Search Results - "YAN, HONG HUA"
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The Pathogenesis of Aspergillus fumigatus , Host Defense Mechanisms, and the Development of AFMP4 Antigen as a Vaccine
Published in Polish journal of microbiology (01-03-2021)“…is one of the ubiquitous fungi with airborne conidia, which accounts for most aspergillosis cases. In immunocompetent hosts, the inhaled conidia are rapidly…”
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Prediction method of soil horizontal displacement caused by non-uniform distribution of disturbance force in shield construction
Published in Facets (Ottawa) (09-03-2023)“…Based on the Mindlin solution, this paper considers the influence of factors such as the non-uniform distribution of additional thrust of the cutter head…”
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Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-β/STAT3 Pathway
Published in Cellular physiology and biochemistry (01-01-2018)“…Background/Aims: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant tumors with poor prognosis. Conventional chemotherapies including…”
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Microstructure and physical properties of Cu-2.3Ni-0.5Si alloy with thermo-mechanical treatment
Published in Rare metals (2023)“…Graphical abstract…”
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Combination Therapy of the Active KRAS-Targeting Antibody inRas37 and a PI3K Inhibitor in Pancreatic Cancer
Published in Biomolecules & therapeutics (01-05-2022)“…KRAS activating mutations, which are present in more than 90% of pancreatic cancers, drive tumor dependency on the RAS/mitogen-activated protein kinase (MAPK)…”
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Deformation behavior of fine-grained 5083 Al alloy at elevated temperature
Published in Transactions of Nonferrous Metals Society of China (01-09-2009)“…The microstructure evolution of the fine-grained 5083 Al alloy was investigated in annealing temperature range of 150–300 °C. Then the effects of the different…”
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Tumor vessel normalization by the PI3K inhibitor HS-173 enhances drug delivery
Published in Cancer letters (10-09-2017)“…Tumor vessels are leaky and immature, which causes poor oxygen and nutrient supply to tumor vessels and results in cancer cell metastasis to distant organs…”
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Comparative immunological evaluation of recombinant Salmonella Typhimurium strains expressing model antigens as live oral vaccines
Published in BMC immunology (26-09-2012)“…Despite the development of various systems to generate live recombinant Salmonella Typhimurium vaccine strains, little work has been performed to…”
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PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis
Published in Biomolecules & therapeutics (01-03-2020)“…Phosphoinositide 3-kinase (PI3K) is considered as a promising therapeutic target for rheumatoid arthritis (RA) because of its involvement in inflammatory…”
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10
Production of mouse monoclonal antibodies against Helicobacter pylori Lpp20 and mapping the antigenic epitope by phage display library
Published in Journal of immunological methods (31-08-2007)“…Lpp20, an outer membrane protein of Helicobacter pylori ( H. pylori), has been identified as an immunodominant antigen. To obtain mouse monoclonal antibodies…”
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ANGPTL4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a
Published in EMBO molecular medicine (07-08-2020)“…Pancreatitis is the inflammation of the pancreas. However, little is known about the genes associated with pancreatitis severity. Our microarray analysis of…”
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PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis
Published in Biomolecules & therapeutics (01-03-2020)“…Phosphoinositide 3-kinase (PI3K) is considered as a promising therapeutic target for rheumatoid arthritis (RA) because of its involvement in inflammatory…”
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13
Anticancer activity of HS-527, a novel inhibitor targeting PI3-kinase in human pancreatic cancer cells
Published in Cancer letters (10-10-2014)“…Highlights • HS-527 inhibits the angiogenesis of pancreatic cancer. • HS-527 induces the apoptosis of pancreatic cancer. • HS-527 inhibit PI3K/Akt signaling…”
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HS-104, a PI3K inhibitor, enhances the anticancer efficacy of gemcitabine in pancreatic cancer
Published in International journal of oncology (01-07-2014)“…Gemcitabine has limited clinical benefits for pancreatic cancer patients. The phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway is important in cell…”
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Pulmonary immune responses to 2009 pandemic influenza A (H1N1) virus in mice
Published in BMC infectious diseases (12-04-2014)“…Well-characterized mice models will afford a cheaper, easy-handling opportunity for a more comprehensive understanding of 2009 influenza A (H1N1) virus's…”
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Numerical and experimental investigations of semi-solid AZ91D magnesium alloy in thixoforming process
Published in Journal of materials processing technology (20-06-2008)“…Many complicated factors affect thixoforming fluidity in thixoforming process of semi-solid metal (SSM). So, it is important to forecast the flow property of…”
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Artemisia Capillaris leaves inhibit cell proliferation and induce apoptosis in hepatocellular carcinoma
Published in BMC complementary and alternative medicine (08-05-2018)“…Natural product is one of the most important sources of drugs used in pharmaceutical therapeutics. Artemisia capillaris has been traditionally used as a…”
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Application of Artificial Intelligence Technology in Short-range Logistics Drones
Published in 2019 8th International Symposium on Next Generation Electronics (ISNE) (01-10-2019)“…With the increasing demand for logistics in China, the shortcomings of the current short-range logistics field are inefficient, and the occupation of labor is…”
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Conference Proceeding -
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Oncolytic adenovirus expressing relaxin (YDC002) enhances therapeutic efficacy of gemcitabine against pancreatic cancer
Published in Cancer letters (28-06-2017)“…Abstract Pancreatic cancer is a highly lethal disease for which limited therapeutic options are available. Pancreatic cancer exhibits a pronounced…”
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Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway
Published in Acta pharmacologica Sinica (01-12-2011)“…Aim: To investigate the effects of wogonin (5,7-dihydroxy-8-methoxyflavone) extracted from Scutellaria baicalensis Georgi (S baicalensis) on…”
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