Search Results - "YAMNIUK, Aaron P"

Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases by Xie, Jenny H, Yamniuk, Aaron P, Borowski, Virna, Kuhn, Robert, Susulic, Vojkan, Rex-Rabe, Sandra, Yang, Xiaoxia, Zhou, Xiadi, Zhang, Yifan, Gillooly, Kathleen, Brosius, Ruth, Ravishankar, Rathna, Waggie, Kimberly, Mink, Kathy, Price, Laura, Rehfuss, Robert, Tamura, James, An, Yongmi, Cheng, Lin, Abramczyk, Bozena, Ignatovich, Olga, Drew, Philip, Grant, Steven, Bryson, James W, Suchard, Suzanne, Salter-Cid, Luisa, Nadler, Steven, Suri, Anish

“…CD40-CD40L interactions play a critical role in regulating immune responses. Blockade of CD40L by Abs, such as the anti-CD40L Ab 5c8, demonstrated positive…”
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Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb by Lan, Wenkui, Valente, Joseph J, Ilott, Andrew, Chennamsetty, Naresh, Liu, Zhihua, Rizzo, Joseph M, Yamniuk, Aaron P, Qiu, Difei, Shackman, Holly M, Bolgar, Mark S

“…During the development of a therapeutic monoclonal antibody (mAb-1), the charge variant profile obtained by pH-gradient cation exchange chromatography (CEX)…”
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Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope by Yamniuk, Aaron P., Suri, Anish, Krystek, Stanley R., Tamura, James, Ramamurthy, Vidhyashankar, Kuhn, Robert, Carroll, Karen, Fleener, Catherine, Ryseck, Rolf, Cheng, Lin, An, Yongmi, Drew, Philip, Grant, Steven, Suchard, Suzanne J., Nadler, Steven G., Bryson, James W., Sheriff, Steven

“…Current clinical anti-CD40 biologic agents include both antagonist molecules for the treatment of autoimmune diseases and agonist molecules for…”
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The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex by Ramamurthy, Vidhyashankar, Yamniuk, Aaron P., Lawrence, Eric J., Yong, Wei, Schneeweis, Lumelle A., Cheng, Lin, Murdock, Melissa, Corbett, Martin J., Doyle, Michael L., Sheriff, Steven

“…The structure of death receptor 4 (DR4) in complex with TNF‐related apoptosis‐inducing ligand (TRAIL) has been determined at 3 Å resolution and compared with…”
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Therapeutic Activity of Agonistic, Human Anti-CD40 Monoclonal Antibodies Requires Selective FcγR Engagement by Dahan, Rony, Barnhart, Bryan C., Li, Fubin, Yamniuk, Aaron P., Korman, Alan J., Ravetch, Jeffrey V.

“…While engagement of the inhibitory Fcγ-receptor (FcγR) IIB is an absolute requirement for in vivo antitumor activity of agonistic mouse anti-CD40 monoclonal…”
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Calcium-dependent and -independent Binding of Soybean Calmodulin Isoforms to the Calmodulin Binding Domain of Tobacco MAPK Phosphatase-1 by Rainaldi, Mario, Yamniuk, Aaron P., Murase, Tomohiko, Vogel, Hans J.

“…The recent finding of an interaction between calmodulin (CaM) and the tobacco mitogen-activated protein kinase phosphatase-1 (NtMKP1) establishes an important…”
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The Solution Structures of Two Soybean Calmodulin Isoforms Provide a Structural Basis for Their Selective Target Activation Properties by Ishida, Hiroaki, Huang, Hao, Yamniuk, Aaron P., Takaya, Yoshiaki, Vogel, Hans J.

“…The intracellular calcium ion is one of the most important secondary messengers in eukaryotic cells. Ca2+ signals are translated into physiological responses…”
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IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells by Ward, Natasha C, Yu, Aixin, Moro, Alejandro, Ban, Yuguang, Chen, Xi, Hsiung, Sunnie, Keegan, James, Arbanas, Jaren M, Loubeau, Martine, Thankappan, Anil, Yamniuk, Aaron P, Davis, Jonathan H, Struthers, Mary, Malek, Thomas R

“…Low-dose IL-2 represents an immunotherapy to selectively expand regulatory T cells (Tregs) to promote tolerance in patients with autoimmunity. In this article,…”
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Metal Ion Binding Properties and Conformational States of Calcium- and Integrin-Binding Protein by Yamniuk, Aaron P, Nguyen, Leonard T, Hoang, Tung T, Vogel, Hans J

“…Calcium- and integrin-binding protein (CIB) is a novel member of the helix−loop−helix family of regulatory calcium-binding proteins which likely has a specific…”
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Solution structures of the SH3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels by Ishida, Hiroaki, Skorobogatov, Anton, Yamniuk, Aaron P., Vogel, Hans J.

