitsunaga, Shuichi, Yoshino, Takayuki, Kinoshita, Takahiro, Ochiai, Atsushi, Shitara, Kohei, Ishii, Genichiro

“…Background Cancer progression following chemotherapy is a significant barrier to effective cancer treatment. We aimed to evaluate the role of drug-exposed…”
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Cancer cells with high-metastatic potential promote a glycolytic shift in activated fibroblasts by Kogure, Akiko, Naito, Yutaka, Yamamoto, Yusuke, Yashiro, Masakazu, Kiyono, Tohru, Yanagihara, Kazuyoshi, Hirakawa, Kosei, Ochiya, Takahiro, Singh, Pankaj K

“…Cancer-associated fibroblasts (CAFs) are activated fibroblasts and are the major stromal component in various types of malignancies. CAFs often undergo…”
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Efficacy of a Third-Generation Oncolytic Herpes Virus G47Δ in Advanced Stage Models of Human Gastric Cancer by Sugawara, Kotaro, Iwai, Miwako, Yajima, Shoh, Tanaka, Minoru, Yanagihara, Kazuyoshi, Seto, Yasuyuki, Todo, Tomoki

“…Advanced gastric cancer, especially scirrhous gastric cancer with peritoneal dissemination, remains refractory to conventional therapies. G47Δ, a…”
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Polyvinyl alcohol scaffolds and supplementation support 3D and sphere culturing of human cancer cell lines by reducing apoptosis and promoting cellular proliferation by Okita, Yukari, Zheng, Ling, Kawanishi, Kunio, Miyoshi, Hirotoshi, Yanagihara, Kazuyoshi, Kato, Mitsuyasu

“…Three‐dimensional (3D) culturing mimics the heterogeneous cellular conditions of the in vivo tumor microenvironment compared to 2D monolayer‐cultured cells and…”
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The Metastasis-Associated microRNA miR-516a-3p Is a Novel Therapeutic Target for Inhibiting Peritoneal Dissemination of Human Scirrhous Gastric Cancer by TAKEI, Yoshifumi, TAKIGAHIRA, Misato, MIHARA, Keichiro, TARUMI, Yuzo, YANAGIHARA, Kazuyoshi

“…Although aberrant microRNA (miRNA) is expressed in different types of human cancer tissues, its pathophysiologic role and the relevance of tumorigenesis and…”
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Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor by Amada, Kohei, Hijiya, Naoki, Ikarimoto, Sawa, Yanagihara, Kazuyoshi, Hanada, Toshikatsu, Hidano, Shinya, Kurogi, Shusaku, Tsukamoto, Yoshiyuki, Nakada, Chisato, Kinoshita, Keisuke, Hirashita, Yuka, Uchida, Tomohisa, Shin, Toshitaka, Yada, Kazuhiro, Hirashita, Teijiro, Kobayashi, Takashi, Murakami, Kazunari, Inomata, Masafumi, Shirao, Kuniaki, Aoki, Masahiro, Takekawa, Mutsuhiro, Moriyama, Masatsugu

“…Constitutive activation of the mitogen‐activated protein kinase (MAPK) signaling pathway is essential for tumorigenesis of pancreatic ductal adenocarcinoma…”
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Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation by Okuyama, Keiichiro, Kitajima, Yoshihiko, Egawa, Noriyuki, Kitagawa, Hiroshi, Ito, Kotaro, Aishima, Shinichi, Yanagihara, Kazuyoshi, Tanaka, Tomokazu, Noshiro, Hirokazu

“…Mitochondrial quality control (MQC) protects against potentially damaging events, such as excessive generation of mitochondrial reactive oxygen species…”
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Cancer-associated fibroblast-dependent and -independent invasion of gastric cancer cells by Kondo, Ryotaro, Sakamoto, Naoya, Harada, Kenji, Hashimoto, Hiroko, Morisue, Ryo, Yanagihara, Kazuyoshi, Kinoshita, Takahiro, Kojima, Motohiro, Ishii, Genichiro

“…Purpose Cancer cells are known to exhibit a cancer-associated fibroblast (CAF)-dependent invasive mode in the presence of CAFs. The purpose of this study was…”
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Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer by Matsukawa, Yasuko, Semba, Shuho, Kato, Hirotaka, Ito, Akihiko, Yanagihara, Kazuyoshi, Yokozaki, Hiroshi

“…Overexpression of the enhancer of zeste homolog 2 (EZH2) protein, a known repressor of gene transcription, has been reported to be associated with biological…”
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Tissue factor-induced fibrinogenesis mediates cancer cell clustering and multiclonal peritoneal metastasis by Miyazaki, Makoto, Nakabo, Ayaka, Nagano, Yoshiko, Nagamura, Yuko, Yanagihara, Kazuyoshi, Ohki, Rieko, Nakamura, Yoshikazu, Fukami, Kiyoko, Kawamoto, Jun, Umayahara, Kenji, Sakamoto, Masaru, Iwaya, Keiichi, Yamaguchi, Hideki

“…Peritoneal metastasis is one of the most frequent causes of death in several types of advanced cancers; however, the underlying molecular mechanisms remain…”
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Exosomes secreted by ST3GAL5high cancer cells promote peritoneal dissemination by establishing a premetastatic microenvironment by Horie, Misato, Takagane, Kurara, Itoh, Go, Kuriyama, Sei, Yanagihara, Kazuyoshi, Yashiro, Masakazu, Umakoshi, Michinobu, Goto, Akiteru, Arita, Junichi, Tanaka, Masamitsu

“…Peritoneal dissemination of cancer affects patient survival. The behavior of peritoneal mesothelial cells (PMCs) and immune cells influences the establishment…”
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Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion by Tanaka, Masamitsu, Kuriyama, Sei, Itoh, Go, Maeda, Daichi, Goto, Akiteru, Tamiya, Yutaro, Yanagihara, Kazuyoshi, Yashiro, Masakazu, Aiba, Namiko

“…Peritoneal mesothelial cells (PMC) cover organ surfaces in the abdominal cavity. In this study, lineage tracing revealed that the PMCs guide cancer cell…”
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Epigenetic modulation and repression of miR-200b by cancer-associated fibroblasts contribute to cancer invasion and peritoneal dissemination in gastric cancer by Kurashige, Junji, Mima, Kosuke, Sawada, Genta, Takahashi, Yusuke, Eguchi, Hidetoshi, Sugimachi, Keishi, Mori, Masaki, Yanagihara, Kazuyoshi, Yashiro, Masakazu, Hirakawa, Kosei, Baba, Hideo, Mimori, Koshi

“…Cancer-associated fibroblasts (CAFs) have recently been linked to the invasion and metastasis of gastric cancer. In addition, the microRNA (miR)-200 family…”
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PLOD2 as a potential regulator of peritoneal dissemination in gastric cancer by Kiyozumi, Yuki, Iwatsuki, Masaaki, Kurashige, Junji, Ogata, Yoko, Yamashita, Kohei, Koga, Yuki, Toihata, Tasuku, Hiyoshi, Yukiharu, Ishimoto, Takatsugu, Baba, Yoshifumi, Miyamoto, Yuji, Yoshida, Naoya, Yanagihara, Kazuyoshi, Mimori, Koshi, Baba, Hideo

“…Peritoneal dissemination is the most common metastatic pattern in advanced gastric cancer (GC) and has a very poor prognosis. However, its molecular mechanism…”
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