“…Shank proteins are abundant scaffold proteins in the postsynaptic density (PSD) region of brain synapses. Mutations in Shank proteins are associated with…”
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Characterization and quantification of histidine degradation in therapeutic protein formulations by size exclusion-hydrophilic interaction two dimensional-liquid chromatography with stable-isotope labeling mass spectrometry by Wang, Chunlei, Chen, Sike, Brailsford, John A., Yamniuk, Aaron P., Tymiak, Adrienne A., Zhang, Yingru

“…•An SEC-HILIC 2DLC method to characterize histidine degradation in protein formulations.•First usage of stable-isotope dilution MS for heart-cutting 2DLC…”
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Protein conformational changes studied by diffusion NMR spectroscopy: Application to helix‐loop‐helix calcium binding proteins by Weljie, Aalim M., Yamniuk, Aaron P., Yoshino, Hidenori, Izumi, Yoshinobu, Vogel, Hans J.

“…Pulsed‐field gradient (PFG) diffusion NMR spectroscopy studies were conducted with several helix‐loop‐helix regulatory Ca2+‐binding proteins to characterize…”
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Calmodulin has the Potential to Function as a Ca2+-Dependent Adaptor Protein by Yamniuk, Aaron P., Rainaldi, Mario, Vogel, Hans J.

“…Calmodulin (CaM) is a versatile Ca 2+ -binding protein that regulates the activity of numerous effector proteins in response to Ca 2+ signals. Several…”
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Structurally Homologous Binding of Plant Calmodulin Isoforms to the Calmodulin-binding Domain of Vacuolar Calcium-ATPase by Yamniuk, Aaron P., Vogel, Hans J.

“…The discovery that plants contain multiple calmodulin (CaM) isoforms having variable sequence identity to mammalian CaM has sparked a flurry of new questions…”
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Bioavailability of protein therapeutics in rats following inhalation exposure: Relevance to occupational exposure limit calculations by Gould, Janet C., Carvajal, Irvith, Davidson, Todd, Graham, Jessica, Hillegass, Jedd, Julien, Susan, Kozhich, Alex, Wang, Bonnie, Wei, Hui, Yamniuk, Aaron P., Mathias, Neil, Haggerty, Helen G., Graziano, Michael

“…Protein therapeutics represent a rapidly growing proportion of new medicines being developed by the pharmaceutical industry. As with any new drug, an…”
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Thermodynamic characterization of the interactions between the immunoregulatory proteins osteopontin and lactoferrin by Yamniuk, Aaron P., Burling, Hans, Vogel, Hans J.

“…The immunoregulatory proteins osteopontin (OPN) and lactoferrin (LF) are both highly abundant in milk, with a conserved ratio between different mammalian…”
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Application of a kosmotrope-based solubility assay to multiple protein therapeutic classes indicates broad use as a high-throughput screen for protein therapeutic aggregation propensity by Yamniuk, Aaron P, Ditto, Noah, Patel, Mehul, Dai, Jun, Sejwal, Preeti, Stetsko, Paul, Doyle, Michael L

“…Aggregation propensity is a critical attribute of protein therapeutics that can influence production, manufacturing, delivery, and potential activity and…”
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Characterization of Mauritian Cynomolgus Macaque FcγR Alleles Using Long-Read Sequencing by Haj, Amelia K, Arbanas, Jaren M, Yamniuk, Aaron P, Karl, Julie A, Bussan, Hailey E, Drinkwater, Kenneth Y, Graham, Michael E, Ericsen, Adam J, Prall, Trent M, Moore, Kristina, Cheng, Lin, Gao, Mian, Graziano, Robert F, Loffredo, John T, Wiseman, Roger W, O'Connor, David H

“…The FcγRs are immune cell surface proteins that bind IgG and facilitate cytokine production, phagocytosis, and Ab-dependent, cell-mediated cytotoxicity. FcγRs…”
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Calmodulin's flexibility allows for promiscuity in its interactions with target proteins and peptides by YAMNIUK, Aaron P, VOGEL, Hans H

“…The small bilobal calcium regulatory protein calmodulin (CaM) activates numerous target enzymes in response to transient changes in intracellular calcium…”
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Thermodynamic Effects of Noncoded and Coded Methionine Substitutions in Calmodulin by Yamniuk, Aaron P., Ishida, Hiroaki, Lippert, Dustin, Vogel, Hans J.

“…The methionine residues in the calcium (Ca 2+) regulatory protein calmodulin (CaM) are structurally and functionally important. They are buried within the N-…”
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